1. Iyo yekutanga chimiro cheHPMC
HyproMellose, Chirungu Zita HydroxyPropyl Methylcellose, Acias HPMC. Yayo molecular formula is c8h15o8- (c10HL8O6) n-c8hl5o8, uye kuremerwa kwemanyorerwe anenge 86,000. This product is a semi-synthetic material, which is part of the methyl group and part of the polyhydroxypropyl ether of cellulose. Inogona kugadzirwa nenzira mbiri: Imwe ndeyekubata methyl cellelose yegiredhi rakakodzera na nooh, wobva waita neProfyeryxo oxide province tembiricha uye yakanyanya kudzvinyirira. Iyo nguva yekuita inofanira kutsigirwa kuti ibve methyl uye hydroxyprupropyl mapoka ekubatanidza neEther. Chimiro chewakabatanidzwa neiyo ashhydroglose mhete yemasero, uye inogona kusvika padanho raunoda; Imwe ndeyekurapa yekotoni yekoter kana huni propiti fiber ine caustic soda, uye wozowana nekuita methane zvichinyatsonaka, uyezve yakanatswa. HPMC ndeye akasiyana-siyana echisikigo chirimwa cellulose, uye zvakare yakanakisa mishonga yakafanana, iyo ine yakafara sosi. Parizvino, inoshandiswa zvakanyanya pamba uye kune dzimwe nyika, uye ndeimwe yemishonga yemishonga ine huwandu hwepamusoro hwekushandisa pakati pemishonga yemuromo.
Ruvara rwechigadzirwa ichi rwakachena kusvika kune Milky White, isina-chepfu uye isina kunaka, uye iri granular, uye fibrous, iri nyore, iri nyore-inoyerera poda. Iyo yakagadzikana pakuratidzwa kwechiedza uye humidyity. Inochekera mumvura inotonhora kuti iite Milky White Coolidal Solution ine imwe mwero wewisikoka. Iyo Sol-Gel Intercension phenomenon inogona kuitika nekuda kwekudziya kwekushisa kwekushanduka kweimwe kusarudzika kwemhinduro. Zviri nyore kwazvo kunyungudika mumakore 70% doro kana dimethyl ketone, uye haizombopunyuka mudoro anoshaya, chloroform kana ethoxyethane.
HyproMellose ine yakagadzikana yakanaka kana iyo pH iri pakati pe40 ne 8.0, uye inogona kuvapo zvine chekuita pakati pe3,0 uye 11.0. Mushure mekuchengetedza kwemazuva gumi pakudziya kwe20 ° C uye humidive yehukama hwe80%, iyo yakanyorova yekubatanidza coefficient yeHPMC ndeye 6.2%.
Nekuda kwemusiyano mune izvo zvevakadzorerwa mune chimiro cheHypromellose, madziridzo uye hydroxypruppropyl, mhando dzakasiyana siyana dzezvigadzirwa dzakaonekwa. Mune imwe pfungwa yakasarudzika, mhando dzakasiyana siyana dzezvigadzirwa zvine zvisizvo viscosity uye mafuta egungwa tembiricha, saka, zvine zvivakwa zvakasiyana uye zvinogona kushandiswa kune zvakaringana. Iyo pharmacooeias yenyika dzakasiyana siyana dzine zvirevo zvakasiyana uye zvirevo zvemuenzaniso: Iyo European Pharmacoeia yakavakirwa pamakiredhi akasiyana ezvikamu zvakasiyana uye madhigirii akasiyana ezvigadzirwa pamusika. Iyo inoratidzwa negiredhi pamwe nhamba. Iyo unit ndeye mpa • s. Mushure mekuwedzera manhamba mana kuratidza zviri mukati uye mhando yeyakajeka kwehypromellose, semuenzaniso, manhamba maviri ekutanga anomiririra chikamu cheboka reChoxy, manhamba maviri ekupedzisira anomiririra hydroxproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproproprever
2.The nzira yekunyungudika HPMC mumvura
2.1 inopisa mvura nzira
Sezvo hyplompellose haina kunyungudutswa mumvura inopisa, inogona kuparadzirwa mumvura inopisa pane imwe nhanho yekutanga pachiitiko chekutanga, uye kana ichinge yapetwa, nzira mbiri dzakajairika dzinotsanangurwa seinotevera:
(1) isa huwandu hunodiwa hwemvura inopisa mumudziyo uye uzvidzise kune anenge 70 ℃. Zvishoma nezvishoma wedzera chigadzirwa chiri pasi pekunonoka kusimuka. Pakutanga, chigadzirwa chinopfugama pamusoro pemvura, uyezve zvishoma nezvishoma zvinoumba slurry. Kutonhora pasi slurry.
. Kumvura inopisa slurry mune slurry, inotonhorera musanganiswa mushure mekukurudzira.
