1.Tipi
Mukureva kwemishonga yemishonga, mabhasitiri anotamba chinzvimbo chakakosha mukuona kutendeka uye kuita kwemhando dzemvura. Pakati akasiyana-siyana masisitimu anowanikwa, hydroxyprusyl methylcellose (HPMC) inomira seyakaverengeka uye yakashandiswa zvakanyanya sarudzo.
2.Properties yeHPMC Binder Systems:
HPMC, iyo semisynthetolet Polymer inotorwa kubva kuCellulose, inopa chirevo chezvivakwa zvine chekuita nemishonga yemishonga yemishonga. Izvi zvinosanganisira:
Kuedza: HPMC inoratidzira huwandu hwakawanda hwehuwandu hwemakiromita, uchibvumira mafomu ekugadzira maitiro ayo anogadzirisa maitiro ake kune chaiyo dosage mafomu uye maitiro ekugadzirisa. Izvi zvinowanza zvinowedzera kushanda kwayo kune akasiyana siyana mishonga yemishonga, kusanganisira mahwendefa, mahwendefa, mafirimu, uye gadziriso dzepasi.
Binder uye Kuparadzanisa: HpMC inoita zvese semubatanidzwa, uchifambisa simba rekubatanidza mumapiritsi, uye sekuparadzaniswa, kusimudzira nekukurumidza kusununguka uye kusunungurwa kwezvinodhaka. Uku kushanda kwakashata kwemhando dzekugadzira matanho ekugadzira uye kusimudzira kuita kwemuromo momuromo matoera mafomu, kunyanya mahwendefa ekusimudzira.
Kuenderana: HPMC inoratidza kuwirirana neakasiyana-siyana kwehuwandu hwekuita mishonga yemishonga (APIS) uye yakajeka, ichiita kuti iite kuti ive yakakodzera kurongedza zvigadzirwa zvezvinodhaka. Yayo inert chimiro uye kushomeka kwekudyidzana neanotarisisa makomputa anoona kuumbwa kwekugadzira uye kushanda.
Mafirimu-ekugadzira zvinhu: HPMC inogona kuumba mafirimu anochinja uye akasimba kana achizvishongedza mukuvandudzwa kwemafirimu emuromo, uye mamwe magiramu edhisheni. Iyi mafirimu anopa zvakanakira zvakadai sekushivirira murwere kutevedzera, chaizvo dosing, uye nekukurumidza kutanga kwechiito.
Kuburitswa Kwekudzorwa: Nekudzora giredhi reViscosity uye kusunganidzwa kweHPMC muzvimiro, zvinodhaka zvinodhaka zvinogona kuvezwa zvakarongedzwa kuti uwane kudzora, kana kutsigirwa zvakare profiles. Kugona uku kunonyanya kubatsira pakugadzira maramu emumuromo
3.Application uye mabhenefiti muzvimiro zvekuumbwa:
Piritsi mafomu:
HPMC Binders inopa yakanakisa compressucess uye kuyerera zvivakwa kune granules, inofambisa inoshanda playtiting maitiro.
Kuzvidzvinyirira kwekuzvimba uye hydration maitiro eHPMC mumabhani kunopa kuyunifomu mushonga zvinodhaka uye zvinofungidzirwa kusimuka kweKinetics, kunoita kuti varatidze kurapwa.
Vagadziri vanogona kuwedzeredza HPMC's kuwirirana nevamwe vanogadzira akawanda-anoshanda piritsi-piritsi mafomu, inosanganisira mamwe mashandiro akadai sekuravira, kudzivirirwa, nekudzivirirwa, uye kusunungurwa.
Capsule Formolation:
HPMC inoshanda seyakaveresa binder mukuumbwa kweakaoma powder-yakazadzwa makapu-akazadzwa makapu, achigonesa encaphulation yeiyo hydrophilic uye hydrophobic apisi.
Kugona kwayo kuumba mafirimu akasimba anofambisa kusimudzira kwemafashama ekusimudzira-akabatanidzwa uye akasimbiswa-kusunungura capsule mafambiro, achiwedzera API kugadzikana uye kusimuka.
Firimu-rakavakirwa mafomu ekugadzira:
HPMC-yakavakirwa nemuromo mataira mafirimu anopa zvakawanda zvakanakira pamusoro pemhando yemhando yemhando, kusanganisira kukurumidza kusarudzika, zvakavandudza kutevedzera kwemurwere, kunyanya muPediatric neGeriatric Poupulation.
Transdermal patched mafirimu anopa mafirimu anodzora zvinodhaka kuburikidza neganda, anopa akatsiga plasma kutarisisa organma uye kuderedza systemic mhedzisiro.
Nzvimbo dzepamusoro:
Mukuumbwa kwepamusoro semagiri, mafuta, uye oints, hpmc anoshanda senge rheology modifier, kupa visikoka yavanoda uye nekuvhunduka.
Yayo firimu-yekuumba midziyo inokwidzirisa kudengenyeka kwenzvimbo dzepamhepo kune ganda, kwenguva refu inodhaka nguva uye kufambisa yakanyorwa zvinodhaka.
HydroxyPropyl methylcellose (HPMC) Binder Systems inopa mapoka emishonga mune mishonga yekuumbwa, nekuda kwezvivakwa zvavo zvakasiyana uye zviyero zvepamusoro mumhando yemadheti. Kubva pamahwendefa uye magiramu kune mafirimu uye mafirimu ekugadzira, HPMC anogonesa maFrench okutanga kudzora pamusoro pekusunungurwa kwezvinodhaka, kuvandudza kugadzikana, uye kuvandudza kutevedzera murwere. Sezvo indasitiri yemishonga yemishonga inoramba ichishanduka, HPMC inoramba iri kongiri mukugadzirwa kwekuumbwa, kutyaira nekuvandudza zvibodzwa zvekurapa.
Kutumira Nguva: May-07-2024