Hydroxypropyl methylcellulose (HPMC) waa polymer isku dhafan oo leh labadaba hydrophobic iyo hydrophilic, taas oo ka dhigaysa mid u gaar ah codsiyada kala duwan ee warshadaha kala duwan. Si loo fahmo hydrophobicity iyo hydrophilicity ee HPMC, waxaan u baahannahay inaan si qoto dheer u barano qaab-dhismeedkeeda, guryaha iyo codsiyada.
Qaab dhismeedka hydroxypropyl methylcellulose:
HPMC waa nooc ka soo jeeda cellulose, polymer dabiici ah oo laga helo gidaarada unugyada dhirta. Wax ka beddelka cellulose waxay ku lug leedahay soo bandhigida hydroxypropyl iyo kooxaha methyl ee laf dhabarta cellulose. Wax ka beddelkaani wuxuu bedelayaa sifooyinka polymer-ka, isagoo siinaya sifooyin gaar ah oo faa'iido u leh codsiyo kala duwan.
Hydrophilicity ee HPMC:
Hydroxy:
HPMC waxa uu ka kooban yahay kooxaha hydroxypropyl waana hydrophilic. Kooxahan hydroxyl waxay xidhiidh sare u leeyihiin molecules-ka biyaha taasoo ay ugu wacan tahay isku xidhka haydaroojin.
Kooxda Hydroxypropyl waxay samayn kartaa curaarta hydrogen oo leh unugyo-biyood, taasoo ka dhigaysa HPMC inay biyaha ku milmaan ilaa xad.
methyl:
Iyadoo kooxda methyl ay gacan ka geysato guud ahaan hydrophobicity ee molecule, kama hortagayso hydrophilicity ee kooxda hydroxypropyl.
Kooxda methyl waa mid aan ahayn polar, laakiin joogitaanka kooxda hydroxypropyl ayaa go'aamisa dabeecadda hydrophilic.
Hydrophobicity ee HPMC:
methyl:
Kooxaha methyl ee HPMC waxay go'aamiyaan ilaa xad hydrophobicity.
In kasta oo aanay ahayn sida hydrophobic sida qaar ka mid ah polymers-ka si buuxda loo sameeyay, joogitaanka kooxaha methyl waxa ay yaraynaysaa guud ahaan hydrophilicity ee HPMC.
Guryaha sameynta filimada:
HPMC waxay caan ku tahay astaamaheeda samaynta filimada waxaana inta badan laga faa'iideystaa codsiyada dawooyinka iyo qurxinta. Hydrophobicity waxay gacan ka geysataa sameynta filim ilaalin ah.
Isdhexgalka walxaha aan dabaylaha ahayn:
Codsiyada qaarkood, HPMC waxay la falgeli kartaa walxaha aan dabaylaha ahayn sababtoo ah qayb ahaan hydrophobicity. Hantidan ayaa muhiim u ah nidaamka gudbinta daroogada ee warshadaha dawooyinka.
Codsiyada HPMC:
daroogada:
HPMC waxa si weyn loogu isticmaalaa habaynta dawooyinka sida xidhe, filim hore, iyo wax ka beddelka viscosity. Awooddeeda filim-samaynta waxay sahlaysa in la xakameeyo siidaynta daroogada.
Waxa loo isticmaalaa qaab qiyaaseed adag oo afka ah sida kiniiniyada iyo kaabsalka.
Warshadaha dhismaha:
Qaybta dhismaha, HPMC waxaa loo isticmaalaa wax soo saarka sibidhka ku salaysan si loo hagaajiyo karti-shaqsiyeedka, haynta biyaha iyo ku dhegganaanshaha.
Hydrophilicity waxay caawisaa in biyaha la ceshado, halka hydrophobicity ay ka caawiso hagaajinta xabagta.
warshadaha cuntada:
HPMC waxa loo istcimaalaa sidii dhumucdiye iyo wakiilka jelling ee warshadaha cuntada. Dabeecaddeeda hydrophilic waxay ka caawisaa samaynta jeelyada xasiloon waxayna xakamaysaa viscosity ee alaabta cuntada.
qurxinta:
Qaababka la isku qurxiyo, HPMC waxaa loo isticmaalaa alaabada sida kiriimyada iyo labeennada ay ka midka yihiin samaynta filimaanta iyo waxyaalaha dhumucdooda.
Hydrophilicity waxay hubisaa fuuq-baxa wanaagsan ee maqaarka.
Gabagabadii:
HPMC waa polymer ka mid ah hydrophilic iyo hydrophobic labadaba. Isku dheelitirka u dhexeeya kooxaha hydroxypropyl iyo methyl ee qaabdhismeedkeeda ayaa siinaya kala duwanaansho gaar ah, taas oo u oggolaanaysa inay haysato codsiyo kala duwan. Fahamka guryahan ayaa muhiim u ah ku-habaynta HPMC ee isticmaalka gaarka ah ee warshadaha kala duwan, halkaas oo awoodda HPMC ay kula falgasho biyaha iyo walxaha aan polarka ahayn loo isticmaalo ujeedooyin kala duwan.
Waqtiga boostada: Dec-15-2023