Qormada unugyada ee loo yaqaan 'ENTERS' ee lagu sii daayo daroogada ee ku jira nidaamyada matriphilic matrix

QODOBKA QODOBKA, gaar ahaanHydroxypropyl methylrcellesulose (HPMC), waxaa si weyn loogu shaqeeyaa qaababka dawooyinka ee la xakameynayo ee lagu sii daayo daroogada ee nidaamyada matrix ee hydrophilic matrix. Siidaynta la xakameeyay ee daroogada ayaa muhiim u ah in la wajaho natiijooyinka daweynta, yareynta waxyeelooyinka, iyo kor u qaadista u hoggaansanaanta bukaanka. Waa tan sida ay ka qaataan gobolka

1. Nidaamka matrix-ga hydrophilic matrix:

• Qeexitaan: Nidaamka matriplic-ka hydrophilic waa nidaam gaarsiinta daroogada ee maaddada dawooyinka firfircoon (api) la kala firdhiyey ama lagu dhejiyo matrophilic polymer polymer polymer.
• Ujeeddada: Matrix-ka ayaa xakameynaya siidaynta daroogada iyadoo la moodayo kala-goynta dhiigga ee polymer.

2. Doorka qabashada unugyada unugyada (tusaale, HPMC):

• Muuqaallada velcosis iyo qaab dhismeedka gel-sameynta:
  • HPMC waxaa lagu yaqaanaa awooda ay u leedahay inay sameyso gels waxayna kordhisaa aragtida xalka aqueous.
  • Nidaamyada Matrix, HPMC waxay gacan ka geysaneysaa samaynta matrix-ka gelatinous ee awood u leh daroogada.
• Dabeecadda hydrophilic:
  • HPMC waa mid aad u daran biyo-biyoodka, iyadoo la fududeeyo is-dhexgalka biyaha ee ku jira marinka caloosha.
• Barar la xakameeyay:
  • Markaad la xiriirto dareeraha caloosha, matriophilic matrix-ka hyrophic wuu bararaa, oo abuuraya lakabka gel hareeraha walxaha dawada.
• Daroogada tamarta:
  • Dawada ayaa si isku mid ah u kala firidhsan ama ku xakameysay matrix gel.

3. Habka loo xakameeyo la xakameeyo:

• Kala-sooca iyo nabaad guurka:
  • Siidaynta la xakameeyo waxay ku dhacdaa isku darka kala-goynta kala-goynta iyo qaababka nabaad-guurka.
  • Biyuhu waxay galeen matrix, taasoo horseedaysa barar, iyo daroogada waxay ku kala duwantahay lakabka gel.
• Amarka Eda-Amarka
  • Astaanta siideynta ee la xakameysay ayaa inta badan raacaysa kenhic-darada eber-amarrada, iyadoo la siinayo heerka sii-deynta daroogada ee isdaba joog ah waqti ka dib.

4. Waxyaabaha saameeya dawada siidaynta dawada:

• U fiirsashada polymer:
  • U fiirsashada HPMC ee matrix-ka ayaa saameyn ku leh heerka siideynta daroogada.
• Miisaanka Molecalar ee HPMC:
  • Darajooyinka kala duwan ee HPMC oo leh miisaanka modol-ka molikal-ka ee kala duwan ayaa loo xulan karaa si loo habeeyo astaanta siideynta.
• Xoolaha Daroogada:
  • Xoolaha daroogada ee matrix waxay saameyn ku leedahay sii deynta sii deynta.
• Prosity Matrix:
  • Heerka geedaha gel bararka iyo porsis prosity ee isqarxintu waxay saameyn ku leedahay kala-goynta daroogada.

5. Faa'iidooyinka ka mid ah anshaxa kaynta unugyada ee nidaamyada matrix:

• Biyo-yareeynta: Qeexida unugyada unugyada ayaa guud ahaanba biococomplepent iyo si fiican loo dulqaadan karo mareenka caloosha.
• Kala-takoorka: Darajooyinka kala duwan ee anshaxa unugyada unugyada waxaa loo dooran karaa inay gaaraan astaanta siidaynta la doonayo.
• Deganaansho: AKHRISKA QIIMEYNTA QARSOONKA Waxay siisaa xasillooni aawadeed nidaamka matrix, hubinta sii-deynta daroogada oo isdaba joogta waqti ka dib.

6. Codsiyada:

• Bixinta daroogada afka ah: Nidaamyada hydrophilic matrix-ka waxaa badanaa loo isticmaalaa qaababka dawada afka ah, iyagoo siinaya siidayn la sii waday oo la xakameeyo.
• Shuruudo daba-dheeraaday: Ku habboon daroogada loo isticmaalo xaaladaha daba-dheeraada halkaas oo loo sii daayo daroogada joogtada ah ee ay faa'iido leedahay.

7. Tixgalinta:

• Kordhinta Samaynta: Qaab-dhismeedka waa in lagu hagaajiyaa si loo gaaro astaanta siidaynta daroogada ee la doonayo ee ku saleysan shuruudaha daweynta daroogada.
• U hoggaansanaanta sharciyeynta: Qormada kelida ee loo adeegsado dawooyinka waa inay u hoggaansamaan heerarka sharciyeynta.

U adeegsiga qalliinka unugyada ah ee ku jira nidaamyada hydrophilic matrix-ga matrix-ka waxay u nugulsaamiyadooda qaababka dawooyinka, oo bixiya qaab isku mid ah oo wax ku ool ah si loo gaaro sii-deynta daroogada ee gacanta lagu hayo.