2.2 powder kusanganisa nzira
Iyo powder zvidimbu uye zvimwe zvinogadzirwa powders eakaenzana kana yakakura huwandu hwakazara nekuroverwa nekuoma kusanganisa, uye mvura inowedzerwa kunyungudika. Panguva ino, hyproomllose inogona kunyungudutswa pasina anounganidzwa.
3. Zvakanakira HPMC
3.1 inotonhora mvura solubility
Izvo zvinonyangadza mumvura inotonhora pazasi 40 ° C kana 70% ethanol. Izvo zvinonyangadza nemvura inopisa pamusoro pe60 ° CL, asi inogona kugomera.
3.2 Chemical Inertness
Hyplomllose (HPMC) rudzi rwe isiri-ionic cellulose ether. Mhinduro yacho haina iyo Ionic mhosva uye haina kupindirana nesimbi simbi kana ionic organic compos. Naizvozvo, mamwe maExccivients haaite nazvo panguva yekugadzirira maitiro.
3.3 Kugadzikana
Iyo yakagadzikana kune ese acid naAlkali, uye inogona kuchengetwa kwenguva yakareba pakati paP 3 kusvika 1l, uye viscosity yayo haina shanduko iri pachena. Mhinduro yekumusoro yeiyo hypromellose (HPMC) ine anti-mold maitiro uye inogona kuchengetedza yakanaka viscosity kugadzikana panguva yekuchengetedza kwenguva refu. Iyo pharmaceucal excpients uchishandisa HPMC ine hutano husina kunaka kupfuura izvo zvinoshandiswa zvechinyakare zvakanaka (senge dextrin, starch, nezvimwewo).
3.4 Kugadziriswa kweViscosity
Yakasiyana viscosity inobva yeHPMC inogona kuvhenganiswa mune dzakasiyana zviyero, uye visikopa yaro inogona kuchinja zvinoenderana nemumwe mutemo, uye ine hukama hwakanaka hwehukama, saka zvinogona kusarudzwa maererano nezvinodiwa.
3.5 metabolic inertia
HPMC haina kubviswa kana metabolized mumuviri, uye haapi macalories, saka inzvimbo yakachengeteka yekugadzirira kurudziro yemishonga.
3.6 kuchengetedzwa
Izvo zvinowanzotenda kuti HPMC ndeye isiri-ine chepfu uye isiri-inotsamwisa zvinhu. Iyo yepakati lethal demo yemakonzo ndeye 5g / kg, uye iyo yepakati lethal dhihwe nemakonzo ari 5.2G / kg. Iyo DOSAGY DOSAG haina kukuvadzwa nemuviri wemunhu.
4. Kushandiswa kweHPMC mukugadzirira
4.1 Inoshandiswa seFirimu Kubata zvinhu uye firimu kuumba zvinhu
HyproMellose (HPMC) inoshandiswa seye firimu-yakafukidzwa piritsi zvinhu. Kuenzaniswa nemahwendefa echinyakare akabatanidzwa senge mahwendefa emahara, mahwendefa akakomberedzwa haana kubhururuka, asi kuomesa, kusvibiswa, kuunganidza uremu uye zvimwe zviratidzo zvemhando yepamusoro zviri nani. Iyo yakaderera-vcosity grade yechigadzirwa ichi inoshandiswa seyakagadziriswa yemvura yekubatanidza zvinyorwa zvemapiritsi nemapiritsi, uye giredhi repamusoro rinoshandiswa seye firimu kuunganidza zvinhu zve organic solvent system. Iyo yekushandisa yekushandisa inowanzoitika 2.0% -20%.
4.2 Senge binder uye kuparadzanisa
Iyo yakaderera-vcosity grade yechigadzirwa ichi inogona kushandiswa seyekuchinjika uye kupaza mapiritsi, mapiritsi, uye giredhi repamusoro, uye giredhi repamusoro, uye giredhi repamusoro rinogona kushandiswa chete seinongoshandiswa. Iyo Dosage inosiyana nemhando dzakasiyana uye zvinodiwa. Kazhinji, huwandu hwehupfu hunoshandiswa kune yakaoma girazi girini ndeye 5%, uye huwandu hwebhinzi hwashandiswa kune mahwendefa emvura egirini iri 2%.
