Hydroxypropyl methylcellulose (HPMC)inoshandiswa seimwe yezvikuru zvemishonga excipients kumba nekune dzimwe nyika. HPMC inogona kushandiswa semumiriri wekugadzira firimu, anonamira, anosimudzira kuburitsa mumiriri, kumiswa mumiriri, emulsifier, disintegrating agent, nezvimwe.
Mishonga yemishonga chikamu chakakosha chekugadzirira kwemishonga, uye basa ravo nderekuona kuti mishonga inotakurwa zvakasarudzwa kune zvitunha mune imwe nzira uye maitiro, kuitira kuti mishonga ibudiswe mumuviri pane imwe nguva uye nguva. Nokudaro, kusarudzwa kwevabatsiri vakakodzera ndechimwe chezvinhu zvinokosha zvehutano hwehutano hwekugadzirira kwemishonga.
1 Zvivakwa zveHPMC
HPMC ine maitiro akawanda ayo mamwe maexcipient asina. Iine yakanakisa solubility yemvura mumvura inotonhora. Chero bedzi iyo yakawedzerwa mumvura inotonhora uye yakavhenganiswa zvishoma, inogona kunyunguduka muine mhinduro yakajeka. Pane zvinopesana, haina kunyungudika mumvura inopisa pamusoro pe60E uye inogona kungonyungudika. Iyo isiri-ionic cellulose ether, mhinduro yayo haina ionic charge, uye simbi munyu kana ionic organic compounds, kuitira kuti ive nechokwadi chekuti HPMC haina kuita pamwe nezvimwe zvinhu zvakasvibirira mugadziriro yekugadzira. Iine simba rinopesana nekunzwa, uye nekuwedzera kwema molecular chimiro chechidimbu chekutsiva, anti-sensitivity inowedzerwawo, uchishandisa HPMC semishonga inogadzirisa, maererano nekushandiswa kwemamwe maitiro echinyakare (starch, dextrin, shuga powder) zvinodhaka, hutano hwenguva inoshanda yakanyanya kugadzikana. Iyo ine metabolic inertia. Semushonga wekubatsira zvinhu, haugone kugadzirwa kana kunyudzwa, saka haupi macalories mumishonga uye chikafu. Iyo ine yakasarudzika yekushandisa kune yakaderera calorific kukosha, munyu-isina uye isiri-allergenic mushonga uye chikafu chinodiwa nevanhu vane chirwere cheshuga. HPMC yakanyanya kugadzikana kune asidhi uye alkali, asi kana ichipfuura pH2 ~ 11 uye ichiiswa kune yakakwirira tembiricha kana kuchengetedza nguva yakareba, viscosity ichaderedzwa. Aqueous solution inopa chiitiko chepamusoro uye inopa kushushikana kuri pakati nepakati uye kukanganiswa kwechiso. Iine emulsification inoshanda mune maviri-chikamu system uye inogona kushandiswa seyakasimba stabilizer uye inodzivirira colloid. Aqueous solution ine yakanakisa yekugadzira firimu zvimiro uye yakanaka yekuputira zvinhu zvemapiritsi nemapiritsi. Iyo firimu inoumbwa nayo haina ruvara uye yakaoma. Yayo plastiki inogonawo kuwedzerwa nekuwedzera glycerol.
2.Kushandiswa kweHPMC mukugadzirwa kwehwendefa
2.1 Kuvandudza kuparara
Kushandisa HPMC ethanol mhinduro kana aqueous mhinduro seye wetting agent ye granulation, yekuvandudza kuparara kwemapiritsi, mhedzisiro yacho inoshamisa, uye yakatsikirirwa mufirimu kuoma kuri nani, kutaridzika kwekutsetseka. Kunyungudika kwehwendefa renimodipine: kunyungudika kweadhesive kwaive 17.34% uye 28.84% apo chinamira chaive 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol solution, 1% sodium dodecyl sulfate (40%) ethanol solution, 3% HP. 10% starch pulp, 3% HPMC mhinduro, 5% HPMC mhinduro, zvichiteerana. 30.84%, 75.46%, 84.5%, 88%. Dissolution rate yepiperic acid mahwendefa: kana adhesive iri 12% ethanol, 1% HPMC(40%) ethanol solution, 2% HPMC(40%) ethanol solution, 3% HPMC(40%) ethanol solution, dissolution rate i80.94% , 86.23%, 90.45%, 99.88%, maererano. Dissolution rate yeCimetidine mahwendefa: apo iyo yakanamatira yaiva 10% starch slurry uye 3% HPMC (40%) ethanol solution, chiyero chekuparara chaiva 76.2% uye 97.54%, maererano.
Kubva pane data iri pamusoro, zvinogona kuonekwa kuti THE ethanol solution uye aqueous solution yeHPMC ine mhedzisiro yekuvandudza kuparara kwemishonga, iyo inonyanya kukonzerwa nekumisa uye kushanda kwepamusoro kweHPMC, kuderedza kushushikana kwepamusoro pakati pemhinduro uye. mishonga yakasimba, kuwedzera hunyoro, iyo inobatsira pakuparara kwemishonga.
2.2 Kuvandudza kunaka kwekupfeka
HPMC sechinhu chekugadzira firimu, ichienzaniswa nemamwe mafirimu ekugadzira zvinhu (acrylic resin, polyethylene pyrrolidone), mukana mukuru ndeyekunyungudika kwemvura, haidi organic solvents, kushanda kwakachengeteka, kuri nyore. UyeHPMCine zvakasiyana-siyana zve viscosity yakatarwa, kusarudzwa kwakakodzera, kupfekedza firimu remhando, kutaridzika kuri nani pane zvimwe zvinhu. Mapiritsi eCiprofloxacin hydrochloride mahwendefa machena akajeka ane mavara ane mativi maviri. Aya mapiritsi ekuputira firimu akaonda, kuburikidza nekuyedza, anosarudza viscosity ye50 mpa # s yemvura-soluble plasticizer, inogona kuderedza kushushikana kwemukati kwemutete firimu, yekuputira piritsi isina bhiriji / dikita 0, 0, 0, 0 / orenji. svuura/permeability mafuta, 0/kutsemuka, senge dambudziko remhando, kupfekedza firimu remvura kuumba, kunamatira kwakanaka, uye kuunza mupendero weshoko pasina kuvuza, inonyoreka, Imwe - yakatarisana kupenya, kwakanaka. Kana ichienzaniswa neyechinyakare yekubatisa mvura, iyi mishonga iri nyore uye inonzwisisika, uye mutengo wakaderedzwa zvakanyanya.
Nguva yekutumira: Kubvumbi-25-2024