Hydroxypronylmethylcylosellose (HPMC) inzvimbo yeClongfional inoshandiswa zvakanyanya muindasitiri yemishonga yemishonga. Iyo ndeyavo cellulose ether chikamu uye inotorwa kubva kune yakasikwa cellulose. HPMC iri kurongedza nekubata cellulose nePropyly oxide uye methyl chloride, inokonzerwa nemakomputa neakavandudzwa solubility uye zvimwe zvinodikanwa. Iyi pharmaceucient excpient inoshandiswa zvakanyanya mukukura uye kugadzira mafomu akasiyana-siyana, kusanganisira mahwendefa, mahwendefa, gadziriro yeOphthalmic uye kudzora-kusunungura zvinodhaka zvinodhaka.
Sumo kuHydroxyPropyl methylcellose:
Chemical chimiro uye zvivakwa:
Hydroxypruppropyl methylcellose ndeye semi-synthetic, inert, mvura-inoyevedza mvura polymer. Chimiro chemoMakemikari chinosanganisira hydroxypropyl uye mapoka mapoka akasungirirwa kune iyo cellulose backbone. Zvikamu zveidzi vevatori vevatengi zvinogona kusiyana, zvichikonzera mumakiredhi akasiyana eHPMC nezvivakwa zvakasiyana. Iyo yekutsiva maitiro anokanganisa paramita senge viscosity, solubility, uye ger genera.
Kugadzira Maitiro:
Iko kugadzirwa kweHPMC kunosanganisira eriraifiti yeCellulose nePropylone oxide uye methyl chloride. Dhigirii rekutsiva
Zvishandiso muindasitiri yemishonga yemishonga:
Binders muLiplet Formation:
HPMC inozoshandiswa zvakanyanya seyakagadzirwa mukugadzira piritsi. Zvivakwa zvaro zvinosunga zvinobatsira mukumanikidza iyo hupfu mumapiritsi akasimba. Kuburitswa kusunungurwa kweiyo inoshanda mishonga mishonga (APSI) inogona kuwanikwa uchishandisa chaiyo mamakisi eHPMC ine yakakodzera viscosity uye kutsiva mazinga.
Firimu rinobatanidza mumiririri:
HPMC inoshandiswa sefirimu yekubatanidza mumiririri wehembe uye granules. Iyo inopa yunifomu yekudzivirira inovhara inovandudza chitarisiko, kuravira masks uye kugadzikana kwemhando yemadheti. Kupfuurirazve, maHPMC-based coatings anogona kunongedza zvinodhaka zvinodhaka profiles.
Kusunungurwa uye Kudzora Kuburitswa:
Iyo hydrophic mhando yeiyi polymer inoita kuti iite yakakodzera kushandiswa mune yakasimbiswa- uye inodzorwa-yekuburitswa mafomu. Iyo HPMC matrix inobvumira kudzora zvinodakadza zvinodhaka pamusoro penguva yakareba, kuvandudza kutevedzera kwemurwere uye kuderedza dosing frequency.
Ophthalms gadziriro:
MuOphthalmic mafomu, HPMC inoshandiswa kuwedzera vhiza yemadonhwe eziso, nekudaro ichipa nguva yekugara kwenguva refu pane ocular pamusoro. Izvi zvinokwazisa zvinodhaka zvinodhaka uye kuratidzira kushanda.
Kuremedza stabilizer:
HPMC inoshandiswa sedhizimusi uye stabilizer mumvura uye semi-yakasimba mafomu akadai segels, mafuta uye kumiswa uye kumiswa. Iyo inopa viscosity kune iyi mafambiro uye inovandudza zvivakwa zvavo zvevakadzvinyirira.
ZVINOKOSHA ZVINOKOSHA zveHPMC:
Solubility:
HPMC inonyungudika mumvura uye inoumba yakajeka, isina ruvara mhinduro. Muyero wekunyungudika unokanganiswa neiyo degree rekutsiva uye viscosity giredhi.
Viscosity:
Iyo viscosity yeHPMC Solutions inokoshesesa mukusarudza maitiro avo mune dzakasiyana siyana application. Mavara akasiyana anowanikwa aine visikoka akasiyana, achibvumira kudzora chaiko kweiyo rheological zvivakwa zvezvimiro zvekuumbwa.
Thermal Glation:
Mamwe mamakisi eHPMC exhibit thermogelling zvivakwa, kugadzira gels pakupisa kwakanyanya. Ichi chivakwa chinoshandiswa kukudziridza kupisa-kwakasimba mafomu.
Kuenderana:
HPMC inoenderana nehuwandu hwakawanda hwemahara emishonga uye apisi, ichigadzira yekutanga sarudzo yemifananidzo. Izvo hazviite ne kana kusvibisa zvinoshanda zvinoshanda.
Zvinonetsa uye kufunga:
Hygroscopicity:
HPMC iri hygroscopic, zvichireva kuti inobata unyoro kubva mumagariro. Izvi zvinokanganisa kugadzikana uye kutaridzika kweiyo fomu, saka mamiriro ekuchengetedza akakodzera anodikanwa.
Kuenderana nevamwe vaenzanisa:
Kunyangwe kazhinji zvinowirirana, maguru anofanirwa kufunga nezve kuenderana neHPMC nevamwe vaipamedza kuti vadzivise zvinogoneka zvinogona kukanganisa maitiro ekuumbwa.
Mhedzisiro yekunyungudika curve:
Sarudzo yeHPMC giredhi inogona kukanganisa zvakanyanya iyo yekunyungudza nhoroondo yemushonga. Iyo formalator inofanira kunyatso sarudza giredhi rakakodzera kuti uwane hunhu hunodiwa kuburitsa hunhu.
Regulatory Kufunga:
HPMC inogamuchirwa zvakanyanya seyakachengeteka uye inoshanda mishonga yechechi. Inosangana nematanho akasiyana ekuzvidzora uye anosanganisirwa muPharmacooeias kutenderera pasirese. Vagadziri vanofanira kuomerera kune yakanaka yekugadzira maitiro (GMP) kuti ive nechokwadi chekuti mhando uye kusawirirana kwezvigadzirwa zvechechi zvine hpmc.
Mukupedzisa:
Hydroxypronylmethylcylsellose (HPMC), seyakazara uye yakashandiswa zvakanyanya uye yakashandiswa zvakanyanya basa, rinotonga basa rakakosha muindasitiri yemishonga. Zvivakwa zvayo zvakasarudzika zvinoita kuti zviite kuti zviite kuti zvishandiswe mumhando dzakasiyana-siyana dzemvura, kusanganisira mahwendefa, mahwendefa uye funghalemic gadziriro. Vagadziri vanobatsirwa nekukwanisa kuitisa zvinhu zveHPMC kusangana nezvakananga kuumbwa, sekusunungurwa kwakadzorwa uye nekugadziriswa kwakadzivirirwa. Pasinei nezvimwe zvinonetsa, HPMC inoramba iri chinhu chakakosha mukuvandudzwa kwezvigadzirwa zvepamusoro-zvemhando yepamusoro, zvichikonzera kuchengetedzeka uye kushanda kwehuwandu hwemhando dzakasiyana-siyana.
Kutumira Nguva: Dec-15-2023