Hydroxypropyl methylcellulose (HPMC) inowanzoshandiswa-soluble polymer, inoshandiswa zvakanyanya mumishonga yemishonga, cosmetics, chikafu uye maindasitiri minda, kunyanya mukugadzira gels. Hunhu hwayo hwemuviri uye hunhu hwekunyunguduka zvine mhedzisiro yakakura pakubudirira mune dzakasiyana maapplication. Iyo tembiricha yegelation yeHPMC gel ndeimwe yeayo akakosha emuviri zvimiro, izvo zvinokanganisa zvakananga kuita kwayo mukugadzirira kwakasiyana, sekudzorwa kuburitswa, kuumbwa kwemafirimu, kugadzikana, nezvimwe.
1. Mamiriro uye zvivakwa zveHPMC
HPMC ipolymer inonyungudika mumvura yakawanikwa nekuunza maviri anotsiva, hydroxypropyl uye methyl, mu cellulose molecular skeleton. Chimiro chayo chemorekuru chine marudzi maviri ezvinotsiva: hydroxypropyl (-CH2CHOHCH3) uye methyl (-CH3). Zvinhu zvakadai seyakasiyana hydroxypropyl yemukati, dhigirii remethylation, uye dhigirii repolymerization zvichave nemhedzisiro yakakosha pakunyungudika, gelling maitiro, uye mechaniki zvinhu zveHPMC.
Mumhinduro dzine aqueous, AnxinCel®HPMC inoumba yakagadzikana colloidal mhinduro nekugadzira hydrogen zvisungo nemamorekuru emvura uye kudyidzana neselulosi-based skeleton. Kana nharaunda yekunze (senge tembiricha, ionic simba, nezvimwewo) ichichinja, kusangana pakati peHPMC mamorekuru kuchachinja, zvichikonzera gelation.
2. Tsanangudzo uye zvinokurudzira zvinhu zvekushisa kwegelation
Tembiricha yeGelation (Gelation Temperature, T_gel) inoreva tembiricha apo mhinduro yeHPMC inotanga kushandura kubva kumvura kuenda kune yakasimba kana tembiricha yemhinduro yakwira kune imwe nhanho. Pane iyi tembiricha, kufamba kweHPMC molecular cheni kuchave kurambidzwa, kuumba matatu-dimensional network chimiro, zvichikonzera gel-senge chinhu.
Iyo tembiricha yegelation yeHPMC inobatwa nezvinhu zvakawanda, chimwe chezvinhu zvakakosha ndeye hydroxypropyl yemukati. Pamusoro peiyo hydroxypropyl yemukati, zvimwe zvinhu zvinokanganisa tembiricha yegel zvinosanganisira huremu hwemamorekuru, kugadzirisa kugadzirisa, pH kukosha, rudzi rwe solvent, ionic simba, nezvimwe.
3. Mhedzisiro yehuwandu hwehydroxypropyl paHPMC gel tembiricha
3.1 Kuwedzera kweiyo hydroxypropyl yemukati kunotungamira mukuwedzera kwekushisa kwegel
Iyo tembiricha yegelation yeHPMC inowirirana zvakanyanya nedhigirii reiyo hydroxypropyl inotsiva mumorekuru wayo. Sezvo iyo hydroxypropyl yemukati ichiwedzera, iyo nhamba ye hydrophilic substituents paHPMC mamorekuru cheni inowedzera, zvichikonzera kukwidziridzwa kwekudyidzana pakati pemorekuru nemvura. Kudyidzana uku kunoita kuti maketani emushonga atambanuke mberi, nokudaro achideredza simba rekubatana pakati pemaketani emushonga. Mukati meimwe nzvimbo yekusimbisa, kuwedzera iyo hydroxypropyl yemukati kunobatsira kuwedzera dhigirii re hydration uye inosimudzira kurongeka kwemamorekuru cheni, kuitira kuti network dhizaini igone kuumbwa pane yakanyanya tembiricha. Naizvozvo, tembiricha yegelation inowanzo wedzera neiyo hydroxypropyl inosimuka nekuwedzera zvirimo.
