Mumunda wemishonga, sodium carboxymellosellose (cmc) uye hydroxyprusterl methylcellose (HPMC) maviri anowanzoshandiswa mishonga yemakemikari ane mari yemakemikari uye mabasa.
Makemikari chimiro uye zvivakwa
CMC imvura-solullose cellulose inobviswa yakawanikwa nekuchinja chikamu cheiyo hydroxyl mapoka emheremanyo mumapoka eCarbolmeymethyl. Iyo solubility yemvura uye viscosity yeCMC inotenderana nedanho rayo rekutsiva uye rinosemesa uremu, uye kazhinji inozvibata seyakanaka yakanaka uye kumhanyisa mumiririri.
HPMC inowanikwa nekutsiva chikamu cheiyo hydroxyl mapoka e cellulose ine methyl uye hydroxpropropyl mapoka. Kuenzaniswa neCMC, HPMC ine salubility yakafara, inogona kunyungudutswa mumvura inotonhora uye inopisa, uye inoratidzira yakagadzikana viscosity pane akasiyana PP kukosha. HPMC inowanzoshandiswa seye firimu yaimbova, inonamatira, yakanamatira uye yakadzorwa kuburitswa mumiriri mumishonga yemishonga.
Chikumbiro munda
Mahwendefa
Mukugadzirwa kwehwendefa, cmc inonyanya kushandiswa sekuparadzaniswa uye kunamatira. Semunhu anoparadzanisa, cmc anogona kutora mvura uye kuzvimba, nekudaro kusimudzira kufambiswa kwemapiritsi uye kuwedzera huwandu hwezvinodhaka. Semhizha, cmc inogona kuwedzera simba rekuita remahwendefa.
HPMC inonyanya kushandiswa seye firimu aimbova uye yakadzorwa kuburitswa mumatanda emapiritsi. Iyo firimu yakaumbwa neHPMC ine simba rakanakisa simba uye kupfeka kurwisa, izvo zvinogona kuchengetedza zvinodhaka kubva pane zvekunze nharaunda. Panguva imwecheteyo, iyo firimu-inoumba midziyo yeHPMC inogona zvakare kushandiswa kudzora huwandu hwekuburitsa mushonga. Nekugadzirisa iyo mhando uye dosage yeHPMC, kusunungurwa kwakasvitswa kana kudzorwa kusunungurwa kunogona kuwanikwa.
Makapu
MuCapsule Kugadzirira, CMC haina kunyatso shandiswa, nepo Hpmc ichishandiswa zvakanyanya, kunyanya mukugadzirwa kwemakapu emiriwo. Zvivakwa zveCapsule Capsule zvinonyanya kugadzirwa neGelatin, asi nekuda kwedambudziko rezvinyorwa zvemhuka, HPMC rave riri nzira yakakodzera imwe zvinhu. Iyo capsule shell yakagadzirwa neHPMC haina chete yakanaka biocomputer, asi zvakare inosangana nezvinodiwa zvevarwi.
Gadziriro dzemvura
Nekuda kwekukakavara kwayo kwakanakisa uye kumiswa kwakasimba, CMC inoonekwa zvakanyanya mukugadzirira kwemvura senge miromo yemuromo, ziso rinodonha uye kugadzirira kwemeso. CMC inogona kuwedzera vhiza yekugadzirira kwemvura, nekudaro ichivandudza kumiswa uye kugadzikana kwezvinodhaka uye kudzivirira madhiragi.
Iko kushandiswa kweHPMC mumifananidzo yekugadzirira kunonyanya kutaurwa mune manhamba uye emulsifiers. HPMC inogona kuramba yakagadzikana pamusoro pakawanda ph range uye inogona kuenderana nemhando dzakasiyana dzemishonga pasina kukanganisa kushanda kwemishonga. Uye zvakare, iyo firimu-inogadzira zvivakwa zveHPMC inoshandiswawo mu gadziriro dzepakati, dzakadai sekudzivirira kwemufirimu wekudzivirira mumadonhwe emaziso.
Kudzoserwa Kuburitswa Kugadzirira
Kugadzirira kwakadzorwa kusunungurwa, kushandiswa kweHPMC kunonyanya kuzivikanwa. HPMC inokwanisa kuumba gel network, uye chiyero chekuburitsa chemushonga chinogona kudzorwa nekugadzirisa iyo yekugadzirisa uye chimiro cheHPMC. Ichi chivakwa chakashandiswa zvakanyanya mumapiritsi ekusimbisa emuromo-ekusimudzira uye zvipuka. Mukupesana, CMC haina kunyatso shandiswa mukugadzirira-gadziriro-gadziriro, kunyanya nekuti iyo gel dhizaini yemafomu haina kugadzikana seHPMC.
Kugadzikana uye kuwirirana
CMC ine kusakwana kusimba pane akasiyana PP kukosha uye kunokanganiswa nyore nyore neacid-base nharaunda. Mukuwedzera, cmc ine kusarongeka kune zvimwe zvinoshandiswa zvinodhaka, izvo zvinogona kukonzera kupopotera zvinodhaka kana kutadza.
HPMC inoratidza kugadzikana kwakanaka pamusoro peyakafara pH ravhu, haina kukanganiswa nyore nyore neak-acid-base, uye ine yakanakisa kuwirirana. HPMC inogona kuwirirana nezvinodhaka zvinodhaka pasina kukanganisa kugadzikana uye kushanda kwemushonga.
Kuchengetedzwa nemirairo
Ose cmc uye HPMC inoonekwa seyakachengeteka mishonga yekukasira uye yakabvumidzwa kushandiswa mukugadzirira kweMishonga nePharmacipoe uye yekuzvidzora masangano munyika dzakasiyana siyana. Nekudaro, panguva yekushandisa, cmc inogona kukonzera kumwe kusagadzikana kwekuita kana kushungurudzika kusagadzikana, nepo hpmc zvisingawanzo kukonzera kuita kwakashata.
CMC uye HPMC ine yavo zvakanakira iwe pachako muzvishandiso zvemishonga. CMC inobata chinzvimbo chakakosha pakugadzirira kwemvura nekuda kwekumisikidzwa kwakakura uye kumiswa kwakazara mumapiritsi, capsuled gadziriro-yekugadzirira-inokonzeresa mafirimu ekugadzira uye kudzora-kubudiswa. Iko kusarudzwa kweMishonga Kugadzirira kunofanirwa kuve kwakavakirwa pane zvakananga zvinodhaka zvivakwa uye zvinodikanwa zvekugadzirira, zvinonzwisisika kuongorora zvakanakira nezvose zviri zviviri, uye kusarudza iyo yakakodzera kwazvo comcihande.
Kutumira Nguva: Jul-19-202024