Hunhu hwepamusoro tekinoroji tekinoroji yehydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC)chinhu chakakosha chemakemikari, chinoshandiswa zvakanyanya mukuvaka, mishonga, chikafu uye mamwe minda. Kunyanya muindasitiri yekuvaka, HPMC inoshandiswa zvakanyanya nekuda kwekuita kwayo kwakanaka. Tekinoroji yepamusoro yekupisa inoita basa rakakosha mukugadzira uye kushandiswa kweHPMC.

1. Basa repamusoro tekinoroji tekinoroji muHPMC

kugadzirwa Hydroxypropyl methylcellulose inowanikwa nekutevedzana kwemakemikari kuita senge alkalization uye etherification yemasikirwo cellulose. Yakakwira tekinoroji tekinoroji inonyanya kushandiswa mukuparara, kuomesa uye kuumba matanho ekuita maitiro. Kurapa kwekushisa kwepamusoro hakungogone kukurumidza kuita chiyero, asiwo kunatsiridza kuchena uye kugadzikana kwechigadzirwa.

Kuvandudza maitiro ekuita

Pasi pemamiriro ekupisa kwepamusoro, chiyero chekuita kweselulosi uye sodium hydroxide inokwidziridzwa, iyo inosimudzira hydroxypropyl uye methyl substitution reactions mukati me cellulose mamorekuru, nekudaro inovandudza dhigirii rekutsiva (DS) uye kufanana kweHPMC.

Bvisa tsvina

Iyo yakanyanya tembiricha nharaunda inogona kunyatsobvisa ne-zvigadzirwa zvinogadzirwa panguva yekuita, senge isina kubatwa alkali mhinduro uye solvent, uye kuvandudza kuchena kweHPMC.

Kuvandudzwa kwekuomesa kushanda

Munguva yekudziya kwepamusoro-tembiricha yekuomesa, hunyoro hweHPMC hunobuda nekukurumidza, kudzivirira chigadzirwa kubva mukusangana kana kudhirowa pakudziya kwakadzika, uye kugadzirisa kugadzikana uye kuchengetedza kuita kwechigadzirwa.

2. Kukanganisa kwepamusoro-tembiricha tekinoroji pakuita kweHPMC

High-tembiricha tekinoroji haingokanganise chimiro chemuviri cheHPMC, asi zvakare ine simba rakadzama pane yayo kemikari zvimiro nemhedzisiro yekushandisa.

Viscosity kugadzirisa

Iyo yepamusoro-tembiricha maitiro anogona kunyatso kudzora kurema kwema molecular kugovera kweHPMC, nekudaro kugadzirisa viscosity yayo. Kupisa kwepamusoro kunobatsira kudzikisira mukana wekutyoka kwemamorekuru, zvichiita kuti viscosity yeHPMC mune aqueous mhinduro igadzikane.

Kuwedzera kupisa kusagadzikana

Kugadzikana kwekupisa kweHPMC kunovandudzwa zvakanyanya kuburikidza nepamusoro-tembiricha kurapwa. Mukuvaka dhaka uye mataira anonamira, HPMC inogona kuramba ichichengetedza yakanaka kunamatira uye anti-sagging zvivakwa pasi pemamiriro ekushisa.

Kuvandudza solubility

Munguva yekupisa kwepamusoro-kuomesa maitiro, iyo microstructure yeHPMC inogadziridzwa, ichiita kuti iwedzere kunyungudika mumvura inotonhora. Kunyanya munzvimbo dzakaderera-tembiricha yekuvaka, HPMC inogona kukurumidza kunyungudika uye kugadzira yunifomu colloidal mhinduro.

3. Kunyatsoshandiswa kwepamusoro tekinoroji tekinoroji muHPMC kugadzira maitiro

Etherification reaction stage

Nekuita etherification reaction patembiricha yepamusoro ye80-100 ° C, iyo inotsiva maitiro ehydroxypropyl uye methyl mapoka anogona kukurumidza, kuitira kuti HPMC ive nedanho repamusoro rekutsiva uye kugadzikana kuri nani.

Kuomesa uye kupwanya danho

Iyo inopisa mhepo yekuomesa tekinoroji inopfuura 120 ° C haigone chete kubvisa unyoro, asi zvakare kudzivirira HPMC hupfu kubva pakusangana panguva yekuomesa. Zvadaro, tekinoroji yepamusoro yekupwanya tekinoroji inoshandiswa kuita iyo HPMC hupfu zvidimbu zvitete uye yunifomu, uye dispersibility yechigadzirwa inovandudzwa.

High tembiricha kurapa kurapwa

Kana HPMC ichishandiswa muzvivakwa zvekuvaka kana machira, tembiricha yekurapa yekurapa inogona kuvandudza kuputika kwayo, sag kuramba uye kuita kwekuchengetedza mvura, kuve nechokwadi chekuvaka kwakanaka munzvimbo dzakaoma.

4. Zvakanakira tekinoroji yakakwirira muHPMC application minda

Zvishandiso zvekuvaka

Pasi pemamiriro ekunze ekupisa, HPMC inoratidza kukora uye kuchengetwa kwemvura mudhaka uye putty poda, kudzivirira dhaka kubva nekukurumidza kupera mvura uye kuputika.

Indasitiri yependi

HPMC yakasanganiswa nekupisa kwakanyanya ine yakanaka kuyera uye anti-sagging mhedzisiro mu latex pendi, inovandudza kunamatira uye kupfeka kuramba kwejasi.

Pharmaceutical industry

Tekinoroji yepamusoro yetembiricha inogona kuvandudza kufanana kweHPMC mukuputira zvinodhaka uye kuve nechokwadi chekugadzikana kwemushonga unosimudzira kuburitsa.

Kushandiswa kweteknolojia yepamusoro yekushisa kwehydroxypropyl methylcellulosehaingonatsiridzi kushanda kwekugadzira, asiwo inovandudza kuita kwechigadzirwa. Kuburikidza nekupisa kwekushisa kwakanyanya, viscosity, solubility uye kugadzikana kwekupisa kweHPMC kwakagadziridzwa zvakanyanya, zvichiita kuti ive netarisiro yakakura yekushandisa muminda yekuvaka, machira uye mushonga. Mune ramangwana, nekuenderera mberi kwekuvandudza tekinoroji yepamusoro tekinoroji, mashandiro eHPMC achavandudzwa zvakare, achiita mipiro yakakura mukusimudzira zvinhu zvakasvibirira uye zvakatipoteredza.