Chii chinonzi rheological propertiesHPMC?
Hydroxypropyl methylcellulose (HPMC) ipolymer inoshanda zvakasiyana-siyana inowana kushandiswa kwakanyanya mumaindasitiri akasiyana siyana, kusanganisira mishonga, kuvaka, chikafu, uye zvizorwa, zvakanyanya nekuda kweiyo yakasarudzika rheological properties. Rheology chidzidzo chekuyerera uye deformation yezvishandiso, uye kunzwisisa rheological zvimiro zveHPMC kwakakosha pakugadzirisa mashandiro ayo mumashandisirwo akasiyana.
Viscosity: HPMC inoratidza pseudoplastic kana shear-kutetepa maitiro, zvichireva kuti viscosity yayo inodzikira nekuwedzera shear rate. Ichi chivakwa chakakosha mumashandisirwo akadai semishonga yekugadzira, uko inobvumira kupomba nyore, kupararira, uye kushandisa. Viscosity inogona kugadzirwa nekugadzirisa dhigirii rekutsiva (DS) uye huremu hwemamorekuru eHPMC.
Thixotropy: Thixotropy inoreva kushandurwa kwegel-sol kunoratidzwa nezvimwe zvinhu pasi pekunetseka kweshear. HPMC gels inoumbwa pakuzorora inogona kudonha pasi pekugera uye kuwanazve yavo gel chimiro kana kushushikana kwabviswa. Ichi chivakwa chinobatsira mumashandisirwo akaita sependi, apo inodzivirira kudonha panguva yekushandiswa asi inova nechokwadi chekuputira kana chaiswa.
Hydration: HPMC ndeye hygroscopic uye inogona kutora mvura, zvichiita kuti kuzvimba uye kuwedzera viscosity. Iyo dhigirii ye hydration inoenderana nezvinhu zvakaita setembiricha, pH, uye ionic simba repakati rakatenderedza. Hydration inoita basa rakakosha mukudzora kuburitswa kwemishonga kubva mukugadzirwa kwemishonga uye kuchengetedza hunyoro muzvigadzirwa zvekudya.
Temperature Sensitivity:HPMCmhinduro dzinoratidza tembiricha-inotsamira viscosity, ine viscosity ichidzikira sezvo tembiricha inowedzera. Nekudaro, maitiro aya anogona kusiyana zvichienderana nezvinhu zvakaita sepolymer concentration uye mhinduro pH. Kunzwa kwetembiricha kwakakosha mumashandisirwo akaita semidziyo yekuvaka, uko kunokanganisa kushanda uye kuseta nguva.
Munyu Sensitivity: HPMC mhinduro dzinogona kuratidza kunzwa kune munyu, neimwe munyu ichikonzera viscosity kuwedzera uye vamwe vachikonzera kuderedzwa kweviscosity. Chiitiko ichi chinokonzerwa nekudyidzana pakati peHPMC mamorekuru uye ion mumhinduro. Kunzwa kwemunyu kwakakosha mukugadzirwa kwemishonga uye zvigadzirwa zvekudya apo munyu wemunyu unoda kunyatsodzorwa.
Shear Rate Kutsamira: Iyo rheological zvimiro zveHPMC mhinduro zvinotsamira pachiyero cheshear chakaiswa. Payero yakaderera yekugera, viscosity yakakwira nekuda kwekuwedzera kwema molecular entanglement, nepo pakakwirira shear rates, viscosity inoderera nekuda kwekuveura kutetepa. Kunzwisisa kutsamira kweshear rate kwakakosha pakugadzira mamiriro ekugadzirisa mune akasiyana maapplication.
Particle Suspension: HPMC inogona kuita senge inomisa mumiriri wezvimedu mumagadzirirwo emvura nekuda kwekukora uye kudzikamisa zvivakwa. Inobatsira kudzivirira kugadzirisa zvimedu zvakasimba, kuve nechokwadi chekugovera yunifomu uye kuenderana mune zvigadzirwa zvakaita sependi, zvinonamira, uye kumiswa kwemishonga.
Kugadzira Gel:HPMCinogona kuumba gels pakukwirira kwakadzika kana pamberi pevanoyambuka vamiririri senge divalent cations. Aya majiroji anoratidza viscoelastic zvimiro uye anoshandiswa mukushandisa senge inodzorwa dhizaini kuendesa, uko kunoenderera kusunungurwa kwezvishandiso zvinoshandiswa.
iyo rheological zvimiro zveHPMC, zvinosanganisira viscosity, thixotropy, hydration, tembiricha uye munyu kunzwa, shear rate kutsamira, chidimbu kumiswa, uye kuumbwa kwegel, inoita basa rakakosha mukuona mashandiro ayo mumaindasitiri akasiyana siyana. Kunzwisisa nekudzora zvivakwa izvi kwakakosha pakugadzirisa kugadzirwa uye kugadzirisa kweHPMC-yakavakirwa zvigadzirwa.
Nguva yekutumira: Kubvumbi-27-2024