Suuqa laxiriira ee guriga iyo dibedda ee diyaarinta dawooyinka samafalka ee dawooyinka ku jira hyroxypropyl methylrcellellase (HPMC) ayaa dib loo eegay, diyaarinta dareeraha, diyaarinta iyo sii-deynta ee la xakameynaya, diyaarinta kaabsooshadda, gelatin kii ugu dambeeyay, gelatin. Codsiyada ku jira garoonka noocyada cusub sida qaababka ku dhaca ku dhaca iyo bioadhes-ka. UGU DAMBEEYA MADAXWEYNAHA MADAXWEYNAHA XIRFADAHA IYO MADAXWEYNAHA HPMC, waxay leedahay astaamaha iyo adeegsiga emulsion, adhesion, qaro, viscosion, viskesion, oo laga joojinayo, sameynta iyo filimka. Waxaa si weyn loogu isticmaalaa diyaarinta dawooyinka waxayna door weyn ka ciyaari doontaa kaalin weyn oo ku saabsan duurka diyaarsanaanta. Iyada oo daraasad qoto dheer ah oo ku saabsan hantideeda iyo hagaajinta tikniyoolajiyadda samaynta, HPMC waxaa si aad ah loogu adeegsan doonaa cilmi baarista foomamka qiyaasta cusub ee qiyaasta qaadashada iyo nidaamyada dhalmada cusub, taasoo ay ku horumarinayso horumarka joogtada ah ee la dhigto.
hydroxypropyl methylrcellulose; diyaarinta dawooyinka; Daawooyinka samafalka ah.
Daawooyinka dawooyinka kaliya maahan arintaas oo keliya samaynta daroogada ceyriinka ah, laakiin sidoo kale waxay la xiriirtaa dhibaatada dhibaatada hannaanka diyaarinta, tayada daroogada, xasilloonida, heerka loo sii daayo daroogada, qaabka ficil, iyo horumarka caafimaadka, iyo horumarka caafimaadka, iyo horumarka caafimaadka. Foomamka Qiyaasta iyo Wadooyinka Cusub ee Maamulka. si dhow ula xiriir. Soo bixitaanka dawooyinka cusub ee dawooyinka cusubi badanaa waxay sare u qaadeysaa hagaajinta tayada diyaarinta iyo horumarinta foomamka qiyaasta cusub. Hydroxypropyl methylcelrelose (HPMC) waa mid ka mid ah kuwa ugu sareeya dawooyinka ugu caansan ee guriga iyo dibedda. Sababo la xiriira miisaankiisa mocilatireed ee kala duwan, waxay leedahay howlo ka mid ah emulsion, xidhitaanka, qaro, dhumuc, qaro, oo la joojinayo, iyo xabagta. Tilmaamaha iyo adeegsiga sida isku-darka iyo filimka ayaa si ballaaran loogu isticmaalaa tikniyoolajiyadda dawooyinka. Maqaalkan ayaa inta badan dib u eegaya dalabka hydroxypropyl methylrcellellase (HPMC) ee qaabab sanadihii ugu dambeeyay.
1.Guryaha aasaasiga ah ee HPMC
@Droxypropyl bylule (HPMC), qaacidada molikaulal waa C8h15o8- (C10 H18O8) N- C10SE6) N- C15- (C10), oo qayb ka ah methyldroxypropyl ether. ee cellulose. Waxaa loo soo saari karaa laba siyaabood: mid ayaa ah in miraha methyl cell ee heerka ku habboon lagu daaweeyo Nax ka dibna ka falceliyay Propylenenemene-ka oo ka hooseysa heerkulka sare iyo cadaadiska sare. Waqtiga falcelinta waa inuu sii dheeraadaa si loogu oggolaado methyl iyo hydroxypropyl si uu u sameeyo dammaanad qalooceed oo ka mid ah giraanta unugyada ee unugyada cellulose, oo ay gaari karto shahaadada la doonayo; Midda kale waa in lagu daaweeyo lidka suufka ah ama pulp pulp oo leh soodhada caustic, ka dibna ka falceli metlane chlorine iyo propylenenene-ka si isdaba joog ah si isdaba joog ah, ka dibna sii daayo. , ku jajabiyey budo fiican oo labis ama granulures.
Midabka sheygan waa cadaan oo caano ah cad, ur la'aan oo aan dhadhan lahayn, qaabkuna waa budo grant ama budo fudud. Alaabtaani waxaa lagu kala diri karaa biyaha si ay u dhisaan si cad oo ah xalka qulqulka caarada cad ee caano leh viscosity gaar ah. Isugeynta Sol-Gel-gel-ka waxay ku dhici kartaa in heerkulka loo beddelo xalka uu ku jiro xoog uruurinta.
