MaBermaceucal excividents uye adjvants anoshandiswa mukugadzirwa kwemishonga uye kuronga mishonga, uye chikamu chakakosha chekugadzirira kweMishonga. Semanyorero ezvakasikwa anotora zvinhu, cellerose ether ane hunhu hwe biodegradability, uye mutengo wakaderera, methyl cellyl methyl cellever, hydroxyprosl cellulose,Cellulose etanasenge hydroxyethyl cellulose uye ethyl cellulose vane kukosha kwakakosha kwekushandisa mumishonga yemishonga. Parizvino, zvigadzirwa zvemabhizimendi mazhinji emasero ether anonyanya kushandiswa pakati uye akaderera-ekupedzisira minda yeindasitiri, uye kukosha kwakawedzerwa hakuna kukwirira. Iyo indasitiri inoda kukurumidza kushandura uye kusimudzira uye kugadzirisa iyo yakakwira-yekupedzisira zvigadzirwa zvezvigadzirwa.
Femaceceucial excividents anotamba yakakosha basa mukusimudzira uye kugadzirwa kwembiridzo. Semuenzaniso, pakuregererwa-kwekusunungura-polymer zvinhu zvakaita sema cellucose vaine mapepa ekusunungurwa Gadziriro uye kugadzirira kwemvura-kusunungurwa kwakashandiswa kwakashandiswa zvakanyanya. Mune ino system, polymers yakadai sema cellulose anait conter inotakura zvinodhaka kuti vadzore mwero wekusunungura zvinodhaka mumuviri mune imwe nguva yakatarwa mukati meimwe nguva yekuzadzisa chinangwa chekurapa.
Zvinoenderana nehuwandu hwekuterera uye department rekutsvaga, kune anenge marudzi mashanu eUnited States (Anopfuura Mhando yeUnited States (Mhando dzeEuropean), pane mutsauko mukuru, uye mhando dzichiri diki. Yangu yenyika pharmaceutical inonyora iyo yekuvandudza mukana wemusika yakazara. Zvinonzwisisika kuti iyo yepamusoro mishonga yekunyepedzera munharaunda yangu yemusika mwero weGelatin Capsules, PVP, HPMC), uye microcrystalline fibers. Vegetarian, HPC, Lactose.
"Script Cellulose erther ndiyo nguva yakateedzana yeCellulose inogadzirwa neiyo Cellulose mapoka emari. makemikari. Minda yese, zvigadzirwa zvegiredhi egiredhi zviri pakati peiyo mishonga yegiredhi. Zvinogona kutaurwa zvakakura simba kudzoreredza, matrix zvinyorwa uye thickener yekugadzira mahwendefa ekusimbisa matanda, gastric-soluble yekubatanidza zvinhu, kusunungura-microcapsule ekuisa zvinhu, zvinosimbisa-zvinosunungura zvinodhaka zvemishonga, nezvimwe.
Sodium carboxymethyl cellerose (cmc-na) ndiyo cellulose ether neyakakura zvinobuda uye kupwanya kumba uye kune dzimwe nyika. Iyo ionic cellulose ether yakagadzirwa kubva kukotoni uye huni kuburikidza neayo neayo uye kuwedzerwa ne chloroacetic acid. CMC-NA is a anowanzoshandiswa pharmaceucal compient. Iyo inowanzoshandiswa seyakagadziridzwa gadziriro dzakasimba uye seyakaomerera, kuremedza uye kumiswa mumiririri ekugadzirira kwemvura. Inogona zvakare kushandiswa seyakagadziriswa mvura-matsrumbo uye mafirimu ekugadzira mafirimu. Iyo inowanzoshandiswa seyakavhurika-inosunungura zvinodhaka mafirimu uye yakasimudzirwa-sununguko matrix templet mune yakasimbiswa (inodzorwa) kuburitswa)
Pamusoro peSodium CarboxyMeym Carbolethyl Cellerose Equcucial Equcitients, Croscarmellose Sodium inogona zvakare kushandiswa seyechishongedzo. Cross-Linked CarboxyMethyl Cellemose Sodium (CCMC-NADY INTERMELME INTERSE ATHECARANGANO (40-80 ° CLECASE ACGANIC ACID CATIDST YAKABVIRAST UYE ZVINOGONESWA. Mumiririri wekuyambuka anogona kuve progressy glycol, succucinoc anhydride, maleic anydride, adipic anydride, uye zvakadai. Croscarmelose Sodium inoshandiswa sekuparadzanisa mahwendefa, makapu uye magirini mune gadziriro yemuromo. Inovimba neCapillary uye kuzvimba kwakashata kuti uwane kuparadzaniswa. Iyo ine yakanaka kuwirirana uye kusimba kusimba. Zvidzidzo zvakaratidza kuti kukura kweCroscarmelose Sodium mumvura zvakakura kupfuura izvo zvezvakaitika zvakajairika zvakadai zvakaderera-zvakadzika sodium carboxym cellever uye hydrate microcrystalline cellulose.
