Hydroxypropyl methylcellulose (HPMC)inowanzoshandiswa mvura-soluble polymer compound, inoshandiswa zvakanyanya mumishonga, chikafu, zvekuvakisa, zvizoro uye mamwe minda. HPMC ine yakanaka solubility uye viscosity maitiro uye inogona kugadzira yakagadzikana colloidal mhinduro, saka inoita basa rakakosha mune akawanda maapplication. Kuti upe kutamba kwakazara kuita kweHPMC, nzira chaiyo yekumisa ndiyo inonyanya kukosha.
1. Normal tembiricha mvura dissolution nzira
HPMC inogona kunyungudika mumvura inotonhora, asi kazhinji humwe hunyanzvi hunodiwa kudzivirira kusangana kwayo. Kuti uvandudze dissolution effect, matanho anotevera anogona kushandiswa:
Danho 1: Wedzera HPMC kumvura
Patembiricha yemumba, tanga wamwaya HPMC zvakaenzana pamusoro pemvura kudzivirira kudira huwandu hukuru hweHPMC mumvura panguva imwe. Nekuti HPMC mukomboni wepolymer, kuwedzera zvakananga huwandu hukuru hweHPMC kuchaita kuti itore mvura nekuzvimba nekukurumidza mumvura kuita gel-sechinhu.
Danho rechipiri: Kukurudzira
Mushure mekuwedzera HPMC, ramba uchikurudzira zvakaenzana. Nekuti HPMC ine zvimedu zvakanaka, inozvimba mushure mekutora mvura kuita gel-sechinhu. Kukurudzira kunobatsira kudzivirira HPMC kubva mukusangana kuita clumps.
Danho rechitatu: Mira uye wedzera kumutsa
Kana HPMC isina kunyungudika zvachose, mhinduro inogona kusiiwa kuti imire kwechinguva uye wozoenderera mberi nekukurudzira. Inowanzove yakanyungudika zvachose mukati maawa mashomanana.
Iyi nzira yakakodzera nguva dzekudziya kusingade, asi zvinotora nguva yakareba kuti ive nechokwadi chekuti HPMC yanyungudika zvachose.
2. Kupisa mvura inopisa nzira
HPMC inonyungudika nekukurumidza mumvura inodziya, saka kupisa tembiricha yemvura kunogona kukurumidza kukurumidza kunyungudika. Iyo inowanzo shandiswa yekudziya yemvura tembiricha ndeye 50-70 ℃, asi yakanyanya kupisa tembiricha (senge inopfuura 80 ℃) inogona kukonzera HPMC kudzikisira, saka tembiricha inoda kudzorwa.
Danho 1: Kupisa mvura
Pisa mvura kusvika pa50 ℃ uye irambe iripo.
Danho 2: Wedzera HPMC
Mwaya HPMC zvishoma nezvishoma mumvura inopisa. Nekuda kwe tembiricha yepamusoro yemvura, HPMC inonyungudika zviri nyore, ichideredza agglomeration.
Danho rechitatu: Kukurudzira
Mushure mekuwedzera HPMC, ramba uchimutsa mhinduro ine aqueous. Iko kusanganiswa kwekudziya uye kukurudzira kunogona kusimudzira kukurumidza kupera kweHPMC.
Danho 4: Chengetedza tembiricha uye ramba uchikurudzira
Iwe unogona kuchengetedza imwe tembiricha uye ramba uchikurudzira kusvika HPMC yanyungudika zvachose.
3. Doro Disolution Method
HPMC inogona kunyungudika kwete mumvura chete, asiwo mune mamwe doro zvinonyungudutsa (zvakadai se ethanol). Mukana mukuru weiyo doro dissolution nzira ndeyekuti inogona kuvandudza solubility uye dispersibility yeHPMC, kunyanya kune masisitimu ane yakakwira yemvura.
Danho 1: Sarudza yakakodzera doro solvent
Doro zvinonyungudutsa senge ethanol uye isopropanol zvinowanzoshandiswa kunyungudutsa HPMC. Kazhinji kutaura, 70-90% ethanol mhinduro ine mhedzisiro iri nani pakunyungudutsa HPMC.
Danho 2: Dissolution
Mwaya zvinyoro nyoro HPMC mudoro solvent, uchikurudzira uchiwedzera kuve nechokwadi chekuti HPMC yakapararira zvizere.
Danho rechitatu: Kumira nekukurudzira
Iyo nzira yekunyungudutsa doro yekunyungudutsa HPMC inokurumidza, uye kazhinji inotora maminetsi mashoma kuti iwane kupera kwakakwana.
