Zvinyorwa zvinowirirana kumba uye kunze kwenyika mugadziriro yemishonga yeiyo hydroxpresslSpropyl metdropyl Zvikumbiro mumunda wezvinyorwa zvitsva zvakadai sekunamatira mafomu uye bioadhemes. Nekuda kwemusiyano muhuremu hwemanyorero uye viscosity yeHPMC, iyo ine hunhu uye kushandiswa kwe emulsificification, kudengenyeka, kusunganidzwa, kusimuka, kuchimisa uye kuumbwa-firimu. Iyo inoshandiswa zvakanyanya kugadzirira gadziriro yemishonga uye ichaita basa rakakura mumunda wekugadzirira. Nekunyatsoradzika kudzidza zvivakwa zvaro uye nekuvandudzwa kwehunyanzvi hwekufananidza, HPMC ichave yakashandiswa zvakanyanya mukutsvagisa kwemafomu matsva emukodhi uye sarudzo itsva yezvinodhaka, nekudaro inosimudzira kukura kwekuenderera mberi kwekugadzira mafomu.
hydroxypruppropyl methylcellose; gadziriso yemishonga; pharmaceutical excividents.
Gadziriso yemishonga haisi chete yezvinhu zvekuumbwa kwekugadzirira zvinodhaka, asi zvine mutsindo, kuchengetedzwa, maitiro ekuita, maitiro ezvekuita, uye kukura kwehunyanzvi madhiri emhando uye nzira nyowani dzekutonga. zvakanyatsoenderana. Iko kubuda kweiyo mitsva mishonga yekunyepedzera inowanzo kusimudzira kuvandudzwa kwegadziriro yekugadzirira uye kukura kwemhando itsva dosi. HydroxyPropyl methylcellose (HPMC) ndeimwe yeanonyanya kuzivikanwa phamaceucial excividents kumba uye kunze kwenyika. Nekuda kwehama dzayo dzakasiyana-nyoro uye zvevasangano, zvine mabasa ekuremedza, kusunga, kuremedza, kuremedza, kusimuka, zvichimanikidzwa. Zvimiro uye zvinoshandiswa senge coagulation uye kuumbwa kwefirimu zvinoshandiswa zvakanyanya mune mishonga tekinoroji. Chinyorwa ichi chinonyanya kuongorora kushandiswa kwehydroxyprupyl methylcellose (HPMC) mukuumbwa mumakore achangopfuura.
1.Basic Prezilies yeHPMC
HydroxyPropyl methyl methyl Cellelose (HPMC), iyo molecular formula8- (C10HELUTE MAHARA of cellulose. Inogona kugadzirwa munzira mbiri: Imwe ndeye iyo methyl cellows yegiredhi rakakodzera rinobatwa na naoh uye rakazoitwa nePropeyone oxide pasi pekudziya kwakanyanya uye nekumanikidza kwakanyanya. Iyo nguva yekuita inofanirwa kugara kwenguva yakareba kuti ubvumire methyl uye hydroxypruppropyl yekuumba zvisungo zveEther zvakabatana neyechuru yechinyoreso mune cellulose, uye inogona kusvika padanho raunoda; Imwe ndeyekurapa yekotoni linter kana huni purp fiber ine caustic soda, uye wozoita neklorinated methane uye procylexo oxide zvine mutsindo, uye wozoenderera mberi zvakare. , akapwanywa muzvakanaka uye yunifomu poda kana granules.
Ruvara rwechigadzirwa ichi rwakachena kusvika kune Milky White Ichi chigadzirwa chinogona kunyungudutswa mumvura kuti ugadzire zvakajeka kusvika kune Milky White cool mhinduro ine imwe viscosity. Iyo Sol-Gel Intercension phenomenson inogona kuitika nekuda kwekudziya kwekushisa kwemhinduro neine imwe pfungwa.
