HydroxyPropyl methylcellose (HPMC) ndeyemakemikari yakakosha dia, inoshandiswa zvakanyanya muminda yakawanda yakadai sekuvaka, mushonga, chikafu, uye zvidyarwa. Iyo ine yakanaka kurongedza, gomba, inoisa, firimu-fomu yekugadzira, uye kusungirirwa zvivakwa, uye zvine chekuita nekudziya uye tembiricha nePH. Iyo solubility yeHPMC ndiyo imwe yenyaya dzinokosha mukushandisa kwayo. Kunzwisisa nzira chaiyo yekunyungudika yakakosha kuti ive nechokwadi chekuita kwayo.
1. Basic dissolution Properties yeHPMC
HydroxyPropyl methylcellose ndeye isiri-ionic mvura-soluble cellolose inoshambwa mumvura inotonhora kana inopisa kuti aumbe fungcous enzancius mhinduro. Yayo solubility inonyanya kukanganiswa nekushisa tembiricha. Zviri nyore kunyungudusa mumvura inotonhora uye nyore kuumba iyo colloid mumvura inopisa. HPMC ine mahara ane green, kureva kuti, ine kusarongeka kwekushamisira kune yakakwirira tembiricha, asi inogona kunyimwa zvachose kana tembiricha yakaderedzwa. HPMC ine zviyero zvakasiyana uye zvevemateki, saka panguva yekunyungudika, iyo yakakodzera HPMC muenzaniso inofanirwa kusarudzwa maererano nezvinodiwa zvechigadzirwa.
2. Dissolution nzira yeHPMC
Cold Mvura Kupararira nzira
Mvura inotonhora yekuparadzira nzira ndiyo inonyanya kushandiswa HPMC yekuparadza nzira uye yakakodzera kune yakawanda yekushandisa zviitiko. Matanho chaiwo ari seanotevera:
Gadzirira mvura inotonhora: dururira huwandu hunodiwa hwemvura inotonhora mumudziyo wekusanganisa. Tembiricha yemvura inowanzokurudzirwa kuve pazasi makumi mana ° C kuti udzivise HPMC kubva kuHPMC kubva pakugadzira mapundu pakugadzira tembiricha yakakwira.
Zvishoma nezvishoma wedzera HPMC: zvishoma nezvishoma wedzera HPMC poda uye ramba uchimutsa. Kuti udzivise poda acglomeroration, chinomhanyisa chinomhanyisa chinomhanyisa kuti chishandiswe kuve nechokwadi chekuti HPMC inogona kuparadzaniswa nemvura.
Kumira uye kupera simba: Mushure meHPMC yakapararira mumvura inotonhora, inoda kumira kwenguva yakati rebei kunyungudika. Kazhinji, inosara yakamira kwemaminitsi makumi matatu kusvika kumaawa akati wandei, uye nguva chaiyo inosiyana zvichienderana neHPMC modhi uye tembiricha yemvura. Munguva yekumira, HPMC ichanyungudika zvishoma nezvishoma kuti iite viscous solution.
Mvura inopisa pre-dissolution nzira
Iyo inopisa mvura pre-dissolution nzira yakakodzera kune mamwe mimwe hpmc mhando neyekumusoro viscosity kana yakaoma kunyungudika mumvura inotonhora. Iyi nzira yekutanga kusanganisa iyo HPMC poda ine chikamu chemvura inopisa kuti iite pasita, uye wozosanganisa nemvura inotonhora kuti uzokurumidza kuwana yunifomu mhinduro. Matanho chaiwo ari seanotevera:
Kupisa mvura: Pisa imwe huwandu hwemvura kusvika pa80 ° C uye dururira mumudziyo wekusanganisa.
Kuwedzera HPMC Powder: Dururira iyo HPMC hupfu mumvura inopisa uye simudzira apo ichidurura kuti aumbe musanganiswa wea paste. Mumvura inopisa, hpmc ichanyungudusa kwenguva pfupi uye inoumba chinhu chakaita sechifuma.
Kuwedzera mvura inotonhora kuti Dilute: Mushure mekunge paste musanganiswa inotonhorera pasi, zvishoma nezvishoma wedzera mvura inotonhorera kuti ubvise uye ichiramba ichinge yanyungudika kusvika yanyatsojeka kana translucent mhinduro.
Organic solvent kupararira nzira
Dzimwe nguva, kuitira kukurumidza kupaza HPMC kana kuvandudza maitiro ekunyungudutswa kweimwe zvikumbiro zvakakosha, solvent solvent inogona kushandiswa kusanganisa nemvura yekunyungudika hpmc. Semuenzaniso, organic sol sol solenol uye acetone inogona kushandiswa kuparadzira HPMC kutanga, uye mvura inogona kuwedzerwa kubatsira HPMC kunyungudika nekukurumidza. Iyi nzira inowanzoshandiswa mukugadzirwa kweimwe zvigadzirwa zvekusimba-zvakadai, senge majasi uye pendi.
