Litlhahlobo tse amanang le lipono le linaheng tse ling ho itokisetsa ho hlophisoa ha hydrocpropypropy Likopo naheng ea liforomo tse ncha tse kang ho latela litlhare tse khomarelang le li-biodheshives. Ka lebaka la phapang ea boima ba li-molek'huoana le pono ea li-hpmc, e na le litšobotsi tsa ho tsubella, ho ts'oaroa, ho emisoa, ho emisoa le ho theha lifilimi. E sebelisoa haholo litokisetsong tsa meriana mme e tla bapala karolo e kholo tšimong ea litokisetso. Ka thuto ea botebo ba thepa ea eona le ntlafatso ea theknoloji ea mofuta oa theknoloji ea maqhubu a macha le lits'ebetso tsa ho tsamaisa lithethefatsi tse ncha, ka tsela eo e khothaletsa nts'etsopele ea liforomo.
hydroxypropypropinyl methylcell; Litokisetso tsa meriana; Litlhaloso tsa meriana.
Litlhaloso tsa meriana ha se feela thepa ea ho thehwa ha lithethefatsi, boleng ba lithethefatsi le botsitso, mokhoa oa ho lokolloa, le nts'etsopele ea kliniki mefuta ea dosage le litsela tse ncha tsa tsamaiso. amanang ka hloko. Ho hlahella ha li-armaties tse ncha tsa meriana hangata li khothaletsa ntlafatso ea boleng ba boitokiso le nts'etsopele ea liforomo tse ncha tsa dosage. HydroxypropypropypropinyL methylcelllulose (HPMC) ke e 'ngoe ea litšoaneleho tse tsebahalang ka ho fetisisa meriana lapeng le kantle ho naha. Ka lebaka la boima ba eona ba moleng le pono, e na le lits'ebetso tsa ho hohela, ho tlamo, ho holisa, ho emisoa. Litlatsetso le ts'ebeliso tse kang ho cheoa le ho theoa ha Filimi li sebelisoa hohle theknoloji ea pharma. Sengoliloeng sena se re sengoliloeng sena li hlahloba ts'ebetso ea hydroxypropyproppyl methylcelllulo, HPMC) ho liforomo lilemong tsa morao tjena.
1.Thepa ea mantlha ea HPMC
Hydroxypropypropypropypropypropiny, formular ea limolecule ke c8h15o8) n- c8h15o8) n- C8h15O8) ea cellulose. E ka hlahisoa ka litsela tse peli: Nako ea karabelo e tlameha ho nka nako e telele ho lumella methyl le hydroxy e hokahane le selikalikoe sa selefounu, mme se ka fihla ho nako e hlokoa; E 'ngoe ke ho phekola k'hothone kapa ho putlama ha pate ea pater ka soda ea catane le proprisene ka katleho, ebe ebe re tsoela pele. , e sithabetseng le phofo kapa granules.
'Mala oa sehlahisoa sena o tšoeu Miny White o tšoeu, o se na ntho e sa utloahaleng ebile o sa utloe,' me sebopeho ke phofo ea granular kapa e bobebe e bobebe. Sehlahisoa sena se ka qhibiliha ka metsing ho theha tharollo ea colloidal e tšoeu e tšoeu ea lebese le 'mala o mosoeu oa li-colloidal e nang le pono e itseng. Pheno ea sol-gel e kopaneng e ka hlaha ka lebaka la phetoho ea mocheso ea tharollo e nang le mahloriso a itseng.
Ka lebaka la phapang ea litaba tsena tse peli ka sebopeho sa mekhoa ea methonox le hydroxypropypropyl, mefuta e fapaneng ea lihlahisoa e hlahile. Ka meahong e tobileng, mefuta e fapaneng ea lihlahisoa e na le litšobotsi tse ikhethang. Visscossity le mocheso oa khanya ea motlakase, ka hona li na le thepa e fapaneng mme li ka sebelisoa bakeng sa merero e fapaneng. Phallo ea linaha tse fapaneng e na le litaelo tse fapaneng mohlala: The European Pharmas ". Ho The Pharmacopoia, linomoro tse 4 li eketsoa kamora lebitso la liphane ho bonts'a litaba le mofuta oa hydroxypropyLulose 2208. Peresente, linomoro tse peli tsa ho qetela li supa liperesente tse lekanang tsa hydroxypropyl.
