Parizvino, zvigadzirwa zvakakura zvezvirimwa capsules zvinonyanya hydroxypropyl methylcellulose (HPMC) uye pullulan, uye hydroxypropyl starch inoshandiswawo seyakagadzirwa.
Kubva pakutanga kwema2010,HPMCyakashandiswa muChinese plant capsule yekugadzira indasitiri, uye zvichibva pakuita kwayo kwakanaka, HPMC hollow capsules yakagara munzvimbo mumusika wecapsule, ichiratidza kudiwa kwakasimba mumakore gumi apfuura.
Zvinoenderana nedata reindasitiri, muna 2020, huwandu hwekutengesa mudzimba hwehollow hard capsules huchave hunosvika mazana maviri emabhiriyoni emakapisi (iyo mishonga yemishonga uye yehutano zvigadzirwa maindasitiri akasanganiswa), ayo huwandu hwekutengesa hweHPMC capsules huchave hunosvika 11.3 bhiriyoni capsules (kusanganisira kunze kwenyika) , kuwedzera kwe4.2% pamusoro pe2019. %, inoverengera inenge 5.5%. Indasitiri isiri-yemishonga inotora 93.0% yekushandiswa kweHPMC capsules muChina, uye kukura kweindasitiri yezvigadzirwa zvehutano zvinotungamira kutengesa kweHPMC capsules.
Kubva 2020 kusvika 2025, iyo CAGR yeHPMC capsules ine gelling agents inotarisirwa kuita 6.7%, iri pamusoro pekukura kwe3.8% yegelatin capsules. Zvakare, kudiwa kwemakapisi eHPMC muindasitiri yezvigadzirwa zvehutano zvehutano yakakwirira kupfuura iyo muindasitiri yemishonga.HPMCmacapsules anogona kubatsira zvese zvine chekuita nemishonga uye kugadzirisa tsika nekudya zvinofarirwa nevatengi pasi rese. Kunyangwe iko kudiwa kwazvino kweHPMC capsules kuchiri kuderera zvakanyanya kupfuura iyo yegelatin capsules, kukura kwekukura kwekuda kwakakwira kupfuura iyo yegelatin capsules.
1) Kubudirira kwekugadzira uye hurongwa, pasina gelling agent; ine kunyungudika kuri nani, hunhu hunoenderana nekunyungudika mune dzakasiyana midhiya, isina kukanganiswa nepH uye ionic simba, uye inosangana nezvinodiwa zvepharmacopoeia yenyika huru nematunhu;
2) Kune isina kusimba alkaline yemukati, kunatsiridza bioavailability uye kunatsiridza dosage fomu optimization;
3) Chitarisiko chakanaka, uye sarudzo dzemavara dzakawanda.
Soft capsule chigadziro chinogadzirwa nekuisa chisimbiso kana mafuta-based suspension mu capsule shell, uye chimiro chayo chakaita denderedzwa, chakaita semuorivhi, chihove diki, chakaita donhwe, etc. Inoratidzwa nekunyunguduka kana kumisa zvinhu zvinoshanda mukati. mafuta, ane kukurumidza kukurumidza kwekuita uye yakakwirira bioavailability kupfuura kugadzira chinhu chimwechete chinoshanda mumapiritsi, uye yakashandiswa zvakanyanya mukugadzirira kwehutano hwehutano nemishonga. Mazuva ano, macapsules akapfava ane hunhu hwakasiyana senge enteric-yakavharwa, chewable, osmotic pombi, inosimudzira-kuburitswa, uye akapfava suppositories atove pamusika. Iyo yakapfava capsule shell inoumbwa ne colloid uye ekuwedzera ekuwedzera. Pakati pavo, colloids yakadai segelatin kana yemiriwo gum ndiyo inonyanya kukosha, uye unhu hwavo hunokanganisa zvakananga kushanda kwezvinyoro zvinyoro. Semuyenzaniso, capsule shell leakage, adhesion, material migration, slow disintegration, and dissolution of soft capsules zvinoitika panguva yekuchengetera Matambudziko akadai sekusateerera ane chekuita nazvo.
Parizvino, mazhinji emidziyo yekapsule yemishonga yakapfava capsules munyika yangu imhuka yegelatin, asi nekudzika kwakadzika uye kushandiswa kwegelatin soft capsules, kukanganisa kwayo uye kushomeka kwave kwakakurumbira, senge yakaoma sosi yezvigadzirwa, uye nyore kuyambuka-kubatanidza maitiro ane aldehyde makomisheni Matambudziko ehunhu akadai senguva pfupi yekuchengetedza uye "marara matatu" anogadzirwa mugelatin refining process ane simba guru pakuchengetedzwa kwezvakatipoteredza. Mukuwedzera, kunewo dambudziko rekuomesera munguva yechando, iyo ine simba rakaipa pahutano hwekugadzirira. Uye muriwo gum akapfava capsules ane zvishoma zvinokanganisa nharaunda yakapoteredza. Nekubuda kunotevedzana kwezvirwere zvinotapukira zvemhuka kubva pasirese, nzanga yepasi rose iri kuwedzera kunetseka nezvekuchengetedzwa kwezvigadzirwa zvemhuka. Kuenzaniswa nemhuka gelatin capsules, chirimwa macapsules ane zvakatanhamara zvakanakira maererano nekushanda, chengetedzo, kugadzikana, uye kuchengetedzwa kwezvakatipoteredza.
Wedzerahydroxypropyl methylcellulosekudiridza uye kuparadzira kuwana mhinduro A; wedzera gelling agent, coagulant, plasticizer, opacifier uye colorant kumvura uye pararira kuti uwane mhinduro B; sanganisa zvinogadzirisa A uye B, uye kupisa kusvika ku90 ~ 95 ° C, funga uye ugare uchidziya kwe 0.5 ~ 2h, kutonhora kusvika ku55 ~ 70 ° C, ramba uchidziya uye umire kuti ubvise furo kuti uwane glue;
Maitiro ekukurumidza kutora glue mvura, iyo yakajairika maitiro kupisa zvishoma nezvishoma mukuita kettle kwenguva yakareba,
Vamwe vagadziri vanokurumidza kupfuura nepaguyo recolloid kuburikidza neglue yemakemikari
Nguva yekutumira: Kubvumbi-25-2024