Hydroxypropyl Cellulose (HPC) iexcipient inoshandiswa zvakanyanya mumunda wemishonga ine zvakasiyana siyana zvinoshanda. Inonyanya kushandiswa mukugadzirira kwakasimba semapiritsi uye capsules. Semi-synthetic cellulose derivative, HPC inogadzirwa nekuunza hydroxypropyl mapoka mu cellulose molecular chimiro, iyo inopa yakanakisa solubility, adhesion uye firimu-kuumba zvivakwa, zvichiita kuti iite zvakasiyana mukugadzirwa kwehwendefa.
1. Thickeners uye Binders
HPC, seyakakora uye bhainda, inogona kubatsira zvimedu chisungo uye kuumbwa panguva yekunyorova granulation maitiro ekugadzirwa kwehwendefa. Iine adhesion yakasimba uye inogona kunamatira yakatsetseka poda zvimedu pamwe chete kuburikidza nekunyorova granulation kuumba zvidimbu zvine kuyerera kwakanaka uye compressibility. Izvi zvimedu zviri nyore kuumba uye zvine zvakanaka kudzvanya panguva yepiritsi, zvichikonzera mahwendefa emhando yepamusoro. Muchigadziro chekugadzirira piritsi, kuwedzerwa kwezvisungo zvinogona kuvimbisa kuoma, kushorwa nekupwanyika uye kuderera kwebrittleness yemapiritsi.
2. Kudzorwa Kusunungurwa Agents
Iyo inodzorwa yekuburitsa mhedzisiro yeHPC mumahwendefa ndeimwe yeayo akakosha maapplication. Nekuda kwekuzvimba kwayo uye viscosity zvivakwa mumvura, HPC inogona kugadzira hydration firimu pamusoro pemahwendefa, ichidzikamisa kuburitswa kwemishonga, nekudaro ichiwana mhedzisiro yekunonoka kuburitswa kwezvinodhaka. Mumapiritsi anodzorwa-akabudiswa, HPC inogona kunyatsogadzirisa chiyero chekusunungurwa kwemishonga kuburikidza nekugadzirisa uremu hwayo hwema molecular uye kuwedzera kwehuwandu, nokudaro kuwedzera nguva yekutora mishonga, kuderedza kuwanda kwekushandiswa kwezvinodhaka, nekuvandudza kutevedza kwevarwere. Iyo hydration layer inonyungudika zvishoma nezvishoma nekufamba kwenguva, uye mwero wekuburitswa kwemushonga unoramba uripo, zvichiita kuti ive netarisiro yakanaka yekushandisa mumapiritsi anoburitswa.
3. Film-forming agent
HPC's film-forming properties inoita kuti ishandiswe zvakanyanya mumachira emapiritsi, kunyanya-soluble coating materials. Kuputira pamusoro pehwendefa neHPC firimu kunogona kuumba ganda rakatetepa uye rakaoma rekudzivirira, iro risingagoni kungovhara kuvava kwemushonga uye kunatsiridza kuravira, asiwo kudzivirira mushonga uye kuwedzera kugadzikana kwemushonga. Nekuti HPC ine kujeka kwakanaka uye kuchinjika, iyo firimu yainoumba yakafanana uye yakatsetseka, uye haina mhedzisiro pakuonekwa kwehwendefa. Uye zvakare, iyo HPC firimu ine yakanaka solubility mudumbu uye haizove nemhedzisiro yakaipa pabioavailability yemushonga.
4. Stabilizer
Kudzivirira kweHPC kunokosha zvakare mukushandiswa kwemapiritsi, kunyanya kune iyo mishonga inonzwa kune chiedza uye hunyoro. HPC inogona kunyatsoparadzanisa pesvedzero yemhepo uye unyoro, uye kudzivirira mushonga kubva pakuipa kana oxidative inactivation nekuda kwekunyorova. Kunyanya kana jira repiritsi rakagadzirirwa mune organic solvents, kugadzikana uye makemikari inertness yeHPC inodzivirira kuti irege kupindirana nemishonga inoshandiswa zvinodhaka, zvichiita kuti kuve nekugadzikana uye hupenyu hwesherufu yemishonga.
