Muyedzo uye kugadzirwa kukuru kweNifrepine mahwendefa ekusimudzira, mahwendefa ekudzivirira, mahwendefa ehuswa, mahwendefa emapiritsi emabhegi, bufledy hydrochloride mahwendefa, etc., isu tinoshandisahydroxyprupyl methylcellose (HPMC)Liquid, hydroxyprusyl methylcellose uye polwacrylic acid resin Mushure meimwe Matambudziko ehunyanzvi, tava kutaurirana nevamwe vatinoshanda navo nezvematambudziko akajairwa uye mhinduro mufirimu rekubatanidza.
Mumakore achangopfuura, firimu rinobatanidza tekinoroji rakashandiswa zvakanyanya mukugadzirira kwakasimba. Iyo firimu inobatanidza inogona kuchengetedza mushonga kubva kuchiedza, kunyorova uye mhepo kuti uwedzere kugadzikana kwemushonga; mask kuravira kwakashata kweanodhaka uye kufambisa murwere kuti abvise; dzora nzvimbo yekuburitsa uye kuburitsa kumhanya kwemushonga; dzivirira kuchinja kunoenderana kwemushonga; kuvandudza kutaridzika kwehwendefa mirira. Izvo zvakare zvine zvakanakira zviyero zvishoma, nguva ipfupi, yakadzika simba rekushandisa, uye zvishoma piritsi uremu uremu. Unhu hwemafirimu-akabatanidzwa marata anoenderana nekuumbwa uye kunaka kwehwendefa remukati, mishonga yekubatanidza, iyo mamiriro ekutakura uye etc .. Muzvinetso zvinoshanda zvehwendefa piritsi, dzakasiyana-siyana uye kutaridzika, kuomesa, zvidimbu, zvimedu zveBrittle, uye piritsi chimiro chechipatara chepiritsi. Kuumbwa kwemvura inobatanidza inowanzove neyakawandisa mapurikisi, madhiri, madhiri, etc., uye mamiriro ekuvharira ari marara ane simba ekupfira uye kuomesa uye midziyo yekubatanidza.
1.one-stident abresion, firimu rethite kupaza uye kupfava
Kuomarara kwepamusoro kweiyo piritsi diki, uye inoiswa pasi pekupokana kwakasimba uye kushushikana panguva yekubatanidza, uye pwere imwe chete inowira pasi, zvichikonzera poresmarks kana pores pamusoro pe Iyo piritsi bhwende, iyo iri pfekisi imwe chete yekupfeka, kunyanya ine yakanyorwa yakaiswa giredhi. Chikamu chakanyanya kutambudzika chemufirimu mune firimu-yakafukidzwa piritsi makona. Kana kudenha kana kuti simba refirimu rakakwana, kupaza uye kubhururuka kwemapepa emufirimu anogona kuitika. Izvi zvinodaro nekuti kulattization yeiyo solvent inokonzera iyo firimu ichipfuura, uye kuwedzera kwakanyanya kweiyo firimu yekubatanidza uye iyo core inowedzera kushushikana kwemukati kwefirimu, iyo inodarika kusimba kwefirimu rekuvhara.
1.1 kuongororwa kwezvikonzero zvikuru zvikonzero
Kusvika paChip yechip iri kunetsekana, chikonzero chikuru ndechekuti kunaka kweiyo chip yechip haina kunaka, uye kuomesa uye kupwanyika zvidiki. Munguva yekubatanidza maitiro, iyo piritsi core inoiswa mukupokana kwakasimba pavanenge vachikanganisa pani, uye zvakaoma kutsungirira kwakasimba. Zvine hukama nehukama hwakakwana, hune hukama nehukama uye nzira yekugadzirira yechipatara. Patakarongedza matafura akasimbiswa, nekuda kwekuomesesa kuomarara kwehwendefa. Uye zvakare, ichi hurema hwekubatanidza hune hukama zvakare nemhando yehomwe yemhando. Kana iyo firimu isina kugadzikana, kunyanya kana iyo firimu ine logo pamusoro wekorona, inowedzeredzwa kune imwe-inotsigirwa kupfeka.
