HydroxyPropyl methylcellose (HPMC) inzvimbo yezvinhu zvakasiyana-siyana inoshandiswa muindasitiri kubva kumishonga yekuvakwa nekuda kwekuvaka nekuda kwezvivakwa zvaro. Icho chinobva kune cellulose, nemapoka e hydroxyl chakatsiviwa neiyo nzira uye hydroxypruspropyl mapoka, achiwedzera solubility mumvura uye mamwe organic sol.
Solubility maitiro eHPMC
1. SoluBility yemvura
Hpmc inowanzoitika mvura-solugle. Yayo solubility mumvura inokurudzirwa nezvikamu zvinoverengeka:
Kupisa: HPMC inodonha mumvura inotonhora kana yemukati-tembiricha. Pakupisa, Hpmc inogona kugadzira gel; Pakutonhora, gel inodurura zvakare, ichiita kuti zvidzorere. Iyi gelation inobatsira mukushandisa mukushandiswa kwezvinodhaka kusunungurwa mumishonga yemishonga.
Kusimbisa: Nzvimbo dzakaderera (0.5-2%) inowanzo nyungudika zvakanyanya nyore. Nzvimbo dzakakwirira kwazvo (kusvika 10%) dzinogona kuda zvakanyanya uye nguva.
PH: HPMC Solutions yakagadzikana pane yakakura pH Range (3-11), kuita kuti vaite zvinoenderana nezvimiro zvakasiyana.
2. Organic solvent
Nepo kunyanya-solullble, hpmc inogona zvakare kunyungudika mune mamwe organic sol soles, kunyanya iyo ine imwe nhanho yehurumende yehupombwe. Izvi zvinosanganisira:
Alcohols: HPMC inoratidza yakanaka solubility mune yakadzika masaga senge methanol, ethanol, uye isopropanol. Bathor of AcalHolls isinganyanyi kushanda nekuda kwekureva kwavo refu hydrophobic maketani.
Glycols: Propylene Glycol uye Polyethylene Glycol (Peg) inogona kunyungudika hpmc. Iyi sol solvent inowanzoshandiswa mukubatanidzwa nemvura kana alcohols yekuvandudza solubility uye mhinduro kugadzikana.
Kotoni: Dzimwe keneti dzakadai seacetone uye methyl ethyl ketone inogona kunyungudika hpmc, kunyanya kana yakasanganiswa nemvura.
3. Mixtures
HPMC inogona zvakare kuve yakanyungudutswa mune solvent musanganiswa. Semuenzaniso, kusanganisa mvura ine alcohols kana glycols inogona kuwedzera solubility. Iyo synergy pakati pemararamiro inogona kudzikisa iyo inodiwa yekuvhara kwe chero imwechete solvent, kuperevedza kuparara.
Michina yekuparadzaniswa
Kupararira kweHPMC mune solventes kunosanganisira kutyora mauto ehupfu pakati peHPMC maketani uye kuumba matsva ekudyidzana ne solvent mamorekuru. Zvinhu zvinokanganisa maitiro aya zvinosanganisira:
Hydrogen Kubatanidza: HPMC inogadzira hydrogen zvisungo nemvura uye imwe polar sols, inofambisa solubility.
Polymer-solvent yekudyidzana: kugona kweiyo solvent mamexcules kuti ipinde uye kudyidzana neHPMC chaina inobata kusanyanyoka.
Mechanical Agitation: Kukurudzira kunobatsira pakurambana uchikwidzana uye kusimudzira yunifomu yunifomu.
Kufunga kunoshanda kwekunyungudika HPMC
1. Dissolution nzira
Nekunyangarika, tevera matanho aya:
Kuwedzera zvishoma nezvishoma: zvishoma nezvishoma wedzera hpmc kune solvent uye kugara uchimutsa kuti udzivise kudzima.
Tembiricha Control: Nyarara HPMC mumvura inotonhora kuti udzivise nguva isati yasvika. Kune mamwe organic solventes, kudziya zvishoma kunogona kubatsira.
Kusanganisa maitiro: Shandisa michina madhiri kana homogeniger yekunyatso kusanganisa, kunyanya pazvinhu zvepamusoro.