4.3 seMumiriri Anomhanya
Kumhanyisa mumiririri ndeye viscous gel chinhu ne hydrophilikuity. Kushandiswa kwekumisikidza mumiririri mukumhanyisa mumiriri kunogona kudzora kukurumidza kwekumhanya kwezvidimbu zvechikamu, uye zvinogona kubatanidzwa kune zvimedu zvekudzivirira zvimedu kubva padzimba uye kudzikisira kuva misa. Kumisa vamiririri kunoshanda kwakakosha mukugadzirwa kwekumiswa. HPMC yakakura zvakasiyana-siyana zvevamiririri vanomisa. Iyo colloidal soluolved mukati inogona kuderedza kusawirirana kwemvura-yakasimba interface uye yakasununguka simba pane zvidiki zvakasikwa zvidimbu, nekukasira kugadzikana kweiyo heteroxious system. Ichi chigadzirwa chiri yakakwira-viscosity kumiswa kwemvura kugadzirira yakagadzirirwa seyemumiriri anomiswa. Iyo ine yakanaka yekukurumidza kushanda, iri nyore kudzoreredza, isina-inonamira, uye yakanaka yakafemerwa zvidimbu. Iyo yakajairwa huwandu ndeye 0.5% kusvika 1.5%.
4.4 Inoshandiswa seye blocker, inononoka uye inodzorwa kuburitswa mumiririri uye pore-fomu yekugadzira mumiririri
Iyo yakakwira-viscosity grade yechigadzirwa ichi inoshandiswa kugadzirira hydrophilic gel mahwendefa ekusimudzira Iyo ine mhedzisiro yekunonoka kusunungurwa kwezvinodhaka. Yayo yekushandisa yekushandisa ndeye 10% ~ 80% (w / w). Iyo yakaderera viscosity giredhi inoshandiswa seyekuumbwa-inogadzira mumiririri wekutsigirwa kana kudzorwa kuburitswa. Iyo yekutanga dosi inoda kuti kurapa kwemhando yerudzi urwu kunogona kukurumidza kusvika, uyezve kusunungurwa kana kudzorwa kana kudzorwa kweropa kwakachengetwa mumuviri. Hypromlllose hydrate kuti iite gel layer kana ichisangana nemvura. Iyo Mechanism yekuburitswa kwezvinodhaka kubva kune iyo matrix piritsi inonyanya kusiyana yeiyo gel layer uye kugumisa kweiyo gel layer.
4.5 inodzivirira glue inoshandiswa seanotherkener uye colloid
Kana chigadzirwa ichi chinoshandiswa seanotenda, iyo yakajairwa kuwirirana ndeye 0.45% ~ 1.0%. Ichi chigadzirwa chinogona zvakare kuwedzera kugadzikana kweiyo hydrophobic glue, gadzira iyo colloid colloid, inodzivisa chidimbu uye chakajaira, nekudaro uchivhiringidza kuumbwa kwezvinorongwa. Yayo yakajairwa kuwirirana ndeye 0.5% ~ 1.5%.
4.6 Inoshandiswa seCapsule zvinhu
Kazhinji, iyo capsule yeganda zvinyorwa zve capsule inonyanya kuwanda. Maitiro ekugadzira kweMing Capsule Shell iri nyore, asi kune mamwe matambudziko uye zviitiko zvakashata zvinodhaka uye zvinodhaka zvinodhaka, uye kunonoka kwekuparadzira capsule shell panguva yekuchengetedza. Naizvozvo, hyplemellose inoshandiswa sechinhu chekutsiva chezvinyorwa zveCapsule mukugadziriswa kwemakapu, izvo zvinovandudza kuumbwa uye kushandisa mhedzisiro yekapu, uye yakakurudzirwa zvakanyanya kumba uye kune imwe nyika.
4.7 sebhizimusi
Bioadesive tekinoroji, kushandiswa kwevanhu vepanyama ne bioadesive polesa, kusimudzira kuenderera mberi nekuenderera mberi kwekugadzirira uye muCoosa kusunungurwa uye kuti kuswededzwa kweiyo mucosa kuzadzisa chinangwa che kurapwa. Iyo inoshandiswa zvakanyanya ikozvino inoshandiswa kurapa chirwere chemhino yemhino uye nemuromo mucosa. Gastrointestinal Bioadhesion tekinoroji rudzi rutsva rwekutumira kwezvinodhaka system yakagadzirwa mumakore achangopfuura. Izvo hazvingowedzera nguva yekugara yekugadzirira zvinodhaka mugwara regastrointestinal, asi zvakare zvinovandudzawo kuita kwemushonga nemushonga membrane yeiyo nzvimbo yekunyudza uye inoshandura fluidity yeiyo sero menduru. Simba rinopinza remushonga kumasero epitheliari emudumbu madiki anowedzerwa, nekukandiratidza nekuvhenekera kwekutya kwemushonga.
4.8 segwenzi repamusoro
Sezvinogadzirira kugadzirira kweganda, gel ine mikana yakanakira senge kuchengeteka, runako, nyore kuchenesa, mutengo wakaderera, maitiro akareruka, uye kuenzanisa kwakanaka nemishonga. Mumakore achangopfuura, yakagamuchira kutarisisa uye yave kukura kwegadziriro yekunze yekunze. kutungamira.
4.9 Sechiratidzo chekutanga mune ye emulsification system
Kutumira Nguva: Dec-16-2021