HyproMellose, anozivikanwa zvakare se hydroxyprupyl methylcellose (HPMC), inzvimbo inoverengeka hafu-synthetic polymer kubva ku cellulose. Nekuda kweiyo yakasarudzika yemakemikari yemakemikari uye hpmc inowanzoshandiswa seyakanyanya, stabilizer uye inonamatira mune yemishonga, yezvikafu uye maindasitiri ekuchengeta. Munyaya ino, isu tinokurukura nezve chemistry yeHPMCs uye zvavanokwanisa kunyorera.
1. Solubility
Imwe yezvinhu zvakakosha zvemakemikari zveHPMC ndiyo yayo solubility. HPMC inonyura mumvura uye yakawanda organic sol solventes, ichiita iyo yakakodzera chikamu chemishonga yekuzvitakura zvinodhaka uye zvimwe zvekushandisa zvinoda kupaza. Nekudaro, iyo solubility yeHPMC inofungidzirwa neiyo degree rayo rekutsiva HPMCs ine yakakwira DS ine yakaderera solubility nekuda kwekuwedzera kwekurindirana kutaurirana.
2. Rheology
Chimwe chinhu chakakosha chemakemikari cheHPMC ndiyo tsika yayo yerateological. Hpmc's kugona kuumba gel-kunge network pane hydration inogona kushandiswa kudzora mavisikopa uye kuyerera maitiro ezvimiro. HPMC inoratidzirawo maitiro asiri eNewotian kuyerera, zvichireva kuti viscosity yayo inoshanduka zvinoenderana neyakaiswa shear rate. Ichi chivakwa chinogona kuenderera mberi nekudzorerwa nekugadzirisa kusunganidzwa kweHPMC uye DS muumbi.
3. Film formation
HPMC inowanzoshandiswa zvakanyanya sefirimu raimbove nekuda kwekugona kwayo kuumba mafirimu unifomu kana akashandiswa kune substrate. Iyo firimu-inogadzira nzvimbo yeHPMC inotsamira pane yayo DS, viscosity uye kuvapo kwepurasitiki, izvo zvinogona kuvandudza elasticity uye kushanduka kwefirimu. Mafirimu akagadzirwa kubva kuHPMC anowanzo kushandiswa mukudhakwa nekuti ivo vanobvumira kudzorwa kwekudzorwa kwezvinhu zvinoshanda zvinoshanda.
4. Kuenderana
HPMC chinhu chinowirirana kwazvo uye chinogona kushandiswa mune dzakasiyana siyana mafomu. Izvo zvinowirirana nezvinhu zvakanyanya mishonga, kusanganisira inoshanda mishonga yemishonga (APIS) uye mamwe maEnscivicients anowanzo shandiswa mukuumbwa kwemishonga. HPMC iri zvakare inoenderana nezvakawanda zvekudya zvekudya, zvichiita sarudzo yakakurumbira yezvekudya zvekudya.
5. Kugadzikana kwemakemikari
HPMC inzvimbo yakagadzikana iyo inoramba hydrolysis uye mamwe maitiro emakemikari. Uku kugadzikana kunoita kuti ive yakanaka yekukwezva yezvinodhaka nzira sezvo inochengetedza iyo inoshanda chinja kubva mukushatisa uye inowedzera kuwanda kwayo. Nekudaro, kugadzikana kwemakemikari kweHPMC kunogona kukanganiswa nekushisa kwakanyanya, kunyorova kwakanyanya, uye mamwe mashiromita, ayo anogona kukonzera iyo polymer yekushambadzira uye kuderedza kushanda kwayo mukugadzirisa.
6. Biocompuility
Pakupedzisira, HPMC inzvimbo yakanyanya biocompatle polymer iyo yakachengeteka yekushandiswa mumishonga yemishonga uye zvigadzirwa zvekutarisira pachako. Izvo hazvisi zvechinjo, zvisiri-immunogenic uye biodegradable, ichiita kuti ive yakakodzera kune fomu inoda kuvezwa zvishoma uye yakachengeteka kwazvo.
Mukupfupikisa, HPMC hypromellose inzvimbo yemilimuntional polymer ine huwandu hwakakosha hwemakemikari, kusanganisira solubility, rheology, firimu kugadzira, kuumbwa, kugadzikana kwemakemikari, uye kusimba kwemakemikari. Izvi zvivakwa zvinoita kuti ive yakanaka yekukwezva yezvinodhaka system uye zvimwe zvinoshanda mune zvekudya uye maindasitiri ekuchengeta vega. Sezvo kutsvagisa kunoenderera mberi nekuwedzera kunzwisisa kwedu HPMPS, zvadzo zvakasarudzika zvinogona kuwana maficha akawandisa mune ramangwana.
Kutumira Nguva: Jul-28-2023