Cellulose ana avaneta nekudzorwa kubudiswa kwezvinodhaka muHydrophilic Matrix Masystem

Cellulose ana vana, kunyanyaHydroxyprupyl methylcellose (HPMC). Kuburitswa kwezvinodhaka kwakakosha kune vanokoshesa kurongedza zvibodzwa zvekurapa, kudzora mhedzisiro, uye nekuvandudza kutevedzera kwemurwere. Heino maitiro ekuti cellucose erithering muHydrophilic Matrix Masystem ekudzora zvinodhaka kuburitswa:

1. Hydrophilic Matrix system:

• Definition: A hydrophilic matrix system is a drug delivery system in which the active pharmaceutical ingredient (API) is dispersed or embedded in a hydrophilic polymer matrix.
• Chinangwa: Iyo Matrix inodzora kusunungurwa kwemushonga nekumhanyisa kusiyana kwayo kuburikidza ne polymer.

2. Basa reCellulose eva (semuenzaniso, HPMC):

• Viscosity uye gel-kugadzira zvivakwa:
  • HPMC inozivikanwa nekugona kwayo kuumba gels uye kuwedzera iyo visikopa yemhinduro mhinduro.
  • MuMatrix Systems, HPMC inobatsira kuumbwa kweiyo gelusinous matrix iyo inogadzirisa mushonga.
• Hydrophilic mamiriro:
  • HPMC yakanyanya hydrophilic, inofambisa kudyidzana kwayo nemvura munzvimbo ine gastrointestinal turakiti.
• Kudzvinyirira Kuzvimba:
  • Paunenge uchionana ne gastric fluid, iyo hydrophilic matrix cholls, inogadzira iyo gel layer yakatenderedza mishonga yemishonga.
• Zvinodhaka encapsilation:
  • Mushonga wacho wakaparadzaniswa kana kutenderwa mukati meiyo gel matrix.

3. Simba rekudzorwa kusunungurwa:

• Kusiyana uye kugura:
  • Kuburitswa kwakadzorwa kunoitika kuburikidza nekusanganiswa kwekusiyana uye merosion mechanisms.
  • Mvura inopinda mumatrate matrix, inotungamira kuGel kuzvimba, uye zvinodhaka zvakasiyana kuburikidza negwenzi regwenzi.
• Zero-Kuburitswa Kusunungurwa:
  • Iyo inodzorwa kuburitswa

4. Zvinhu zvinokuvadza zvinodhaka zvinodhaka:

• Polymer Concenation:
  • Kushungurudzika kweHPMC mune matrix anofurira muyero wekuburitswa kwezvinodhaka.
• Molecular uremu hweHPMC:
  • Mavara akasiyana eHPMC nehuremu hwemanyoreri hunokwanisa kusarudzwa kuti ugadziriswe kuburitsa nhoroondo yekuburitsa.
• Zvinodhaka Salubility:
  • Iyo solubility yemushonga mune matrix inokanganisa hunhu hwayo hwekuburitsa.
• Matrix Porosity:
  • Dhigirii reGEL yekuzvimba uye matrix porosity kukanganisa zvinodhaka.

5

• Biocompulibility: cellulose ana anawanzowanzoitika uye yakanyatsotsauswa mugwara regastrointestinal.
• Kuedza: mamakisi akasiyana e cellulose anainth anogona kusarudzwa kuti uwane iyo yaunoda kuburitsa chimiro.
• Kugadzikana: Cellulose ana ana anaitter inopa kugadzikana kune iyo Matrix system, inovimbisa kusarongeka kwekusunungurwa kwemazuva.

6. Zvikumbiro:

• Kudhirowa kweMushonga Diki: Hydrophil Matrix Masystem anowanzo shandiswa kune mboga zvinodhaka zvinodhaka, kupa kusunungurwa kwakasimba uye kudzorwa.
• Mamiriro ezvinhu asingaperi: Yakanakira zvinodhaka inoshandiswa mumamiriro asingaperi okusunungurwa kwezvinodhaka zvinobatsira.

7. Kufunga:

• Kuumbidzwa kwechikumbiro: Iyo yekuumbwa inofanirwa kuve yakagadzirirwa kuzadzisa iyo yaunoda zvinodhaka zvinodhaka zvinodhaka zvichibva pane zvinodhaka zvinodiwa zvinodhaka.
• Kutonga kutevedzera: cellulose eter inoshandiswa mumishonga inofanirwa kutevedzera zviyero zvekutonga.

Kushandisa cellulose ana anaither muHydrophilic Matrix Systems kunoratidza kukosha kwavo mune mishonga yemishonga yekugadzira, kupa nzira inopesana uye inoshanda yekuwana kudzorwa kwezvinodhaka.