UGU DAMBEEYA QOYSKA QOYSKA EE QOFKA LACAG-LA'AAN EE MADAXWEYNAHA CIIDAMADA IYO HYDROXYPropyl, noocyo kala duwan oo alaabooyin ah ayaa soo muuqday. Isugeynta gaarka ah, noocyo kala duwan oo alaabooyin ah ayaa leh astaamo gaar ah. Viscosity iyo heerkulka gelitaanka kuleylka, sidaa darteed waxay leeyihiin guryo kaladuwan waxaana loo isticmaali karaa ujeedooyin kala duwan. Parmakooriyada dalal kala duwan ayaa leh qawaaniin kala duwan iyo wakiillo ku saabsan moodalka: Parmakooyinka Yurub waxay ku saleysan tahay fasalada kala duwan ee fiilooyinkii muuqaalka kala duwan iyo heerar kala sooc ah oo lagu iibiyo suuqa lagu daro lambarrada, iyo cutubka waa "Mpa s ". In the US Pharmacopoeia, 4 digits are added after the generic name to indicate the content and type of each substituent of hydroxypropyl methylcellulose, such as hydroxypropyl methylcellulose 2208. The first two digits represent the approximate value of the methoxy group. Boqolkiiba, labadii lambar ee ugu dambeeyay waxay metelaan qiyaasta boqolkiiba ee hydroxypropyl.
Kaabocaan-ka-Hydroxypropylypelrelose wuxuu leeyahay 3 taxane, ta 18 oo ah E taxane, taxane taxane ah iyo taxane ah, taxane kasta waxay leeyihiin noocyo kala duwan oo laga soo xusho noocyo kala duwan oo laga xusho moodooyin kala duwan oo laga xusho. Taxanaha Taxanaha waxaa inta badan loo isticmaalaa sidii jaakad filim, loo isticmaalo dahaarka miiska, digaagga kiniinka xiran; E, taxanaha F waxaa loo istcimaalaa maqaaxida iyo siideynta wakiillada loo diyaariyo isugeynta indhaha, oo laga joojinayo wakiillada, culaysyada dareeraha, kibirkooda iyo xirmooyinka granules; Kiiska taxanaha ah ayaa inta badan loo isticmaalaa sidii loo siideyn karaa xakamaynta kuwa xakameeyayaasha ah iyo qalabka biyaha ku jira ee gel-ga
Soosaarayaasha guryaha ayaa badanaa ku jira fuzhou No. 2 kiimikood, Huzhou Cuntada iyo kiimikada Co., LTD., SICHIN LUZHOU RUSS, LTD., SHDONG DOUOEcheng Asaa Dawooyinka Common .
2.Faa'iidooyinka HPMC
HPMC waxay noqotay mid ka mid ah dawooyinka ugu badan ee dawooyinka iyo dibedda ah, sababtoo ah HPMC waxay leedahay faa'iidooyin ay ku faa'ideystaan in samafalka kale aysan haysan.
2.1 Xabsi biyo qabow
Biyo qabow oo ka hooseeya 40 ℃ ama 70% ethanol, asal ahaan ku dhexjiraan biyo kulul oo ka sarreysa 60 ℃, laakiin wuu karaa.
2.2 Kimikal ahaan
HPMC waa nooc ka mid ah unugyada aan in-in-inic chether lahayn, xalkani ma leh khidmad la'aan, oo aan la macaamilin cusbada birta ama xeryaha kale ee dabiiciga ah, sidaa darteed samafalka kale ayaa ka falcelinta inta lagu gudajiro nidaamka wax soo saarka.
2.3 deganaansho
Waa mid deggan oo aashito ah iyo alkali labadaba, waana lagu keydin karaa muddo dheer inta u dhaxaysa PH 3 iyo 11 iyada oo aan isbeddel weyn ku dhicin Viscosity. Xalka aqueous ee HPMC waxay leedahay saameynta kahortagga-wax-hayeeya waxayna haysaa xasilloonida muuqda ee aragga inta lagu jiro kaydinta muddada-dheer. Daawooyinka samafalka ah ee isticmaalaya HPMC waxay leeyihiin xasillooni tayo sare leh oo ka badan kuwa adeegsanaya kuwa wax soo dhigta (sida dextrin, istaarijka, iwm.).
2.4 La-qabsashada Viscosity
Soosaarista vmcosity of vmcosity of HPMC-ka ayaa lagu qasi karaa cabirro kaladuwan, codkeedana waa la beddeli karaa iyadoo loo eegayo sharci gaar ah, oo uu leeyahay xiriir wanaagsan oo toosan, sidaa darteed saamiga ayaa loo dooran karaa iyadoo loo eegayo baahiyaha.
2.5 Xadhiga dheef-shiid kiimikaadka
HPMC kama nuugo ama ka qaadanayso jirka, oo masiino kuleyl, marka waa dib-u-beddel daawo aamin ah. 2.6 Nabdoonaanta Waxaa guud ahaan loo qaddariyo in HPMC ay tahay shey aan sun lahayn oo aan xanaaqin, qaddarka khafiifka ah ee jiirka ee jiirka waa 5 g · kg - iyo qaddarka khaaska ah ee jiirka ee jiirka ayaa ah 5. 2 Kg - 1. Qiyaasta maalinlaha ahi wax dhib ah kuma lahan jirka bini-aadamka.