Nekuda kwemusiyano mune zvirimo mune aya maviri ezvikamu mune chimiro che methxy uye hydroxypruppropyl, mhando dzakasiyana-siyana dzezvigadzirwa dzakaonekwa. Mune zvakananga, mhando dzakasiyana dzezvigadzirwa zvine hunhu hunhu. Viscosity uye iyo thermal gelation tembiricha, saka ine zvivakwa zvakasiyana uye zvinogona kushandiswa nekuda kwezvikonzero zvakasiyana. Pharmacpoeia yenyika dzakasiyana siyana ane mitemo dzakasiyana uye mumienzaniso iri pamusoro pemakiredhi akasiyana ezvigadzirwa zvakatengeswa mumusika. ". MuUS Papsacoeia, 4 manhamba anowedzerwa mushure mezita renyama kuratidza kuti zvirimo zvine hutsinye zve hydroxproproprollose, vakadai manhamba maviri ekutanga anomiririra kukosha kweiyo nzira yeiyo nzira. Peresenti, manhamba maviri ekupedzisira anomiririra iyo yakaenzana muzana yehydroxyropropyl.
CaCan's HydroxyPropyl methylcellose ine 3 dzakatevedzana, kureva E Series, F Revedzeri uye K Seriety, imwe neimwe yakatevedzana ine mhando dzakasiyana siyana kusarudza kubva. E e Series inonyanya kushandiswa seyemafirimu matsara, inoshandiswa piritsi yekuvhara, yakavhara piritsi cores; E, F Series inoshandiswa seVascotififels uye kusunungura vamiririri vekugadzirira kweOphthalmic gadziriro, kumisa vamiririri, mahwendefa ekugadzirira kwemvura, mahwendefa uye mahwendefa emakonzo; K nhare inonyanya kushandiswa seyinosunungura inhibitors uye hydrophilic gel matsrix midziyo yekugadzirira uye inodzorwa yekugadzirira gadziriro.
Vagadziri vepamba vanonyanya kusanganisira Fuzhou Nhamba 2 Chemical fekitori uye Hubei Jinxian Comical Acomputer Cemical Comical Co. ., Ltd., Xi'an Huian makemikari zvidyarwa, nezvimwe.
2.Zvakanakira HPMC
HPMC yave iri imwe yeanonyanya kushandiswa mishonga yekunyepedzera kumba uye kunze kwenyika, nekuti Hpmc ine zvakanakira izvo zvimwe zvinyoreso zvisina.
2.1 inotonhora mvura solubility
Shoma mumvura inotonhora pazasi makumi mana emvura
2.2 chemakemikari inert
HPMC rudzi rusina-ionic cellulose ether, mhinduro yayo haina iyo yeionic mhosva uye haina kupindirana nemazwi esimbi
2.3 Kugadzikana
Iyo yakagadzikana kune ese acid naAlkali, uye inogona kuchengetwa kwenguva yakareba pakati pH 3 ne1 11 pasina shanduko yakakosha muViscosity. Mhinduro yemvura yeHPMC ine anti-nyoro-nyoro uye inochengetedza yakanaka viscosity kugadzikana panguva yekuchengetedza kwenguva refu. Iyo pharmaceucal excpients uchishandisa HPMC ine hutano husina kunaka kupfuura izvo zvinoshandiswa zvechinyakare zvakanaka (senge dextrin, starch, nezvimwewo).
2.4 Viscossity Kuwedzeredza
Yakasiyana viscosity inobva Hpmc inogona kusanganiswa mune dzakasiyana zviyero, uye zvavakaita zvinogona kushandurwa zvinoenderana nemumwe mutemo, uye zvine hukama hwakanaka hwehukama, saka chikamu chinogona kusarudzwa maererano nezvinodiwa.
2.5 metabolic inerness
HPMC haina kunyudzwa kana metabolized mumuviri, uye haipe kupisa, saka ndiyo yakachengeteka mishonga gadziriro yekugadzirira. 2.6 Kuchengetedzeka kunowanzoonekwa kuti HPMC ndeyekutora zvinhu zvisingaiti uye zvisiri zvekutsamwa, iyo yedhodhi yedhodhi yemizi iri 5 GG Iyo DEGY DEE haina kukuvadzwa nemuviri wemunhu.