HydroxypropyL methylcellselese o na le li-3 Lisebelisoa, tsa letoto le Series le Kiti tsa Series le Kitis, letoto le le leng li na le mefuta e fapaneng ho khetha. Lithato li sebelisoa haholo joalo ka makhapetla a lifilimi, a sebelisetsoang ho koahela letlapa, li-cores tsa matlakala; E, leqele le sebelisoa e le liketsahalo tsa Viscosilifers tsa Viscosilifers tsa Prices bakeng sa Litokisetso tsa Ophllhanic, li-granune tsa litokisetso, matlapa a metsi a metsi, matlapa a granules; KRT ea lihlooho e sebelisoa haholo joalo ka lisebelisoa tsa hydrophilic tsa hydrophilic tsa hydrophilic gel matrix
Baetsi ba lapeng ba kenyelletsa haholo Fuzhou No. ., Ltd., Xi'an Huian Barmm ba lik'hemik'hale, joalo-joalo
2.Melemo ea HPMC
HPMC e fetohile e 'ngoe ea meriana e sebelisoang haholo malapeng le kantle ho naha, hobane HPMC e na le melemo eo e seng na eona.
2.1 Scobility ea Metsi a batang
O qhibiliha ka metsing a batang ka tlase ho 40 ℃ kapa 70%, ka ho hlaka, ha e le hantle, ha e le hantle ka metsing a chesang kaholimo ho 60 ℃, empa gel e ka khona.
2.2 ka lik'hemik'hale ka lik'hemik'hale
HPMC ke mofuta oa se seng sa Ioni sa Ionic
2.3 Ho tsitsa
E tsitsitse ho asiti le alkali, 'me e ka bolokoa nako e telele pakeng tsa PH 3 le 11 ntle le phetoho ea bohlokoa Viscosty in. Tharollo ea metsi a HPMC e na le tšusumetso e anti-ford le boloka botsitso bo botle ba liqhomane tsa pono. Ho ba le litlatsetso tsa litlhare tse sebelisang HPMC ho na le botsitso ba boleng bo botle ho feta ba sebelisang tsebiso ea setso (joalo ka Dextrin, ETC.).
2.4 Liphetoho tsa liketsahalo tsa Viscosity
Li-derivavaticatives tse fapaneng tsa HPMC li ka fetoloa ho ea ka molao o itseng, ka hona, boholo bo ka khethoa ho latela litlhoko.
2.5 Metabolic ho loka
HPMC ha e kenelletse 'meleng, ebile ha e fane ka mocheso, kahoo ke boitokisetso bo sireletsehileng sa meriana. 2.6 Ts'ireletso ka kakaretso e nkuoa e le ntho e sa khopisang le e sa khopiseng lethali la mice ke tekanyetso ea litopo ke 5. 2 GQg. Tekanyetso ea letsatsi le letsatsi ha e na kotsi ho 'mele oa motho.
3.Kopo ea HPMC ka liforomo
3.1 Ha filimi e koahelang lifilimi le thepa e etsang lifilimi
Ho sebelisa HPMC e le thepa e entsoeng ka lifilimi, letlapa le kopaneng ha le na melemo e hlakileng ea matlapa le matlapa a setso a kang tsoekere, tekanyo ea mongobo. , phaello ea boima ba 'mele ea' mele ea ho koahela 'me e bontša boleng. Sehlopha sa Lihlahisoa tse tlase sa sehlahisoa sena se sebelisoa e le thepa e potlakileng ea metsi bakeng sa litafole le lipilisi, hangata litsamaiso tsa lifilimi tsa khale bakeng sa 2% ho isa ho tse 20 %.
