Ts'ebeliso ea lisebelisoa tse thusang tsa hydroxypropyl cellulose ho boithuto bo tiileng

Contlase ea hydroxypropyl, ho hlomphuoa ha meriana, e arotsoe ka celdroxypropypropyl cellulose (L-hpc) le hydroxypropypropypropyl cellulose ea hydrox ea hau e nkiloeng. L-hpc e kena ka tharollo ea colloidal ka metsing, e na le thepa ea ho latela moea, e nang le thepa ea ho latela moea, sebopeho sa lifilimi, e entsoe e le moemeli ea sa tsitsang Le ha H-hpc e qhibiliha ka metsing le li-solvent tsa manyolo mocheso oa kamore, 'me e na le thermoplatrical. , ho hokahana le thepa ea lifilimi, filimi e thehileng, e benya ebile e sebelisoa e le ntho e etsang lintho tse etsang lifilimi le thepa e koahelang lifilimi. Ts'ebeliso e ikhethang ea Clldroxypropyl Clloulose ea litokisetso tse tiileng hona joale e se e tsebisitsoe.

1. E le ho se be le tšilafalo bakeng sa litokisetso tse tiileng tse kang matlapa

Bokaholimo ba setšoantšo sa Hydroxypropyl likaroloana tsa kristale tsa kristale tsa crystalli li sa lekana, tse nang le sebopeho se kang majoe. Sebopeho sena se se nang palo ha se se e etsa sebaka se seholo feela, empa le ha ho hatisoa letlapa hammoho le lithethefatsi tse ngata haholo ka matlapeng, e le hore leseli le ka eketsa mongobo sekhahla sa ho monya le maemo a metsi a eketseha. U sebelisaL-hpcJoalokaha ho hlomphuoa ho ka etsa hore letlapa le belehe ka potlako phofo ea junifomo, 'me le ntlafale haholo ho qhalana haholo, ho qhalana le ho felisoa ha letlapa. Mohlala, tšebeliso ea L-HPC e ka potlakisa ho sitisoa ha matlapa a paracetamol, matlapa a aspirin le matlapa a chlopromine, le ho ntlafatsa sekhahla sa disfor. Ho qhalana le ho felisoa ha lithethefatsi tse qhibilihang tse joalo ka matlapa a matala a kang l-hpc Using L-HPC as an internal disintegrant of the granules in the capsules is beneficial to the disintegration of the granules, increases the contact surface area between the drug and the dissolution medium, promotes the dissolution of the drug, and improves the bioavailability. Litokisetso tse tiileng kapele li emeloang kapele ho lokisoa ka potlako le litlatsetso tse tiileng tsa ho qhibiliha ka potlako, lithethefatsi tse fokotsehileng, 'me li bonolo ho li nka 'me u tsebe ho lateloa hantle. Melemo e meng, e etsa boemo ba bohlokoa tšimong ea meriana. L-HPC e fetohile e 'ngoe ea litokisetso tsa bohlokoa ka ho fetisisa bakeng sa litokisetso tse tiileng tsa hydrophphilication, lebelo la li-hygroscopity, lebelo la ho monya metsi le ho monya metsi a potlakileng. Ke tšenyo e ntle bakeng sa litafole tse sa feleng. Matlapa ka molomo a paracetamol a ne a lokiselitsoe le L-HPC e le ho senyeha, 'me matlapa a ile a arohana kapele nakong ea 20s. L-HPC e sebelisoa e le moferefere bakeng sa matlapa, 'me litekanyetso tsa eona tse akaretsang ke 2% ho 10%, boholo ba 5%.

