Makemikari maitiro mune fermentation ye hydroxyprupylpropyl methylcellose

Hydroxyprupyl methylcellose (HPMC)Iyo polymer ine mvura inowanzoitika inowanzo shandiswa muminda yeindasitiri uye yekurapa, uye ine huwandu hwenzvimbo dzekushandisa, dzakadai sekusunungurwa zvinoitwa zvinodhaka, zvekugadzira uye zvekuvakisa. Iyo yemakemikari maitiro mune yayo yekufemera maitiro inonyanya kuve nehurumende uye kugadziridzwa kwemheremalose uye zviitiko zve metabolic zvehutachiona. Kuti vanzwisise zviri nani maitiro emakemikari eHPMC muFermentation maitiro, isu tinotanga tichida kunzwisisa chimiro chayo chakakosha uye maitiro ekushambadzira kwemheremello.

1. Chimiro chakakosha uye zvivakwa zve hydroxyprupyl methylcellose

HPMC ndeyekuti inobviswa yakawanikwa nemakemikari kugadziridzwa kwemasikirwo cellulose (cellulose). Iyo backbone yeiyo yayo molecular cheni ndeye glucose mamorekuru (C6H12O6) yakabatana ne β-1,4 zvisungo zvegumi zvegumi. Cellulose pachayo yakaoma kunyungudika mumvura, asi nekuunza methyl (-Och3) uye hydroxypruppropyl (-C3KoxprEpyl (-c3h7Oop) mapoka, iyo solubility yemvura inogona kuvandudzwa kwazvo kuumba polymer. Maitiro ekugadziridza eHPMC anowanzo kusanganisira kuitwa kweCellulose ne methyl chloride (Ch3cl) uye procylene doro (C3H6O) pasi peAlkaline mamiriro, uye chigadzirwa chinokonzerwa nehydrophilikuti yakasimba uye solubility.

2. Kemical maitiro panguva yekufemerwa

Iyo fermentation maitiro eHPMC inowanzoenderana nekuita kwehutachiona, iyo inoshandisa HPMC seCarbon Source uye zvinovaka muviri. Maitiro eFermentation yeHPMC inosanganisira inotevera huru matanho:

2.1. Kusvibiswa kweHPMC

Cellulose pachayo yakaumbwa neye glucose zvikamu zvakabatana, uye HPMC ichasvibiswa necroormanisms panguva yekufemerwa, yakatanga kuiswa mune zvidiki zvinoshandiswa zvinoshandiswa (senge glucose, xylose, etc.). Maitiro aya anowanzobatanidza chiitiko chehuwandu hweCelliple Cellulose Shoging enzymes. Iyo huru yekusagadzikana maitiro inosanganisira:

Cellulose Hydrolysis Reaction: Iyo β-3,4 3,4 yeGlycosices mamorekuru ichavhunika neCellulose Hydrolases (senge cellulose) (endocellause), senge oligosachacrides, leachcharides, etc.). Aya mashuga anozoenderera mberi metabolized uye akashandiswa ne microorganisms.

Hydrolysis uye kusvibiswa kweHPMC: Iyo methyl uye hydroxypruppropyl inoongorora muHPMC Molecule ichabviswa neHydrolysis. Iyo chaiyo mechina yeiyo hydrolyis yekuita haisati yanzwisiswa, asi inogona kufuratirwa kuti mumativi emvura, iyo hydrolyis yakagadziriswa ne enzymes yakavanzika neHollemms (senge hydroxyl esterase). Maitiro aya anotungamira kuzororo reHPMC mamekari ngetani uye kubviswa kwemapoka anoshanda, pakupedzisira achiumba madiki madiki madiki mamorekuru.

2.2. Microbial metabolic maitiro

Kamwe HPMC yakanyungudutswa kuita madiki madiki mamorekuru, microorganisms anokwanisa kushandura aya mashuga kupinda mune enzymatic maitiro. Kunyanya, microorganisms lecome glucose mu ethanol, lactic acid kana mamwe metaboliting kuburikidza neFermentation nzira. Mikana Yakasiyana Yakasiyana May Metabolize HPMC Degradation Zvigadzirwa nenzira dzakasiyana nzira. Zvakajairika metabolic nzira dzinosanganisira:

Glycolysis Pathy: Glucose yakaiswa muPyruvate ne enzymes uye yakaenderera ichishandurwa kuita simba (ATP) uye metabolit acid, ethanol, etc.).

Chigadzirwa Chigadzirwa Chigadzirwa: Under anaerobic kana Hypoxic Mamiriro ezvinhu

2.3. Redox reaction

Munguva yeFermentation maitiro eHPMC, mamwe mikana yehutachiona anogona kuwedzera shanduko yepakati pezvigadzirwa kuburikidza neRedox maitiro. Semuenzaniso, maitiro ekugadzira ethanol anoperekedzwa neRedox maitiro, Glucose is oxidized yekugadzira pyruvate, uyezve pyruvate inoshandurwa kuita ethanol kuburikidza nekudzikiswa maitiro. Izvi zvinoitwa zvakakosha kuti urambe uine metabolic chiyero chemasero.

3. Dzora zvinhu mune yekufemerwa maitiro

Munguva yekufemerwa kwemaficha eHPMC, zvakatipoteredza zvinhu zvine pesvedzero yakakosha pane zvemakemikari maitiro. Semuenzaniso, ph, tembiricha, yakanyungudika oxygen yezvinyorwa, zvinovaka muviri sosi, etc. ichaita iyo metabolic chiyero chehutachiona uye mhando yezvigadzirwa. Kunyanya kupisa uye pH, basa rezvisikwa zvechisimba vanogona kusiyana zvakanyanya pasi pedzimba dzakasiyana uye nekukasira kudzora kusvibiswa kweHPMC uye kufambira mberi kwakapfava kweiyo metabolic maitiro ehutachiona.

Maitiro ekufemerwa aHpcInosanganisira maitiro akaoma emakemikari, kusanganisira hydrolysis yemheremalose, kusvibiswa kweHPMC, iyo metabolism yemashu, uye chizvarwa chezvigadzirwa zvekufemerwa. Kunzwisisa izvi zviitiko hazvingobatsire kungoita kuti ugadzirise maitiro eHPMC, asi zvakare inopawo rutsigiro rwezvekutsigirwa kwechigadzirwa zvine chekuita neindasitiri. Nekunetseka kwekutsvagisa, nzira dzinobudirira uye dzehupfumi dzinogona kuvandudzwa mune ramangwana kuti dzivirane neHPMC uye goho reHPMC muBiotransformation, kuchengetedzwa kwezvakatipoteredza uye nezvimwe minda.