Tembiricha tekinoroji yehydroxypropyl methylcellulose (HPMC)

Hydroxypropyl Methyl Cellulose (HPMC) isiri-ionic cellulose ether inoshandiswa zvakanyanya mukuvaka, mushonga, chikafu, machira uye mamwe maindasitiri. Yayo yakasarudzika yemuviri uye makemikari zvimiro zvinopa iyo yakanakisa kugadzikana uye kushanda kwekuita munzvimbo dzekushisa kwepamusoro. Nekukura kuri kudiwa kwekushandiswa kwekushisa kwepamusoro, iyo tembiricha kuramba uye gadziriso tekinoroji yeHPMC zvishoma nezvishoma yave hotspot yekutsvaga.

1. Zvinhu zvakakosha zveHPMC

HPMC ine mvura yakanaka solubility, thickening, film-forming, emulsifying, kugadzikana uye biocompatibility. Pasi pemamiriro ekupisa kwepamusoro, kunyungudika, gelation maitiro uye rheological zvimiro zveHPMC zvinokanganiswa, saka iyo optimization ye tekinoroji yepamusoro inonyanya kukosha pakushandiswa kwayo.

2. Hunhu hunokosha hweHPMC pasi pemamiriro ekushisa kwepamusoro

Thermal gelation

HPMC inoratidza yakasarudzika thermal gelation phenomenon munzvimbo dzakanyanya tembiricha. Kana tembiricha ichikwira kune imwe siyana, viscosity yeHPMC mhinduro inoderera uye gelation ichaitika pane imwe tembiricha. Iyi ficha inonyanya kukosha mukuvaka (senge semende dhaka, dhaka rinozvimisa) uye indasitiri yezvekudya. Semuenzaniso, munzvimbo dzekushisa kwepamusoro, HPMC inogona kupa kuchengetedza kwemvura kuri nani uye kudzoreredza fluidity mushure mekutonhora.

Kugadzikana kwekushisa kwepamusoro

HPMC ine yakanaka yekudziya kugadzikana uye haisi nyore kuora kana denature pakupisa kwakanyanya. Kazhinji kutaura, kugadzikana kwayo kwekupisa kune hukama nedhigirii rekutsiva uye dhigirii repolymerization. Kuburikidza nekugadziriswa kwekemikari chaiyo kana kugadziridzwa kwekugadzirisa, kupisa kwayo kupisa kunogona kuvandudzwa kuitira kuti irambe ichichengetedza yakanaka rheological zvimiro uye kushanda munzvimbo dzekushisa kwepamusoro.

Munyu kuramba uye alkali kuramba

Munzvimbo dzekushisa kwepamusoro, HPMC ine kushivirira kwakanaka kune acids, alkalis uye electrolytes, kunyanya yakasimba alkali resistance, iyo inoita kuti ibudirire kuvandudza kushanda kwekuvaka mune simenti-based materials uye inoramba yakagadzikana panguva yekushandiswa kwenguva refu.

Kuchengetedza mvura

HPMC's yakakwirira tembiricha yekuchengetedza mvura chinhu chakakosha pakushandisa kwayo kwakakura muindasitiri yekuvaka. Mune tembiricha yakanyanya kana yakaoma nharaunda, HPMC inogona kunyatso kudzikisa mvura evaporation, kunonoka simende hydration reaction, uye kunatsiridza kushanda kwekuvaka, nekudaro ichidzikisa chizvarwa chekutsemuka nekuvandudza kunaka kwechigadzirwa chekupedzisira.

Basa repamusoro uye dispersibility

Pasi pemamiriro ekushisa akanyanya, HPMC inogona kuramba ichichengetedza yakanaka emulsification uye dispersibility, kudzikamisa sisitimu, uye kushandiswa zvakanyanya mumachira, pendi, zvekuvakisa, chikafu nemimwe minda.

