Hydroxypropyl methylrcellesulose (HPMC)Waa unug-qarsoodi aan dabiici ahayn oo leh filim wanaagsan oo sameeya filim wanaagsan, isku dhaf, cufnaanta iyo xakamaynta la xakameeyo oo la xakameeyo, waxaana si weyn loogu isticmaalaa warshadaha dawooyinka. Daawooyinka dawooyinka, walxaha dheeriga ah ee walbahaarka waxaa loo isticmaali karaa kiniiniyada, kaabsalka, diyaarinta joogtaynta, diyaarinta indhaha ee indhaha iyo nidaamyada gudbinta maandooriyaha jirka.
1. Hantida Pityfochical ee HPMC
HPMC waa shey polymer-ka-senemy-ka ah ee loo yaqaan 'polymer polyly' oo lagu helo methylating iyo hydroxypropylating cellulose dabiiciga ah, oo leh culeys biyo ah oo aad u wanaagsan iyo biocompattate. Wadajirnimadeeda waxay ka yar tahay heerkulka iyo qiimaha ph, oo waxay ku barari kartaa biyaha si ay u sameeyaan xalka jeebka, kaas oo ka caawiya siideynta daroogada ee la xakameeyo. According to the viscosity, HPMC can be divided into three categories: low viscosity (5-100 mPa·s), medium viscosity (100-4000 mPa·s) and high viscosity (4000-100000 mPa·s), which are suitable for Shuruudo Diyaarinta Kala Duwan.
2. Codsiga HPMC ee dawada diyaargarowda dawooyinka
2.1 Codsiga kiniiniyada
HPMC waxaa loo isticmaali karaa inuu yahay laba-geesood, kala-soocid, agab dahab ah iyo shey la-talin oo la xakameynayo oo ka tirsan kiniiniyada.
Xannibaada:HIPMC waxaa loo isticmaali karaa in uu yahay shandad ku dhex jirta geeska qoyan ama kan luqadda qalalan si loo wanaajiyo xoogga walxaha, kiniinka adkeynta iyo xasilloonida makaanikada ee daroogada.
Kala-sooc:HPMC-VOMCCC waxaa loo isticmaali karaa inuu yahay mid kacaya in lagu hormariyo kala-goynta kiniinka oo uu kordhiyo heerka kala-baxa maandooriyaha ka dib markii barar ka soo baxo biyo yaraanta biyaha.
Qalabka daboolka:HPMC waa mid ka mid ah agabyada kiniinka kiniiniga, kaas oo horumarin kara muuqaalka daroogada, dabooli kara dhadhanka xun ee daroogada, waxaana loo isticmaali karaa daboolida qorista ama dahaarka filimka.
Qalabka la xakameeyo Tusaale ahaan, HPMC K4m, HPMC K15M iyo HPMC K100m waxaa badanaa loo isticmaalaa in lagu diyaariyo kiniinnada siidaynta ee la-daadka.
2.2 Codsi ku yaal diyaarinta kaabsalka
HPMC waxaa loo isticmaali karaa in lagu soo saaro kaabsaad hunyood oo kacsan oo lagu beddelo kaabsooshadii Gelatin, oo ku habboon khudradda iyo dadka xasaasiyad u leh kaabsalka xayawaanka dumarka. Intaas waxaa sii dheer, HPMC waxaa loo isticmaali karaa buuxinta dareeraha ama kaabsarka semisolid si loo wanaajiyo xasilloonida iyo siideynta astaamaha daroogada.
2.3 Codsi ku saabsan Diyaargarowga OphthalMic
HPMC, oo ah qaybta ugu weyn ee ilmada macmalka ah, waxay kordhin kartaa dib-u-fiirinta dhibcaha indhaha, dheereynta waqtiga deganaanshaha ee daroogada dusha sare, iyo hagaajinta bisiavulability. Intaas waxaa sii dheer, HPMC waxaa sidoo kale loo isticmaali karaa diyaarinta geedaha indhaha, filimada indhaha, iwm, si loo wanaajiyo saameynta sii-haynta ee daroogada isha.
2.4 Codsi ku saabsan diyaarinta dawada ee mobical ah
Hy'iserl®HPMC waxay leedahay filim-filim oo wanaagsan oo qaab-dhismeedka ah iyo biocompitib-ku-kalsoonida, waxaana loo isticmaali karaa in lagu diyaariyo boodhadhka trandermal, gels iyo kareemada. Tusaale ahaan, nidaamyada gaarsiinta daroogada ee daroogada, HPMC waxaa loo isticmaali karaa maaddo matrix ah si loo kordhiyo heerka galka daroogada oo uu sii dheeraado muddada ficil.
2.5 Codsi ku jira dareeraha afka ah iyo hakinta
HPMC waxaa loo isticmaali karaa sidii cufnaanta si loo wanaajiyo guryaha rheolololojiyada ee dareeraha afka laga qaado iyo ka-hakinta, ka hortagga walxaha adag ee dejinta, iyo hagaajinta isku habboonaanta iyo xasilloonida daroogada.
2.6 Codsi ku saabsan diyaarinta
HIPMC waxaa loo isticmaali karaa sidii side oo loogu talagalay qalabka neefsashada budada ah ee budada ah (dpis) si loo wanaajiyo dareeraha iyo kala-sooca daroogada, kordhinta heerka dhigashada ee daroogada, sidaasna ay kor u qaadaan saameynta daaweynta.
3. Faa'iidooyinka HPMC ee ku saabsan diyaarinta joogtada ah
HPMC waxay leedahay astaamaha soosocda inay tahay mid is-sii-saadaalineed:
Xoolaha biyaha ee wanaagsan:Waxay si dhakhso leh ugu bararsan kartaa biyaha si ay u dhisaan caqabad jahwareer ah oo ay habeeyaan heerka sii deynta daroogada.
Biyoodka wanaagsan:aan sun-lahayn iyo kuwa aan xanaaqin, oo aan ka nuugin jidhka bini-aadamka, waxayna leedahay waddo dheef-shiid kiimikaad oo cad.
Laqabsashada adag:Ku habboon noocyada kala duwan ee daroogada, oo ay ku jiraan dawooyinka biyaha-milmiga iyo hydrophophobic.
Habka Fudud:Ku habboon hanaanno kala duwan oo diyaarinta ah sida miiska tooska ah iyo kan qoyan.
Sida dawooyin muhiim ah oo muhiim ah,HpmcWaxaa si weyn loogu isticmaalaa qaybo badan sida kiniinno, kaabsoosha, diyaarinta indhaha, diyaarinta mowduucyada, gaar ahaan diyaarinta joogtada ah. Mustaqbalka, oo leh horumarka joogtada ah ee tikniyoolajiyadda diyaarinta ee dawooyinka, baaxadda arjiga ee walwalka 'walxaha' walxaha 'walxaha' walxaha 'walxaha' walxaha 'walxaha' walxaha 'walxaha' walxaha 'walxaha' walwal
Waqtiga Post: Feb-08-2025