MetHyl Cellulose (mc) is non-ionic cellulose monether yakagadzirwa kubva kukotoni uye huni kuburikidza neayo alkalization uye methyl chloride. MetHyll Cellulose ine yakanakisa mvura solubility uye yakagadzikana muPP huwandu hwe2,0 kusvika ku13.0. Iyo inoshandiswa zvakanyanya mumishonga yemishonga, uye inoshandiswa mumapiritsi epurasitiki, jekiseni remukati, gadziriro dzePoralmic, miromo yemuromo, mapiritsi emuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzepfungwa. Pamusoro pezvo, muzvimiro zvekusunungurwa
HydroxyPropyl methylcellose (HPMC) is non-ionic cellolose ether yakagadzirwa kubva kukotoni uye huni kuburikidza neayo procyl copylone oxide. Izvo hazvina musoro, zvisingarambiki, zvisiri zvepfu, zvine simba mumvura inotonhora, uye geri mumvura inopisa. HydroxyPropyl methylcellose ndeye cellulose yakasanganiswa ether akasiyana siyana iyo yakakurumidza kuwedzera mukugadzirwa, kuputika uye mhando mumakore gumi nemashanu apfuura. Iyo zvakare imwe yeiyo yakakura mishonga yemishonga inoshandiswa kumba uye kunze kwenyika. Iyo yakashandiswa semishonga yemishonga yemakore anoda kusvika makumi mashanu. Makore enhoroondo. Parizvino, kushandiswa kweHPMC kunonyanya kuratidzwa mune inotevera zvinhu:
Imwe yakafanana nekubhuroka uye kuparadzanisa. HPMC Semabhandi inogona kuita kuti zvinodhaka zviri nyore kunyora, uye zvinogona kuwedzera mazana ezvenguva mushure mekutora mvura, saka zvinogona kuvandudza zvakanyanya kupaza kana kusunungurwa kwehwendefa. HPMC ine yakasimba viscosity, uye inogona kusimudzira iyo temple viscosity uye kugadzirisa iyo compress yezvinhu zvisina kugadzirwa zvine crisp kana kuomarara. HPMC ine yakaderera viscosity inogona kushandiswa seyekubhoni uye kupaza, uye HPMC ine yepamusoro viscosity inogona kungoshandiswa seye binder.
Kechipiri, inoshandiswa sechinhu chakasimbiswa uye chakadzorwa kuburitswa kwegadziriro yemuromo. HPMC chinhu chinowanzoshandiswa hydrogel matsrum zvinyorwa mukugadzirira-kusunungura gadziriro. HPMC yeGreen viscosity giredhi (5 ~ 50mpa ~ 50mpa ~ Mahwendefa. HPMC inokonzeresa kuita gastrointestinal fluid, ine zvakanakira kuumbwa kwakanaka, fluidity yakanaka, yakasimba inodhaka kurodha kugona uye zvinodhaka zvinodhaka zvisina kubatwa naPH. Icho chakanyanya kukosha hydrophilic carrier mune yekugadzirira-gadziriro yekugadzirira uye inowanzoshandiswa sehydrophilic Gel gadziriro, uye inoshandiswa muGastric inowedzera kugadzirira uye yakasungirirwa-inobata-sununguko membrane zvigadzirwa zvezvinhu zvezvinhu zvezvinhu.
Yechitatu yakafanana nemumiriri wefirimu rekugadzira firimu.Hpcine yakanaka firimu-inogadzira nzvimbo. Iyo firimu yakaumbwa neyunifomu, inoonekera, uye yakaoma, uye hazvisi nyore kuomerera panguva yekugadzira. Kunyanya kune zvinodhaka zviri nyore kutora zvinyoro nyoro uye hazvina kugadzikana, kuishandisa seyekuparadzanisa chikamu kunogona kuvandudza kugadzikana kwemushonga uye kudzivirira iyo firimu inoshandura ruvara. HPMC ine akasiyana siyana viscossity yakatarwa. Kana ikasarudzwa nemazvo, hunhu uye kutaridzika kwemapiritsi akakomberedzwa ari nani pane zvimwe zvinhu, uye zvakajairika zvakajairika ndeye 2% kusvika 10%.
