Zvakanakira zveHpcMune zvakadzama kuburitswa mafomu
HydroxyPropyl methylcellose (HPMC) ndeye polymer yakashandiswa zvakanyanya mumishonga yemishonga, kunyanya mune yakadzorwa kuburitswa. Kuzivikanwa kwaro kunobva pane zvaro zvakasarudzika izvo zvinoita kuti ive yakanyatsokodzera kunyorera kwakadaro. Heano zvimwe zvakanakira kushandisa HPMC mune yakadzorwa kuburitswa mafomu ekuburitswa:
Kuedza Izvi zvinosanganisira zvinobvumidza kuchinjika mukugadzira magadzirirwo ekusangana kwakananga kusunungura zvinodhaka zvinodiwa.
Kuburitswa Kuburitswa: Chimwe chezvakanyanya zvakanakira HPMC ndiko kugona kwayo kudzora kusunungurwa kwezvinodhaka pane imwe nguva yakawedzerwa. HPMC inoumba gel layer kana hydrate, iyo inoita sechipinganidzo, kudzora kusiyana kwezvinodhaka kubva kune iyo dosge fomu. Ichi chivakwa chakakosha pakuzadzisa kusunungurwa zvinodhaka zvinodhaka, kuvandudza kutevedzera kwemurwere, uye kuderedza kuwanda kwekurasa.
Hydration Rate: HPMC's Hydration chiyero chinogona kuchinjwa nekuchinja uremu hwayo, kutsiva chikamu, uye giredhi reViscosity. Izvi zvinobvumidza kutonga kwakanyanya pamusoro pemuyero wekuburitswa kwezvinodhaka, kugonesa masayendisiti ekuumbwa kuti agadzirise mafambiro ezvakananga eharmacokinetic zvido zvemushonga.
Kuenderana:Hpcinoenderana nehuwandu hwakawanda hwekuita basa rinoshanda mishonga (APIS), maEnccivients, uye maitiro ekugadzirisa. Inogona kushandiswa nehydrophilic uye hydrophobic zvinodhaka, zvichiita kuti zviite kuti zvidzoreredze kuenzanisa huwandu hwezvinhu zvechinangwa zvigadzirwa.
Asiri-ane chepfu uye biocompable: HPMC inotorwa kubva kuCellulose, yakasikwa inoitika polymer, ichiita kuti isipo-ine muchetura uye biocompable. Iyo inogamuchirwa zvakanyanya yekushandiswa mumishonga yemishonga uye inosangana inodzora zvinodiwa zvekuchengetedza uye kushanda.
Kuvandudzwa Kugadzikana: HPMC inogona kuwedzera kugadzikana kwezvinodhaka nekuvadzivirira kubva pakusvibiswa kwakakonzerwa nezvinhu zvemhoteredzo, oksijeni uye mwenje. Ichi chivakwa chinonyanya kubatsira zvinodhaka izvo zvine hanya nekushatisa kana kuratidza kuratidzira kudzikisira.
Kufanana kweDosage: HPMC AIDS mukuwana yunifomu yekugoverwa kwemushonga mukati meiyo dosge fomu, zvichikonzera kusanzwisisika zvinodhaka kubva kuyuniti kusvika kuyuniti. Izvi zvinovimbisa kufanana kweDosage uye kuderedza kusiyana-siyana mune zvinodhaka maplasma mazinga, zvichitungamira kuvandudza zvibodzwa zvekurapa.
Kuvira
Zvakanaka zvehupfumi: HPMC inodhura-inoshanda kana ichienzaniswa nedzimwe polymers inoshandiswa mukudzorwa kwakadzorwa. Kuwanika kwayo kwakapararira uye kusununguka kwekugadzira kunobatsira kune izvo zvakanaka zvehupfumi, zvichiita sarudzo inokwezva yemakambani emishonga.
Regulatory Kugamuchirwa:Hpcyakanyorwa muPharmacous dzakasiyana-siyana uye ine nhoroondo refu yekushandiswa mune mishonga yemishonga. Kugamuchirwa kwaro kwekugamuchira kwakarerutsa maitiro ekubvumidza kwezvigadzirwa zvinodhaka zvine hpmc, kupa iyo nzira inokurumidza kuenda kumusika kune mishonga yekugadzira mishonga.
HPMC inopa zvizhinji zvakanaka zvakaburitswa zvinodzorwa, zvinosanganisira zvinodzorwa zvinodhaka, zvinopesana, zvinoenderana, kugadzikana, kugashira, uye kugamuchirwa kwekutonga. Zvivakwa zvaro zvakasarudzika zvinoita kuti ive yakakosha polymer mukuvandudzwa kwekusunungurwa
Kutumira Nguva: Kubvumbi-27-2024