Hydroxyprupyl methylcellose (HPMC)Iyo inowanzo shandiswa-inowanzo shandiswa-inoshandiswa polymer yakaenzana, inoshandiswa zvakanyanya mumishonga yemishonga, chikafu, zvekuvakisa, zviumbwe uye mamwe minda. HPMC ine yakanaka solubility uye viscosity hunhu uye inogona kuumba mhinduro yakagadzikana, saka inoita basa rakakosha mune akawanda mashandisiro. Kuti upe izere nekutamba nekuita kweHPMC, nzira chaiyo yekunyungudika inonyanya kukosha.
1. Zvakajairika kupisa kwemvura mvura yekunyungudza nzira
HPMC inogona kunyungudutswa mumvura inotonhora, asi kazhinji humwe hunyanzvi hunodiwa kuti udzivise zvakaunganidzwa. Kuti uvandudze kupaza maitiro, matanho anotevera anogona kushandiswa:
Nhanho 1: Wedzera hpmc kumvura
Pamhepo tembiricha, tanga wasasa hpmc zvakaenzana pane iyo mvura yemvura kuti urege kudurura huwandu hweHPMC mumvura panguva imwe chete. Nekuti HPMC iri polymer yakanangana, yakananga kuwedzera huwandu hweHPMC ichaita kuti itore mvura uye nekuzvimba nekukurumidza mumvura kuti aumbe chinhu chakaita sejel.
Nhanho yechipiri: Kumutsa
Mushure mekuwedzera hpmc, ramba uchimutsa zvisina kufanira. Nekuti HPMC ine zvimedu zvakanaka, ichazvimba mushure mekutora mvura kuti iite chinhu chakafanana nejee. Kukurudzira kunobatsira kudzivirira HPMC kubva pakuwedzera mumakwenzi.
Nhanho 3: Mira uye uwedzere kumutsa
Kana HPMC isina kunyungudutswa zvachose, mhinduro yacho inogona kusiiwa kuti umire kwechinguva uye wozoramba uchimutsa. Izvo zvinowanzo kuve zvakanyungudutswa zvizere mukati memaawa mashoma.
Iyi nzira yakakodzera kune dzimwe nguva dzisingadiwe hazvidikanwe, asi zvinotora nguva yakareba kuti uve nechokwadi chekuti HPMC yakanyungudutswa zvachose.
2. Mvura inopisa mvura yekunyungudika
HPMC inodonha nekukurumidza mumvura inodziya, saka ichipfura tembiricha yemvura inogona kumisikidza zvakanyanya kudzvinyirira maitiro. Iyo inowanzoshandiswa kupisa kwemvura tembiricha iri 50-70 ℃,
Nhanho 1: Kupisa mvura
Pisa mvura kusvika pamakumi mashanu ℃ uye chengetedza nguva dzose.
Nhanho yechipiri: Wedzera hpmc
Svina HPMC zvishoma nezvishoma mumvura inopisa. Nekuda kwekushisa kwemvura yakakwira, HPMC ichanyungudika nyore nyore, kuderedza anokwezva.
Nhanho 3: Kukurudzira
Mushure mekuwedzera HPMC, ramba uchimutsa mhinduro yemakwikwi. Iko kusanganiswa kwekudziya uye kumutsa kunogona kusimudzira kukurumidza kwekupaza kweHPMC.
Nhanho 4: Chengetedza tembiricha uye ramba uchimutsa
Iwe unogona kuchengeta imwe tembiricha uye uenderere mberi nekumuka kusvikira HPMC yakanyungudutswa zvachose.
3. Doro Doro Dissolution Nzira
HPMC inogona kunyungudutswa kwete mumvura chete, asiwo mune imwe doro sol soles (senge ethanol). Mukana wakanyanya wekunwa doro dissexolution nzira ndeyekuti inogona kuvandudza iyo solubility uye kuvharidzirwa kweHPMC, kunyanya kune masisitimu ane zvemvura yakakwira.
Nhanho 1: Sarudza doro rakakodzera solvent
Doro rinonwa solvent rakadai seEthanol uye isopropanol anowanzo shandiswa kunyungudika hpmc. Kazhinji, 70-90% ethanol Solution ine iri nani maitiro ekunyungudika hpmc.
Nhanho yechipiri: Kupaza
Zvishoma nezvishoma kusasa HPMC mumakirogiramu solvent, kumutsa uchiwedzera kuona kuti HPMC yakavharidzirwa zvakakwana.
