HPMC (hydroxypropyl methylcellulose) chinhu chinonyungudika nemvura chinoshandiswa zvakanyanya muminda yekuvaka, mishonga, chikafu uye makemikari ezuva nezuva. Iyo ine yakanaka thickening, emulsification, film-forming, inodzivirira colloid uye zvimwe zvinhu. Mune emulsion systems, HPMC inogona kudzora viscosity ye emulsion nenzira dzakasiyana-siyana.
1. Molecular chimiro cheHPMC
Iyo viscosity yeHPMC inonyanya kukanganiswa nehuremu hwayo hwemamorekuru uye dhigirii rekutsiva. Iyo yakakura iyo molecular uremu, iyo yakakwirira viscosity yemhinduro; uye dhigirii rekutsiva (kureva, dhigirii rekutsinhanisa hydroxypropyl uye methoxy mapoka) inokanganisa solubility uye viscosity zvivakwa zveHPMC. Kunyanya, iyo yakakwirira dhigirii yekutsiva, zviri nani kunyungudika kwemvura kweHPMC, uye viscosity inowedzera zvinoenderana. Vagadziri vanowanzopa zvigadzirwa zveHPMC zvine huremu hwakasiyana hwemamorekuru uye madhigirii ekutsiva kusangana nezvinodiwa zvekushandisa kwakasiyana.
2. Shandisa kuisa pfungwa
Iko kusungirirwa kweHPMC mune aqueous mhinduro ndechimwe chezvinhu zvakakosha zvinokanganisa viscosity. Kazhinji kutaura, iyo yakanyanya kuwanda kweHPMC, iyo yakakura viscosity yemhinduro. Nekudaro, iyo viscosity yemhando dzakasiyana dzeHPMC panguva imwechete yekusangana inogona kusiyanisa zvakanyanya. Naizvozvo, mumashandisirwo anoshanda, zvinodikanwa kuti usarudze yakaringana yeHPMC mhinduro zvichienderana neakananga viscosity zvinodiwa. Semuenzaniso, mumashandisirwo ekuvaka, kuwanda kweHPMC kunowanzo kudzorwa pakati pe0.1% ne1% kupa yakakodzera kushanda viscosity uye kuita kwekuvaka.
3. Disolution nzira
Iyo yekumisa maitiro eHPMC zvakare ine yakakosha kukanganisa pane yekupedzisira viscosity. HPMC iri nyore kuparadzira mumvura inotonhora, asi kuparara kwehuwandu kunononoka; inonyungudika nekukurumidza mumvura inopisa, asi zviri nyore kuunganidza. Kuti udzivise agglomeration, nzira yekuwedzera zvishoma nezvishoma inogona kushandiswa, ndiko kuti, kutanga zvishoma nezvishoma kuwedzera HPMC kumvura inotonhora kuti iparadzire, wozopisa uye kurunga kusvika yanyungudika zvachose. Pamusoro pezvo, HPMC inogona zvakare kuve yakasanganiswa nehumwe hupfu hwakaoma uye yobva yawedzerwa kumvura kuti inyunguduke kunatsiridza kunyungudika uye kugadzikana kwe viscosity.
4. Tembiricha
Tembiricha ine mhedzisiro yakakosha pane viscosity yeHPMC mhinduro. Kazhinji, viscosity yeHPMC mhinduro inoderera sezvo tembiricha inowedzera. Izvi zvinodaro nekuti kukwira kwekushisa kunonetesa iyo hydrogen bonding pakati pemamorekuru, zvichiita kuti HPMC molecular chain islide zviri nyore, nekudaro ichidzikisa viscosity yemhinduro. Naizvozvo, mumashandisirwo anoda high viscosity, HPMC mhinduro dzinowanzo shandiswa pakudzika kwakadzika. Semuenzaniso, mumashandisirwo emishonga, HPMC mhinduro dzinowanzo shandiswa pakamuri tembiricha kuti ive nechokwadi chekugadzikana uye kushanda kwemushonga.
5. pH kukosha
Iyo viscosity yeHPMC mhinduro inobatwawo ne pH kukosha. HPMC ine yakanyanya viscosity pasi pekusarerekera uye isina kusimba acidic mamiriro, nepo viscosity ichaderera zvakanyanya pasi pemamiriro akasimba ane acidic kana alkaline. Izvi zvinodaro nekuti yakanyanyisa pH kukosha inoparadza iyo molecular chimiro cheHPMC uye kunetesa kukora kwayo. Naizvozvo, mumashandisirwo anoshanda, iyo pH kukosha kwemhinduro inoda kudzorwa uye kuchengetedzwa mukati meiyo yakagadzikana renji yeHPMC (kazhinji pH 3-11) kuve nechokwadi chekukora kwayo. Semuenzaniso, mumashandisirwo echikafu, HPMC inowanzo shandiswa mune acidic chikafu senge yoghurt uye muto, uye yakanakira viscosity inogona kuwanikwa nekugadzirisa pH kukosha.
6. Zvimwe zvinowedzera
Mune emulsion masisitimu, iyo viscosity yeHPMC inogona zvakare kugadziriswa nekuwedzera mamwe makobvu kana zvinonyungudutsa. Semuenzaniso, kuwedzera huwandu hwakakodzera hwemunyu munyu (senge sodium chloride) inogona kuwedzera viscosity yemushonga weHPMC; uchiwedzera organic solvents senge ethanol inogona kuderedza viscosity yayo. Mukuwedzera, kana yakashandiswa pamwe chete nemamwe thickeners (akadai xanthan gum, carbomer, nezvimwewo), viscosity uye kugadzikana kwemulsion kunogonawo kuvandudzwa zvakanyanya. Naizvozvo, mune chaiyo dhizaini dhizaini, zvakakodzera zvinowedzerwa zvinogona kusarudzwa sezvinodiwa kuti uwedzere viscosity uye kuita kweemulsion.
HPMC inogona kuwana chaiyo kudzora emulsion viscosity kuburikidza neiyo molecular chimiro, kushandiswa kwekuisa, kunyungudika nzira, tembiricha, pH kukosha uye zvinowedzera. Mumashandisirwo anoshanda, zvinhu izvi zvinofanirwa kutariswa zvizere kuti usarudze iyo yakakodzera HPMC mhando uye mashandisiro emamiriro ekushandisa kuti uwane yakanakira kukora mhedzisiro. Kuburikidza nesainzi fomula dhizaini uye kudzora maitiro, HPMC inogona kuita basa rakakosha muminda yekuvaka, mishonga, chikafu uye makemikari ezuva nezuva, ichipa mashandiro akanaka uye ruzivo rwemushandisi.
Nguva yekutumira: Jul-17-2024