Mukubata kwekunyora, kunononoka kupfira kumhanya uye kwakakura kwemhepo yekunyepedzera tembiricha ichatungamira kukurumidza kuomarara, nguva refu yekudyara yehomwe yesheni, uye nguva refu yekubatanidza. Kechipiri, kudzvinyirira kweatomu kwakakura, iyo visikopo yemvura inoderedza yakaderera, madonhwe ari muAtomization Center akaomeserwa, uye solateil talateilts mushure mekushushikana kwemadonhwe. Panguva imwecheteyo, kupokana pakati peiyo-yakagadzirirwa nzvimbo inowedzerawo kushushikana kwemukati kwefirimu uye nekumhanyisa firimu. Kupaza kwemicheto.
Mukuwedzera, kana kumhanya kwekutenderera kwenzvimbo yekuvhara kwakanyanya inokonzeresa kupfeka kwesimba.
Kubva pamifananidzo inobatanidza, inonyanya kukonzerwa nesarudzo ye polymer mune yekuumbwa uye yakaderera viscosity (kusunganidzwa) yemvura inovhara pakati pefirimu yekubatanidza uye piritsi.
1.2 Solution
Imwe ndeyekugadzirisa mishonga kana maitiro ekugadzira yehwendefa kuti uvandudze kuomarara kwehwendefa. HPMC chinhu chinowanzo shandiswa kuvhara zvinhu. Kudonhedza kwehwendefa kwehwendeya kunoenderana neiyo hydroxyl mapoka pamamolekyudhi ehuma, uye maHydroxyl Mapoka anogadzira hydrogen zvisungo ne mapoka anowirirana eHPMC kuti audze yakakwira kuderedza. Kudyira kwacho kunorasika, uye iyo-yakatarisana uye iyo firimu inovhara inowanzoparadzana. Nhamba yeiyo hydroxyl mapoka pamakero emicrocular yeMicrocrystalline Cellen Cellows yakakwira, uye ine simba rakanyanya kudenha, uye mahwendefa akagadzirira kubva kuLactose uye mamwe mashuga ane simba rekuchinjika. Iko kushandiswa kweLubricants, kunyanya hydrophobic lubricants yakadai seyekuba, Magnceryl Steatate, ichaderedza hydrogen solution solution, kuita kuti kuderedza simba rinoderera, uye nekuwedzera kweLubricity, Simba rekudyira rinopera zvishoma nezvishoma. Kazhinji, huwandu hwehuwandu hwe lubricant, zvakanyanya kuderedza kunorasika. Uye zvakare, mukusarudzwa kwetirivheri yemhando piritsi, iyo inotenderera biconvex piritsi remhando yemhando inofanirwa kushandiswa kusvika pakubata, iyo inogona kuderedza kuitika kwekubatanidza hurema.
Yechipiri ndeyekugadzirisa mishonga yekubatanidza mvura, wedzera iyo yakasimba zvirimo mumvura inovhara kana iyo visikopo yemvura inobatanidza, uye uvandudze iyo firimu yekubatanidza, iyo iri nzira yakapusa yekugadzirisa dambudziko. Kazhinji, zvirimo zvakasimba mune iyo yekukwirisa yekubatanidza system ndeye 12%, uye zvirimo zvakasimba zviri mu organic solvent system ndeye 5% kusvika 8%.
Musiyano muViscosity of the coating mvura inokanganisa kumhanya uye degree rekupinda kwemvura yekubatanidza mumvura muhomwe. Kana paine zvishoma kana kusapindira, kuderedza kwakanyanya kuderera. Iyo viscosity yemubatanidzwa wemvura uye zvivakwa zveiyo firimu yekubatanidza ine chekuita neyevhareji yemanyorerwe emucheche mune iyo polymer mune yekuumbwa. Iyo yepamusoro iyo avhareji inorema uremu, yakakura kuomarara kweiyo firimu yekuvhara, kushoma kwekushamisika uye kupfeka kupokana. Semuenzaniso, anotengeserana HPMC ane akasiyana viscosity mamakisi ekusarudza nekuda kwemusiyano muvhesi molecular uremu. Pamusoro pekumanikidza kwePolymer, kuwedzera mapurasitiki kana kuwedzera zvirimo zve talc kunogona kuderedza chiitiko chefirimu uye titanium dioxide inogona zvakare kukanganisa simba refirimu rekubatanidza, saka rinofanira kunge riri inoshandiswa mune mwero.
