Hunhu hwehydroxypropyl methylcellulose (HPMC)inogona kuongororwa kuburikidza nezviratidzo zvakawanda. HPMC inotorwa selulosi inoshandiswa zvakanyanya mukuvaka, mishonga, chikafu uye cosmetics maindasitiri, uye hunhu hwayo hunokanganisa zvakananga kuita kwechigadzirwa.
1. Chitarisiko uye particle size
Kuonekwa kweHPMC kunofanira kunge kwakachena kana kusina-white amorphous powder. High-quality HPMC poda inofanira kuva neyunifomu particles, pasina agglomeration, uye pasina tsvina yekunze. Kukura uye kufanana kwezvikamu zvinokanganisa kunyungudika kwayo uye kupararira. HPMC ine yakakura kana agglomerated zvimedu haingokanganisa solubility chete, asi inogona kukonzera kusaenzana kwekuparadzira mhedzisiro mumashandisirwo chaiwo. Naizvozvo, yunifomu particle size ndiyo hwaro hwekuongorora kunaka kwayo.
2. Kunyungudika kwemvura uye kuparara kwehuwandu
Kunyungudika kwemvura kweHPMC ndechimwe chezviratidziro zvayo zvakakosha zvekuita. Yepamusoro-mhando HPMC inonyungudika nekukurumidza mumvura, uye mhinduro yakanyungudika inofanirwa kuve yakajeka uye yakafanana. Muedzo wekunyungudika kwemvura unogona kutongwa nekuwedzera imwe huwandu hweHPMC kumvura uye kuona kana ichigona kunyungudika nekukurumidza uye kugadzira mhinduro yakagadzikana. Kuslow dissolution kana kusaenzana mhinduro inogona kureva kuti mhando yechigadzirwa haina kuenderana nechiyero.
3. Viscosity maitiro
Iyo viscosity yeHPMC ndeimwe yeakakosha paramita yekuongorora mhando yayo. Viscosity yaro mumvura inowanzowedzera nekuwedzera kwehuremu hwayo. Iyo yakajairwa viscosity bvunzo nzira ndeye kushandisa inotenderera viscometer kana viscometer kuyera viscosity kukosha kwemhinduro dzeakasiyana siyana. Kazhinji kutaura, yemhando yepamusoro HPMC inofanirwa kuve yakagadzikana viscosity, uye iyo viscosity shanduko nekuwedzera kwekusungwa kunofanirwa kuenderana nemumwe mutemo. Kana iyo viscosity isina kugadzikana kana pasi peiyo chiyero chiyero, inogona kureva kuti chimiro chayo chema molecular haina kugadzikana kana ine tsvina.
4. Hunyoro hwemukati
Hunyoro hwemukati muHPMC huchakanganisawo kunaka kwayo. Kunyanya kunyorova kunogona kuita kuti iumbe kana kushata panguva yekuchengetedza. Chiyero chehuwandu hwehunyoro hunofanirwa kudzorwa mukati me5%. Nzira dzekuyedza dzakadai senzira yekuomesa kana nzira yeKarl Fischer inogona kushandiswa kuona hunyoro hwemukati. Yepamusoro-soro HPMC ine hunyoro hwakaderera uye inoramba yakaoma uye yakagadzikana.
5. pH kukosha kwekugadzirisa
Iyo pH kukosha kweiyo HPMC mhinduro inogona zvakare kuratidza hunhu hwayo. Kazhinji, iyo pH kukosha kweiyo HPMC mhinduro inofanira kuva pakati pe6.5 ne8.5. Yakawandisa acidic kana yakawandisa alkaline mhinduro inogona kuratidza kuti chigadzirwa chine isina kuchena chemakemikari zvikamu kana chave chakabatwa makemikari zvisizvo panguva yekugadzira. Kuburikidza nepH yekuyedza, unogona kunzwisisa zvine hungwaru kana mhando yeHPMC inosangana nezvinodiwa.
6. Kusachena kwemukati
Izvo zvisina kuchena zvemukati zveHPMC zvinokanganisa zvakananga mashandiro ayo, kunyanya mumunda wemishonga uye chikafu, uko kusingakodzeri kusvibiswa kwemukati kunogona kutungamira kune zvigadzirwa zvisina kuchengetedzeka kana mhedzisiro yakaipa. Kusachena kunowanzo sanganisira zvisina kukwana zvakagadziriswa zvigadzirwa, mamwe makemikari, kana zvinosvibisa zvinogadzirwa panguva yekugadzira. Izvo zvisina kuchena zviri muHPMC zvinogona kuonekwa nenzira dzakadai seyepamusoro-inoshanda mvura chromatography (HPLC) kana gasi chromatography (GC). Yepamusoro-mhando HPMC inofanirwa kuona yakaderera yekusachena zvemukati uye kusangana neakakodzera zviyero.
