Mumunda wemishonga, sodium carboxymethylcellulose (CMC) uye hydroxypropyl methylcellulose (HPMC) maviri anowanzo shandiswa emishonga excipients ane akasiyana makemikari zvinhu uye mabasa.
Chimiro chemakemikari uye maitiro
CMC imvura inonyungudika selulosi inotorwa nekushandura chikamu chemapoka ehydroxyl e cellulose kuita mapoka ecarboxymethyl. Kunyungudika kwemvura uye viscosity yeCMC inoenderana nedhigirii rayo rekutsiva uye huremu hwemamorekuru, uye inowanzoita seyakanaka gobvu uye inomisa mumiriri.
HPMC inowanikwa nekutsiva chikamu chemapoka ehydroxyl e cellulose ne methyl uye hydroxypropyl mapoka. Kuenzaniswa neCMC, HPMC ine kunyungudika kwakakura, inogona kunyungudika mumvura inotonhora uye inopisa, uye inoratidza yakagadzikana viscosity pane akasiyana pH kukosha. HPMC inowanzo shandiswa seyaimbova firimu, inonamira, yakakora uye inodzorwa kuburitsa mumiriri mumishonga.
Nzvimbo yekushandisa
Mahwendefa
Mukugadzirwa kwemapiritsi, CMC inonyanya kushandiswa se disintegrant uye inonamira. Sekusagadzikana, CMC inogona kutora mvura nekuzvimba, nekudaro ichikurudzira kuparara kwemapiritsi uye kuwedzera kuburitswa kwemishonga. Sebhainda, CMC inogona kuwedzera simba remagetsi remapiritsi.
HPMC inonyanya kushandiswa seyaimbova firimu uye inodzorwa kuburitsa mumiriri mumapiritsi. Iyo firimu yakaumbwa neHPMC ine yakanakisa mechanical simba uye kupfeka kuramba, izvo zvinogona kudzivirira mushonga kubva pesvedzero yekunze kwezvakatipoteredza. Panguva imwecheteyo, iyo firimu-yekugadzira zvimiro zveHPMC inogona zvakare kushandiswa kudzora kuburitswa kwemushonga. Nekugadzirisa mhando uye dosi yeHPMC, kuburitswa kwakasimba kana kudzorwa kuburitsa maitiro kunogona kuwanikwa.
Capsules
Mukugadzirira capsule, CMC haishandiswe zvishoma, nepo HPMC ichishandiswa zvakanyanya, kunyanya mukugadzirwa kwemakapulisi emiriwo. Traditional capsule shells anonyanya kugadzirwa gelatin, asi nekuda kwedambudziko remhuka masosi, HPMC yave yakanakira imwe nzira. Iyo capsule shell yakagadzirwa neHPMC haina kungoita yakanaka biocompatibility, asi zvakare inosangana nezvinodiwa nevarimi.
Kugadzirira kwemvura
Nekuda kwekunaka kwayo kukora uye kumiswa zvivakwa, CMC inoshandiswa zvakanyanya mukugadzirira kwemvura senge mhinduro dzemuromo, madonhwe eziso uye gadziriro dzepamusoro. CMC inogona kuwedzera viscosity yegadziriro yemvura, nekudaro ichivandudza kumiswa uye kugadzikana kwezvinodhaka uye kudzivirira kuputika kwezvinodhaka.
Iko kushandiswa kweHPMC mukugadzirira kwemvura kunonyanya kuisirwa mumakobvu uye emulsifiers. HPMC inogona kuramba yakagadzikana pamusoro pehupamhi hwepH uye inogona kuenderana nemhando yemishonga pasina kukanganisa kushanda kwemishonga. Mukuwedzera, iyo firimu-inogadzira zvimiro zveHPMC inoshandiswawo mukugadzirira kwepamusoro, senge firimu-inogadzira inodzivirira maitiro mumadonhwe eziso.
Kudzorwa kusunungurwa gadziriro
Mukugadzirisa kusunungurwa gadziriro, kushandiswa kweHPMC kunonyanya kuoneka. HPMC inokwanisa kugadzira gel network, uye chiyero chekuburitswa kwemushonga chinogona kudzorwa nekugadzirisa kusungwa uye chimiro cheHPMC. Ichi chivakwa chave chichishandiswa zvakanyanya mumuromo inosimudzira-kuburitsa mahwendefa uye ma implants. Kusiyana neizvi, CMC haishandiswe zvishoma mukugadzirisa-kuburitsa gadziriro, kunyanya nekuti iyo gel chimiro chainoumba haina kugadzikana seHPMC.
Kugadzikana uye kuenderana
CMC ine kugadzikana kwakashata pane akasiyana pH kukosha uye inokanganiswa nyore neasidhi-base nharaunda. Pamusoro pezvo, CMC haina kufambirana zvakanaka nezvimwe zvinosanganisa zvinodhaka, izvo zvinogona kukonzera kunaya kwezvinodhaka kana kutadza.
HPMC inoratidza kugadzikana kwakanaka pamusoro pehupamhi pH renji, haisi nyore kukanganiswa neasidhi-base, uye ine kugarisana kwakanaka. HPMC inogona kufambirana nemishonga yakawanda inosanganiswa pasina kukanganisa kugadzikana uye kushanda kwemushonga.
Kuchengetedzwa nemitemo
Ose CMC neHPMC anoonekwa seakachengeteka emishonga excipients uye akabvumidzwa kuti ashandiswe mukugadzirira kwemishonga ne pharmacopoeias uye masangano anodzora munyika dzakasiyana siyana. Nekudaro, panguva yekushandiswa, CMC inogona kukonzera kumwe kusawirirana kwemuviri kana kusagadzikana kwemudumbu, nepo HPMC isingawanzo kukonzera maitiro akashata.
CMC neHPMC vane zvazvakanakira mukushandisa kwemishonga. CMC inogara pachinzvimbo chakakosha mukugadzirira kwemvura nekuda kwekukora kwayo uye kumisa zvivakwa, nepo HPMC yakashandiswa zvakanyanya mumapiritsi, makapisi uye inodzorwa-kuburitsa gadziriro nekuda kweakanakisa kugadzira firimu uye kudzora-kuburitsa zvivakwa. Kusarudzwa kwemishonga yemishonga kunofanirwa kuve kwakavakirwa pane chaiwo zvinodhaka zvinodhaka uye zvinodiwa zvekugadzirira, kunyatsotarisa zvakanakira nekuipira kwezvose zviri zviviri, uye kusarudza akakodzera anobatsira.
Nguva yekutumira: Jul-19-2024