Yetatu, mune yekubatanidza kushanda, kunyanya kuwedzera kukurumidza kwekumhanya, kunyanya kana iyo yekubatira ichitanga, iyo yekumhanya ichinyanya kufukidzwa neyakafukidzwa firimu munguva pfupi, iyo inotora basa rekudzivirira iyo piritsi. Kuwedzera iyo spray rate kunogona zvakare kuderedza tembiricha yemubhedha, rate rate uye tembiricha yefirimu, kuderedza kushushikana kwemukati, uye kuderedza zviitiko zvekupaza mafirimu. Panguva imwecheteyo, gadzirisa kumhanya kwekutenderera kwevhavha yekuvhara kune yakanakisa mamiriro, uye isa iyo baffle zvine musoro kuti uderedze kupokana uye kupfeka.
2.Adgesion uye kupunzika
Mukufamba kwekucheka, apo kubatana kwenhamba pakati pezvimedu kwakakura kupfuura iyo ma molecular kupatsanurana simba, zvidimbu zvakawanda (zvidimbu zvakawanda) zvichasungwa muchidimbu uye wozoparadzanisa. Kana iyo chiyero pakati pekupfira uye kuoma haina kunaka, iyo firimu yakanyorova, iyo firimu ichanamatira kumadziro ehari kana kuti inonamatira kune mumwe nemumwe, asi zvakare inokonzeresa kuputsa kwefirimu panzvimbo yekushambadzira; Mukupuruzira, kana madonhwe asina kuomeswa zvakakwana, madonhwe asina kubhururuka acharamba ari mufirimu rekubatanidza emunharaunda, kune madiki madiki, achiumba bubble coubble coubles, kuitira kuti pepa rekubatanidza rinoonekwa bubbles.
2.1 kuongororwa kwezvikonzero zvikuru
NGUVA uye chiitiko cheichi chakakomberedza chinonyanya kukonzeresa nekuda kwekubatanidza mamiriro ekushandira, kusakwana pakati pekupfira nekuomesa. Iyo yekumhanyisa yekumhanyisa yakanyanya kukurumidza kana iyo vhoriyamu yeAatomized Gasi yakakura kwazvo. Iko kuomesa kumhanya kwakanyanya kunonoka nekuda kwemhepo yakaderera inlet vhoriyamu kana yakadzika mhepo inlet tembiricha uye tembiricha yakadzika yemubhedha. Iyo pepa haina kuomeswa layer ne layer munguva uye inoshambidzwa kana mabhuru anoitika. Mukuwedzera, nekuda kwekupfira zvisina kufanira kona kana chinhambwe, iyo cone yakaumbwa nehuremu idiki, uye mvura yekubatanidza inokonzerwa mune imwe nzvimbo, ichikonzera kudedera mumuno, zvichikonzera kudengenyeka. Iko kunonoka kumhanya kuunganidza pot, centrifugal simba idiki, firimu rinotenderera haina kunaka inoburitsa zvakare kuderedza.
Kubatanidza zvemvura zvevengozi kwakakura kwazvo, zvakare chimwe chezvikonzero. Zvipfeko zvevengozi zvevengo Asi izvi hazvina basa zvakanyanya pane zvinonzwika zvinonzwika.
Mukuwedzera, mhando isina kunaka yemhando yeFirimu icharatidzikawo kunamatira. Kana iyo flat firimu iri mumoto wekubatanidza haina kunaka haina kunaka, ichawedzera pamwe chete, zviri nyore kukonzera kaviri kana yakawanda-layer firimu. Mukutongwa kwedu kwekutongwa kweBufleddil hydrochloride mahwendefa, zvidimbu zvakawanda zvakajeka zvakaonekwa mumvura yakajairika yemvura inobatanidza muhari nekuda kweiyo flat yekuvhara.
2.2 mhinduro
Iyo inonyanya kugadzirisa iyo yekupuruzira uye yekuomesa kumhanya kuti uwane simba rakazara. Kuderedza kumhanya kwekumhanya, wobva wabatidza iyo inlet mweya vhoriyamu uye tembiricha yemhepo, wedzera tembiricha yemubhedha nekumhanyisa kumhanya. Wedzera nzvimbo yekuvhara yekupuruzira, kuderedza iyo avhareji svutugadzike yemadonhwe ekupfira kana kugadziridza mubhedha wepfuti
Gadzirisa mishonga yekuverenga, wobva wabudirira mukati meiyo solid solid solution, kuderedza huwandu hwe solvent kana kuwedzera kusunganidzwa kwe ethanol zvakakodzera mukati mehuwandu hwehuwandu hwehuwandu hwemisangano; Anti-anonamatira anogona zvakare kuwedzerwa nenzira kwayo, senge talcum poda, magnesium stearate, silica gel poda kana oxide peptide. Inogona kuvandudza nemazvo kumhanyisa kwehari yekubatanidza, wedzera simba rezango remubhedha.
