Hydroxypropyl methylcellulose (HPMC) waa polymer-ka biyaha ku milma oo caadi ahaan loo isticmaalo, si weyn loogu isticmaalo dawooyinka, waxyaalaha la isku qurxiyo, cuntada iyo warshadaha, gaar ahaan diyaarinta jelka. Hantideeda jireed iyo habdhaqanka kala diridda ayaa saameyn weyn ku leh waxtarka codsiyada kala duwan. Heerkulka gelation ee HPMC gel waa mid ka mid ah sifooyinka muhiimka ah ee jirka, kaas oo si toos ah u saameeya waxqabadkiisa diyaarinta kala duwan, sida sii-deynta la kantaroolo, sameynta filimka, xasilloonida, iwm.
1. Qaab dhismeedka iyo sifooyinka HPMC
HPMC waa polymer-ka biyaha-milmi kara oo la helay iyada oo la soo saaray laba beddel, hydroxypropyl iyo methyl, oo la galiyay qalfoofka molecular cellulose. Qaab dhismeedkeeda kelli waxa uu ka kooban yahay laba nooc oo beddel ah: hydroxypropyl (-CH2CHOHCH3) iyo methyl (-CH3). Waxyaabaha ay ka midka yihiin maadooyinka kala duwan ee hydroxypropyl, heerka methylation, iyo heerka polymerization ayaa saameyn muhiim ah ku yeelan doona milanka, dabeecadda gelling-ka, iyo sifooyinka farsamada ee HPMC.
Xalalka aqueous, AnxinCel®HPMC waxay samaysaa xalalka kolloidal ee deggan iyadoo la samaynaysa curaarta hydrogen iyo molecules biyaha iyo la falgalka qalfoofkeeda ku salaysan cellulose. Marka jawiga dibadda (sida heerkulka, xoogga ionic, iwm.) is beddelo, isdhexgalka ka dhexeeya molecules HPMC ayaa isbeddeli doona, taas oo keenta gelation.
2. Qeexida iyo saamaynta saamaynta heerkulka gelation
Heerkulka Gelation ( Heerkulka Gelation, T_gel) waxaa loola jeedaa heerkulka uu xalka HPMC ka bilaabo ka beddelashada dareeraha una guuro adag marka heerkulka xalku kor u kaco ilaa heer gaar ah. Heerkulkan, dhaqdhaqaaqa silsiladaha molecular ee HPMC waa la xaddidi doonaa, samaynta qaab-dhismeedka shabakad saddex-geesood ah, taasoo keentay walax jel oo kale ah.
Heerkulka gelation ee HPMC waxaa saameeya arrimo badan, mid ka mid ah arrimaha ugu muhiimsan waa content hydroxypropyl. Marka lagu daro maadada hydroxypropyl, arrimaha kale ee saameeya heerkulka jelka waxaa ka mid ah miisaanka molecular, xoojinta xalka, qiimaha pH, nooca dareeraha, xoogga ionic, iwm.
3. Saamaynta maadada hydroxypropyl ee heerkulka jelka HPMC
3.1 Korodhka maadada hydroxypropyl waxay keenaysaa korodhka heerkulka jelka
Heerkulka gelation ee HPMC wuxuu si dhow ula xiriiraa heerka beddelka hydroxypropyl ee unugyadiisa. Marka maaddada hydroxypropyl ay korodho, tirada beddelka hydrophilic ee silsiladda molecular ee HPMC ayaa kordheysa, taasoo keentay is-dhexgalka sare ee u dhexeeya molecule iyo biyaha. Isdhexgalkaani wuxuu keenaa in silsiladaha molecular ay sii fidaan, si ay u yareeyaan xoogga isdhexgalka ka dhexeeya silsiladaha molecular. Qayb gaar ah oo ka mid ah fiirsashada, kordhinta maadada hydroxypropyl waxay gacan ka geysataa kor u qaadista heerka fuuq-baxa waxayna kor u qaadaa habaynta wadajirka ah ee silsiladaha molecular, si qaab-dhismeedka shabakad uu u samayn karo heerkul sare. Sidaa darteed, heerkulka gelation caadi ahaan wuu kordhiyaa iyadoo hydroxypropyl ay kor u kacdo iyada oo la kordhinayo maadada.