Ina inoshandiswa seyakavharwa kapu. Mumakore achangopfuura, nekubuda kakawanda kwedenda remhuka dzemhuka, kana zvichienzaniswa neGelatin Capsules, chirimwa capsules zvave mudhara mutsva weiyo maindasitiri emishonga uye ezvekudya. PFIZER yakabudirira kubvisa HPMC kubva kune zvakasikwa zvidyarwa uye zvakagadzirirwa VCaptm yemiriwo capsules. Kuenzaniswa neExthial Gelatin Hollow Capsiles Capsules, Vegetable Capsules vane zvakanakira kushandurwa kwakakura, hapana njodzi yekubatanidza maitiro, uye kugadzikana kwakanyanya. Iyo yekuburitsa zvinodhaka yekuburitswa inogadzikana, uye kusiyana kwemunhu madiki. Mushure mekuparadzirwa mumuviri wemunhu, haina kunyudzwa uye inogona kubviswa. Yakakwidziridzwa kubva mumuviri. Panyaya yemamiriro ekuchengetedza, mushure meyedzo yakawanda, ingangoita brittle pasi pemamiriro ezvinhu akadzika, uye zvivakwa zveCapsule zvichiri kugadzikana pasi penzvimbo dzakakwirira, uye indekisi dzakasiyana dzemari dzemari dzakanyanyisa. Nenjodzi dzevanhu dzemari dzemvura uye shanduko yemishonga yeruzhinji pamba uye kunze kwenyika, iyo yemusika kudiwa kwezvirimwa capules ichakura nekukurumidza.
Yechishanu yakaita seyemumiriri anomiswa. Kumiswa Kwemhando yekugadzirira kwechirimwa inowanzo shandiswa sisitimu, inova tsika yekudzikisira nzira iyo yakaoma mishonga yakasimba inopararira mumvura yekuparadzira mvura. Iko kusimba kwegadziriro inosarudza mhando yekugadzirira kwemvura gadziriso. HPMC collodal Solution inogona kuderedza iyo yakasimba-yemvura interfcial tenension, kuderedza iyo yemahara simba rezvikamu zvakasimba, uye kudzikamisa tsika yekuparadzira yechokwadi. Iyo inomisikidza kumhanyisa mumiriri. HPMC inoshandiswa seanoridza mhere yeziso, ine zvirimo zve 0.45% kusvika 1.0%.
HydroxyPropyl Cellulose (HPC) is non-ionic cellulose monether yakagadzirwa kubva kukotoni uye huni kuburikidza neayo HPC is usually soluble in water below 40°C and a large amount of polar solvents, and its performance is related to the content of hydroxypropyl and the degree of polymerization. HPC inogona kuenderana nemishonga dzakasiyana-siyana uye ine yakanaka.
Yakaderera-yakatsiva hydroxypropyl cellulose(L-HPC)inonyanya kushandiswa sehwendefa yekuparadza uye binder. Hunhu hwayo ndehwekuti: Nyaradzo yekudzvanya uye fomu yakasimba, zvakanyanya kuomesa kuomesa kwehwendefa.
Yakakwira yakakwira hydroxypropyl cellulose H-HPC ine yakanaka firimu-yekuumba midziyo, uye iyo firimu yakakonzerwa yakaoma uye yakasarudzika, iyo inogona kufananidzwa neplasticzeers. Nekusanganisa nevamwe vanorwisa-vanyoro-nyoro vanobatanidza, kuita kwefirimu kunogona kuitika kwakawedzerwa, uye kunowanzoshandiswa seye firimu kuunganidza zvinyorwa zvemahwendefa. H-HPC inogona zvakare kushandiswa seye matsrum zvinyorwa kugadzirira matrix masisitimu ekusimudzira-matafura, ekusunungurwa-akasunungura pellets uye maviri-denderedzwa masisitimu ekusimbisa.
Hydroxethyl Cellulose (Hec) is is is-ionic cellulose monether yakagadzirwa kubva kukotoni uye huni kuburikidza neayo neAslalization uye ethylyone oxide kuwedzerwa. HEC inonyanya kushandiswa seanoratidzika, collodal yekudzivirira mumiririri, anoparadzira, stabilizer, kumisa mumiririri, kusunungura mumiririri uye kusunungura zvinhu mumunda wekurapa. Inogona kuiswa kumamambo, mafuta emazino, uye ziso rinodonha nemishonga yepamusoro. Muromo wemuromo, mahwendefa akasimba, makapu uye mamwe mafomu madhiragi. HydroxytHyl Cellulose yakabatanidzwa muUS Pharmacoeia / US National Formulary uye European Pharmacoeia.
