Ose ari maviri hydroxypropyl methylcellulose uye hydroxyethyl cellulose ari cellulose

Hydroxypropyl methylcellulose (HPMC)uye hydroxyethyl cellulose (HEC) zvinhu zviviri zvakakosha zveserulosi zvinonyanya kushandiswa mumaindasitiri akasiyana siyana nekuda kwehunhu hwawo hwakasiyana. Nepo ese ari maviri achitorwa kubva ku cellulose, ane akasiyana makemikari zvimiro uye anoratidza akasiyana maitiro uye mashandisiro.

1. Nhanganyaya kune Cellulose Derivatives:
Cellulose inonzi polysaccharide yakasikwa inowanikwa mumiti yesero masvingo, inoumbwa nemaketani akaenzana emayuniti eglucose akabatanidzwa ne β (1 → 4) glycosidic bonds. Cellulose derivatives inowanikwa nemakemikari ekugadzirisa cellulose kuwedzera chaiwo zvivakwa kana kuunza hutsva hunoshanda. HPMC neHEC zvinhu zviviri zvakadaro zvakabva kunoshandiswa zvakanyanya mumaindasitiri kubva kumishonga kusvika pakuvaka.

2. Synthesis:
HPMC inogadzirwa nekuita cellulose nepropylene oxide kuunza hydroxypropyl mapoka uyezve methyl chloride kuunza methyl mapoka. Izvi zvinoguma nekutsiviwa kwemapoka ehydroxyl mucheni ye cellulose, ichipa chigadzirwa chine kunyungudika kunyungudika uye kuumba firimu.

HEC, kune rumwe rutivi, inogadzirwa nekuita cellulose ne ethylene oxide kuti ibatanidze mapoka e hydroxyethyl. Iyo dhigirii yekutsiva (DS) mune zvese HPMC neHEC inogona kudzorwa nekugadzirisa maitiro ekuita, inokanganisa zvimiro zvavo senge viscosity, solubility, uye gelation maitiro.

3. Chimiro cheKemikari:
HPMC neHEC dzinosiyana mumhando dzemapoka anotsiva akabatanidzwa kune cellulose musana. HPMC ine ese ari maviri hydroxypropyl uye methyl mapoka, nepo HEC ine hydroxyethyl mapoka. Izvi zvinotsiva zvinopa hunhu hwakasiyana kune chimwe nechimwe chinotorwa, zvichipesvedzera maitiro avo mumashandisirwo akasiyana.

4. Zvinhu Zvenyama:
Ose ari maviri HPMC neHEC mapolymer anonyungudika nemvura ane kunaka kwekukora zvivakwa. Nekudaro, ivo vanoratidza misiyano mune viscosity, hydration simba, uye firimu-kugadzira kugona. HPMC inowanzo kuve nepamusoro viscosity kana ichienzaniswa neHEC pamitsetse yakaenzana, ichiita kuti ive yakakodzera kune zvikumbiro zvinoda kukora zvakanyanya.

Pamusoro pezvo, HPMC inoumba mafirimu akajeka uye akabatana nekuda kwemamethyl substituents, nepo HEC ichigadzira akapfava uye anochinja-chinja mafirimu. Iyi misiyano yezvivakwa zvemufirimu inoita kuti imwe neimwe inotorwa ikwane kune chaiyo kunyorera mumishonga, zvigadzirwa zvekuchengeta munhu, uye maindasitiri ezvekudya.

5. Zvikumbiro:
5.1 Indasitiri Yezvemishonga:
Ose ari maviri HPMC neHEC anoshandiswa zvakanyanya mukugadzira mishonga semabhainda, makobvu, uye firimu-coating agents. Ivo vanovandudza kutendeseka kwepiritsi, kudzora kuburitswa kwezvinodhaka, uye kuwedzera muromo mukugadzirwa kwemvura. HPMC inosarudzirwa magadzirirwo anoramba achiburitswa nekuda kwekunonoka kwayo hydration mwero, nepo HEC ichiwanzo shandiswa mumhinduro dzemaziso uye topical creams nekuda kwekujeka kwayo uye kuenderana nemvura yebiological.

5.2 Indasitiri yeKuvaka:
Muindasitiri yekuvaka,HPMCuyeHECanoshandiswa sezvekuwedzera mune simende-based zvinhu, senge madhaka, grouts, uye renders. Vanovandudza kushanda, kuchengetedza mvura, uye kunamatira, zvichiita kuti kuwedzere kushanda uye kusimba kwechigadzirwa chekupedzisira. HPMC inowanzofarirwa kune yakakwirira yekuchengetedza mvura, iyo inoderedza kupaza uye inovandudza kuseta nguva.

5.3 Zvigadzirwa Zvekuchengetedza Pamunhu:
Zvese zviri zviviri zvinobva zvawana maapplication muzvigadzirwa zvekuchengeta zvemunhu zvakaita seshamposi, lotions, uye makirimu seanokora maajenti, emulsifiers, uye stabilizers. HEC inopa kugadzirwa kwakatsetseka uye kupenya kune maumbirwo, zvichiita kuti ive yakakodzera kune zvigadzirwa zvekuchengeta bvudzi uye ganda. HPMC, ine hunyanzvi hwayo hwekugadzira firimu, inoshandiswa mumafuta ekudzivirira zuva uye zvizorwa zvinoda kumira nemvura uye kupfeka kwenguva refu.

5.4 Indasitiri yeChikafu:
Muindasitiri yechikafu, HPMC neHEC inoshanda seanokora maajenti, anosimbisa, uye mameseji muzvigadzirwa zvakasiyana zvinosanganisira sosi, madhirezi, uye madhiri. Ivo vanovandudza muromo, kudzivirira syneresis, uye kuwedzera hunhu hwekunzwa kwekuumbwa kwechikafu. HPMC inowanzofarirwa kujeka kwayo uye kugadzikana kwekupisa, zvichiita kuti ive yakakodzera kune zvikumbiro zvinoda sparent gels uye emulsions yakagadzikana.

6. Mhedziso:
hydroxypropyl methylcellulose (HPMC) uye hydroxyethyl cellulose (HEC) zvinotorwa selulosi ane akasiyana makemikari zvimiro, zvivakwa, uye mashandisirwo. Nepo ese ari maviri achipa yakanakisa kukora uye firimu-kugadzira zvivakwa, ivo vanoratidza misiyano mune viscosity, kujeka kwefirimu, uye hydration maitiro. Kunzwisisa misiyano iyi kwakakosha pakusarudza chinobva chakakodzera kune chaiwo mashandisirwo mumaindasitiri akadai semishonga, kuvaka, kutarisira wega, uye chikafu. Sezvo tsvakiridzo ichienderera mberi, kumwe kugadziridzwa uye mashandisirwo ezvinobva muselulosi zvinotarisirwa, zvichipa kuti varambe vachikosha mumaindasitiri akasiyana siyana.