HPMC (Hydroxypropyl Methylcellulose) is nonionic cellulose ether inoshandiswa zvakanyanya mumishonga, chikafu, kuvaka uye cosmetics. Magiredhi akasiyana eHPMC anonyanya kuiswa zvichienderana nechimiro chavo chemakemikari, zvimiro zvemuviri, viscosity, dhigirii rekutsiva uye akasiyana mashandisiro.
1. Chimiro chemakemikari uye dhigirii yekutsiva
Iyo molecular chimiro cheHPMC ine hydroxyl mapoka pane cellulose cheni ichitsiviwa nemethoxy uye hydroxypropoxy mapoka. Hunhu hwemuviri nemakemikari eHPMC anosiyana zvichienderana nedanho rekutsiva methoxy uye hydroxypropoxy mapoka. Iyo dhigirii yekutsiva inokanganisa zvakananga kunyungudika, kugadzikana kwekupisa uye chiitiko chepamusoro cheHPMC. Zvakananga:
HPMC ine methoxy yakakwira inotaridza kuratidza tembiricha yepamusoro yekupisa gelation, izvo zvinoita kuti ive yakakodzera kune tembiricha-inonzwa maapplication akadai seanodzorwa-kuburitsa zvinodhaka kugadzirira.
HPMC ine yakakwira hydroxypropoxy content ine nani kunyungudika kwemvura, uye kunyungudika kwayo hainyanyi kukanganiswa netembiricha, zvichiita kuti ikwane kushandiswa munzvimbo dzinotonhora.
2. Viscosity giredhi
Viscosity ndechimwe chezviratidzo zvakakosha zvegiredhi reHPMC. HPMC ine zvakasiyana-siyana zveviscosities, kubva kune mashoma centipoise kusvika makumi ezviuru zve centipoise. Iyo viscosity giredhi inokanganisa kushandiswa kwayo mumashandisirwo akasiyana:
Low viscosity HPMC (senge 10-100 centipoise): Iri giredhi reHPMC rinonyanya kushandiswa mumaapplication anoda yakaderera viscosity uye yakakwirira fluidity, senge film coating, tablet adhesives, etc. Inogona kupa imwe dhigirii rekubatana kwesimba pasina kukanganisa. iyo fluidity yekugadzirira.
Medium viscosity HPMC (yakadai se100-1000 centipoise): Inowanzoshandiswa muchikafu, zvizorwa uye mamwe magadzirirwo emishonga, inogona kuita seyakakora uye inovandudza magadzirirwo uye kugadzikana kwechigadzirwa.
High viscosity HPMC (sepamusoro pe1000 centipoise): Iri giredhi reHPMC rinonyanya kushandiswa mumaapplication anoda high viscosity, senge glues, anonamira uye zvekuvakisa. Ivo vanopa yakanakisa thickening uye kuturika kugona.
3. Zvinhu zvemuviri
Iwo emuviri zvimiro zveHPMC, senge solubility, tembiricha yegelation, uye kugona kwemvura, inosiyanawo negiredhi rayo:
Solubility: Mazhinji HPMC ane yakanaka solubility mumvura inotonhora, asi solubility inodzikira sezvo methoxy yemukati inowedzera. Mamwe mamakisi akakosha eHPMC anogona zvakare kunyungudika mune organic zvinonyungudutsa kune chaiwo maindasitiri maapplication.
Gelation tembiricha: Iyo tembiricha yegelation yeHPMC mune aqueous solution inosiyana nerudzi uye zvirimo zvezvinotsiva. Kazhinji kutaura, HPMC ine yakakwira methoxy yemukati inoita kuumba gels pane tembiricha yepamusoro, nepo HPMC ine yakakwira hydroxypropoxy yemukati inoratidza yakadzika gelation tembiricha.
Hygroscopicity: HPMC ine yakaderera hygroscopicity, kunyanya yakakwira-inotsiviwa mamakisi. Izvi zvinoita kuti ive yakanaka munzvimbo dzinoda hunyoro kuramba.