3.Codsiga HPMC ee qaababka
3.1 Sida filimka filimada ee filimada iyo astaan-abuurista filimka
U adeegsiga HPMC maaddaama kiniin ah oo dahab ah, kiniinka dahaarka ah ma leh faa iidooyin muuqda oo ah in la barbar dhigo kiniinno isku dhafan oo la barbardhigo kuwa sonkorta leh sida kiniinnada sonkorta ah sida kiniinnada sonkorta lagu buuxiyo, laakiin adkaadee, dareenka, dareenka qoyaanka, qoyaanka, heerka nuujinta qoyaanka, qoyaanka, heerka nuujinta qoyaanka, qoyaanka, heerka nuujinta qoyaanka, heerka nuujinta qoyaanka, qoyaanka, heerka nuujinta qoyaanka, heerka nuujinta qoyaanka, heerka nuujinta qoyaanka, qoyaanka. , Kordhinta miisaanka oo miisaanka iyo tilmaamayaasha kale ee tayada leh ayaa ka fiican. Fasalka hoose ee badeecadan waxaa loo istcimaalaa sida aaladda filim-biyo-biyo-uruurinta loogu talagalay kiniiniyada iyo kaniiniyada, iyo heerka sawirka sare waxaa loo isticmaalaa maadada dahaarka ee nidaamka dareeraha dabiiciga ah, sida caadiga ah uruurinta 2% illaa 20 %.
Zhang Jixing et al. Waxaa loo adeegsaday habka salka sare ee saamaynta si loo wanaajiyo sameynta propix ee HPMC oo ah dahabka filimka. Qaadashada Filimka-Samaynta Filimka HPMC, qadarka polyvinyl ee aalkolada iyo balastar-ka glycol waa qodobada baaritaanka, aragtida filimka iyo aragtida filimka ee filimka, iyo xiriirka ka dhexeeya kormeerka. Tusmada iyo qodobbada kormeerka waxaa lagu sharaxay qaab xisaabeed, oo nidaamka qaab dhismeedka ugu habboon ayaa ugu dambeyntii la helaa. Isticmaalaheeda ayaa ah mid si loo kala horeeyo wakiilka filim-ka sameysan @droxypropylylulose (hpmce5) 11.88 g, polyvinyllen ee 24.00 g, iyo xoogga qalloocan ee filimka ayaa gaadhay saameynta ugu fiican . Zhang Yuan ayaa wanaajiyey hannaanka diyaarinta, oo loo adeegsaday HPMC sidii xayiraad si uu u beddelo kiniiniyada istaarijka ah si loo wanaajiyo tayada diyaaradda, si fudud loo hagaajiyo, kiniinnada dabacsan, ee kiniinnada. kor u qaad xasilloonida kiniinka. Hawsha qaab-dhismeedka ugu habboon ee lagu go'aamiyay tijaabooyin orthogonal ah, oo ah, uruurinta slurry wuxuu ahaa 2% HPMC oo ah 80% etMolin inta lagu gudajiro dahaarka, iyo waqtiga kareyda inta lagu gudajiro muddadii ay tiriyeen 15 daqiiqo. Natiijooyinka kiniiniyada filimka ee Janua ee ay diyaariyeen hawsha cusub iyo rijeetada si weyn ayaa loo hagaajiyey muuqaalka, waqtiga kala-baxa iyo saamiga aasaasiga ah ee ay soo saareen hanaanka loo qoro ee kiniinnada asalka ah, iyo heerka kiniinnada filimka si weyn loo wanaajiyey. gaartay in kabadan 95%. Liang Meiyi, LU Xiahohoi, iwm. saameeya sii deynta daroogada. Huang Yunran oo diyaar garowga xidhmada daadadka ee kiniiniga ah kiniiniga, oo lagu dabaqay HPMC xalka dahaarka ee lakabka bararka, oo jajabkiisa ballaaran wuxuu ahaa 5%. Waxaa la arki karaa in HPMC si weyn loogu isticmaali karo nidaamka gaarsiinta daroogada ee loo yaqaan 'Coast Dawooyinka'.
Hydroxypropylkyl methylcelrelolose kaliya maahan qalab filim oo quruxsan oo keliya, laakiin sidoo kale waxaa loo isticmaali karaa maaddaama filim lagu sameeyo qaab dhismeedka filimka. Wang trackswun iwm. Propylene Glycol waxay buuxisaa shuruudaha sii-daynta gaabis iyo badbaadada, waxaana loo istcimaali karaa sidii rijeetada qoritaanka ee filimka isku-darka ah.
3.2 sida caqabadda iyo kala-sooca
Heerka hoose ee sawirka ee sheygan waxaa loo isticmaali karaa inuu yahay laba-geesood iyo kala-soocidda kiniiniyada, kiniiniga iyo granules, fasalka sarena loo isticmaali karo oo keliya shandad. Qiyaasta waxay ku kala duwan tahay tusaalayaal iyo shuruudo kala duwan. Guud ahaan, qaadashada qafiifka loogu talagalay kiniiniyada dilaaga ah ee qallalan ee kiniiniga ah waa 5%, oo qaadashada caqabadaha kiniinnada qoyan ee qoyan waa 2%.