3.Kushandiswa kweHPMC mune mafambiro
3.1 Sezvo firimu inovhara zvinhu uye mafirimu-ekugadzira zvinhu
Uchishandisa HPMC seyakagadzirwa firimu zvinyorwa, iyo piritsi rakakomberedzwa harina kuvharira kuravira mahwendefa akabatanidzwa senge mahwendefa, asi kuomarara, kuomesa, kunyorova, kusvibiswa. , kuunganidza uremu kuwana uye zvimwe zviratidzo zvemhando yepamusoro zviri nani. Iyo yakaderera-vcosity grade yechigadzirwa ichi inoshandiswa seyakagadzirwa firimu yekubatanidza zvinhu nemapiritsi nemapiritsi anoshandiswa seyakafambisa zvinyorwa zvemhando yepamusoro, kazhinji pakusangana kwe2% kusvika makumi maviri muzana kusvika makumi maviri %.
Zhang jixing et al. yakashandisa nzira yemamiriro ekunze kuti uwedzere premix kuumbwa neHPMC sezvo iyo firimu yekuvhara. Kutora iyo firimu-yekugadzira zvinyorwa HPMC, huwandu hwePolyvinyl doro uye planticz Index uye zvinhu zvekuongorora zvinotsanangurwa nemhando yemasvomhu, uye maitiro akanaka ekuumbwa anozowanikwa. Kunwa kwaro kuri kuremekedzwa firimu-kuumba mumiririri hydroxypressletl . Zhang Yuan Yakavandudzwa Maitiro, Yakashandiswa HPMC Sekutsiva marara ekugadzirira, uye achinja hygraphscopicpicols yayo, kugadzirisa hygroscopicpiciticolix yayo, iri nyore kupedza, mahwendefa akasununguka, mamwe mahwendefa uye mamwe matambudziko, simbisa kugadzikana piritsi. Iyo yakaringana yekufananidza maitiro yakatemwa neOrthogonal mayedzo, zvinoti, iyo slurnration yaive 2% HPMC mu 70% Ethanol Solution panguva yekuvhara, uye nguva inosimudzira panguva yeGranulation yaive 15 min. Mhedzisiro yeJaya-mahwendefa mahwendefa idzva uye mishonga yacho yakave yakagadziridzwa kwazvo muchitarisiko, nguva yekubatira uye yakaomesesa mwero wekunyoreswa, uye mwero unokwanisa wemabhurandi akabatanidzwa kwazvo. yakasvika kupfuura 95%. Liang Meiyi, Lu Xiaohui, etc. Akashandiswawo hydroxprelselsloselslose seyekugadzira mafirimu ekugadzira iyo Patinae Colon Plett piritsi uye neColon Colon Soming piritsi, zvichiteerana. kukanganisa kusunungurwa kwezvinodhaka. HUang Yunran akagadzirira Drag's Ropa Pointing mahwendefa, uye akaisa HPMC kumhinduro yekubatanidza yekuzvimba kwekuzvimba, uye chidimbu charo chakaita chidimbu che5%. Inogona kuoneka kuti HPMC inogona kushandiswa zvakanyanya muColon-yakatarisana nedhorobha Dhivha system.
HydroxyPropyl methylcellose haisi chete firimu rakanakisa rekubatanidza zvinhu, asi zvakare rinogona kushandiswa seyakagadzirwa mafirimu ekugadzira mafirimu ekugadzira mafirimu. Wang Tongsun etc. Vanoongororwa kune mishonga yeCompound Zinc Licorice uye kushanduka, kufanana neyekuchinjisa indekisi Propylene Glycol inosangana nezvinodiwa zvekusunungurwa uye kuchengetedzeka, uye kunogona kushandiswa semishonga yekugadzirira yeyakajaira firimu.