Iyo nzira yekunyungudutsa doro inowanzo shandiswa mumamiriro ekushandisa anoda kukurumidza kupera uye kuderera kwemvura.
4. Solvent-mvura yakasanganiswa dissolution nzira
Dzimwe nguva HPMC inonyungudika mumusanganiswa weimwe chikamu chemvura uye solvent. Iyi nzira inonyanya kukodzera mamiriro ezvinhu apo viscosity yemhinduro kana chiyero chekuparara chinoda kugadziriswa. Kazhinji zvinonyungudutsa zvinosanganisira acetone, ethanol, nezvimwe.
Danho 1: Gadzirira mhinduro
Sarudza chiyero chakakodzera chezvinonyungudutsa nemvura (semuenzaniso 50% mvura, 50% inonyungudutsa) uye kupisa kune tembiricha yakakodzera.
Danho 2: Wedzera HPMC
Paunenge uchikurudzira, zvishoma nezvishoma wedzera HPMC kuve nechokwadi chekuparara kweyunifomu.
Danho rechitatu: Kumwe kugadzirisa
Sezvinodiwa, chikamu chemvura kana chinonyungudutsa chinogona kuwedzerwa kugadzirisa solubility uye viscosity yeHPMC.
Iyi nzira yakakodzera kune dzimwe nguva apo organic solvents inowedzerwa kune aqueous solutions kuti ivandudze chiyero chekuparara kana kugadzirisa zvinhu zvekugadzirisa.
5. Ultrasonic-assisted dissolution method
Uchishandisa iyo yakakwira-frequency oscillation maitiro eiyo ultrasound, iyo ultrasonic-yakabatsira dissolution nzira inogona kukurumidzira kuparara kweHPMC. Iyi nzira inonyanya kukodzera kuwanda kweHPMC inoda kunyungudika nekukurumidza, uye inogona kuderedza dambudziko rekusangana rinogona kuitika panguva yechinyakare yekukurudzira.
Danho 1: Gadzirira mhinduro
Wedzera HPMC kune huwandu hwakakodzera hwemvura kana mvura-inonyungudika yakasanganiswa mhinduro.
Danho 2: Ultrasonic kurapwa
Shandisa ultrasonic cleaner kana ultrasonic dissolver uye ibate zvinoenderana neyakagadzikwa simba uye nguva. Iyo oscillation mhedzisiro ye ultrasound inogona kukurumidzira zvakanyanya kuparara kweHPMC.
Nhanho 3: Tarisa iyo dissolution maitiro
Mushure mekurapa kwe ultrasonic, tarisa kana mhinduro yacho yakanyungudika zvachose. Kana paine chikamu chisina kunyungudika, kurapwa kwe ultrasonic kunogona kuitwa zvakare.
Iyi nzira yakakodzera kune zvikumbiro zvinoda kugadziriswa uye nekukurumidza.
6. Pretreatment before dissolution
Kuti udziviseHPMCagglomeration kana kuomerwa mukunyunguduka, dzimwe nzira dzepretreatment dzinogona kushandiswa, sekusanganisa HPMC nekamwe kashoma kezvimwe zvinonyungudutsa (senge glycerol), kuiomesa kutanga, kana kunyorova HPMC usati wawedzera solvent. Aya matanho ekutanga ekurapa anogona kunyatso kuvandudza solubility yeHPMC.
Pane nzira dzakawanda dzekupedza HPMC. Kusarudza nzira yakakodzera yekunyungudutsa kunogona kuvandudza zvakanyanya kuparara kwekuita uye kunaka kwechigadzirwa. Iyo yekamuri tembiricha yekumisa nzira inokodzera nharaunda yakapfava, iyo inopisa mvura yekunyungudika nzira inogona kukurumidzira nzira yekunyungudika, uye nzira yekunyungudika doro uye nzira yekunyungudutsa-mvura yakasanganiswa yakasanganiswa inokodzera kunyungudika nezvinodiwa zvakakosha. Iyo ultrasonic-assisted dissolution method inzira inoshanda yekugadzirisa kukurumidza kupera kwehuwandu hweHPMC. Zvinoenderana nezvinodiwa zvekushandisa, iyo inochinjika sarudzo yeakakodzera nzira yekumisa inogona kuve nechokwadi chekushanda kwakanyanya kweHPMC mundima dzakasiyana.
Nguva yekutumira: Zvita-19-2024