2. E le mokhoa oa ho lokisa tse kang matlapa le granules

Sebopeho se thata sa L-HPC se boetse se etsa hore e be le phello e meholo ea lithethefatsi le lipisisi, e eketsang bongoli ba botsofe. Ka mor'a ho hatelloa litafole, ho bontša ho thata haholo le ho lela, ka hona, ho ntlafatsa boleng ba ponahalo ea tafole. Haholo-holo bakeng sa matlapa a thata ho alima, a hlephileng kapa a bonolo ho a bona, ho eketsa L-HPC ho ka ntlafatsa phello. Letlapa la Ciprofloxloxide le na le khatello e mpe, ho aroloa le ho ba thata, 'me tekanyo e ntle e na le litlhoko tse tloaelehileng. Kamora ho kenyelletsa L-HPC letlapeng le ka fokolloang, ponahalo ea eona, ponahalo ea eona, ho senyeha, ho lahla lintho tse itseng le likarolo tse ling ho ntlafatsoa haholo. Kamora setumeliso ho ngaka ea pele e nkeloa sebaka ke L-HPC, ho thatafala ha letlapa le lahlehileng tsa letlapa la pele ho ile ha rarolloa. L-HPC e sebelisoa e le motaki oa matlapa, 'me ketso e akaretsang e 5% ho 20%; Le ha H-hpc e sebelisoa e le motaki oa matlapa, granules, joalo-joalo, 'me phello e akaretsang e le 1% ho ea pele ho 5% ho ea ho 5% ho 5% ho litokisetso.

3. Sebetsa leqepheng la lifilimi le litokisetso tse matlafatsang le tse laoloang

Hajoale, lisebelisoa tse tsitsitseng tsa metsi hangata li sebelisoang ho chiating ea lifilimi li kenyelletsa hydroxypropyLyproPulloseth (HPMCLCEUNDEA HeldroxypropyLel clloulose hangata e sebelisoa e le moemeli oa lifilimi ka lebaka la lifilimi ka lebaka la ho ba thata, e nang le motlakase. Haeba celdroxypropyl Cemulose e tsoakoa le batho ba bang ba loantšang mocheso, ts'ebetso ea bosholu ba eona e ka ntlafatsoa haholoanyane.

Ho sebelisa litšoaneleho tse loketseng le mekhoa ea ho etsa matlapa a matrim, matlapa a maholo a ho atisa, le matla a botšehaling le a mang a laoloang ke ho amohela lithethefatsi le ho tiisa sethethefatsi maling. Ho tsepamisa mohopolo, ho fokotsa karabelo e mpe, meriana e mengata, 'me u loanele ho eketsa phello e hlakileng ka tekanyetso e nyane haholo,' me u fokole. HydroxypropypropyLel ke e 'ngoe ea tse tummeng tsa litokisetso tse joalo. Ho qhalana le ho lokolloa ha matlapa a sodium sodium a laoloa ke ho sebelisa celdroxypropypropyl cellulose le lisebelisoa tsa bo-Skeleton. Kamora tsamaiso ea molomo le ho ikopanya le lero la gastric, bokaholimo ba matlapa a digloferial sodium e tsitsitseng li tla isoa ka serethe. Ka lebaka la ho felisoa ha gel le ho afforal tsa limolek'hule tsa lipalesa tsa sel lekhalo la limoletsi, morero oa ho lokolloa butle-butle ke ho fihlella. HydroxyproPypropyl Cellulose ea Tloaelo ea Letlapa, ha litaba tsa sesebelisoa sa blocker li lula li le teng kamehla, le moriti ho letlapeng le nang le litaba tse phahameng Ho lokolloa ha hydroxypropyl tokollo e liehang. Lipere tse kopaneng li ne li hlophisitsoe ka ho sebelisaL-hpcle karolo e itseng ea HPMC e le tharollo ea koae bakeng sa ho koaheloa e le karolo ea ho ruruha ha ho hlaseloa ka cellular. Ha lengolo la ho ruruha la leru le ruruhang le laola ho laola botebo ba karolo e laoloang, liperekisi tse koahetsoeng li ka lokolloa makhetlo a fapaneng a neng a lebelletse. Mefuta e mekae ea li-pellets tse koahetsoeng ka boima ba 'mele e fapaneng ea khoele e laoloang li tsoakane ho etsa li-capsules tse tšehelitsoeng ke Shungongod. Ka mokhoa oa khefu ea khefu, li-pellets tse fapaneng tse fapaneng li ka lokolla lithethefatsi ka linako tse fapaneng, e le hore thepa ea lik'hemik'hale e fihle ka nako e ts'oanang le tokollo e tsitsitseng


Nako ea ho romella: April 25-2024