HydroxyPropyl Cellulose (HPC) ndeyemhando yepamusoro inoshandiswa zvakanyanya mumunda wemishonga ane akasiyana siyana ezvivakwa. Iyo inonyanya kushandiswa mukugadzirira kwakasimba senge mapiritsi nemakapuru. Semi-semi-synthetic mherender, hpc inoitwa nekuunza hydroxpropropyl mapoka mu cellulose molecular, inopa iyo salhibility mapoka, inokanda-firimu yekuumba, ichiita kuti zvive zvinoenderana nekuumbwa kwemabhirabhu.
1. Manhamba uye mabheti
HPC, seyakakwenenzverwa uye binder, inogona kubatsira zvimisikidzo uye fomu panguva yekunyorova granulation maitiro ekugadzira piritsi. Iyo ine yakasimba kuamatira uye inogona kuamatira poda powder zvikamu pamwe chete kuburikidza nekunyorova granulation kuumba zvidimbu zvine kuyerera kwakanaka uye kuomarara. Izvi zvimedu zviri nyore kuumba uye kuve nekukakavara kwakanaka panguva yekudyara, zvichikonzera mahwendefa emhando yepamusoro. Muchiitiko chekugadzirira piritsi, kuwedzera kwemahofisi kunogona kuve nechokwadi chekuomesa, kuramba kupwanya uye kuderera kwehwendefa dzemahwendefa.
2. Kudzora kusunungurwa vamiririri
Iyo inodzorwa kuburitswa kweHPC mumahwendefa ndeimwe yezvakanyanya kukosha. Nekuda kwekuzvimba kwayo uye viscosity zvivakwa mumvura, HPC inogona kuumba iyo hydration firimu pamusoro pemapiritsi, kudzikisira mwero wekusunungura, nekudaro kuwana mhedzisiro yekunonoka kusunungurwa kwezvinodhaka. Mune mabhebhi ekudzorwa-anodzora, HPC anogona kunyatso shandura huwandu hwekuburitsa zvinodhaka nekuwedzera huremu hwayo uye nekuwedzera mari yekuita, kuderedza kuwanda kwezvinodhaka, uye kuvandudza kutevedzera kwemurwere. Yayo hydration layer ichipedza zvishoma nezvishoma nekufamba kwenguva, uye chiyero chekusunungura zvinodhaka chinogara chichigara, zvichiita kuti ive neyakajeka kushandisa mashandisiro ekushandisa mumahwendefa ekusimudzira.
3. Firimu-inogadzira mumiririri
HPC's film-yekuumba midziyo inoita kuti ishandiswe zvakanyanya muzviyo zvebhwendeya, kunyanya mhepo-yekunyungudza mvura yekubatanidza. Kuvhara piritsi piritsi neye hpc firimu kunogona kuumba dhizaini rakatetepa uye dense yekudzivirira, iyo isingakwanise kungoita shungu dzemushonga uye nekuvandudza kuravira, asi zvakare chengetedza iyo mushonga uye wedzera kugadzikana kwemushonga. Nekuti HPC ine transpency yakanaka uye kuchinjika, iyo firimu iyo mafomu yunifomu uye yakatsetseka, uye haina simba pakuonekwa kwehwendefa. Uye zvakare, iyo HPC firimu ine yakanaka solubility mune gastrointestinal turakiti uye haizove neyakaipisisa pakubata kwemushonga.
4. Stabilizer
Iyo yekudzivirira yeHPC yakanyanya kukosha mukushandiswa kwemahwendefa, kunyanya kune izvo zvinodhaka zvine hanya nechiedza uye humidity. HPC inogona kubatsira zvinobudirira pesvedzero yemhepo uye unyoro, uye kudzivirira mushonga kubva pakugadzirisa kana oxidative singivation nekuda kwekunyorova. Kunyanya kana piritsi yekubatanidza yakagadzirirwa mu organic sol sol sol soles
5. disintegrant
Kunyangwe HPC ichinyatsoshandiswa seyakavharirwa kuburitswa mumiririri, inogona zvakare kushandiswa sekuparadzaniswa mune mamwe mahwendefa ekusunungura. Low-viscosity HPC inogona kukurumidza kunyungudika uye kuzvimba mushure mekusangana nemvura, zvichikonzera kukurumidza kuparadzaniswa kwehwendefa, nekudaro kusimudzira kupaza uye kusimuka kwemushonga mugwara regastrointestinal turakiti. Ichi chishandiso chakakodzera pane zvimwe zvinodhaka zvinoda kutora mhedzisiro nekukurumidza. HPC inogona kuzadzisa zvakasiyana-siyana kusataurisa hunhu mune dzakasiyana piritsi mafomu nekugadzirisa iyo smecular uremu, kuwedzera huwandu uye zvimwe zviitiko.
6. Chikumbiro mumuromo momuromo disintegating mapiritsi
Iyo mvura solubility uye viscosity yeHPC zvakare inoratidza zvakanaka mhedzisiro mumuromo momuromo disintegating mapiritsi (ODT). Mune piritsi iri, HPC inogona kuwedzera huwandu hwekunyungudika kweiyo piritsi mune yemuromo yemuromo, zvichiita kuti zvive nyore kune varwere, kunyanya vakweguru kana vana, kumedza. Iyo solubility yemvura yeHPC inogonesa kunyungudika uye kupaza munguva pfupi, nepo viscosity yayo ichivimbisa simba rebiritsi uye rinodzivirira kubva pakupwanya panguva yekugadzira nekuchengetedza.
7. Synergy nevamwe vezvidzidzo
HPC zvakare ine yakanaka yekukonzeresa kugadzirwa kwehwendefa uye inogona kuyanana nedzimwe nzira (dzakadai microcrystalline cellen Celleth cellever, etc.) inosimudzira kuita kwehwendefa. Semuenzaniso, kana ichishandiswa mukubatanidzwa nemicrocrystalline cellulose, HPC inogona kuvandudza iyo fluidity uye kufanana kwehwendefa apo ichiratidzira kuomarara kwehwendefa; Kana ichishandiswa mukubatanidzwa pamwe nemamwe maonomisheni, inogona kuwedzera kusimudzira kudengenyeka kwehwendefa, kuvandudza hunhu hwedheji uye kumanikidza kuumba maitiro.
8. Kufurira zvinhu uye zvisingakwanisi
Kunyangwe HPC ine zvakawanda zvakanakira mumahwendefa, maitiro ayo anokanganiswawo nezvinhu zvakawanda, zvakadai serembozha, etcompory uremu hweHPC, iyo yakakwira viscosity, uye yakasimba kugona kudzora iyo Rate yezvinodhaka Panguva imwecheteyo, kunyanyisa kwenzvimbo yemagariro kunokonzeresa iyo piritsi kuti ibatwe kunyorova, kukanganisa kugadzikana kwayo. Naizvozvo, paunenge uchishandisa HPC, inodikanwa kune zvine musoro kusarudza ma parameter akakodzera kuti ave nechokwadi chakanakira mukugadzira piritsi.
HydroxyPropyl Cellerose ine akawanda mabasa muThepireti, kusanganisira, inosungirwa, yefirimu yaimbova, inokanganisa, iyo inogona kunyatsovandudza kunaka kwemapiritsi uye kuita kwezvinodhaka. Zvinoenderana nezvinodiwa zvezvinodhaka uye zviyero zvakasiyana uye zviyero zveHPC zvinogona kuongorora zvevatenzi, kusunungura uye kuita kuti ive yakakosha application indasitiri yemishonga.
Kutumira Nguva: Nov-04-2024