Hydroxypropyl methylcellulose (HPMC) is a semi-synthetic, inert, isiri-chepfu mvura-soluble polymer inoshandiswa zvakanyanya mumaindasitiri akadai semishonga, chikafu, zvizorwa uye zvekuvakisa. Hukama huri pakati pehuremu hwayo hwemamorekuru uye viscosity ine mhedzisiro yakakura pakuita kwayo mumashandisirwo akasiyana siyana.
1. Solubility uye firimu-kugadzira zvinhu
Iyo viscosity yeHPMC inokanganisa zvakananga kunyungudika kwayo mumvura. HPMC ine yakaderera viscosity inogona kunyungudika mumvura nekukurumidza uye kugadzira yakajeka uye yunifomu mhinduro, iyo inokodzera zvikumbiro zvinoda kukurumidza kupararira, sezvinwiwa pakarepo kana mishonga yekukurumidza. HPMC ine viscosity yakakwira inoda nguva yakareba yekunyungudika, asi inogona kupa ukobvu uye simba zviri nani paunenge uchigadzira firimu, saka yakakodzera kuvharisa piritsi, firimu rekudzivirira uye sechinhu chematrix mukugadzirira-kuburitswa kwakasimba.
2. Kugadzikana uye kunamatira
HPMC ine viscosity yakakwirira kazhinji ine kugadzikana kwakasimba uye kunamatira. Semuyenzaniso, kana yakashandiswa seyakakora yesimende kana gypsum-yakavakirwa zvigadzirwa mune zvekuvaka, yakakwirira viscosity HPMC inogona kuvandudza zvakanyanya kuchengetwa kwayo kwemvura uye kusaga kuramba, zvichibatsira kuwedzera nguva yekuvaka uye kuderedza kutsemuka. Muindasitiri yemishonga, yakakwira-viscosity HPMC inoshandiswa kudzora mwero wekuburitswa kwemishonga. Kubata kwayo kwakakwirira kunobvumira kuti mushonga wacho usunungurwe zvishoma nezvishoma mumuviri uye unovandudza bioavailability yemushonga.
3. Kumiswa uye emulsification
Shanduko muviscosity inokanganisawo kumiswa uye emulsification zvivakwa zveHPMC. Nekuda kweiyo pfupi molecular cheni, yakaderera-viscosity HPMC yakakodzera kushandiswa seanomisa mumiriri. Inogona kunyatso kumisa zvisinganyunguriki mumishonga yemvura uye kudzivirira kunaya. HPMC ine high viscosity inogona kuumba yakasimba network chimiro mune mhinduro nekuda kweiyo yakareba molecular cheni, saka inoita zvirinani mukugadzikana kwe emulsions uye suspensions uye inogona kuchengetedza kufanana kwenguva yakareba.
4. Rheology uye maitiro ekushandisa
Iyo rheological properties yeHPMC zvakare chinhu chakakosha chinokanganiswa ne viscosity. Yakaderera-viscosity HPMC mhinduro dzinoratidza kuyerera kuri nani, zviri nyore kupfapfaidza nekuisa, uye zvinowanzo shandiswa muzvigadzirwa zvekuchengetedza ganda nependi. Iyo yepamusoro-viscosity HPMC mhinduro inoita senge isiri-Newtonian fluid uye ine shear-kutetepa maitiro. Hunhu uhwu hunoita kuti high-viscosity HPMC ive nyore kubata pasi pemamiriro ekugera, uku ichichengetedza yakakwira viscosity pasi pemamiriro akasimba, nekudaro ichivandudza kuumbwa kwefirimu uye kugadzikana kwechigadzirwa.
5. Mienzaniso yekushandisa
Pharmaceutical field: Low-viscosity HPMC (yakadai se50 cps) inowanzoshandiswa kuvhara mahwendefa anobudiswa pakarepo kuti ave nechokwadi chekubudiswa kwemishonga nokukurumidza, nepo high-viscosity HPMC (yakadai se4000 cps) inoshandiswa kune mahwendefa anoramba achisunungurwa kugadzirisa zvinodhaka kusunungurwa rate.
Munda wekudya: Muchinwiwa chekare, yakaderera-viscosity HPMC inogona kunyungudika nekukurumidza pasina clumping; muzvigadzirwa zvakabikwa, high-viscosity HPMC inogona kuvandudza mvura inobata simba remukanyiwa uye kuwedzera kuravira uye kunyorovesa zvinhu zvezvigadzirwa zvakabikwa.
Munda wekuvaka: Mune putties uye machira, yakaderera-viscosity HPMC inofambisa kuvaka uye inovandudza kushanda zvakanaka; nepo yakakwirira-viscosity HPMC inosimudzira ukobvu uye sag kuramba kwejasi.
Iyo viscosity yeHPMC ndiyo yakakosha parameter inotaridza kuita kwayo mumashandisirwo. Low viscosity HPMC inowanzo shandiswa uko kukurumidza kunyungudika uye kuyerera kunodiwa, nepo high viscosity HPMC inonyanya kubatsira mumashandisirwo anoda yakakwirira adhesion, yakanaka firimu kuumbwa uye kugadzikana. Naizvozvo, kusarudza HPMC ine viscosity chaiyo kwakakosha kukwenenzvera kuita kwayo munzvimbo dzakasiyana siyana.
Nguva yekutumira: Jul-08-2024