Sarudza yakakodzera sheet coating. Nekudaro, for sheets flat, senge buflededy hydrochloride mahwendefa, kuunganidzwa kwakabudirira kuitwa mushure mekushandisa pani yekubatanidza kana nekuisa bhajeti mune yakajairika coating pani kusimudzira kutenderera kwepepa.
3.Kwirwa-kwakatungamirwa neganda rakatsetseka uye rakakoromoka
Mukufamba kwekuchera, nekuti mvura yekubatanidza haina kuparadzirwa, iyo Polymer haina kuparadzirwa, isina kujairika kubhadharwa kana kuisirwa pamusoro pefirimu, zvichikonzera murudzi rusina musoro uye isina kufanana. Ganda rakakwenenzverwa rudzi rwemhando yepamusoro, yakawandisa yakajeka yekuona yekuona.
3.1 kuongororwa kwezvikonzero zvikuru
Yekutanga inoenderana neiyo chip core. Iyo yakakura iyo yekutanga mamiriro ekunyora kweiyo core ndeye, iyo yakakura nzvimbo yekukomba kwechigadzirwa chakachekwa chichava.
Kechipiri, ine hukama hukuru nemunyorerwe solitiki yekuverenga. Izvo zvinowanzoda kuti iyo smecular uremu, yekuwedzera uye yekuwedzera ye polymer mumhinduro yekubatanidza ine chekuita nekukatyamadza kweiyo firimu yekuvhara firimu. Ivo vanoita nekukanganisa zvisizvo zvemhinduro yekubatanidza, uye kuomarara kwefirimu coating kwazopfumiswa neiyo visikopo kwemhinduro yekubatanidza, kuwedzera nekuwedzera kweiyo viscosity. Zvakawandisa zvakaringana zvirimo mumhedzisiro yekubatanidza inogona kukonzera nyore kuwanda.
Chekupedzisira, zvinoenderana nekushanda kwekubata. Iyo tomentation kumhanya yakanyanya kuderera kana yakanyanya kuderera (iyo atomization mhedzisiro haina kunaka), iyo isina kukwana kuparadzira madonhwe madonhwe uye gadzira ganda rakakoromoka. Uye yakawandisa vhoriyamu yemhepo (mweya wakakura kwazvo) kana kupisa zvakanyanya tembiricha, kunyanya kubuda kwemhepo kwakakura kwazvo, kubereka kweddy zvazvino, zvakare kuita kuti donhwe kupararira hakuna kunaka hakuna kunaka.
3.2 mhinduro
Yekutanga ndeyekuvandudza kunaka kweiyo core. Pamungambo nekufunga nezve kunaka kweiyo core, gadzirisa iyo coating solituriti yekunyoreswa uye kuderedza viscosity (kusunganidzwa) kana zvemukati zvemukati zvemamiriro ekugadzirisa. Doro-rinokudzwa kana doro-2-mvura coating mhinduro inogona kusarudzwa. Wobva wachinja mamiriro ekushanda, zvakanyatsonetsera kumhanya kwehari yekubatanidza, ita kuti firimu rizungugere, wedzera kukakavara, kusimudzira kupararira kwemvura inobata. Kana tembiricha yemubhedha ikakwira, deredza iyo Intake Mhepo Vhoriyamu uye Intake Tembiricha yemhepo. Kana paine zvikonzero zvekupfira, kudzvinyirirwa kweatomu kunofanirwa kuwedzerwa kukurumidza kukurumidza kumhanya, uye iyo tomokazation degree inofanira kuvandudzwa kuti iite kuti isimbe pamusoro pepepa, kuitira kuti ugadzire fog madonhwe ane zvidiki Avhareji diamita uye kudzivirira kuitika kwehombe hombe fog madonhwe, kunyanya yekubatanidza mvura ine viscosity yakakura. Iyo chinhambwe pakati pepfuti yekupuruzira uye mubhedha wepepa unogona zvakare kugadziriswa. Iyo Spray Pfuti ine Diki Nozzle Lizzle Diameter (015 MM ~ 1.2 mm) uye yakakwira kuyerera huwandu hweatomu gasi rinosarudzwa. Chimiro chekupfava chinogadziriswa kune huwandu hwakawanda hwegirazi coly cone ingle fog kuyerera, kuitira kuti madonhwe akaparadzirwa munzvimbo yakakura yepakati.