LIOUTAO Et Al Baadhis oo ka mid ah kiniinnada Tindazoole. 8% polyvinylpyrrolidone (pvp-k30), 40% sharoobada, 10% sluprry, 2.0% hydroxypropylrcellrcellerose methylcelrcylcellcelrelose chylcylcelrelosol bykylcelrcylcellcellcellellase methylcelrcylcellcelrelose methylcelrcylcellcellcellcelrelose methylcelrcelrelose chylcylcellcelrelose methylcelrcylcellcelrelose chylcelcelrelose chals ', oo ah Ethinol-ka ayaa loo baaray kiniiniyada kiniinnada Tindazoole. Diyaarinta kiniiniga Tindazoole. Muuqaalka muuqaalka kiniiniyada cad ee ka dib marka la barbar dhigo, iyo kartida, iyo adkaynta, adkaanta, waqtiga kala-goynta waqtiga kiniinnada dawooyinka ee loo qoro ayaa la cabiray. Natiijooyinka kiniiniyada ay diyaariyeen 2.0% hydroxypropylylulolose methylcelrellase waxay ahayd dhalaalaya, iyo cabirrada cracication-ka majiraan ciribtirka iyo daaha, qaabka kiniiniga ah, muuqaalku wuu fiicnaa oo muuqaalkanna wuu fiicnaa. Sidaa darteed, kiniiniyada Tunidazoole ee loo diyaariyey 2.0% HPMC-K4 iyo 50% ethanol maadaama la isticmaalay. Guan Shihaa wuxuu bartay hannaanka sameynta kiniiniga kiniiniga, la baaray, oo uu ka baaray 50% etchch, oo ah 100% PVP iyo 50% Startch iyo 50% States Statessis, iyo Franol Lightless, iyo Muhiimad ahaan sida Tilmaamayaasha Qiimeynta. , 5% cmc-na ilaa 15% xalka HPMC (5 MPA S). Natiijooyinka xaashida ay diyaariyeen 50% ethanol, 15% istaarijka Statech, 10% PVP 50% SETIMOL 50% CMC-NA waxay lahaayeen dusha sare, laakiin si adag oo aan fiicnayn, oo aan buuxin karin baahiyaha daboolka; 15% Xalka HPMC (5 MPA ·) Dusha sare ee kiniinka waa mid siman, qaataha ayaa u qalma, oo is-ururinta waa mid wanaagsan, oo buuxin karta baahiyaha daboolka. Sidaa darteed, HPMC (5 MPA S) ayaa loo xushay inuu ku dhaco.
3.3 sidii loo joojiyay wakiilka
Fasalka sawirka-sare ee badeecadan waxaa loo isticmaalaa inuu yahay wakiilka laga joojiyo si uu u diyaariyo diyaarinta dareeraha ka joojinta ee nooca hakinta. Waxay leedahay saameyn wanaagsan oo laga joojiyo, waa sahlan tahay in la xaliyo, kuma xirna derbiga, oo uu leeyahay walxo jilicsan oo wanaagsan. Qiyaasta caadiga ah waa 0.5% illaa 1.5%. Song tian et al. Qalabka pommer si caadi ah loo isticmaalo Cayrinta qallalan. Iyada oo loo marayo saamiga mugdiga ee ganaaxyada kaladuwan, tusmada dib-u-eegista, iyo rhessiology, iyo rnescology, peyrta, mopphology-ka micnoscopic-ka iyo xasilloonida dadka dawada ka mid ah ayaa la baaray tijaabada. Natiijooyinka ganaax qalalan ee loo diyaariyey 2% HPMC maadaama wakiilka joojinta uu lahaa hanaan fudud iyo xasillooni wanaagsan.
Marka la barbar dhigo bedyl bylulose, hydroxypropyl bylulose methyluse methyluse waxay leedahay astaamaha lagu sameeyo xalka cad, sidaa darteed HPMC waxaa sidoo kale caadi ahaan loo adeegsadaa wakiil ka socda diyaarinta ophthalmic diyaarinta. Liu Jie et al. Waxaa la adeegsaday HPMC, Hydroxypropyl Cellulose (HPC), Carbomer 940, polyethylen glycol (ha ahaado jihada, iyo isku darka ah ee hakavovir-ka ee loo yaqaan 'Exhlthovir OphthalMir', Cabbirka mugga Cabbirka, cabirka walxaha waxaa loo xushay in tilmaamayaasha kormeerka ah si ay u baaraan wakiilka ugu fiican ee laga joojiyay. Natiijooyinka ayaa muujinaya in eryida ophcloveer acycloveer ay diyaarisay 0.05% HA iyo 0.05% HPMC oo ah wakiilka joojinta, cabirka suuxdintu waa labis, oo ay diyaarinadu waa wanaagsan tahay, oo diyaarintaadu waa mid galmo xasilloon.
3.4 sidii xayndaab, oo tartiib tartiib ah oo la xakameeyay oo la xakameeyay wakiilka qaab dhismeedka
Heerka aragga-indhaha ee badeecadan waxaa loo isticmaalaa diyaarinta kiniinnada biyaha ee Hydrophilic ee kiniiniyada sii waday, xirmooyinka iyo wakiilada la xakameynayo ee kiniiniyada sii-deynta ee matrix-ka-la-daadanaya, oo ay saameyn ku leedahay dib-u-dhigista dawada. U fiirsashada ay tahay 10% ilaa 80%. Darajooyinka viscosity-ka hooseeya waxaa loo istcimaalaa sida pomages-ka ee sii-haynta joogtada ah ama sii-deynta la xakameeyo. Qiyaasta bilowga ah ee looga baahan yahay saameynta daweynta ee kiniiniyada noocan oo kale ah si dhakhso leh ayaa loo gaari karaa, ka dibna saameynta sii-deynta ama la-daadanaya ee la xakameeyaa daroogada daroogada ee wax ku oolka ah ayaa lagu hayaa jirka. . Hydroxypropyl methylcelrelose ayaa biyo raacinaya si loo sameeyo lakabka gel marka ay buuxiso biyaha. Habka loo sii daayo dawada lagu sii daayo kaniiniga matrix inta badan waxaa ku jira kala-goynta lakabka gel iyo nabaad-guurka lakabka gel. Jung Bo Shim et al ee loo diyaariyey kiniiniyada sii-deynta ee CarticLol oo leh HPMC maadaama ay tahay wax sii daaya oo sii daaya.