5. Disintegrant
Kunyangwe HPC ichinyanya kushandiswa seanodzorwa kuburitsa mumiriri, inogona zvakare kushandiswa seanoparadza mune mamwe mahwendefa anoburitswa pakarepo. Low-viscosity HPC inogona kukurumidza kunyungudika nekuzvimba mushure mekusangana nemvura, zvichikonzera kukurumidza kuparara kwehwendefa, nekudaro ichikurudzira kuparara uye kutorwa kwemushonga mudumbu remudumbu. Ichi chishandiso chakakodzera kune mamwe mishonga inoda kushanda nekukurumidza. HPC inogona kuwana akasiyana disintegration maitiro mune akasiyana piritsi magadzirirwo nekugadzirisa ayo mamorekuru huremu, huwandu hwekuwedzera uye zvimwe zvinobatsira.
6. Kushandiswa mumuromo kuparara mapiritsi
Kunyungudika kwemvura uye viscosity yeHPC inoratidzawo mhedzisiro yakanaka mumuromo disintegrating mapiritsi (ODT). Muhwendefa iyi, HPC inogona kuwedzera kuparara kwehwendefa mumuromo wemuromo, zvichiita kuti zvive nyore kune varwere, kunyanya vakwegura kana vana, kumedza. Kunyungudika kwemvura kweHPC kunoita kuti inyunguduke uye iparare munguva pfupi, nepo viscosity yayo inosimbisa kusimba kwehwendefa uye inodzivirira kubva pakuputsika panguva yekugadzira nekuchengetedza.
7. Synergy pamwe nezvimwe excipients
HPC inewo yakanaka excipient kugarisana mukugadzirwa kwehwendefa uye inogona kuwiriranisa nezvimwe zvinobatsira (senge microcrystalline cellulose, carboxymethyl cellulose, nezvimwewo) kuwedzera kushanda kwehwendefa. Semuenzaniso, kana yakashandiswa pamwe chete ne microcrystalline cellulose, HPC inogona kuvandudza fluidity uye kufanana kwepiritsi paunenge uchiona kuoma kwehwendefa; kana ichishandiswa pamwe chete nezvimwe zvinonamira, inogona kuwedzera kunamatira kwehwendefa, kuvandudza granulation mhando uye compression molding maitiro.
8. Kufurira zvinhu uye miganhu
Kunyange zvazvo HPC ine mabhenefiti akawanda mumapiritsi, mashandisirwo ayo anokanganiswawo nezvinhu zvakawanda, senge molecular uremu, kutarisisa, humidity, etc. Iyo yakakura iyo molecular uremu hweHPC, iyo yakakwirira viscosity, uye yakasimba kugona kudzora kusunungurwa kwezvinodhaka; panguva imwecheteyo, kunyorova kwezvakatipoteredza kunogona kuita kuti piritsi racho ritore unyoro, richikanganisa kugadzikana kwayo. Naizvozvo, kana uchishandisa HPC, zvinodikanwa kuti usarudze zvine hungwaru maparamendi kuti ive nechokwadi chezvakanakisa mhedzisiro mukugadzira piritsi.
Hydroxypropyl cellulose ine mabasa akawanda mukugadzirwa kwehwendefa, kusanganisira thickener, binder, controlled release agent, firimu yekare, stabilizer uye disintegrant, iyo inogona kunyatso kuvandudza kunaka kwemapiritsi uye kushandiswa kwezvinodhaka. Zvinoenderana neiyo chaiyo yemishonga zvivakwa uye magadzirirwo zvinodiwa, akasiyana mamolecular uremu uye madosi eHPC anogona kuchinjika kugadzirisa viscosity, kuparara uye kuburitswa kwemahwendefa, zvichiita kuti ive yakakosha kukosha kwekushandisa muindasitiri yemishonga.
Nguva yekutumira: Nov-04-2024