3.2 sekubhuka uye kuparadzanisa
Iyo yakaderera viscosity grade yechigadzirwa ichi inogona kushandiswa seyekuchinjika uye kuparadzira mapiritsi, mapiritsi uye giredhi reViscousity, uye giredhi repamusoro rinogona kushandiswa chete seinongoshandiswa. Iyo Dosage inosiyana nemhando dzakasiyana uye zvinodiwa. Kazhinji, iyo dosage yeBinder yehwendefa dzakaoma mahwendefa ndeye 5%, uye dosage yeBinder yeaiplate mahwendefa egirini iri 2%.
Li Houtao et al akaongorora iyo binder yemapiritsi tinidazole. 8% Polyvinylpyrrolleidone (PVP-K30), 40% SARCHE SLEURRYS ,,50% Ethanol yakafemerwa sezvo iyo kudedera mahwendefa eTinidazole. kugadzirira kwehembe dze tinidazole. Kuonekwa kwekuchinja kwemahwendefa matafura uye mushure mekutunganidzwa kwakaenzaniswa, uye kuomesa, kuomarara, kuomesa nguva nemarara madiki ezviratidzo zvakasiyana. Mhedzisiro mahwendefa akagadzirirwa na 2.0% hydroxyprusyl methylcellose aive akasindimara, uye kuyerwa kwemaitiro akawana mupendero uye mushure mekutunganidzwa, chimiro chetsiva chaive chakakwana uye kutaridzika kwacho kwaive kwakanaka. Naizvozvo, tinidazole mapiritsi akagadzirirwa ne2,0% HPMC-K4 uye 50% ethanol sezvo maBinders akashandiswa. Guan Shihai akadzidza maitiro ekuumbwa emapiritsi eFuganning, akaongorora madekwana, gumi neshanu eStHanol, , 5% cmc-na uye 15% HPMC Solution (5 MPA S). Mhedzisiro yakagadzirirwa masheya ne50% ethanol, 15% starch paste, 10% pvp 50% yeEtHanol Solution uye 5% yeCMC. 15% HPMC Solution (5 Mpa · · · · · · · ·), pamusoro pemuchiroto inotsvedza, kuoma kwakakodzera, uye kutevedzera kwakanaka, uko kunogona kuita zvinodiwa nekucheka. Naizvozvo, hpmc (5 mpa s) yakasarudzwa sekunamatira.
3.3 sekumhanyisa mumiriri
Iyo yakakwira-vcosity grade yechigadzirwa ichi inoshandiswa seyekumisa mumiriri kugadzirira kumiswa-mhando yekugadzirira kwemvura. Iyo ine maitiro akanaka, ari nyore kutsausa, haanamatire kumadziro, uye ane madziro akanaka ehururu. Iyo yakajairwa dosage ndeye 0.5% kusvika 1.5%. Rwiyo Tian et al. Inoshandiswa inowanzo shandiswa polymer zvinhu (hydroxyprusyl methylcellose, sodium carboxylethosellose, podone, xanthan gamu, methylcellulose, etc.) sekumisa vamiririri kugadzirira rabocadril. kumiswa kwakaomeswa. Kuburikidza neyakagadziriswa vhoriyamu yemhando dzakasiyana, iyo indekisi yekudzoreredza, uye rheology, yekufungidzira morpology yakacherechedzwa, uye kugadzikana kwezvigadzirwa zvinoitwa pasi pekuedza kwakanyatsoongororwa. Mhedzisiro yekuomiswa kwakagadzirirwa ne 2% HPMC sekumhanyisa mumiririri aive nemaitiro akapusa uye kugadzikana kwakanaka.
Kuenzaniswa neMethyl Cellulose, HydroxyprEpyl Methyl Cellers Liu Jie et al. Yakashandiswa HPMC, HydroxyPropyl Cellulose (HPMOMMER 940, Polyethyle Glycol vanosarudzwa sezviratidzo zvekuongorora kuti zvidzorerwe zvakanakisa kumhanyisa mumiriri. Mhedzisiro inoratidza kuti iyo acyclovic kumiswa kwakagadzirirwa ne 0.05% ha uye 0.05% HPMC sekumhanya, saizi yemukati yunifomu, kuyananiswa kwakanaka, uye kugadzirira kwakasimba bonde kunowedzera.
