Hydroxyprupyl methylcellose (HPMC)is nonitic cellulose ether neakanaka firimu-kugadzira, kudenha, kurwadziswa uye kudzora zvivakwa, uye inoshandiswa zvakanyanya muindasitiri yemishonga. Semishonga yemishonga, kusagadzikana ®hpmc inogona kushandiswa mumapiritsi, makapindu, gadziriro-yekugadzirira-gadziriro, gadziriro yekugadzirira uye misoro yekuzvitakura.
1. Phyicochemical Properties yeHPMC
HPMC ndeye semi-synthetic polymer yakawanikwa ne methylating uye hydroxyprupylating natural cellows, ine yakanakisa mvura solubility uye biocomputer. Yayo solubility haina kukanganiswa nekushisa uye pro kukosha, uye inogona kuzvimba mumvura kuti iite viscous mhinduro, iyo inobatsira kuburitswa kwezvinodhaka. Sekureva kweiyo viscosity, HPMC inogona kukamurwa kuita zvikamu zvitatu: Low viscosity (5-100 mpa · · ·), pakati peviscosity (100-4000 mpa · ara) uye yakakwira viscosity (4000-100000 MPA м), iyo yakakodzera zvinodiwa zvakasiyana zvinodikanwa.
2. Kushandiswa kweHPMC mune mishonga gadziriso
2.1 application mumahwendefa
HPMC inogona kushandiswa seinobatanidza, kupaza, inovhara zvinhu uye inodzorwa-yakadzora-skleton skeleton zvinyorwa mumapiritsi.
Binder:HPMC inogona kushandiswa seyekuchinjika mune yakanyorova granulation kana yakaoma granusation yekuvandudza kusimba kwesimba, piritsi kuomarara uye kuomarara kuomarara kwezvinodhaka.
Kuparadzanisa:Low-viscosity HPMC inogona kushandiswa sekuparadzanisa kusimudzira piritsi yekuparadza uye kuwedzera zvinodhaka kukuvara kwemvura mushure mekunyanyisa kwemvura.
Kubata zvinhu:HPMC ndechimwe chezvinhu zvikuru zvekutakura piritsi, izvo zvinogona kuvandudza kutaridzika kwemishonga, kufukidza kuravira kwakashata kwezvinodhaka, uye kunogona kushandiswa mukubatanidza kana kuunganidza neyekuvhara nePlatedzeers.
Kudzoserwa-Kuburitswa Zvinhu: Yakakwira-viscosity HPMC inogona kushandiswa seyechikamu cheSkeleton kunonoka kuburitswa kwezvinodhaka uye kuzosunungurwa kana kudzorwa kusunungurwa. Semuenzaniso, HPMC K4m, HPMC K11m uye HPMC K100m inowanzoshandiswa kugadzirira mahwendefa ekudzora.
2.2 Chikumbiro muKapsule Kugadzirira
HPMC inogona kushandiswa kugadzira chirimwa-yakatorwa muhombodo capules kutsiva gachati capules, izvo zvakakodzera kune vadiki uye vanhu vanoregedza kumabhonzo emhuka. Mukuwedzera, HPMC inogona kushandiswa kuzadza mvura kana semisolid capsules kuvandudza kugadzikana uye kusunungura maitiro emishonga.
2.3 Chikumbiro muOphthalmic gadziriro
HPMC, sechinhu chikuru chemisodzi yekuzvidza, inogona kuwedzera zviso zvemaziso emaziso, inowedzera nguva yekugara yemishonga pane iyo ocular pamusoro, uye kugadzirisa bioavalability. Mukuwedzera, HPMC inogona zvakare kushandiswa kugadzirira ziso ziso, mafirimu emaziso, nezvimwe, kugadzirisa zvinogadziriswa kuburitswa kwemishonga yemaziso.
2.4 Chikumbiro muMusoro wepamusoro-mushonga wekutumira kugadzirira gadziriro
Simbacelcele®hpmc ine yakanaka firimu-inoumba midziyo uye biocompuility, uye inogona kushandiswa kugadzirira transdermal patches, gaels nemakiromita. Semuenzaniso, muTransdermal Draust Dance Systems, HPMC inogona kushandiswa seye matstix zvinyorwa zvekuwedzera iyo mishonga yekubuda uye inowedzera nguva yekuita.
2,5 application muOral Liquid uye kumiswa
HPMC inogona kushandiswa seanotenderedza uye stabilizer yekuvandudza zvivakwa zvemuromo zvemuromo uye kumiswa, kudzivirira zvimedu zvakasimba kubva pakugadzirisa, uye kugadzirisa kufanana uye kugadzikana kwezvinodhaka.
2.6 Kushandisa Mukugadzirira Kugadzirira
HPMC inogona kushandiswa seinotakura kune yakaoma poda inhalers (dpis) yekuvandudza madhiragi uye kuwanda kwemishonga, wobva wawedzera mwero wemishonga, uye nekudaro inosimudzira maitiro ekurapa.
3. Zvakanakira HPMC mukugadzirira-kusunungurwa kugadzirira
HPMC ine hunhu hunotevera sekusunungurwa-kwakasunungurwa:
Yakanaka mvura solubility:Zvinogona kukurumidza kuzvimba mumvura kuti ugadzire chipinganidzo cheGel uye utore iyo yezvinodhaka kuburitsa kwezvinodhaka.
Zvakanaka Biocompuility:Isiri-ine chepfu uye isiri-inotsamwisa, haina kuyamwiswa nemuviri wemunhu, uye ine yakajeka metabolic nzira.
STROPT YEMAHARA:Inokodzera mhando dzakasiyana dzemishonga, kusanganisira yemvura-inonaka uye hydrophobic zvinodhaka.
Maitiro akapusa:Inokodzera mhando dzakasiyana siyana dzekugadzirira dzakadai seyakagadzika playting uye yakanyorova granulation.
Semunhu akakosha mishonga yekuwedzera,Hpcinoshandiswa zvakanyanya muminda yakawanda senge mapiritsi, macaps, gadziriro yeOfhticmic, gadziriro dzepamusoro, nezvimwe, kunyanya mukugadzirira-gadziriro dzekusunungurwa. Mune ramangwana, nekukura kuri kuenderera mberi kwechigadzirwa chekugadzirira kwechigadzirwa, iyo application chiyero chekusagadzikana ®hpmc ichave yakawedzera kuwedzerwa, kupa iyo indasitiri yemishonga ine sarudzo dzakachengeteka uye dzakachengeteka dzechokwadi.
Kutumira Nguva: Kukadzi-08-2025