HPMC oo leh maaddooyin sare oo hydroxypropyl ah (sida HPMC K15M) waxay u janjeertaa inay muujiso heerkul gelation sare oo la mid ah AnxinCel®HPMC oo leh maaddo hydroxypropyl hoose ah (sida HPMC K4M). Tani waa sababta oo ah maadada hydroxypropyl ee sare waxay ka dhigaysa mid aad u adag in molecules ay is dhexgalaan oo ay sameeyaan shabakado heerkul hoose ah, oo u baahan heerkul sare si ay uga gudbaan fuuq-celintan oo ay kor u qaadaan isdhexgalka intermolecular si ay u sameeyaan qaab-dhismeedka shabakad saddex-cabbir ah. .
3.2 Xiriirka ka dhexeeya nuxurka hydroxypropyl iyo xoojinta xalka
U fiirsashada xalalka sidoo kale waa arrin muhiim ah oo saameeya heerkulka gelation ee HPMC. Xalalka HPMC ee xoogga leh, isdhexgalka isdhexgalka ayaa ka xoog badan, markaa heerkulka gelation wuxuu noqon karaa mid sarreeya xitaa haddii maadada hydroxypropyl ay hooseeyso. Heerkulka hoose, isdhexgalka ka dhexeeya molecules HPMC waa daciif, xalkuna wuxuu u badan yahay inuu galo heerkul hoose.
Marka maadada hydroxypropyl ay korodho, inkasta oo hydrophilicity-ku uu kordho, heerkul sare ayaa weli loo baahan yahay si loo sameeyo jel. Gaar ahaan xaaladaha feejignaanta hooseeya, heerkulka gelation-ka ayaa si aad ah u kordha. Tani waa sababta oo ah HPMC oo leh maadooyin sare oo hydroxypropyl ah ayaa aad u adag in la keeno isdhexgalka silsiladaha molecular iyada oo loo marayo isbeddelka heerkulka, iyo geeddi-socodka gelation wuxuu u baahan yahay tamar kulayl oo dheeraad ah si looga gudbo saameynta fuuqbaxa.
3.3 Saamaynta maadada hydroxypropyl ee habka gelation
Qayb gaar ah oo ka kooban hydroxypropyl, habka gelation-ka waxaa u badan isdhexgalka ka dhexeeya fuuq-celinta iyo silsiladaha molecular. Marka maadada hydroxypropyl ee ku jirta molecule HPMC ay hooseyso, fuuq-baxa waa daciif, isdhexgalka ka dhexeeya molecules waa mid xoogan, heerkulka hoose wuxuu kor u qaadi karaa sameynta jel. Marka maadada hydroxypropyl ay ka sarreyso, fuuq-baxa ayaa si weyn loo wanaajiyey, isdhexgalka ka dhexeeya silsiladaha molecular wuxuu noqonayaa mid daciif ah, heerkulka gelation-ka ayaa kordha.
Mawduuca sare ee hydroxypropyl waxa kale oo laga yaabaa inuu horseedo korodhka viscosity ee xalka HPMC, isbeddel mararka qaarkood kordhiya heerkulka bilawga ah ee gelation.
Waxyaabaha ku jira Hydroxypropyl waxay saameyn weyn ku leedahay heerkulka gelation-kaHPMC. Marka maaddada hydroxypropyl ay korodho, hydrophilicity ee HPMC wuu kordhaa iyo isdhexgalka silsiladaha molecular wuu daciifaa, sidaa darteed heerkulkeeda gelation caadi ahaan wuu kordhaa. Dhacdadan waxaa lagu sharxi karaa habka isdhexgalka ee u dhexeeya fuuq-celinta iyo silsiladaha molecular. Iyadoo la hagaajinayo nuxurka hydroxypropyl ee HPMC, xakamaynta saxda ah ee heerkulka gelation ayaa lagu gaari karaa, taas oo kor u qaadeysa waxqabadka HPMC ee daawooyinka, cuntada iyo codsiyada kale ee warshadaha.
Waqtiga boostada: Jan-04-2025