3.4 Senge blocker, inononoka uye inodzorwa kuburitswa mumiriri uye pore-fomu yekugadzira mumiririri
Iyo yakakwira-viscosity grade yechigadzirwa ichi inoshandiswa kugadzirira kwehydrophilic gel matrix mahwendefa, mabhureki ekudzivirirwa-matsotsi ekusunge Yayo yekuvharidzira ndeye 10% kusvika 80%. Mamakisi-ekuvenga-viscosity anoshandiswa kunge mapundu ekusunungurwa-kusunungura kana kudzorwa-gadziridzwa gadziriro. Iyo yekutanga dosi inoda kuti iyo yekurapa yematafura akadai anogona kukurumidza kusvika, uyezve kusunungurwa-kwakasunungurwa kana kudzorwa-kusunungura zvinoitwa nemushonga unochengetwa mumuviri. . Hydroxyprishlpyl methylcellose inosimbisa kuti iite gel layer kana ichisangana nemvura. Iyo Mechanism yekuburitswa kwezvinodhaka kubva kune iyo matrix piritsi inonyanya kusanganisira kusiyana kweiyo gel layer uye kugumisa kweiyo gel layer. Jung bo shim et al akagadzirira carvedilool yakachengetedzwa-masisitimu ekusimudzira neHPMC seyakagadzirirwa-kuburitswa.
HydroxyPropyl methylcellose inoshandiswawo zvakanyanya mumatafura ekusunungurwa ematiriya emhando yeChinyakare, uye mazhinji ezvikamu zvinoshanda uye gadziriro imwechete yemushonga weChinese weChinese unoshandiswa. Liu wen et al. Yakashandiswa 15% HydroxyPropropyl methylcellose seMatrix zvinyorwa, 1% Lactose uye 5% Microcrystalline Celler Iyo modhi ndeye iyo HigUchii equation. Iyo formula yekunyora system iri nyore, kugadzirira kuri nyore, uye data rekusunungurwa rakanyatsogadzikana, rinosangana nezvinodiwa zveChinese repocoeia. Tang Guanguang et al. Inoshandiswa masaga eSaponini eAsttragalus seMuenzaniso wedhisheni, uye akaongororwa mahwendefa emari, uye akaongorora zvinhu zvinokanganisa zvinodhaka kubva kune zvikamu zvechinyakare zveChinese mushonga muHPMC matrix mahwendefa ematroni. Mhedzisiro yeHPMC yakawedzera, kusunungurwa kweAstragelode kwakadzikira, uye iyo yekuburitswa muzana yemushonga waive neyenzizi yehukama nehukama hwekunyungudika kwematrix. Mune hypolose hpmc matrix piritsi, pane hukama hwokuburitswa kwechikamu chinoshanda chechinyakare cheChinese mushonga uye madhiri eHPMC, uye maitiro ekusunungurwa emakemomeri akafanana nahwo. Hydroxyprishpropyl methylcellose haina chete yakakodzera kune hydrophilic compiyound, asi zvakare kune isina-hydrophilic zvinhu. Liu Guihua Sports Maitiro ekusunungurwa aive pachena, uye maitiro ekugadzirira aive akagadzikana uye anogoneka.
HydroxyPropyl methylcellose haishandiswe chete kune masheya ekusimudzira matani ezvinyorwa zvinoshanda uye zvikamu zvinobudirira zvemishonga yechinyakare, asi zvakare uye zvinoshandiswa zvakanyanya mune yeChinyakare mechi kurapa kugadzirira gadziriro. Wu huichao et al. Yakashandiswa 20% HydroxyPropyl methyl Cellelose (HPMC4M) seyenti yeMatrix yakananga kugadzirira iyo Yizhi Hydrophilic Gel Pirleti SAPONIN RG1, Ginsenoide Rb1 uye Panax notoginseng SAPONIN R1 Mhedzisiro yekuburitsa zvinodhaka
3.5 inodzivirira glue se thickener uye colloid
Kana chigadzirwa ichi chishandiswe seanotenderera, iyo yakajairwa muzana yekuvhara ndeye 0.45% kusvika 1.0%. Inogona zvakare kuwedzera kugadzikana kweiyo hydrophobic glue, gadzira iyo colloid colloid, kudzivirira zvimedu kubva mukushambadzira uye negglomering, nekudaro ichivhiringidza kuumbwa kwemadimikira. Yayo yakajairika muzana yekuvhara ndeye 0.5% kusvika 1.5%.