Hydroxypropylykelrelolose sidoo kale si ballaaran ayaa loo isticmaalaa kiniinnada matrix-ka sii joogtada ah ee dawada Shiinaha ee caadiga ah, iyo maaddooyinka firfircoon iyo kaliya diyaarinta hal dawada Shiinaha ee caadiga ah ayaa la isticmaalaa. Liu wen et al. Waxaa loo adeegsaday 15% hydroxypropyl methylcelrelose matrix shey, 1% Lactose iyo 5% Microcrystall-ka Microcrystallenel Celyer, oo loo diyaariyey Jingfang Tao Engenqi ah kiniiniyada sii-deynta ee afka ah. Moodhku waa isla'egta Higuchi. Nidaamka Qaab-dhismeedka qaaciddada waa mid fudud, diyaarintu way fududahay, xogtuna waa mid deggan, oo buuxisa shuruudaha dawooyinka dawooyinka Shiinaha. Tang Guiguang et al. Wadarta loo adeegsaday saphonis ee astragalus oo ah daroogo moodel ah, kiniinnada matrix ee loo diyaariyey HPMC matrix, oo ay sahamisay qodobbada saameeya sii deynta daroogada ee dawada dhaqanka Shiinaha ee kiniiniyada HPMC matrix. Natiijooyinka sida qaadashada ee HPMC kordhay, sii deynta Astragloside, iyo boqolleyda la siidaynta ee daroogada ayaa ku dhowaad xiriir toosan oo leh heerka kala-baxa ee matrix. Kiniiniga HanpMC Matrix, waxaa jira xiriir gaar ah oo ka dhexeeya siidaynta qayb ka mid ah dawada Shiinaha ee dhaqanka Shiinaha iyo qiyaasta iyo nooca la siidaayo ee kiimikada kiimikada ee kiimikada ah ee momerophilic-ka momerophilic-ka monomenic. Hydroxypropylyl methylcelrenose kaliya kuma haboona xeryaha biyaha ku jira, laakiin sidoo kale walxaha aan hydrophilic ahayn. Liu niihua waxay isticmaashay 17% hydroxypropyl methylrcellellase (HPMCK15M) maaddaama ashyaa'da sii--daynta sii joogtada ah, oo ay u diyaarisay Tianshan-ka kaniiniyada matrix sii-daynta matrix-ka ee waardiyaha iyo kabaxaynta. Saamaynta joogtada ah ee sii-deynta waxay ahayd mid iska cad, oo hannaanka diyaarinta ayaa xasilloon oo macquul ah.
Hydroxypropyl methylcelrellase kaliya looma adeegsan karo kiniinnada matrix-ka sii joogta ee maaddooyinka firfircoon iyo qaybaha wax ku oolka ah ee dawada Shiinaha, laakiin sidoo kale loo adeegsaday oo ka badan diyaarinta xididdada dawooyinka ee caadiga ah ee Shiinaha. Wu Huichao et al. Waxaa loo adeegsaday 20% hydroxypropyl bylulose (hpmck4m) sida ashyaa'da matrix, oo loo adeegsaday habka budada ah si loo diyaariyo kiniinnada 'zhidrophilic's meldrophilic-ka' ee zhippophilic 'ee si joogto ah loo sii daayo daroogada oo macquul ah. Saponin rg1, Ginnenoside RB1 iyo Panax noginring Saponineng Sapotineng Saponineng Saponineng Saponineng Sapotineng Saponineng Sapotineng Saponineng Saponineng Saponineng Saponinent Saponineng Saponineng Saponineng Saponineng Saponinent Saponineng Saponineng Saponineng SAPONEN R1 SHOUS Natiijooyinka loo siidaayo daroogada waxay la jaan qaadaa isleegyada qiimaha-eber-pereppas, kaas oo gital-ka-dhigga lagu soo daayo ee aan fid ahayn, iyo saddexda qaybood ee ka mid ah pax noginring ayaa lagu sii daayay nabaad-guurka.
3.5 Koollo ka difaac leh sida dhumuc weyn iyo isku-darka
Markii badeecadan loo isticmaalo sidii dhumuc weyn, feejignaanta boqolkiiba caadiga ah waa 0.45% illaa 1.0%. Waxay sidoo kale kordhin kartaa xasilloonida xabagta hydrophobic ee, samee colloid difaac, walxaha ka soo baxa is-xoqashada iyo agglomeritering, taas oo ka horjoogsanaysa dhismaha suuxinta. Kordhinta boqolkiiba ee guud waa 0.5% illaa 1.5%.