2. Kubata uye viscosity
Hpmc's Constentration inokanganisa iyo visikopa yeiyo mhinduro:
Kuderera-kuderera: Mhedzisiro mune yakaderera-viscosity solution, yakakodzera kune zvikumbiro senge zvipfeko kana mabhasi.
Kuwedzeredza kusimba: kunogadzira mhinduro yepamusoro-viscosity kana gel, inobatsira muzvimiro zvemishonga kuti isunungurwe.
3. Kuenderana
Paunenge uchishandisa HPMC muzvimiro, chivimbe nekuwirirana nezvimwe zvinoshandiswa:
PH SUBLICALE: Simbisa kuti zvimwe zvikamu hazvishanduri iyo PH inodarika iyo yakagadzikana huwandu hweHPMC.
Tembiricha yekupisa: funga iyo yedhiramu yeGenational yeGenational Pfuma iyo inogadzira maitiro inosanganisira tembiricha shanduko.
Zvikumbiro zveHPMC Solutions
HPMC Solutions inoshandirwa maindasitiri akasiyana-siyana nekuda kwezvivakwa zvavo zvakasarudzika:
1. Pharmaceuticals
HPMC inoita seyekubhusa, yefirimu yaimbova, uye yakadzorwa kuburitswa mumiriri:
Mahwendefa uye makapu: HPMC Solutions inobatsira mukusunga zvisungo uye kuumba mafirimu ekudzora zvinodhaka kusunungurwa kwezvinodhaka.
Gels: Inoshandiswa mune zvemusoro zvemukati zvekukonzeresa zvaro uye kusimbisa zvivakwa.
2. Indasitiri yechikafu
Sezvinoita chikafu chekudya, hpmc chinoshandiswa pakusimbisa kwayo uye nekufungidzira zvivakwa:
THICKEERS: Kuvandudza kuumbwa uye kugadzikana mumasokisi uye kupfeka.
Film Ford: inogadzira mafirimu emafirimu ekutenderera uye encaption.
3. Kuvaka
HPMC Solutions inosimudzira zvinhu zvezvivakwa zvekuvaka:
Simende uye motsi: yakashandiswa seyekukakavara uye kumazera kumirimo mumutauriri wezvemument-based zvigadzirwa.
Pendi uye kuungana: inopa kudzora kwe rheological kudzora uye kugadzikana mumapendi.
Yepamberi Dissolution Matipi
1. Ultrasonung
Uchishandisa mafungu ehuvheri kuti adzivise hpmc inogona kuwedzera iyo yekunyungudza chiyero uye kushanda kwayo nekuputsa zvimedu uye kusimudzira yunifomu.
2. Yakakwira-shear kusanganisa
Vazhinji vanovhiringidza vanovhenganisa zvakanyanya kusanganisa, vachidzora nguva yekushambadzira uye nekuvandudza homogeneity, kunyanya mukuumbwa-yepamusoro-viscosity mafomu.
Zvemamiriro ekunze uye Kuchengetedza Kufunga
1. Biodegradability
HPMC iri biodegradable, ichiita kuti ive neushamwari. Iyo inosvibisa muzvikamu zvakasikwa, kuderedza mamiriro ekunze.
2. Kuchengetedza
HPMC isiri-ine chepfu uye yakachengeteka yekushandiswa mune chikafu, mishonga yemishonga, uye cosmetics. Nekudaro, mashizha ekuchengetedza data (sD) anofanirwa kuongororwa kuti abate uye ekuchengetedza mirayiridzo.
Kudonha HPMC zvinobudirira kunoda kunzwisiswa kwayo maitiro ayo solubility uye iyo yekubatanidza ine akasiyana sol sol. Mvura inoramba iri yekutanga solvent, apo alcohols, Glycols, uye solvent musanganiswa inopa imwe mhinduro dzezvakangoita zvekushandisa. Maitiro akakodzera uye kufunga kuve nechokwadi chekunyanyisa kupaza, kururamisa hpmc's shandisa kushandiswa kweshanduro maindasitiri.
Kutumira Nguva: Jun-14-2024