7. Kujeka uye kugadzirisa kugadzikana
Iyo transmittance yeHPMC mhinduro zvakare inowanzoshandiswa mhando chiratidzo. Mhinduro ine kujeka kwepamusoro uye kugadzikana kunowanzoreva kuti HPMC ndeyekuchena kwepamusoro uye ine tsvina shoma. Mhinduro yacho inofanira kuramba yakajeka uye yakajeka panguva yekuchengetedza kwenguva refu, pasina kunaya kwemvura kana turbidity. Kana iyo HPMC mhinduro ikanaya kana kuita turbid panguva yekuchengetera, inoratidza kuti inogona kunge iine zvimwe zvisingaite zvinhu kana tsvina.
8. Kugadzikana kwekushisa uye kupisa kwekushisa kwekushisa
Thermal stability test inowanzoitwa ne thermogravimetric analysis (TGA). HPMC inofanirwa kunge iine kugadzikana kwakanaka kwekupisa uye haifanirwe kuora pakajairwa tembiricha yekushandisa. HPMC ine tembiricha yakadzikira yekuora inozosangana nekuderera kwekuita mukupisa kwepamusoro-tembiricha maapplication, saka kugadzikana kwakanaka kwekupisa chinhu chakakosha chemhando yepamusoro HPMC.
9. Kugadzirisa kugadzirisa uye kushushikana kwepamusoro
Iko kushushikana kwepamusoro kweHPMC mhinduro kunogona kukanganisa kushanda kwayo kwekushandisa, kunyanya mumachira uye zvekuvaka. Yepamusoro-soro HPMC ine yakaderera pamusoro tension mushure mekuparadzwa, iyo inobatsira kuvandudza kwayo dispersibility uye fluidity mune zvakasiyana midhiya. Kudzvinyirirwa kwayo kwepamusoro kunogona kuedzwa nemeter tension meter. Iyo yakanakira HPMC mhinduro inofanirwa kuve yakaderera uye yakagadzikana pamusoro tension.
10. Kugadzikana uye kuchengetedza
Kugadzikana kwekuchengetedza kweHPMC kunogonawo kuratidza hunhu hwayo. Yemhando yepamusoro HPMC inofanirwa kuchengetwa yakatsiga kwenguva yakareba pasina kushatisa kana kushatiswa kwekuita. Paunenge uchiita ongororo yemhando, kugadzikana kwayo kunogona kuongororwa nekuchengetedza sampuli kwenguva yakareba uye kuyedza kuita kwavo nguva nenguva. Kunyanya munzvimbo dzine hunyoro hwepamusoro kana shanduko huru yekushisa, yepamusoro-soro HPMC inofanirwa kukwanisa kuchengetedza yakagadzikana yemuviri nemakemikari zvinhu.
11. Kuenzanisa kwemigumisiro yekuedza nemitemo yeindasitiri
Chekupedzisira, imwe yedzakanyanya intuitive nzira yekuona mhando yeHPMC ndeyekuienzanisa nemaindasitiri zviyero. Zvichienderana nendima yekunyorera (yakadai sekuvaka, mushonga, chikafu, nezvimwe), zviyero zvemhando yeHPMC zvakasiyana. Paunenge uchisarudza HPMC, unogona kutarisa kune akakodzera zviyero uye nzira dzekuyedza uye kusanganisa mhedzisiro yekuyedza kutonga zvizere kunaka kwayo.
Kuongororwa kwehutano hweHPMCinoda kutarisisa zvinhu zvakawanda, zvinosanganisira chitarisiko, kunyungudika, viscosity, kusachena kwemukati, pH kukosha, hunyoro hwemukati, nezvimwe. Kuburikidza nenhevedzano yeyakajairwa nzira dzekuyedza, mhando yeHPMC inogona kutongwa zvakanyanya. Kune zvinodikanwa zveakasiyana maficha ekushandisa, mamwe chaiwo maratidziro ekuita angangoda kutariswa. Kusarudza HPMC zvigadzirwa zvinosangana neakakodzera zviyero zvinogona kuve nechokwadi chemhando uye kugadzikana kwechigadzirwa chekupedzisira.
Nguva yekutumira: Zvita-19-2024