Hypromellose (HPMC) inoshandiswa sei mukuwedzera-kuburitsa matrix mapiritsi?

Muindasitiri yemishonga, hypromellose (HPMC, METHOCEL ™) inogona kushandiswa seyekuzadza, binder, piritsi rekuisa polymer uye kiyi yekubatsira kudzora kuburitswa kwezvinodhaka. Hypromellose yakashandiswa mumapiritsi kweanopfuura makore makumi matanhatu uye ndiyo yakakosha excipient inoshandiswa zvakanyanya mu hydrophilic gel matrix mapiritsi.

Mazhinji makambani emishonga anoshandisa hypromellose yekudzora kuburitswa kwezvinodhaka, kunyanya mune hydrophilic gel matrix piritsi rekugadzira. Kana zvasvika kune zvigadzirwa zve hypromellose, unogona kunge uchinetseka kuti woita sei sarudzo - kunyanya kana iwe uchitsvaga chimwe chinhu chine label-chine hushamwari uye chakasimba kushambadzira kune vatengi vako. Mugwaro iri, tichataura pamusoro pezvinhu zvakakosha zvaunoda kuziva nezve hypromellose.

Chii chinonzi hypromellose?

Hypromellose, inozivikanwawo sehydroxypropyl methylcellulose (HPMC), inonzi polymer inoshandiswa semushonga wemishonga kudzora kusunungurwa kwemishonga kubva mumuromo we hydrophilic gel matrix mapiritsi.

Hypromellose ndeye semi-synthetic zvinhu zvakatorwa kubva ku cellulose, iyo yakanyanya kuwanda polima mune zvakasikwa. Zvimwe zvezvinowanikwa zvayo zvinosanganisira:

. soluble mumvura inotonhora

. isinganyungudika mumvura inopisa

. Nonionic

. Inosarudza soluble mu organic solvents

. Reversibility, thermal gel properties

. Hydration uye viscosity yakazvimirira yepH

. Surfactant

. non-chepfu

. Kuravira uye kunhuwa zvakapfava

. Enzyme kuramba

. pH (2-13) kugadzikana kwemhando

. Inogona kushandiswa se thickener, emulsifier, binder, rate regulator, firimu rekare

Chii chinonzi Hydrophilic Gel Matrix Tablet?

Hydrophilic gel matrix tablet ifomu remushonga rinogona kudzora kuburitswa kwemushonga kubva pahwendefa kwenguva yakareba.

Hydrophilic gel matrix piritsi yekugadzirira:

. zviri nyore

. Inoda chete yakajairwa piritsi yekumanikidza michina

. Dzivirira kuraswa kwezvinodhaka

. Haina kukanganiswa nekuomarara kwehwendefa kana kumanikidza simba

. Kusunungurwa kwezvinodhaka kunogona kugadziriswa zvichienderana nehuwandu hwezvinobatsira uye mapolymers

Kushandiswa kwe hypromellose mu hydrophilic gel-matrix mahwendefa akagamuchira kubvumidzwa kwakawanda kwekutonga, uye hypromellose iri nyore kushandisa uye ine yakanaka yekuchengetedza rekodhi, iyo yakaratidzwa nezvidzidzo zvakawanda. Hypromellose yave sarudzo yakanakisa kumakambani emishonga kugadzira uye kugadzira mahwendefa anoramba achiburitswa.

Zvinhu Zvinokanganisa Kuburitswa Kwezvinodhaka kubva kuMatrix Tablets:

Paunenge uchigadzira piritsi rekuwedzera-kuburitswa, pane zvinhu zviviri zvakakosha zvekufunga nezvazvo: kugadzira uye kugadzirisa. Kune zvakare zvidiki-zvinhu zvekufunga nezvazvo kana uchitarisa kuumbwa uye kuburitsa chimiro chekupedzisira chigadzirwa chemushonga.

Formula:

Zvinhu zvakakosha zvekufunga nezvazvo pakukura kwekutanga:

1. Polymer (inotsiva mhando, viscosity, huwandu uye saizi yechikamu)

2. Mishonga (chikamu chekukura uye kunyungudika)

3. Bulking agents (solubility uye dosage)

4. Zvimwe zvekubatsira (stabilizers uye buffers)

Craft:

Izvi zvinhu zvine chekuita nemagadzirirwo emushonga:

1. Nzira dzekugadzira

2. Tablet Kukura uye Chimiro

3. Tablet simba

4. pH nharaunda

5. Firimu yekuvhara

Mashandiro anoita skeleton chips:

Hydrophilic gel matrix mapiritsi anogona kudzora kusunungurwa kwemishonga kuburikidza nejel layer, kusanganisira nzira mbiri dzekupararira (soluble active ingredients) uye kudengenyeka (insoluble active ingredients), saka viscosity yepolymer ine simba guru pakusunungurwa kweprofile. Kushandisa hypromellose, makambani emishonga anogona kushandisa hydrophilic gel matrix tablet teknolojia kugadzirisa kusunungurwa kwemushonga, kupa chiyero chinoshanda uye kutevedza zviri nani kwevarwere, nokudaro kuderedza mutoro wemishonga kune varwere. Nzira yekutora mushonga kamwe pazuva ndeyechokwadi iri nani pane chiitiko chekutora mapiritsi akawanda kakawanda pazuva.