3. HPMC yakakwirira tembiricha shanduko tekinoroji

Mukupindura kune yakakwira tembiricha yekushandisa zvinodiwa, vaongorori nemabhizinesi vakagadzira akasiyana siyana eHPMC ekugadzirisa matekinoroji kuti ivandudze kupisa kwayo kudzivirira uye kugadzikana kwekushanda. Zvikuru zvinosanganisira:

Kuwedzera dhigirii yekutsiva

Iyo dhigirii yekutsiva (DS) uye molar substitution (MS) yeHPMC ine yakakosha mhedzisiro pakupisa kwayo. Nekuwedzera dhigirii rekutsiva hydroxypropyl kana methoxy, tembiricha yayo yekupisa gelation inogona kuderedzwa zvinobudirira uye kugadzikana kwayo kwekushisa kwakanyanya kunogona kuvandudzwa.

Copolymerization shanduko

Copolymerization nemamwe mapolymers, akadai sekubatanidza kana kusanganisa ne polyvinyl doro (PVA), polyacrylic acid (PAA), nezvimwewo, inogona kuvandudza kupisa kweHPMC uye kuchengetedza yakanaka inoshanda zvivakwa pasi pekupisa kwakanyanya.

Cross-linking shanduko

Kugadzikana kwekupisa kweHPMC kunogona kuvandudzwa nekemikari kuyambuka-kubatanidza kana yemuviri kuyambuka-kubatanidza, zvichiita kuti kuita kwayo kugadzikane pasi pemamiriro ekushisa. Semuenzaniso, kushandiswa kwesilicone kana polyurethane kugadziriswa kunogona kuvandudza kupisa kwekupisa uye simba remagetsi reHPMC.

Nanocomposite kugadziriswa

Mumakore achangopfuura, kuwedzerwa kwemananomaterials, senge nano-silicon dioxide (SiO₂) uye nano-cellulose, inogona kunyatso kusimudzira kupisa kwekudzivirira uye michina yeHPMC, kuitira kuti irambe ichichengetedza yakanaka rheological zvimiro pasi pemamiriro ekunze ekupisa.

4. HPMC yakakwirira tembiricha application munda

Zvishandiso zvekuvaka

Muzvivakwa zvekuvaka senge dhaka rakaoma, tile inonamira, putty poda, uye yekunze madziro ekudzivirira system, HPMC inogona kunyatso kuvandudza mashandiro ekuvaka pasi pemamiriro ekunze ekupisa, kuderedza kuputika, nekuvandudza kuchengetedza kwemvura.

Indasitiri yezvokudya

Sekuwedzera kwechikafu, HPMC inogona kushandiswa mune yakakwira-tembiricha yakabikwa chikafu kuvandudza kuchengetwa kwemvura uye kugadzikana kwechikafu, kuderedza kurasikirwa kwemvura, uye kunatsiridza kuravira.

Munda wezvokurapa

Muindasitiri yemishonga, HPMC inoshandiswa senge piritsi yekuputira uye inoenderera-yakaburitswa zvinhu kuvandudza kugadzikana kwekupisa kwemishonga, kunonoka kuburitswa kwezvinodhaka, uye kugadzirisa bioavailability.

Kuchera Oiri

HPMC inogona kushandiswa sechinhu chinowedzera chemafuta ekuchera mvura kuvandudza tembiricha yakadzikama yemvura yekuchera, kudzivirira kudonha kwemadziro, uye kugadzirisa kuchera.

HPMC ine yakasarudzika thermal gelation, yakakwirira tembiricha kugadzikana, alkali kuramba uye kuchengetedza mvura pasi pemamiriro ekunze ekupisa. Kupisa kwayo kupisa kunogona kuvandudzwa nekushandurwa kwemakemikari, kuchinjika kwekopolymerization, kuchinjika-kuchinjika kuchinjika uye nano-composite shanduko. Inoshandiswa zvakanyanya mumaindasitiri mazhinji akadai sekuvaka, chikafu, mushonga, uye peturu, inoratidza yakakura musika mukana uye tarisiro yekushandisa. Mune ramangwana, nekutsvagisa uye kusimudzira kwepamusoro-kuita HPMC zvigadzirwa, mamwe maapplication munzvimbo dzekupisa tembiricha achawedzerwa.