HydroxyPropyl methylcellose, inowanzozivikanwa seHPMC, ishandiswe zvakanyanya phamaceucexical excicient uye chikafu chinowedzera. Nekuda kwekunyora kwayo solubility, kusunga kugona uye mafirimu-ekugadzira midziyo, iyo yakashandiswa zvakanyanya muindasitiri yemishonga yemishonga. HPMC inowanzo shandiswa mune indasitiri yechikafu sedhizimikira, emulsifieri uye stabilizer. Kuchena kweHPMC kwakakosha mukukosha kweshanduro yemishonga uye ezvekudya sezvinoita zvinobudirira uye kuchengeteka kwechigadzirwa. Chinyorwa ichi chinokurukura kutsunga kweHPMC uye nzira dzayo.
Ndezvipi hpmcs?
Hydroxypronylmethylcellose (HPMC) ndeye cellulose ether inotorwa kubva methylcellose. Huremu hwayo hunoremerwa zviuru gumi kusvika ku19,000,000 maDaltonons, uye izena chena kana rakachena-jena, kusava neutsinye uye zvisina kunaka. Hpmc inochema nyore mumvura, uye zvakare inonyudza mune mamwe organc sol sol solanol, Butanol, uye chloroform. Iyo ine zvimwe zvakasarudzika zvivakwa zvakadai sekuchengetwa kwemvura, kuremerwa uye kusunga kugona, izvo zvinoita kuti ive yakakodzera kune maindasitiri emishonga uye ekudya.
Kutsunga kweHPMC kuchena
Iko kuchena kweHPMC kunoenderana nezvinhu zvinoverengeka zvakadai sedanho rekutsiva (DS), zvinyoro-nyoro uye zvisikwa zvemukati. DS inomiririra nhamba yeiyo hydroxyl mapoka yakatsiva ne hydroxypruspropyl mapoka muCellulose Molecule. Dhigirii rakakwirira rekutsiva rinowedzera iyo solubility yeHPMC uye inovandudza kugona kwemufirimu. Zvekare, huwandu hwakadzika hwekutsiva hwaizoguma hwakaderedzwa solubility uye hurombo firimu-kugadzira zvivakwa.
HpMc Purity Kutsunga nzira
Pane nzira dzinoverengeka dzekusarudza kuchena kweHPMC, kusanganisira acid-base titration, Elemental ongororo, yakakwirira-performangraphy chromato (Hplc), uye infrared spectroscopy (IR). Heano iwo mamiriro enzira imwe neimwe:
acid-base titration
Nzira yacho inoenderana neyakaitwa nearralization maitiro pakati pemapoka ealidic uye yekutanga muHPMC. Kutanga, HPMC yakanyungudutswa mune solvent uye inhongwe inozivikanwa yeiyo acid kana base mhinduro yekuziva kuzivikanwa kunowedzerwa. Titranation yakaitwa kusvika iyo ph yasvika isina kwayakarerekera. Kubva pane huwandu hwe acid kana chigadziko chakadyiwa, iyo degree rekutsiva rinogona kuverengerwa.
Elemental Analysis
Elemental ongororo inoyera iyo muzana yezvinhu chimwe nechimwe chinhu chiripo mumuenzaniso, kusanganisira kabhoni, hydrogen, uye oksijeni. Dhigirii rekutsiva rinogona kuverengerwa kubva kuhuwandu hwezvinhu chimwe nechimwe chiripo muHPMC sampuli.
Yakakwira performance yemvura chromatography (HPLC)
HPLC ndeyekunyatsoongorora maitiro ayo anoparadzanisa zvikamu zvemusanganiswa zvichienderana nekudyidzana kwavo neyekufambiswa uye nhare mbozha. In HPMC, the degree of substitution can be calculated by measuring the ratio of hydroxypropyl to methyl groups in a sample.
Infrared Spectroscopy (IR)
Infrared spectroscopy ndeye ongororo yekuongorora iyo inoyera iyo yekukanda kana kutapurirana kwemavhiringidzwe redhiation nemuenzaniso. HPMC ine akasiyana-siyana ekunyudza kwehydroxyl, methyl uye hydroxypruppropyl, iyo inogona kushandiswa kuona iyo degree rekutsiva.
Kuchena kweHPMC kwakakosha mumishisheni yemishonga uye yekudya, uye kutsunga kwayo kwakakosha kuti uve nechokwadi chekuchengetedza uye kushanda kwechigadzirwa chekupedzisira. Nzira dzinoverengeka dziripo kuti dzione kuchena kweHPMC, kusanganisira acid-base titration, Elemental ongororo, HPLC, uye IR. Imwe neimwe nzira ine zvayo zvakanakira uye zvakashata uye zvinogona kusarudzwa zvichienderana nezvinodiwa zvekushandisa. Kuti uchengetedze kuchena kweHPMC, inofanira kuchengetwa munzvimbo yakaoma, inotonhorera kure nezuva uye zvimwe zvinosvibisa.
Kutumira Nguva: Aug-25-2023