Hydroxylopyolin (HPMC) ndeye polymer yakashandiswa zvakanyanya muindasitiri yemishonga uye ndeye fomu yakakosha. Iyo inonyanya kushandiswa seinonamatira mudenga rakasimba (senge mapiritsi, makapini, uye zvimedu), viscosity yakawedzera mumiririri uye kuora.
Mukugadzirira kwezvinodhaka, kupaza kwezvinhu zvinoshanda zvakakosha kuti utore uye kuburitsa kurapwa. Nekudaro, kutsvuka kwezvinhu zvinoshanda zvinogona kudziviswa nefomula. Naizvozvo, zvakakosha kuti unzwisise maitiro ekunyungudutswa yeHPMC mune yezvinodhaka formula nekuti inokanganisa mashandiro emhando yemugodhi.
Hpmc's Crutsution nzira
US pharmacy (USP) yakaenzanisa nzira yekuedzwa yekunyungudika HPMC. Iyi nzira inowanzobatanidza kushandiswa kwemidziyo yekunyungudika, iyo inofungidzira uye inoyera iyo solubility yemhando yemhando mune svikiro yemhinduro yepasi. Muedzo unosanganisira kuisa dosage mubhasikiti kana paddle, uye bhasiketi kana paddle rinotenderera mumudziyo une mwero wakanyungudika.
Iyo solubility yepakati inofanirwa kusarudzwa maererano nekutarisirwa kushandiswa kweiyo dosage (yakadai se gastric kana mudumbu kupera). Common Solubility yeHPMC inosanganisira mvura, phosphathe buffer solution uye simpulation gastric juice (sgf) kana analog mumbenderekedzo yemvura (SIF).
Kuti muve nechokwadi chekudzokorora uye kurongeka, ma parmeter anofanirwa kunge akaenzana, sekumhanya kwekutenderera, tembiricha, uye kusvetuka pakati uye sampling nguva. Wobva washandisa nzira yakakodzera yekuongorora kuti uongorore mhinduro yemuenzaniso yakawanikwa nenguva dzakasiyana nguva dzekusarudza huwandu hweHPMC DISSOLULT.
Kudzivirira matanho kana uchiita HPMC inonyungudika bvunzo
1. Kusarudzwa kweiyo chaiyo yekunyungudika pakati: Iko kusarudzwa kwekunyungudika kwepakati kwakavakirwa pane iyo inotarisirwa kushandiswa kweiyo dosge fomu. Kusarudza nzvimbo yakakodzera yekunyungudika yakakosha nekuti ichakanganisa maitiro eHPMC.
2.. Verified inofanira kusanganisira kusimba uye kudzokorora kweyekuyerwa.
3. Kubata kweye bvunzo paramita: test paramita, sekumhanya kwekutenderera, tembiricha, uye isina kunyungudika mwezhonga vhoriyamu inokanganisa mhedzisiro yekunyungudika bvunzo. Naizvozvo, aya paramita anofanira kuve akaenzana kuti ave nechokwadi chekureva uye kunyatsoongorora.
4. Teerera kune nguva uye sampling mapoinzi kuti uone kuti sampuli inounganidzwa munguva yakabatana.
5. Kuongorora nzira: Sarudza nzira yekuongorora yekuongorora ichasimbiswa, uye inofanirwa kuve nekunzwa kwakakodzera, kusarudza uye chokwadi.
Muchidimbu, iyo yekunyungudika bvunzo yeHPMC chishandiso chakakosha mukuvandudza zvinodhaka uye zvinodhaka formula. Iyo mhando yekudzora rabhoritari inoitwa nguva dzose kuti ive nechokwadi chekuburitswa chaiko kwezvinhu zvinoshanda, uye zvinodhaka zvakachengeteka uye zvinoshanda. Iko kukanganisa munzira yakakodzera nzira kunogona kutungamira kusanzwisisana uye zvirevo zvekunyepedzera pane zvinodhaka zvinodhaka. Naizvozvo, zvakakosha kutevedzera zviyero uye matanho ekudzivirira panguva yekubvunzurudzwa kwebvunzo.
Tumira nguva: Jun-29-2023