Wang zhen et al. Waxaa loo adeegsaday habka naqshadeynta naqshadeynta tijaabada ee LO9 Orthogonal si loo baaro geedi socodka diyaarinta ee kaarboon firfircoon oo daweeya. Shuruudaha ugu habboon ee loo gaaro go'aanka ugu dambeeya ee kaarboon ee loo adeegsado Dawradda Gaarbadeed waa in la adeegsadaa 0.5% Gaarium CarboxyMelyl (HPMC Choxropykyl (HYDROXYPROSLYL Saldhigga 11.6%) inuu yahay xayeysiis ah, xaaladaha hawsha ayaa ka caawiya kor u qaadista deganaanshaha kaarboon firfircoon ee daawada. Zhang zhiqiang et al. Waxay soo saartay ph-nufloxacin hydrochloride ophthalmide-ka-u-adeegsiga ee saamaynta joogtada ah, adoo adeegsanaya matrix-ka gel matrix iyo hydroxypropyl metylcellcellcellus inuu yahay wakiilka qadka dheer. Warqadda ugu habboon ee loo qoro, ugu dambeyntii waxay helayaan rijeetada ugu habboon ee loo yaqaan 'levimal' waa heafloxacin hydrochloride 0.1 g, carbropol (9400) @phoporalphyl (@phoporic phosphate) 0.45 g, yourdrogegyl (.45 g oo ah sodium dihydrogen, 0.50 g oo ah sodium chloride , 0.03 g oo ah lagu nooleeyo etherl lagu bamaadin, oo biyuhuna lagu daray si ay u sameeyaan 100 ml. Imtixaanka, qoraaga ayaa la baaray shirkadda 'hyroxypropyl methocel methocel methocel' oo ay weheliso faahfaahinta kala duwan (k4m, e1m, e1m, e1m, e4m, e1m, e1m, e1m, e1m, e1m, e1m, e1m, e1m, e1m, e4m, e1m, e4m, e1m, e4m, e15 lv) oo ay ka dhasheen hpmc e50 lv sida dhumucdu. Qadaadirku wuxuu u leeyahay ph-schofloxacin hydrochloride hydrochloride oo ku yaal qulqulka degdega ah.
3.6 Sida kaabsoosha ah
Badanaa, sheyga kaabsalka kaabsoosha ah ee kaabsalka ah badanaa waa gelatin. Geedi socodka wax soo saarka ee qolofta kaabsalka ah waa mid fudud, laakiin waxaa jira dhibaatooyin iyo ifafaale oo ka mid ah kahortagga xudunta ee qoyaanka iyo daawooyinka dawooyinka oksijiinta ah, iyo dib u dhaca kala-sooca, iyo kala-sooca burburka qolofta kaabsalka. Sidaa daraadeed, hydroxypropyly methylcelrellose waxaa loo isticmaalaa bedelka kaabsoodka gelatin ah diyaarinta kaabsoosha, kaas oo hagaajiya soosaarka kaabsooshadda iyo saameynta isticmaalka, oo si weyn loogu dhiirrigeliyay guriga iyo dibedda.
U adeegsiga 'thephophyline' oo ah daroogada kontaroolka, podczeck et al. Waxaa la ogaaday in heerka kala-baxa daawada ee kaabsoosha ee kaabsoosha ah ee leh hydroxypropylyl methylcelrellase 'wills' ay ka weynaatay tii kaabsoobiyada gelatin. Sababta falanqaynta ayaa ah in kala-goynta HPMC ay tahay kala-baxa kaabsoosha oo dhan isla waqtigaas, halka kala-goynta kaabsooshadii gelatin uu yahay kala-baxa qaabdhismeedka shabakadda marka hore, ka dibna kala goynta kaabsoosha oo dhan, sidaa darteed Kaabsalka HPMC wuxuu aad ugu habboon yahay qolofka kaabsalka kaabsalka si deg deg ah loo sii daayo qaababka. Chiwele et al. Waxa kale oo uu helay gunaanad la mid ah oo isbarbar dhigaya kala dirida gelatin, gelatin / polyetylne glycol iyo qolofta HPMC. Natiijooyinka ayaa muujinaya in qolofka HPMC si dhakhso ah loogu kala diray xaaladaha kala duwan ee PH-da, halka Gelatin kaabsaadka ay si weyn u saameysay xaaladaha kala duwan ee PH. Tang Yue et al. Waxaa la baaray nooc cusub oo kabasho ah qolof ah oo qolof ah oo ah dawada-qaddarka oo yar oo dawo ah oo lagu neefsado budada lagu neefsado ee budada ah ee budada ah. Marka la barbar dhigo qolofta kaabsoosha ah ee hydroxypropylylulose methsulepelrellase iyo qolofta kaabsooshaha ee gelatin, xasilloonida kaabsalka qolofta leh iyo sifooyinka budada ah ee qolofta leh, iyo baaritaanka cudurka lagu sameeyay. Natiijooyinka ayaa muujinaya in marka la barbar dhigo kaabsooshadii Gelatin, qolofka HPMC kapsule-ka ah ay ku fiican yihiin xasilloonida iyo kahortagga wasakhda, sidaa darteed xiidmaha kaabsata ee gelatin kaabssule, sidaa darteed xarkaha kapssule-ka ayaa ku habboon kaabsooshayaasha budada budada ah.