HPMC ine yakakwira hydroxypropyl content (yakadai seHPMC K15M) inotaridza kuratidza tembiricha yepamusoro yegelation panguva imwecheteyo kupfuura AnxinCel®HPMC ine yakaderera hydroxypropyl content (senge HPMC K4M). Izvi zvinodaro nekuti yakakwira hydroxypropyl yemukati inoita kuti zvinyanye kuomera kuti mamorekuru adyidzane uye kuumba network pane tembiricha yakadzikira, ichida tembiricha yepamusoro kukunda iyi hydration uye kukurudzira kupindirana kweintermolecular kuita matatu-dimensional network chimiro. .
3.2 Hukama pakati pehydroxypropyl yemukati uye kugadzirisa kugadzirisa
Kugadziriswa kwekugadzirisa zvakare chinhu chakakosha chinokanganisa tembiricha yegelation yeHPMC. Mupamusoro-concentration HPMC mhinduro, iyo intermolecular kupindirana kwakasimba, saka tembiricha yegelation inogona kunge yakakwira kunyangwe iyo hydroxypropyl yemukati yakaderera. Pakudzika kwakadzika, kupindirana pakati peHPMC mamorekuru hakuna simba, uye mhinduro yacho inowanzoita gel pakudzika kwakadzika.
Kana iyo hydroxypropyl yemukati ichiwedzera, kunyangwe iyo hydrophilicity ichiwedzera, tembiricha yepamusoro ichiri kudikanwa kugadzira gel. Kunyanya pasi peyakadzika mamiriro ekugadzirisa, tembiricha yegelation inowedzera zvakanyanya. Izvi zvinodaro nekuti HPMC ine yakakwira hydroxypropyl yemukati yakanyanya kuoma kupinza kudyidzana pakati pemacheni cheni kuburikidza nekuchinja kwekushisa, uye iyo gelation process inoda yakawedzerwa simba rekupisa kukunda iyo hydration maitiro.
3.3 Mhedzisiro yehydroxypropyl yemukati pane gelation process
Mukati mehumwe huwandu hwe hydroxypropyl yemukati, iyo gelation process inotongwa nekudyidzana pakati pe hydration uye molecular cheni. Kana iyo hydroxypropyl yemukati muHPMC molecule yakaderera, iyo hydration haina kusimba, kupindirana pakati pemamorekuru kwakasimba, uye tembiricha yakaderera inogona kukurudzira kuumbwa kwegel. Kana iyo hydroxypropyl yemukati yakakwira, iyo hydration inokwidziridzwa zvakanyanya, kupindirana pakati pemaketani emamorekuru kunopera simba, uye tembiricha yegelation inowedzera.
Higher hydroxypropyl content inogonawo kutungamirira kukuwedzera kweviscosity yeHPMC mhinduro, shanduko iyo dzimwe nguva inowedzera kupisa kwekutanga kwegelation.
Hydroxypropyl yemukati ine chekuita kwakakura pane tembiricha yegelation yeHPMC. Sezvo iyo hydroxypropyl yemukati ichiwedzera, iyo hydrophilicity yeHPMC inowedzera uye kudyidzana pakati pemaketani emamorekuru kunopera simba, saka tembiricha yayo yegelation inowanzowedzera. Ichi chiitiko chinogona kutsanangurwa neiyo yekudyidzana nzira pakati pe hydration uye molecular cheni. Nekugadzirisa iyo hydroxypropyl yemukati meHPMC, kunyatso kudzora tembiricha yegelation kunogona kuwanikwa, nekudaro optimize mashandiro eHPMC mumishonga, chikafu uye mamwe maindasitiri maapplication.
Nguva yekutumira: Jan-04-2025