Wang zhen et al. used the L9 orthogonal experimental design method to investigate the preparation process of medicinal activated carbon enema. Iyo Optimum mamiriro ekutsunga kwekupedzisira kweMishonga CarbonMaCarbolose enem Carbolsel Cellylcellose kugadzikana kweMishonga Inoshanda Carbon. Zhang zhiqiang et al. Akagadzira iyo ph-inotyisa leevofloxide hydrochloride ophthalmic yakagadzirirwa-yekushandisa gel-yekusunungura maitiro uye hydroxypropyl Optimal mushonga nekuedzwa, pakupedzisira unowana mishonga yekunyoreswa iri quevofloxide 0.1 g, carbopolicl , 0.03 g yeTEthyl Paraben, uye mvura yakawedzerwa kuita 100 ml. Muedzo, munyori akaongorora hydroxyprusylculose methylcellulose Series of colorcon kambani (k4m, e15, e4m, uye mhedzisiro yakasarudzwa HPMC E50 Lv seiyo thickener. Thickener yePH-inokatyamadza levofloxacin hydrochloride Instant Gels.
3.6 Sekapindu yeCapsule
Kazhinji, iyo capsule shell zvinyorwa zve capsules inonyanya kuwanda. Maitiro ekugadzira kaCAPSUL yekapu iri nyore, asi kune mamwe matambudziko uye zviitiko zvakashata zvinodhaka uye zvinodhaka zvinodhaka, uye zvakanonoka kuparadzaniswa kwemakapu yekapu panguva yekuchengetedza. Naizvozvo, hydroxyprupyl methylcellose inoshandiswa seyinotsiva yeGelatin Capsules yekugadziriswa kwemakapu, iyo inovandudza kugadzirwa kwekugadzira capulule uye kushandiswa kwemabasa, uye kwakakurudzirwa zvakanyanya kumba uye kune imwe nyika.
Uchishandisa Theophylline seMushonga wekutonga, Podczeck et al. Wakawana kuti iyo inodhaka inodhaka yemakapu ane hydroxyprupyl methylcellese mabhero aive mukuru kune ayo egwenzi capsules. Chikonzero chekuongorora ndechekuti kuparadzaniswa kweHPMC ndiko kuunganidzwa kweCapsule rese panguva imwe chete, nepo kuparadzaniswa kwegwendefa regwenzi rekutanga, uyezve nekuparadzaniswa kwekapu yese, saka HPMC capsule yakakodzera kune capsule mabhonzo ezvinyorwa zvekusunungura nekukurumidza. Chiwele et al. Zvakare vakawana mhedziso dzakafanana uye dzichifananidza nekuparadzwa kweGelatin, Gelatin / Polyethylene Glycol uye HPMC Magazini. Mhedzisiro yacho yakaratidza kuti HPMC madhimoni akanyungudutswa pasi pemamiriro akasiyana eph, nepo greenin capules inokanganisika zvakanyanya nemamiriro ezvinhu akasiyana. Tang yue et al. akaongorora mhando nyowani yeCapsule yeCapsule yeColl-DOSE DEGH BUTLE STOPL HOTH YAKAITWA POWOLLER POWERS inhaler Carriers system. Kuenzaniswa neCapsule Shell yeHydroxyPropyl Methylcellose uye Iyo Capsule Shell yeGehlin, iyo midziyo yehupfu mumamiriro ezvinhu akasiyana akaongororwa, uye muedzo wakashata wakaitwa. Mhedzisiro yacho inoratidza iyo inoenzaniswa neGelatin capsules, HPMC Capsule Capsies iri nani mukugadzikana kwemashells, saka zvine simba capsule shells zvakanyatso kukodzera kune capsuled yemakapu emakapu emuchadenga.
