HydroxyPropyl methylcellose (HPMC), anozivikanwawo seHyprollose, inzvimbo inoverengeka inoshandiswa zvakanyanya muindasitiri yemishonga. Icho chiSynthetic, inert, viscoelastic polymer kubva ku cellulose, chivakwa chechipfuva. HPMC inokosheswa kuti isimbe mumvura, isina kujairika yemvura, uye kugona kwayo kuumba mafirimu uye gels.
1. Binder mune piritsi mafomu
Chimwe chezvinyorwa zvekutanga zveHPMC mumishonga inokwana kuita seyakagadzirwa mune piritsi mafomu. HPMC inoshandiswa kuve nechokwadi chekuti izvo zvinongedzo mudapheni zvine chekuita uye kuramba wakagadzikana kusvika kumeression. Zvivakwa zvaro zvinosunga zvinovandudza mashandiro emapiritsi, achivaita kuti varege kushatisa kuhukura kana kupaza panguva yekurongedza, zvifambiso, uye kubata. Pamusoro pezvo, HPMC's is-ionic yakasikwa inovimbisa hazviite nezvimwe zvinoshandiswa, ichichengetedza kugadzikana uye kushanda kweiyo inoshanda mishonga yemishonga (APSI).
2. Kudzora Kuburitswa Matrix
HPMC yakakosha mukuvandudzwa kwekusunungurwa kwekusunungurwa (CR) uye kusunungurwa (SR) mafomu. Aya mafambiro akagadzirirwa kusunungura mushonga pachigadziko chakatemerwa, kuchengetedza zviyero zvinopindirana zvinodhaka muropa pamusoro penguva yakareba. Hpmc's gel-yekugadzira kugona kusangana neine gastrointestinal fluid inoita kuti ive yakakodzera nekuda kwechinangwa ichi. Iyo inoumba viscous gel danda rakatenderedza piritsi, kudzora kusiyana kwemushonga. Hunhu uhwu hwounonyanya kubatsira zvinodhaka neinonyepedzera index, sezvazvinobatsira pakuchengetedza iyo yadikanwa plasma constentation, nekukasira kushanda kwemhedzisiro uye kudzora mhedzisiro.
3. Firimu kuunganidza
Chimwe chinhu chakakosha cheHPMC iri mufirimu yekuvhara mahwendefa nemakapu. HpMC-yakavakirwa machira anochengetedza piritsi kubva pazvinhu zvemunharaunda zvakadai seunyoro, mwenje, uye mhepo, iyo inogona kushatisa izvo zvinoshanda zvinoshanda. Mafirimu ekuchengeterawo anowedzera kukwikwidza kwehasha Uyezve, huku HPMC dzinogona kugadzirwa kuti ugadzirise iyo yekuburitsa nhoroondo yemushonga, kubatsira mune yakanangidzirwa kuburitsa masisitimu.
4. Kuomesa mumiririri
HPMC inoshanda seyekubudirira mumiririri anowedzera mune zvemvura mafomu akadai seumidhi uye kumiswa. Kugona kwayo kuwedzera viscosity pasina kudzikisira zvimwe zvinhu zvekuumbwa zvinobatsira mukugoverwa kwemushonga mukati meiyo mvura, kudzivirira sosi yezvimisikidzwa, uye kupa muromo unodikanwa muromo. Ichi chivakwa chinonyanya kukosha muPediatric uye Geriatric mafomu, uko kusunungurwa kwekutonga kwakaoma.
5. STabilizer mune yepamusoro mafomu
Mune zvemukati zvemukati semakiromita, Gels, uye mafuta, hpm zviito sechigadzirwa sedhizimusi uye emulsifier. Iyo inobatsira kuchengetedza kusakwana uye kugadzikana kweiyo fomu, ichiva nechokwadi chekuti izvo zvinoshandiswa zvinoshanda zvinogovaniswa. HPMC zvakare inopawo chimiro chakatsiga, kuvandudza chikumbiro uye kusiira kwechigadzirwa paganda. Yayo isiri-isiritiri chisikwa inoita kuti iite yakakodzera kushandiswa mune mafambiro eganda renje.
6. Ofthhalmic gadziriro
HPMC yakanyanya kushandiswa muEfhthalm Yayo viscoelastic zvivakwa kutevedzera iyo yakasikwa yemaziso firimu, inopa lubrication uye kunyorova kumaziso. HPMC-yakavakirwa ziso rakanyatsobatsira kune vamwe vanhu vane yakaoma ziso ziso syndrome, kupa zororo kubva mukutsamwa uye kusagadzikana. Pamusoro pezvo, HPMC inoshandiswa muOcular Dishm Dishms Systems, uko iyo inobatsira mukuwedzera nguva yekufonera yemushonga neocular pamusoro, kuvandudza maitiro ekuratidzira.
7. Capsule fomu
HPMC inoshandiswawo mukugadzira kwakaoma uye zvakapfava capsules. Iyo inoshanda seimwe nzira yekugezesa, ichipa sarudzo yemakwenzi emakapu eCapule. HPMC capsules inodiwa kune yavo yakadzika manyoreredzo, iyo inobatsira kune zvinodhaka zvinodhaka. Ivo vanopa zvakare kugadzikana kuri nani mumamiriro ezvinhu epakatiririka uye vasingakwanisi kuyambuka-chinongedzo, nyaya yakajairika neGelatin Capules inogona kukanganisa zvinodhaka zvekusunungurwa zvinodhaka.
8. BioavhaBility Kuwedzera
Mune mamwe mafambiro, HPMC inogona kuwedzera kusimudzira kwezvinhu zvinodhaka zvisina kufanira. Nekugadzira gel matrix, HPMC inogona kuwedzera iyo yekuvhenekera kwemushonga mugwara regastrointestinal, kufambisa zviri nani kutumira. Izvi zvinonyanya kukosha kuti zvinodhaka neyakaderera mvura solubility, sekudzikira kwekunyungudika kunogona kukanganisa zvakanyanya zvinobata zvinodhaka.
9. Mucoadhesive application
HPMC inoratidza many-mucoadhesive zvivakwa, zvichiita kuti zviite zvakakodzera uye zvinodhaka zvinodhaka zvinodhaka. Masisitimu aya anoda mushonga wekutevedzera mucous membranes, kupa kusunungurwa kwenguva refu uye kusihwa zvakananga mumugwagwa, uchikanganisa yekutanga-yekupfuura metabolism. Iyi nzira inobatsira kuti zvinodhaka zvinosvibisa munzvimbo yeaidhi yemudumbu kana ine zvisina kunaka emuromo bioavilability.
Iyo inopesana ne hydroxypruppropyl methylcellose (HPMC) mune mishonga mafomu haigone kuve yakachengeteka. Zvinoshandiswa zvaro zvinobva piritsi kubva piritsi zvinosungirwa uye firimu kuunganidza kusvika pakubata uye kusimbisa vamiririri mune dzakasiyana siyana mafambiro. Hpmc's kugona kugadzirisa zvinodhaka zvekusunungura zvinodhaka Sezvo indasitiri yemishonga inoenderera mberi nekushanduka, iyo hpm ingangowedzera, inotungamirwa nekuenderera mberi nekutsvaga nekuvandudza kuedza kwakaringana nekukwezva kwezvinodhaka uye zvabuda murwere.
Kutumira Nguva: Jun-05-2020