HPMC (hydroxypruppyl methylcellose)is is is is-ionic semi-synthetic polymer inoshandiswa zvakanyanya mumushonga, chikafu, kuvaka, kuungana uye mamwe maindasitiri. Kana iri iyo HPMC inogona kunyungudika mumvura inopisa, maitiro ayo ekusimbisa uye mhedzisiro yekushisa pane zvayo zvekupaza maitiro anofanirwa kufungwa nezvayo.
Kuongorora kweHPMC Solubility
HPMC ine yakanaka mvura salubility, asi maitiro ayo ekunyungudika ane hukama zvakanyanya nekushisa kwemvura. Kazhinji, HPMC inogona kuparadzaniswa nyore uye yakanyungudika mumvura inotonhora, asi inoratidzira maitiro akasiyana mumvura inopisa. Iyo solubility yeHPMC mumvura inotonhora inonyanya kukanganiswa neyechigadzirwa chayo uye yakatsiva mhando. HPMC ichisangana nemvura, iyo hydrophic mapoka (senge hydropixl uye hydroxyprusyl) mumamolekyudhi yayo inogadzira hydrogen zvisungo nemamolekyudhi emvura, zvichiita kuti zviitike zvishoma nezvishoma uye zvidimbu. Nekudaro, iyo solubility maitiro eHPMC yakasiyana mumvura kune dzakasiyana tembiricha.
Solubility yeHPMC mumvura inopisa
Iyo solubility yeHPMC mumvura inopisa inotsamira pane tembiricha tembiricha:
Sypturisitures yakaderera (0-40 ° C): HPMC inogona kutora zvishoma nezvishoma mvura uye kuzvimba, uye pakupedzisira gadzira yakajeka kana translucent viscous mhinduro. Iyo yekunyorovesa chiyero inononoka kupisa, asi magasi haaiti.
Kupisa kwepakati (40-60 ° C): HPMC SWLLS mune ino tembiricha yekushisa, asi haina kunyungudika zvachose. Panzvimbo iyoyo, inogadzira nyore mafomu asina kufanana nehasha kana kumiswa, kukanganisa kufanana kwemhinduro.
Kupisa kwakanyanya (pamusoro pe60 ° C): HPMC ichaita chikamu chekuparadzaniswa kwepamusoro tembiricha, inoratidzwa segwenzi kana kuti yakajeka, ichiita kuti zviome kunyungudika. Kazhinji, kana tembiricha yemvura ichidarika 60-70 ° C, iyo yekufambisa yeHPMC molecular keteni inowedzera, uye iyo inozodzikira inoderera, uye inogona kuguma ikaita gel kana kufungidzira.
Thermogel zvivakwa zveHPMC
HPMC ine akafanana thermoge midziyo, kureva kuti, inoumba gel pane yakakwirira tembiricha uye inogona kuve yakadzvanywa pane yakaderera tembiricha. Iyi pfuma yakakosha kwazvo mune akawanda maapplication, yakadai se:
Indasitiri yekuvaka: HPMC inoshandiswa seyakakora yeiyo siment frar. Inogona kuchengetedza yakanaka kunyorova panguva yekuvaka uye kuratidza glation munzvimbo dzakasimba dzekudziya kudzikisa kurasikirwa kwemvura.
Kugadzirira kwechechi: kana ichishandiswa seyakavharidzira zvinyorwa mumapiritsi, yayo yedhiramu denderedzwa inoda kutariswa kuve nechokwadi chekunyama.
Indasitiri yechikafu: HPMC inoshandiswa seyekukasira uye emulsifier mune zvimwe zvekudya, uye igwenzi rayo rekunze rinobatsira kusimba kwechikafu.
Maitiro ekunyungudika hpmc nenzira kwayo?
Kuti udzivise HPMC kubva pakugadzira gel mumvura inopisa uye kutadza kunyungudika, nzira dzinotevera dzinowanzoshandiswa:
Cold Mvura Kuparadzira nzira:
Kutanga, kunyatso kupararira HPMC mumvura inotonhora kana mukamuri tembiricha mvura yekunyorova uye kuzvimba.
Zvishoma nezvishoma kuwedzera tembiricha panguva yekukurudzira kuenderera mberi nekunyungudika hpmc.
Mushure mekunge zvanyungudika zvizere, tembiricha inogona kuwedzerwa nenzira kwayo kuti inyorere kuumbwa kwemhinduro.
Kupisa kwemvura inopisa nzira inotonhorera nzira:
Kutanga, shandisa mvura inopisa (anenge 80-90 ° C) kukurumidza kuparadzira HPMC kuitira kuti insulle gel yekudzivirira inoumbwa pamusoro pechiso chacho kuti ishandise kuumbwa kwezvinonamira.
Mushure mekutonhorera kumhepo tembiricha kana kuwedzera mvura inotonhora, HPMC zvishoma nezvishoma inodonha kuumba yunifomu mhinduro.
Dry musanganiswa nzira:
Sanganisa HPMC nedzimwe zvinhu zvinonyungudutswa (senge shuga, starch, mannitol, nezvimwewo) uye wozowedzera mvura kuti uderedze Agglomeration uye kusimudzira yunifomu.
Hpchaigoni kunyungudika zvakananga mumvura inopisa. Zviri nyore kuumba gel kana kugadzirira pakupisa kwakanyanya, iyo inoderedza iyo solubility. Nzira yakanakisa yekunyungudika ndeyekupararira mumvura inotonhora kutanga kana pre-kupararira nemvura inopisa uye wozotonhorera kuti uwane yunifomu uye yakagadzikana mhinduro. Mune zvinoshandiswa zvinoshanda, sarudza iyo yakakodzera yekunyungudika nzira maererano nezvainoda kuve nechokwadi chekuti HPMC inoita zvakanyatsonaka.
Kutumira Nguva: Mar-25-2025