3.7 sebhizimusi
Bioadhesion tekinoroji inoshandisa inonakidza ne bioadhesive polymers. Nekuomerera kune iyo bika yechiBasa, inosimudzira kuenderera mberi uye kusimba kwekusangana pakati pekugadzirira uye mucosa, kuti mushonga wacho waburitswa zvishoma nezvishoma uye unonwa nemucosa kuzadzisa chinangwa chekurapa. Inoshandiswa zvakanyanya parizvino. Kurapwa kwezvirwere zvegakava turakiti, vagina, emuromo mucosa uye zvimwe zvikamu.
Gastrointestinal Bioadhesion tekinoroji isarudzo itsva yezvinodhaka inogadzirwa mumakore achangopfuura. Izvo hazvingowedzera nguva yekugara yekugadzirira zvinodhaka mugwara regastrointestinal turakiti, asi zvakare zvinokonzeresa mishonga yezvinodhaka Masero madiki emumiriri epitheliari anowedzerwa, nokudaro achinatsa bioavilalility yemushonga. Wei keda et al. Wakaongorora piritsi repiritsi repireni neiyo Dosage yeHPMC4M uye Carbommer 940 seyakafarisisa zvinhu, uye yakashandisa chishandiso cheBioadhesion kuyera simba pakati pemubiriya nemhando yemvura muhomwe yepurasitiki. , uye pakupedzisira vakasarudza zvirimo zveHPMMOCT 540 kusvika 1540 kusvika gumi nemashanu uye makumi maviri nemashanu, kuti vagadzirire zvinhu zveNCEBT (senge hydroxypropyl kuderedza kwekugadzirira kune tishu.
Kugadzirira kwemuromo kweBioadhesive zvakare ndiyo mhando itsva yehunhu hwekutumira zvinodhaka iyo yakatorwa zvakanyanya mumakore achangopfuura. Kugadzirira kwemuromo kweBioadhesive kunogona kuyemura mushonga kune chikamu chakakanganisika chechiratidzo chemuromo, icho chisingori nguva yekugara yemushonga muCoera muCofa, asi zvakare inodzivirira iyo muCosa muCosa. Zvirinani kuridza maratidziro uye kuvandudza zvinodhaka bioavilability. Xue Xiaoyant et al. Optimised iyo kuumbwa kweInsulin Oral Anderin, Chitosan, Carbemer, HPMC K332) uye Sodium Allging seyezvinhu zvinhu zveBioderesive, uye kusununguka-kuomesa kugadzirira muromo insulin. Anamatira kaviri sheya sheet. Iyo yakagadzirirwa insulin yemuromo okunyudza piritsi ine purohwiro piritsi, iyo inofarirwa kusunungurwa, uye ine hydrophobic yekudzivirira, iyo inogona kuve nechokwadi chekuburitswa kwemushonga uye kudzivirira kurasikirwa kwemushonga. Hao ifu et al. Zvakare akagadzirirawo bhuruu-yero bead
Mumashura asina kujairika anodhaka, bioadhesion tekinoroji yakave yakashandiswa zvakanyanya. Zhu yting et al. Yakashandiswa carbomer (CP) uye HPMC semidziyo yekuzvininipisa uye inogadziriswa Matrix kugadzirira mahwendefa emukati mavo , mishonga yakakodzera yakaongororwa seCP-HPMC1: 1, iyo pepa rekushambadzira raive rakanyatso kudiwa kuita, uye maitiro aive akapfava uye anogoneka.
