Hydroxypropyl methyl cellulose uye carboxymethyl cellulose sodium inogona kusanganiswa

Hydroxypropyl methyl cellulose (HPMC) uye carboxymethyl cellulose sodium (CMC).) maviri anoshandiswa zvakanyanya selulosi anobva mumaindasitiri akasiyana nekuda kweakasarudzika zvimiro uye kushanda kwawo. Nepo ese ari ese ari cellulose-akavakirwa mapolymer, anosiyana muchimiro chavo chemakemikari uye zvimiro, izvo zvinoita kuti ive yakakodzera kune akasiyana maapplication. Nekudaro, mune dzimwe nguva, iwo anogona kusanganiswa kuti awane chaiwo maitiro ekuita kana kuwedzera zvimwe zvimiro zvechigadzirwa chekupedzisira.

Hydroxypropyl methyl cellulose (HPMC), inozivikanwawo se hypromellose, isiri-ionic cellulose ether inotorwa kubva kune yakasikwa polymer cellulose. Inogadzirwa kuburikidza nekuita kwealkali cellulose ine propylene oxide uye methyl chloride. HPMC inoshandiswa zvakanyanya mumishonga yemishonga, zvekuvaka, zvigadzirwa zvekudya, uye zvekuzora nekuda kweakanakisa kugadzira firimu, kukora, kusunga, uye kuchengetedza mvura. HPMC inowanikwa mumagiredhi akasiyana ane akasiyana viscosity mazinga, ayo anobvumira kushandiswa kwayo mune dzakasiyana siyana dzekushandisa.

Kune rimwe divi, carboxymethyl cellulose sodium (CMC) inonyungudika nemvura anionic cellulose derivative inowanikwa nekuita kwe cellulose ine sodium hydroxide uye chloroacetic acid. CMC inozivikanwa nekukwira kwayo kwekuchengetedza mvura, kugona kukora, firimu-kugadzira zvimiro, uye kugadzikana mune dzakasiyana siyana pH mamiriro. Inowana mashandisirwo muzvigadzirwa zvechikafu, mishonga, zvizorwa, machira, uye kugadzira mapepa nekuda kwekusiyana-siyana uye biocompatibility.

Nepo HPMC neCMC vachigovana zvimwe zvakajairwa zvivakwa zvakaita sekunyungudika kwemvura uye kugona kugadzira firimu, ivo vanoratidzawo hunhu hwakasiyana hunovaita kuti vakwane kune chaiwo maapplication. Semuenzaniso, HPMC inosarudzwa mukugadzirwa kwemishonga senge mahwendefa nemakapisi nekuda kweiyo inodzorwa-kuburitsa zvimiro uye kuenderana neanoshanda emishonga zvinongedzo. Kune rimwe divi, CMC inowanzo shandiswa muzvigadzirwa zvekudya zvakaita sesosi, madhirezi, uye zvinhu zvakabikwa sechinhu chinokora uye chinosimbisa.

Zvisinei nekusiyana kwavo, HPMC neCMC inogona kusanganiswa pamwechete mune mamwe mafomati kuti iwane synergistic mhedzisiro kana kuwedzera chaiwo zvivakwa. Iko kuenderana kweHPMC neCMC kunoenderana nezvinhu zvakati wandei senge chimiro chavo chemakemikari, huremu hwemamorekuru, dhigirii rekutsiva, uye zvimiro zvinodiwa zvechigadzirwa chekupedzisira. Kana yakasanganiswa pamwechete, HPMC neCMC inogona kuratidza yakavandudzwa kukora, kusunga, uye kugadzira firimu zvivakwa zvichienzaniswa nekushandisa chero polymer chete.

Imwe yakajairika application yekusanganisa HPMC neCMC iri mukugadzirwa kwehydrogel-based drug delivery system. MaHydrogels matatu-dimensional network zvimiro zvinokwanisa kutora uye kuchengetedza yakawanda yemvura, zvichiita kuti ive yakakodzera kune inodzorwa kuburitsa zvinodhaka. Nekubatanidza HPMC neCMC mumaratio akakodzera, vaongorori vanogona kugadzirisa zvimiro zvemahydrogel senge kuzvimba maitiro, simba remuchina, uye kinetics yekuburitsa zvinodhaka kuti isangane nezvinodiwa.

Kumwe kushandiswa kwekusanganisa HPMC neCMC kuri mukugadzirira kwependi-yemvura uye mapendi. HPMC neCMC zvinowanzo shandiswa sezvikobvu uye rheology modhifita mumapendi akavakirwa pamvura kuti avandudze zvimiro zvavo zvekushandisa, senge brushability, sag resistance, uye spatter kuramba. Nekugadzirisa reshiyo yeHPMC kuCMC, vagadziri vanogona kuwana iyo inodiwa viscosity uye kuyerera maitiro epende ichichengetedza kugadzikana kwayo uye kuita kwayo nekufamba kwenguva.

Pamusoro pemishonga uye machira, HPMC neCMC misanganiswa inoshandiswawo muindasitiri yechikafu kuvandudza magadzirirwo, kugadzikana, uye muromo wezvakasiyana zvigadzirwa zvekudya. Semuyenzaniso, HPMC neCMC zvinowanzowedzerwa kune zvigadzirwa zvemukaka zvakaita seyogati neaizikirimu sezvitsigiso kudzivirira kupatsanurwa kwechikamu uye kunatsiridza kirimu. Muzvinhu zvakabikwa, HPMC neCMC inogona kushandiswa sezvigadziriso zvehupfu kuwedzera hupfu hwekubata hupfu uye kuwedzera hupenyu hwesherufu.

nepo hydroxypropyl methyl cellulose (HPMC) uye carboxymethyl cellulose sodium (CMC) ari maviri akasiyana cellulose anobva kune akasiyana zvimiro uye mashandisirwo, anogona kusanganiswa pamwechete mune mamwe magadzirirwo kuti awane synergistic mhedzisiro kana kuwedzera chaiwo zvivakwa. Iko kuenderana kweHPMC neCMC kunoenderana nezvinhu zvakasiyana senge chimiro chavo chemakemikari, huremu hwemamorekuru, uye zvimiro zvinodiwa zvechigadzirwa chekupedzisira. Nekunyatsosarudza reshiyo uye musanganiswa weHPMC neCMC, vanogadzira vanogona kugadzirisa zvimiro zvemagadzirirwo avo kuti asangane nezvinodiwa mumishonga, machira, zvigadzirwa zvekudya, uye mamwe maindasitiri.