4. Nzvimbo dzekushandisa
Nekuti magiredhi akasiyana eHPMC ane akasiyana emuviri uye makemikari zvivakwa, mashandisiro awo mundima dzakasiyana zvakare akasiyana:
Indasitiri yemishonga: HPMC inowanzoshandiswa mumachira emapiritsi, kugadzirira-kusunungurwa kwegadziriro, zvinonamira, uye makobvu. Pharmaceutical giredhi HPMC inoda kusangana yakananga pharmacopoeia mwero, akadai United States Pharmacopoeia (USP), European Pharmacopoeia (EP), etc. siyana mamakisi HPMC anogona kushandiswa kugadzirisa kusunungurwa mwero uye kugadzikana kwezvinodhaka.
Indasitiri yechikafu: HPMC inoshandiswa seyakakora, emulsifier, stabilizer uye firimu rekare. Chikafu giredhi HPMC inowanzodiwa kuti ive isina muchetura, isingaravike, isinganhuhwi, uye inoda kutevedzera mirau yekuwedzera chikafu, senge iyo yeUS Food and Drug Administration (FDA) neEuropean Food Safety Authority (EFSA).
Indasitiri yekuvaka: Yekuvaka giredhi HPMC inonyanya kushandiswa mune simende-yakavakirwa zvinhu, zvigadzirwa zvegypsum uye machira kukora, kuchengetedza mvura, kuzora uye kuwedzera. HPMC yeakasiyana viscosity mamakisi anogona kukanganisa kushanda kwezvinhu zvekuvaka uye kuita kwechigadzirwa chekupedzisira.
5. Mitemo yehutano nemirairo
Akasiyana mamakisi eHPMC zvakare ari pasi peakasiyana emhando zviyero nemirairo:
Pharmaceutical giredhi HPMC: inofanira kusangana ne pharmacopoeia zvinodiwa, zvakadai se USP, EP, etc. Kugadzirwa kwayo uye maitiro ekugadzirisa zvinodiwa zvakakwirira kuti ave nechokwadi chekuchengetedzwa kwayo uye kubudirira mukugadzirira kwemishonga.
Chikafu-giredhi HPMC: Inofanirwa kuenderana nemirairo yakakodzera pane zvekuwedzera chikafu kuti ive nechokwadi chekuchengetedza kwayo muchikafu. Nyika dzakasiyana uye matunhu anogona kunge aine akasiyana maratidziro echikafu-giredhi HPMC.
Indasitiri-giredhi HPMC: HPMC inoshandiswa mukuvaka, machira uye mamwe minda kazhinji haidi kutevedzera chikafu kana zvinodhaka zviyero, asi ichiri kufanira kuzadzisa zvinoenderana nemaindasitiri zviyero, senge ISO zviyero.
6. Kuchengetedza uye kuchengetedzwa kwezvakatipoteredza
HPMC yemagiredhi akasiyana zvakare akasiyana mukuchengetedza uye kuchengetedza kwezvakatipoteredza. Pharmaceutical-giredhi uye chikafu-giredhi HPMC kazhinji inoongororwa kwakasimba kuchengetedzwa kuti ive nechokwadi chekuti haina kukuvadza kumuviri wemunhu. Indasitiri-giredhi HPMC, kune rumwe rutivi, inobhadhara zvakanyanya kuchengetedzeka kwayo kwezvakatipoteredza uye kuparara panguva yekushandiswa kudzikisa kukanganisa kwezvakatipoteredza.
Misiyano pakati pemagiredhi akasiyana eHPMC inonyanya kuratidzwa muchimiro chemakemikari, viscosity, zvimiro zvemuviri, nzvimbo dzekushandisa, mhando dzemhando uye chengetedzo. Zvinoenderana nezvinodiwa zvekushandisa, kusarudza giredhi rakakodzera reHPMC kunogona kuvandudza zvakanyanya mashandiro uye kunaka kwechigadzirwa. Kana uchitenga HPMC, zvinhu izvi zvinofanirwa kutariswa zvizere kuti ive nechokwadi chekushanda uye kushanda kwechigadzirwa.
Nguva yekutumira: Aug-20-2024