Hydroxypropyl methylcellulose (HPMC)inokosha cellulose ether ine zvakasiyana-siyana zvekushandiswa, kunyanya muminda yekuvaka, mishonga, zvokudya, nezvimwewo Maererano nenzira dzakasiyana-siyana dzekugadzirisa, HPMC inogona kugoverwa mumhando-yakagadziriswa uye isina kubatwa.
1. Kusiyana kwemaitiro ekugadzira
HPMC isina kurapwa
Isina kubatwa HPMC haiitirwe yakakosha yekumusoro yekubatisa kurapwa panguva yekugadzira, saka hydrophilicity yayo uye solubility zvinochengetwa zvakananga. Iyi mhando yeHPMC inoputika nekukurumidza uye inotanga kunyungudika mushure mekusangana nemvura, ichiratidza kukurumidza kuwedzera kwe viscosity.
Pamusoro-yakarapwa HPMC
Surface-yakarapwa HPMC ichave neimwe yekuwedzera coating process yakawedzerwa mushure mekugadzirwa. Zvinhu zvakajairika zvekurapa pamusoro peacetic acid kana mamwe makomisheni akakosha. Kuburikidza nekurapa uku, firimu rehydrophobic richaumbwa pamusoro pezvikamu zveHPMC. Kurapa uku kunononotsa kunyungudika kwayo, uye kunowanzodikanwa kumisa kunyungudika neyunifomu kubvongodza.
2. Kusiyana mu solubility properties
Dissolution maitiro eiyo isina kurapwa HPMC
HPMC isina kurapwa ichatanga kunyungudika pakarepo mushure mekusangana nemvura, iyo inokodzera zviitiko zvine zvakakwirira zvinodiwa pakuparara kwekukurumidza. Nekudaro, sezvo kukurumidza kunyungudika kuri kuita maagglomerates, kukurumidza kwekudya uye kufanana kunomutsa kunoda kudzorwa zvakanyanya.
Dissolution maitiro epamusoro-akarapwa HPMC
Iko kupfekedza pamusoro pepamusoro-yakagadziriswa HPMC zvimedu zvinotora nguva kunyungudika kana kuparadza, saka nguva yekunyungudika irefu, kazhinji maminetsi akati wandei kusvika anopfuura maminetsi gumi. Iyi dhizaini inodzivirira kuumbwa kweagglomerates uye inonyanya kukodzera zviratidziro zvinoda yakakura-yekukurumidza kusimudzira kana yakaoma mhando yemvura panguva yekuwedzera maitiro.
3. Kusiyana muviscosity maitiro
Surface-treated HPMC haizobudise viscosity nekukurumidza isati yaparara, nepo HPMC isina kurapwa ichikurumidza kuwedzera viscosity yehurongwa. Naizvozvo, mumamiriro ezvinhu apo viscosity inoda kugadziridzwa zvishoma nezvishoma kana iyo nzira inoda kudzorwa, iyo yepamusoro-yakagadziriswa mhando ine zvimwe zvakanakira.
4. Misiyano muzviitiko zvinoshanda
Unsurface-yakarapwa HPMC
Inokodzera zviratidziro zvinoda kukurumidza kunyungudika uye nekukasira kuita, senge instant capsule coating agents mumunda wemishonga kana kukurumidza kukora muindasitiri yechikafu.
Inoitawo zvakanaka mune zvimwe zvidzidzo zvemurabhoritari kana kugadzirwa-diki nekudzora kwakasimba kwekutevedzana kwekudya.
Pamusoro-yakarapwa HPMC
Inoshandiswa zvakanyanya muindasitiri yekuvaka, semuenzaniso, mune yakaoma dhaka, tile yekunamatira, machira uye zvimwe zvigadzirwa. Zviri nyore kuparadzira uye haigadziri agglomerates, iyo inonyanya kukodzera kune mechanized kuvaka mamiriro.
Inoshandiswawo mune mamwe magadzirirwo emishonga anoda kuburitswa kwakasimba kana chikafu chekuwedzera chinodzora chiyero chekuparara.
5. Mutengo nekuchengetedza kusiyana
Mutengo wekugadzira wepamusoro-yakarapwa HPMC wakakwira zvishoma pane iyo isina kurapwa, iyo inoratidzwa mumusiyano wemutengo wemusika. Mukuwedzera, rudzi rwepamusoro-soro rine chidziviriro chekudzivirira uye chine zvishoma zvinodiwa kune humidity uye tembiricha yenzvimbo yekuchengetera, nepo rudzi rusina kubatwa rune hygroscopic uye rwunoda zvakanyanya kuomarara mamiriro ekuchengetedza.
6. Sarudzo hwaro
Pakusarudza HPMC, vashandisi vanofanirwa kufunga zvinotevera mapoinzi zvinoenderana nezvinodiwa chaizvo:
Mwero wekuparara wakakosha here?
Zvinodiwa zve viscosity kukura mwero.
Kunyangwe nzira dzekudyisa uye dzekusanganisa dziri nyore kugadzira agglomerates.
Iyo maindasitiri maitiro echinangwa chekushandisa uye yekupedzisira kuita zvinodiwa zvechigadzirwa.
Yakagadziriswa pamusoro uye isina-pamusoro-yakarapwaHPMCvane hunhu hwavo. Iyo yekutanga inovandudza kureruka kwekushandisa uye kugadzikana kwekushanda nekushandura maitiro ekuparara, uye inokodzera kugadzirwa kwakakura kwemaindasitiri; iyo yekupedzisira inochengetedza yakakwira yekunyungudika uye yakanyanya kufanirwa kune yakanaka makemikari indasitiri inoda yakakwira yekuparara. Sarudzo yerudzi rwupi runofanira kusanganiswa neiyo chaiyo application mamiriro, maitiro mamiriro uye mutengo bhajeti.
Nguva yekutumira: Nov-20-2024