3.8 seyenzi yezvikamu
Kugadzirira kunonamatira, Gel ine manyorerwe ezvakanaka zvekuchengetedza, runako, nyore kuchenesa, mutengo wakaderera, kugadzirira kwegadziriro, uye kuenzanisa kwakanaka nemishonga. Kutungamira kwekusimudzira. Semuenzaniso, transdermal gel ndiyo itsva dosge fomu iyo yakatakwa zvakanyanya mumakore apfuura. Hazvigone kungodzivisa kuparadzwa kwezvinodhaka mune gastrointestinal turakiti uye kuderedza kusiyana-kusiyanisa kweropa kweropa, asi zvakare yave imwe yeiyo inoshanda zvinodhaka system yekukurira zvinodhaka. .
Zemara jingjie et al. Akafunda mhedzisiro yematanho akasiyana pakuburitswa kwescutellarin doro plastid gel glastid Gel matrix of doro plastids. Mhedzisiro yekuedza inoratidza kuti 1. 0% carbomer, 1. 5% carbomer, 1. 0% HPMMO + 1. 0% HPMC seGel Matsrix ari maviri akakodzera . Munguva yekuedza, yakawanikwa kuti HPMC inogona kuchinja iyo yekuburitsa mishonga yeCarbomer Chikonzero chingave icho hpmc chinowedzera nekukurumidza, uye kukurumidza kwekuwedzera muchikamu chekutanga chekuedza kunoita kuti molecular gap ye carbomer glummer yakakura, nekudaro inokurumidza kuburitsa zvinodhaka. Zhao wencui et al. Yakashandiswa carbomer-934 uye hydroxyprupyl methylcellose sevatakuri kugadzirira Norfloxacin Ofhthemic Gel. Maitiro ekugadzirira ari nyore uye anokwanisa, uye mhando yemhando yemhando yeiyo Ofhthalmic Gel ye "Chinese Formacoeia" (2010 edition) zvinodiwa zvemhando yepamusoro.
3.9 Precipitation inhibitor yekuzvifunga-microemulesifying system
Kuzvidemba-microemulsing Kuumbwa kwemishonga yacho iri nyore, uye kuchengeteka uye kugadzikana kwakanaka. Zvemishonga isinganyorerwe, yakachena-mvura-fibr polymer zvinhu, yakadai seHPMC, pvp), etc. wedzera iyo inodhaka yekubata uye kugadzirisa iyo bioavhalubility.
Peng xuan et al. Yakagadzirirwa silibinin yakavanzika yekuzviisa -kura-zvinodhaka kutumira system (s-sedds). Oxythylene Hydrogenated Castor Oiri Mafuta (Cremophor Rh40), 12% CapRylic Capric Acd polyethyle Glycolene Glyceride (Labrasol) seCo-emlasifier, uye 50 mg ·-1 hpmc. Kuwedzera HPMC kune Sceds Kuenzaniswa neyechinyakare kuzvimiririra-microemulsion mafomu, huwandu hwakakura hwefactant hunowanzowedzerwa kudzivirira zvisina kukwana zvinodhaka. Kuwedzerwa kweHPMC kunogona kuchengeta solubility yeSilibinin mumvere dzemukati memukati menguva dzose nguva dzose, ichidzora emulsification mukuzvimirira microemulsion. dosage yemumiririri.
4.concliussion
Zvinogona kuoneka kuti HPMC yakashandiswa zvakanyanya mugadziriro nekuda kwenzvimbo yayo yemuviri, yemakemikari, asi Hpmc ine zvakare zvikanganiso zvakawanda mukugadzirira, uye post-kupururudza-uye post-burst. methyl methacrylate) kuvandudza. Panguva imwecheteyo, vamwe vaongorori vakaongorora chikumbiro chedzidziso yeOsmoti Mune izwi, vazhinji vanotsvaga vari kuita basa rakawanda rekushandiswa kweHpmc mukugadzirira, uye nekunyorwa kwezvinhu zvaro zvehunyanzvi, HPMC ichave yakashandiswa zvakanyanya mumhando itsva mitsva uye mafomu matsva emadhora. Mukutsvaga kweiyo mishonga system system, uye wobva wasimudzira kukura kwekuenderera kwemishonga.
Kutumira Nguva: Oct-08-2022