Yakaoma kusanganisa nzira
Iyo yakaoma yekusanganisa nzira yakakodzera kune yakakura-nhanho maindasitiri kugadzirwa. HPMC inowanzo kuve yakasarudzika yakasanganiswa nedzimwe zvinhu zvakavezwa (senge simende, gypsum, etc.), uyezve mvura inowedzerwa kusanganisa kana ichishandiswa. Iyi nzira yakarerutsa mashandiro ekuvhiya uye anodzivisa iyo HPMC yakanyungudutswa, asi inoda kumutsa kukwana mushure mekuwedzera mvura kuti ive nechokwadi chekuti HPMC inogona kunyatsojekeswa uye kutamba danho rakakura.
3. Zvinhu zvinokanganisa HPMC Dissolution
Kupisa Tembiricha yakaderera inokodzera kuparadzaniswa uye kupaza kwemvura, nepo tembiricha yakakwira ichikonzera HPMC kuti hpmc kuumba mikadzi, ichitadzisa kupaza kwaro kwakakwana. Naizvozvo, zvinowanzokurudzirwa kushandisa mvura inotonhora kana kudzora tembiricha yemvura pazasi 40 ° C kana ichinyungudika hpmc.
Kumhanyisa kumhanya: Kukurudzira kwakakodzera kunogona kudzivisa hpmc agglomeration, nekudaro zvichikura mwero wekunyungudika. Nekudaro, nekukurumidza kukurudzira kumhanya kunomhanyisa kunogona kuunza huwandu hukuru hwemabubbles uye kukanganisa kufanana kwemhinduro. Naizvozvo, mukushanda chaiko, zvakakodzera kumhanyisa kumhanya uye michina inofanira kusarudzwa.
Hunhu hwemvura: Kusvibiswa, kuomarara, ph kukosha, nezvimwe mumvura kuchakanganisa iyo solubility yeHPMC. Kunyanya, calcium uye maganium ion mumvura yakaoma inogona kuita neHPMC uye kukanganisa iyo solubility. Naizvozvo, kushandisa mvura yakachena kana mvura yakapfava inobatsira kuvandudza kusanzwisisika kweHPMC.
HPMC modhi uye molecular uremu: mhando dzakasiyana dzeHPMC dzakasiyana mukupaza kumhanya, viscosity uye kupaza tembiricha. HPMC ine yakakura molecular uremu inovhara zvishoma nezvishoma, ine yepamusoro yekugadzirisa zviso, uye inotora nguva yakareba kunyungudutsira zvizere. Kusarudza iyo chaiyo HPMC modhi inogona kuvandudza kusanzwisisika kwekunyatsoita uye kusangana nezvinodiwa zvakasiyana.
4. Zvinetso zvakajairika uye mhinduro muHPMC Dissolution
Dambudziko reAgglomer: Kana HpMC yakanyungudutswa mumvura, aglomerations inogona kuumba kana hupfu hahuparadzwi. Kuti udzivise dambudziko iri, HPMC inofanirwa kuwedzerwa zvishoma nezvishoma panguva yekupararira uye kuchengetwa kune yakakodzera kumhanyisa kumhanya, nepo ichidzivirira kuwedzera hpmc poda pamhepo high tembiricha.
Mhinduro Isina Kukosha: Kana iko kusimudzira kusiri kwakaringana kana kuti nguva yakamira haina kukwana, HPMC inogona kunge isina kunyungudutswa, zvichikonzera mhinduro isina kufanana. Panguva ino, nguva yekukurudzira inofanira kutambanudzwa kana nguva yakamira inofanira kuwedzerwa kuve nechokwadi chekuparadzwa kwakazara.
BUBLBLE Dambudziko: Kwakanyanya kukurumidza kumutsa kana kusvibiswa mumvura kunogona kusuma huwandu hukuru hwemabhuru, zvichikanganisa kunaka kwemhinduro. Nechikonzero ichi, chinokurudzirwa kudzora kumhanya kwekukurudzira apo kupera HPMC kuti udzivise mabhuru akawandisa, uye wedzera defoamer kana zvichidikanwa.
Iko kushungurudzika kweHPMC ndiyo kiyi yekubatanidza mukushandisa kwayo. Kushandisa nzira chaiyo yekunyungudika inobatsira kuvandudza zvigadzirwa zvemhando yepamusoro uye kunyatsogadzira. Maererano nemhando dzakasiyana dzeHPMC uye zvishandiso zvinodiwa Panguva imwecheteyo, kutariswa kunofanirwa kubhadharwa kune zvinodzora zvinhu zvakadai sekupisa, kumhanyisa kumhanyisa uye nemhando yemvura panguva yekunyungudika kuti udzivise matambudziko akadaro, Nekutsvagira mamiriro ekupaza
Kutumira Nguva: Sep-30-2024