Melemo ea HPMC (Hydroxypropypropyproxel methylcelulose) indastering ea pharmacele e bontšoa likarolo tse ngata, 'me thepa ea hae e ikhethang e etsa hore e sebelisoe ka bongata.
1. LITLHAKISO TSE KHOLO TSA BOTSOALLE LE LITLHAKISO
HPMC ke thepa e qholotsang metsi e nang le thepa e ntle ea ho teba le e greaming. Ho iphahamisa meroho, HPMC e ka sebelisoa e le thipa le moemeli oa ho hlophisa hore o ntlafatse pono le botsitso ba litokisetso. Sena se bohlokoa haholo ho litokisetso tsa metsi (joalo ka lino tsa molomo le marotholi), tse ka ntlafatsang thepa ea Rheology le ho etsa bonnete ba ho tšoana le botsitso.
2. Bicondomatight
HPMC e na le biocompatice e ntle le phetiso ea biodogramate Kaha e tsoa ho limela, HPMC ha e chefo ebile e se kotsi ho 'mele oa motho, e fokotsa kotsi ea ho etsa lintho tse bohloko ea lithethefatsi.
3. Thepa ea ho lokolloa
HPMC hangata e sebelisoa ho lokisa litefiso tse rekotiloeng le litokisetso tsa lithethefatsi tse tobileng. Thepa ea eona ea hydration e ka laola sekhahla sa ho lokolloa ha moriana, ho fihlela ho lokolloa ha lithethefatsi, fokotsa khafetsa ho holisa tsamaiso, le ho ntlafatsa ho latela mamello. Senotlolo sena se bohlokoa haholo tšoaro ea mafu a sa foleng a sa foleng, a kang hypertte le lefu la tsoekere.
4. Ho tsitsipana hantle le botsitso
HPMC e qhibiliha habonolo ka metsing mme e ka lula e tsitsitse tlasa maemo a fapaneng a ph. Sena se e lumella ho sebelisoa haholo mefuta e fapaneng ea litokisetso tsa meriana. Ebang ke tikolohong ea acidic kapa ea alkaline, hpMC e khona ho boloka tšebetso ea eona le ho netefatsa botsitso ba sethethefatsi.
5. Ntlafatsa BiaAvali motle ea lithethefatsi
HPMC e ka ntlafatsa phallo ea bilavali motle ea lithethefatsi tse itseng, haholo-holo bakeng sa lithethefatsi tse qhibilihileng. Ka ho kopanya lithethefatsi, HPMC e ka ntlafatsa ho monya lithethefatsi 'meleng ebe u ntlafatsa phello ea kalafo. Sena ke sa bohlokoa bo boholo bakeng sa nts'etsopele ea lithethefatsi tse ncha, haholo-holo litlhare tse nyane le lithethefatsi tsa likokoana-hloko.
6. Formetop e ntle
Ts'ebetsong ea meriana, HPMC e ka sebelisoa e le mokhoa oa ho hlophisoa ha matlapa le li-capsules ho ntlafatsa sebopeho le thata tsa litokisetso. E ka ntlafatsa maikutlo a moriana, netefatsa hore o tšoana le botsitso ba matlakala le ho fokotsa sekhahla sa bophahamo.
7. Ho etsa kopo e pharaletseng
HPMC e lumellana le lithethefatsi tse fapaneng 'me e sebelisoa haholo litopo, lilabiso, liliba, li-lolm.
8. Litsenyehelo tse tlase
Ha ho bapisoa le lisebelisoa tse ling tsa polymer, HPMC e na le litšenyehelo tse tlase, 'me thepa ea eona ea lik'hemik'hale e ka fetoloa ka ho fetola boemo ba li-hydroyl. Ka hona, ts'ebeliso ea HPMC indastering ea meriana ha e ntlafatse feela ts'ebetso ea sehlahisoa, empa hape e fokotsa litšenyehelo tsa tlhahiso.
Ts'ebeliso e pharalletseng ea HPMC indastering ea meriana e hlahisoa ke thepa e ngata e mengata haholo. Hore na HAAvavalivality ea lithethefatsi le Sebeletso ea Lithethefatsi Kapa ho Ntlamisetsa Melemo ea Litokisetso, HPMC e bontšitse melemo ea bohlokoa. Ka ntlafatso ea theknoloji ea meriana, tebello ea ts'ebetso ea HPMC e ntse e pharaletse, 'me ho lebelletsoe ho ba le karolo e kholo ho nts'etsopele le tlhahiso ea lithethefatsi tse ncha.
Nako ea poso: Sep-26-2024