4.Ridend Bridge
4.1 Kuongororwa kwezvinhu zvikuru zvikonzero
Izvi zvinoitika kana pamusoro pemufirimu wakarongedzwa kana kuiswa chiratidzo. Nekuti zvipfeko zvipfeko zvechipfeko zvine chekuita nemakaniki emakambani Imwe-yakagadziriswa notch yakanyangarika kana logo haina kujeka, zvikonzero zveichi chiitiko chiri mumubhadharo wekubatanidza.
4.2 Solution
Gadzirisa mishonga yekubatanidza mhinduro. Shandisa yakaderera molecular uremu polymers kana yakakwirira Dhiziri yemafirimu mafirimu ekugadzira zvinhu; Wedzera huwandu hwesolvent, kuderedza zvevisiko zvemari coating; Wedzera huwandu hweplatizer, kuderedza kushushikana kwemukati. Yakasiyana planticzer mhedzisiro yakasiyana, polyethylene glycol 200 iri nani pane procaryylene glycol, glycerin. Inogona zvakare kuderedza kukurumidza kumhanya. Wedzera mhepo inclet tembiricha, wedzera tembiricha yemubhedha mubhedha, zvekuti iyo yakaumbwa yekuvhara yakasimba, asi kudzivirira kupaza. Mukuwedzera, mukugadzirwa kweakarongedzwa kufa, isu tinofanirwa kutarisisa kuupamhi hwekuparadza kona uye dzimwe pfungwa dzakanaka, kusvika pakugona kudzivirira kuitika kwebhiriji.
5.Clothing MeMbrane Chromatism
5.1 kuongororwa kwezvikonzero zvikuru zvikonzero
Mune akawanda ekubatanidza mishonga kana madhiri ayo anomiswa mumhedzisiro yekubatanidza uye nekuda kwekusavimbika kwekuverenga mari, mutsauko hauna kufanana uye mutsauko weruvara unogadzirwa pakati pezvimedu kana munzvimbo dzakasiyana dzezvidimbu. Chikonzero chikuru ndechekuti kumhanya kwehari yekubatanidza kunononoka kana kusanganisa kugona kwemusanganiswa murombo, uye yunifomu yekubatanidza mhedzisiro haigone kuwanikwa pakati pezvimedu zvakajairika; Kusunganidzwa kwekutyaira kana dhayi mumvura ine ruvara kunze nenguva; Kuderedza kwefirimu kunogona kukonzerwawo; Chimiro chechidimbu hachina kukodzera, chakadai senge chidimbu chakareba, chidimbu chakaumbwa chakavezwa, nekuda kwekutenderera sechikamu chinotenderera, zvichaitawo mutsauko wevara.
5.2 mhinduro
Wedzera kumhanya kweiyo coating pan kana nhamba yebhoti, gadzirisa kune yakakodzera mamiriro, kuitira kuti pepa riri mupani rinotenderera. Kuderedza iyo yekubatanidza mvura spray kumhanya, kuderedza tembiricha yemubhedha. Muchirimwa dhizaini yemavara ekuverenga mari, iyo dosage kana yakasimba zvirimo zvekutanga kana dhayi inofanira kuderedzwa, uye iyo pigment ine chifukidziro chakasimba chinofanira kusarudzwa. Iyo pigment kana dhayi inofanira kunge yakaomesesa uye zvidimbu zvinofanirwa kunge zviri zvidiki. Mvura Insoluble Dyes ari nani pane mvura svutugadzike, mvura insoluble madhiri haatamiri nemvura inochema, uye mukudzikisira kwemvura. Zvakare sarudza iyo yakakodzera chidimbu mhando. Mukutonga kwemafirimu ekucheka, pane matambudziko akasiyana-siyana, asi zvisinei kuti nderipi matambudziko, anogona kugadziriswa nekuvandudza kunaka kweiyo core, kugadzirisa mishonga yekubatanidza uye kushanda, kuitira kuti ubate chinja chishandiso uye dialectical kushanda. Nesimba rekubatanidza tekinoroji, kushanda uye kushandisa kwemashini matsva ekubatanidza uye kuunganidza tekinoroji
Kutumira Nguva: Kubvumbi-25-2024