Nhanho 3: Kumira uye kumutsa
Maitiro ekunwa doro solvent kunyungudusa Hpmc iri kutsanya, uye kazhinji inotora maminetsi mashoma kuti uwane kupaza kwakazara.
Iyo doro disselution nzira inowanzoshandiswa mukushandisa zviitiko zvinoda kukurumidza kupaza uye kuderera kwemvura.
4.. Solvent-Mvura Yakadzika Yakasanganiswa Dissolution Nzira
Dzimwe nguva HPMC yakanyungudutswa musanganiswa weimwe chikamu chemvura uye solvent. Iyi nzira inonyanya kukodzera mamiriro ezvinhu apo iyo visikopa yemhinduro kana iyo yekunyungudika inoda kugadziriswa. Zviitiko zvakajairika zvinosanganisira acetone, ethanol, nezvimwe.
Nhanho 1: Gadzirira mhinduro
Sarudza chiyero chakakodzera chesolu uye mvura (semuenzaniso 50% mvura, 50% solvent) uye kupisa kune yakakwana tembiricha.
Nhanho yechipiri: Wedzera hpmc
Ndichiri kumutsa, zvishoma nezvishoma wedzera hpmc kuve nechokwadi chekuparadzaniswa kwunifomu.
Nhanho 3: Kuwedzera Kugadziriswa
Sezvazvinodiwa, chikamu chemvura kana solvent chinogona kuwedzerwa kugadzirisa iyo solubility uye viscosity yeHPMC.
Iyi nzira yakakodzera yenzvimbo iyo organic sol sol sol soles inowedzerwa pamvura mhinduro kuti uvandudze muyero wekunyungudza kana kugadzirisa zvivakwa zvemhinduro.
5. Ultrasonic-Yakabatsirwa Dissolution nzira
Uchishandisa iyo yakakwira-frequency oscillation mhedzisiro yeiyo Ultrasound, iyo Ultrasonic Dissolution nzira inogona kukurudzira maitiro ekunyungudza kweHPMC. Iyi nzira inonyanya kukodzera huwandu hukuru hweHPMC inoda kunyungudika nekukurumidza, uye inogona kuderedza dambudziko rekukwevera rinogona kuitika panguva yechinyakare vachimhanya.
Nhanho 1: Gadzirira mhinduro
Wedzera hpmc kune yakakodzera huwandu hwemvura kana mvura-solvent yakasanganiswa mhinduro.
Nhanho yechipiri: Ultrasonic kurapwa
Shandisa iyo ultrasonic yakachenesa kana ultrasonic dissolver uye ubate maererano nesimba rekuseta uye nguva. Iyo Oscilation mhedzisiro yeiyo Ultrasound inogona kukurumidza kukurudzira maitiro ekunyungudza kweHPMC.
Nhanho 3: Tarisa iyo yekunyungudika maitiro
Mushure mekurapa kwekupedzisira, tarisa kana mhinduro yacho yakanyungudutswa zvachose. Kana paine chikamu chisina kuvharwa, kurapa kwekupedzisira kunogona kuitwa zvakare.
Iyi nzira yakakodzera kune zvinoshandiswa zvinodiwa zvinoda kushanda uye nekukurumidza kuparara.
6. Kufungidzira usati wanyungudika
Kuti udziviseHpcAgglomeration kana kuoma mukunyungudika, dzimwe nzira dzekunyepedzera dzinogona kushandiswa, dzakadai sekusanganisa hpmc neine huwandu hweimwe sol sol sol sol sol sol sol sol, Aya matanho ekunyepedzera anogona kuvandudza zvinobudirira iyo solubility yeHPMC.
Pane nzira dzakawanda dzekunyungudika hpmc. Kusarudza nzira yakakodzera yekunyungudika inogona kuvandudza zvakanyanya kusanzwisisika kwekunyora uye zvigadzirwa zvechigadzirwa. Iyo yemakamuri tembiricha yekudziya yakakodzera munharaunda ine munyoro, iyo nzira inopisa yemvura inogona kukurumidza kukurumidza kuita, uye nzira yekudonhedzwa doro uye iyo solvent-Mvura yakasanganiswa yekunyungudika nzira yakakodzera kupaza nezvinodiwa zvakakosha. Iyo Ultrasonic-Yakabatsirwa Dissolution nzira nzira inoshanda yekugadzirisa iyo yekukurumidza kupaza kweiyo hpmc. Zvinoenderana nezvinodiwa zvekushandisa zvekushandisa
Kutumira Nguva: Dec-19-2024