3.7 sida bioadhesive
Teknolojiyadda bioadhesion waxay isticmaashaa saboolnimo leh polymos biodhesive. Adigoo u hoggaansamaya xabka bayoolajiga ah, waxay kor u qaadeysaa sii wadida iyo adkaanta xiriirka ka dhexeeya diyaarinta iyo xabka, si daroogada si tartiib tartiib ah loo sii daayo oo uu nuugo xarkaha si loo gaaro ujeeddada daaweynta. Waxaa si ballaaran loo isticmaalaa xilligan. Daaweynta cudurada ku dhaca marinka caloosha ee caloosha, siilka, xagasha afka iyo qaybaha kale.
Teknolojiyadda biouthpartrestinal-ka ayaa ah nidaam cusub oo dawooyin cusub oo la soo saaray sannadihii ugu dambeeyay. Kaliya ma dheereeyso waqtiga deganaanshaha ee diyaarinta daroogada ee ka dhaca marinka caloosha, laakiin sidoo kale waxay wanaajisaa waxqabadka xidhiidhka ee u dhexeeya daroogada iyo xuubka unugyada ee goobta nuugaya, waxay beddeshaa dareeraha xuubka unugyada, waxayna ka dhigeysaa galka daroogada Unugyada yaryar ee xiidmaha xiidmaha ayaa la wanaajiyaa, sidaasna ay u hagaajiso bioavaulaliska daroogada. Wei Keda et al. Waxaa laga baaray warqadda kaniiniga ah ee kiniinka ah ee ku saabsan qiyaasta HPMCK4M iyo Carbomer 940 oo ah qodobada baaritaanka, waxayna u adeegsadeen aaladda hubinta si ay u kala baxaan xoogga iyo bioolilm-ka ku dhex jira tayada biyaha bacda. , iyo ugu dambeyntiina loo xushay waxa ku jira HPMCK40 iyo carbomer 940 ilaa 15 iyo 27.5 mg oo ku saabsan aagga loo yaqaan 'cores cores', oo muujinaya in qalabka kiniinka ee ncabberesportportpropyl (sida hydroxypropyl methylcellcellus) si weyn ayaa loo yareyn karaa horumarka asiinta u diyaar garowga unugyada.
Diyaargarowga afka ah ee afka ayaa sidoo kale ah nooc cusub oo ah nidaamka gudbinta daroogada ee la bartay inbadan sanadihii la soo dhaafay. Diyaargarowga afka ah ee afka laga qaato ayaa u hoggaansami kara qaybta ay dhibaatadu saameysey ee afka daloolka afka, oo aan ka dheerayn karin waqtiga deganaanshaha ee daroogada ee xabka afka, laakiin sidoo kale ilaaliyaa xabka afka. Saamaynta ku habboon daweynta iyo saamaynta daroogada ee la hagaajiyay. Xeuemionan et al. Kordhinta sameynta kiniiniyada afka ah ee maskaxda, iyadoo la adeegsanayo pectin pectin, chitosan, carbomer 934p, hydroxypropylkellus methylcelrelose (hpmc k392) iyo sodium k392) iyo qalajinta-qallajinta si loo diyaariyo insulin afka ah. Xaashiyaha lakabka labajibbaarane. Kiniinka insulinta ee loo diyaariyey insulinta insulinta ee loo diyaariyey ayaa leh qaab-dhismeedka isbuunyada oo kale ah, oo ay habboon tahay in insulin siidaynta, oo ay leedahay lakab ilaalin oo biyo ah, oo hubin kara in la sii daayo daroogada oo ay ka fogaadaan lumitaanka daroogada. Hao jifa et al. Waxa kale oo loo diyaariyey buluug buluug ah oo buluug ah oo buluug ah oo ku saabsan boodhka 'beadhes' ee afka ah ee isticmaala xabagta baiji, HPMC iyo carbomeer oo ah agabyada saqafka.
Nidaamyada gaarsiinta daroogada xubinta taranka, tikniyoolajiyada saqafka ayaa sidoo kale si ballaaran loo istcimaalaa. Zhu yuting et al. Carbomeer loo adeegsaday (CP) iyo HPMC inay yihiin agabyo dhameystiran iyo matrix sii-deyn joogto ah si loogu diyaariyo kiniiniyada siilka ah oo leh xubno kaladuwan iyo saamiyadooda, iyo boqolkiiba qaabbirka iyo bararka ee jawiga dheecaanka siilka ee aan dabiici ahayn. , dawada ku habboon ee loo qoro sida CP-HPMC1: 1, xaashida xaashida loo diyaariyey waxay lahayd wax qabad wanaagsan oo adhesion ah, hawshuna waxay ahayd mid fudud oo macquul ah.
3.8 sida jel topical
Iyada oo loo diyaariyo adhesit, gel wuxuu leeyahay faa iidooyin taxane ah sida badbaadada, quruxda, nadiifinta fudud, qiimaha yar, hanaanka sahlan, iyo iswaafajinta wanaagsan ee daroogada. Jihada horumarka. Tusaale ahaan, gelddermal gel waa qaab qaadasho qiyaaseed oo cusub oo la bartay inbadan sanadihii la soo dhaafay. Kaliya ma ka fogaan karo burburka daroogada ee ku jira mareenka caloosha ee ku jira mareenka caloosha iyo yareynta kala duwanaanshaha ugu sarreeya ee dawada daroogada dhiigga, laakiin sidoo kale waxay noqotay mid ka mid ah nidaamyada sii deynta daroogada ee waxtarka leh si looga gudbo dhibaatooyinka daroogada. .