Ethyl Cellulose (EC) ndeimwe yemvura inonyanya kushandiswa-insoluble cellulose inobva. EC isiri-ine chepfu, isina kugadzikana, kuisirwa mumvura, acid kana acid mhinduro, uye yakachena mu organic solhasi senge ethanol naMethanol. Iyo inowanzo shandiswa solvent yakasanganiswa solvent yeToluene / ethanol 4/1 (uremu). EC inoshandisa yakawanda yekugadzirira zvinogadziriswa zvinodhaka, uye inoshandiswa zvakanyanya seyekugadzira mictarns, et. Pellets, seyakavharirwa zvinhu zvebetsero kugadzirira yakasimudzirwa-inoburitswa microcaps; Inogona zvakare kushandiswa zvakanyanya seyekukutakura zvinhu zvinoshandiswa kugadzirira kuparadzaniswa kwakasimba; Inogona kushandiswa zvakanyanya tekinoroji seyakagadzirwa firimu chinhu uye inodzivirira yekuvhara, uye inogona kushandiswawo seyekuchinjika uye inochengetera. Sechivimbo chekuchengetera mahwendefa, zvinogona kuderedza kunzwira tsitsi mahwendefa kuti utsinye uye kudzivirira zvinodhaka kubva mukudzikiswa uye kusvibiswa nekunyorova; Inogonawo kuumba kusunungura-kusunungura glue glue layer uye microenpartaplate iyo polymer kuti ienderere mberi nekusunungura zvinodhaka.
Mukupfupikisa, iyo-mvura-sodium carboxymeyl Cellemose, hydroxypressl cellyl cellout disintegraphi, zvinosimbiswa uye zvinodzorwa zvishandiso zvekugadzirira zvemuti Kutarisa nyika, makambani mazhinji ekunze (shin-etu Japan, dow wolff uye ashland) akaziva musika wepfungwa muChina mune ramangwana, uye nekuwedzera kugadzirwa kana kuumbwa, ivo vakawedzera kuvapo kwavo mundima iyi. Investment mukati meiyo application. Dow wolff akazivisa kuti ichawedzera kutarisisa kune iyo kuumbwa, zvisungo uye zvido zveMusika weChinese gadziriso yekugadzirira, uye kutsvagurudza kwayo kuchaedza zvakare kuswedera kumusika. Iyo Wolff Cellulose Division Yemakemikari uye Colorcon Corporation yeUnited States yakagadzira yakasimudzwa uye yakadzorwa kuburitsa gadziriro yekugadzirira mubatanidzwa. Iyo ine vashandi vanopfuura chiuru chimwe nemazana matanhatu mumaguta 9, masisitimu gumi nemashanu nemakambani matanhatu eGPM. Vagadziri venhau dzekutsvagisa vanopa masevhisi kune vatengi munharaunda dzinosvika 160. Ashland ine zvigadziko zvekugadzira muBeijing, Tianjin, Shanghai, Nanjin, Kunshan naJiangmen, uye akaisa mari mune tekinoroji yekutsvaga tekinoroji kuShanghai uye Nanjing.
Sekureva kwehuwandu kubva kune webhusaiti yeChina Cellulose Association, muna 2017, kugadzirwa kweMusangano weCellulose Erth Muna 2017, iyo chaiyo yekutengesa vhoriyamu yeionicCmcAive matani zviuru makumi maviri nezvishanu, ne16,61% gore-pagore-gore, uye huwandu hwekutengesa hwasiri-ionic cmc hwaive matani gumi nemaviri, kuwedzera kwe8,2% gore-pagore. Kuwedzera kune HPMC (kuvaka zvinyorwa zvegwaro) zvisiri-ionic zvigadzirwa,Hpc. VaCogest Cellulose vaTiers vanga vachikura nekukurumidza kweanopfuura makore gumi, uye kubuda kwacho kwave kutanga nyika. Nekudaro, mazhinji emheremellose ether makambani emakambani ezvimwe zvigadzirwa zvinonyanya kushandiswa pakati uye akaderera maindasitiri, uye kukosha kwakawedzerwa hakuna kukwirira.
Parizvino, mazhinji eimba yemusangano emusangano ether ether enterprises ari mune yakaoma nguva yekushandurwa uye kusimudzira. Vanofanira kuenderera mberi nekuwedzera kwechigadzirwa kutsvagisa uye kusimudzira kuedza, kushandisa zvizere zveChina, musika mukuru wepasi rose, uye kuwedzera mabasa ekuti mabhaisikopo anokwanisa kuwedzera nekukurumidza sezvinobvira. Zadzisa iyo shanduko uye kusimudzira, pinda iyo yepakati-kusvika-yakakwira yekupedzisira yeindasitiri, uye kuzadzisa bendugined uye green budiriro.
Kutumira Nguva: Kubvumbi-25-2024