Zhu Jingjie et al. Shuruucda la soo saaray saameynta mataanaha kaladuwan ee lagu sii daayo Gel matrix oo ay ku jiraan aalkolada aalkolada. Natiijooyinka tijaabada ah ayaa muujinaya in 1. 0% carbmer, 1. 5% carbomer, 1% carbomeer + 1% HPMC matrix ay ku habboon yihiin scutkarin aalkolada . Intii lagu gudajiray tijaabada, waxaa la ogaaday in HPMC uu wax ka badali karo qaabka loo sii daayo daroogada ee gatrix matrix anaga oo ku habboon isleegyada kiimikada, iyo 1.0% HPMC-ga ayaa hagaajin kara 1.0% carbomer matrix iyo 1.5% carbomeer matrix. Sababta ayaa laga yaabaa inay si dhakhso leh u fidiso in HPMC ay sii ballaariso si dhakhso ah, iyo ballaarinta deg-degga ah ee marxaladda hore ee tijaabada waxay ka dhigeysaa farqiga moliga ah ee maaddada carbmeeyaha weyn, taas oo dardargelinaysa heerka sii-deynta daroogada. Zhao Wentui et al. Carbome-934 iyo hydroxypropyl methylcelrelolose maadaama sideyaasha loo diyaariyo si loo diyaariyo Norflowacin ophthalmic gel. Hannaanka diyaarinta waa mid fudud oo macquul ah, iyo tayada tayada leh ee loo yaqaan 'ophthalmic gel' ee "dawooyinka dawooyinka Shiinaha" (2010 daabacaadda) (2010).
3.9 ROONTIOSITY Nidaamka iskiis u ah
Isku-kalsoonida nidaamka gaarsiinta daroogada (SMEDDDs) waa nooc cusub oo ah Nidaamka Gaarka Daroogada ee afka, oo ah isku-darka isku-dhafka ah, oo deggan oo hufan oo ka kooban daroogada, wejiga saliida, emulsifier iyo co-emulfifier. Halabuurka dawooyinka dhakhtarku qoro waa mid sahlan, nabadgelyada iyo xasilloonida ayaa wanaagsan. Daawooyinka polymper ee liita, sida HPMC-ka-biyaha-biyaha, sida HPMC, polyvinylpyrrolidolidone (PVP), iwm, waxaa badanaa lagu daray in lagu sameeyo daroogada oo lacag-dhimista ah ee daroogada lagu gaaro ka-goynta marinka caloosha, si Kordhinta salaanta daroogada oo hagaajisaa bioavailabnimada.
Peng Xuan et al. Waxaa loo diyaariyey silibin oo loo yaqaan 'stibis supperssaturin' ee nidaamka gudbinta daroogada (s-cards). Oxyethylene hydrogenated castor oil (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) as co-emulsifier, and 50 mg·g-1 HPMC. Ku darista HPMC ee SSEDD-yada waxay kicin kartaa silibin oo bilaash ah si ay ugu milmaan S-cards-ka oo ka hortagaan silibin ka samatabbixinta. Marka la barbardhigo qaababka is-dhexgalka ee is-dhexgalka ah, qadar weyn oo ka mid ah salka lagu daro waxaa badanaa lagu daray si looga hortago dawada aan dhameystirnayn. Ku darista HPMC waxay ku hayn kartaa xariiga salka silsiladda silibinin ee kala-baxa dhexdhexaadka ah, yareynta emulsification-ka ee is-hoosaysiinta microemusoition. qiyaasta wakiilka.
4.
Waxaa la arki karaa in HPMC si weyn loogu isticmaalo diyaarinta sifooyinkiisa jir ahaaneed, kiimikada iyo bayoolaji, laakiin HPMC sidoo kale waxay leedahay wax-ka-dhac badan oo diyaarsanaanta, sida ifafaalaha sii deynta horudhaca ah iyo siideynta post-burst. Metherl methacrylate) si loo wanaajiyo. Isla mar ahaantaana, cilmi baarayaashu waxay baaraysay arjiga aragtida Osmotic ee HPMC iyadoo loo diyaariyo kaarbamazepine kiniinnada sii-deynta ee sii-deynta iyo kaniiniyada sii-deynta ee Verapamil ee kaniiniyada sii-deynta si ay u sii baraneyso farsamada sii-deynta. Erey, cilmi baadhayaal badan oo ka badan ayaa qabanaya shaqo badan oo ku saabsan adeegsiga ugu fiican ee HPMC diyaarinta, iyo daraasad qoto dheer oo ku saabsan tikniyoolajiyada diyaarinta, HPMC ayaa si aad ah loogu adeegsan doonaa foomamka qiyaasta cusub iyo foomamka qiyaasta qiyaasta cusub. Daraasaadka nidaamka dawooyinka, ka dibna kor u qaadida horumarka joogtada ah ee farmashiyaha.
Waqtiga Post: Oct-08-2022