Zhang Jixing et al. Sebelisa mokhoa oa ho phahamisa phello ho ntlafatsa foromo ea Premiv ho HPMC e le sekoaelo sa filimi. Ho nka li-filimi tse etsang lifilimi tsa filimi, palo ea polyvinyl afleylene glycol geronity Index le lintlha tsa tlhahlobo li hlalosoa ke mohlala oa lipalo, 'me ts'ebetso e nepahetseng ea ho theha e felile. Tšebeliso ea eona ke hydroxypropypropypropy-gethylcelllulos . Zhang Yuan o ile a ntlafatsa ts'ebetso ea ho hlophisa, a sebelisa hpmc e le blogros ea eona, 'me a ntlafatse matlapeng a eona a ho lokisa lifilimi,' me a leleka matla a hae a ho nchafala, ntlafatsa botsitso ba tafole. Ts'ebetso ea foromo e nepahetseng e ne e khethiloe ke liteko tsa Orthogonal, ho tsepamisa mohopolo ho ne ho le ka 70% Etanol nakong ea moralo oa granution e ne e le metsotso e 15. Liphetho tsa Jaheaua Combol li lokiselitsoe ke ts'ebetso e ncha le mongolo o ntlafalitsoeng hantle le sekhahla sa matlakala a mantlha a play-pele se ile sa ntlafala haholo la filimi. e fihlile ho tse fetang 95%. Liang Meiyi, Lu Xiahuai, joalo-joalo. ama ho lokolloa ha lithethefatsi. Huang Yung YINT e lokiselitsoeng ke mafura a nang le mali a holima mebala ea "COPMC e lekantsoeng ka tharollo e koahelang karolo ea sekaka sa ho ruruha, le karoloana ea eona e ne e le 5%. Ho ka bonoa hore HPMC e ka sebelisoa haholo tsamaisong ea lithethefatsi e lebisitsoeng.
HydroxyproPullpropypropyLulose ke lintho tse ntle haholo tsa baesekele, empa hape li ka sebelisoa e le thepa e khethollang lifilimi litabeng tsa lifilimi. Wang Tonun jj Proplyze Glycol o tobana le litlhokahalo tsa ho kholoa butle le polokeho, 'me li ka sebelisoa e le lengolo la filimi e hlophisitsoeng ea lifilimi.
3.2 joalo ka binder le ho qhalana
Sehlopha se tlase sa Viscosity sa sehlahisoa sena se ka sebelisoa e le mokhoa oa ho hlaba le ho silafatsa litafole, lipilisi le lihlahla le sehlopha se phahameng sa litaba se ka sebelisoa e le sebali. Tekanyetso e fapana ka mefuta le litlhokahalo. Ka kakaretso, litekanyetso tsa ho tlanya le matlaba a granulation a 5%, le litekanyetso tsa ho tlama le matlaba a granulation ea 2%.
Li houtao et al e hlakisitse tekanyetso ea matlapa a matlakala a tinidazole. 8% Polyvinylpylpylpronylpronedone (PVP-K30), 40% Hydroxypropypropypropy Ho hlophisoa ha matlapa a Tinidazole. Ponahalo ea matlapa a hlakileng le ka mor'a hore a khone ho oela le ho tsuba, ho ile ha lekanngoa moea oa ho qhalana. Liphetho li lokiselitsoe ke 2,0% hydroxypropyl methylcelulese li ne li le bobebe, 'me ka mor'a hore sebopeho sa matlaka se felletse,' me ha sebopeho se ne se nepahetse. Ka hona, matlapa a tinidazole a lokiselitsoe ka 2.0% hpmc-k4 le 50% Ethanol e le binders e neng e sebelisoa. Guan Shihai studied the formulation process of Fuganning Tablets, screened the adhesives, and screened 50% ethanol, 15% starch paste, 10% PVP and 50% ethanol solutions with compressibility, smoothness, and friability as evaluation indicators. , 5% cmc-na le likhakanyo tsa 15% hpmc tharollo (5 mpa s). Liphetho tse lokiselitsoeng ke 50% Ethanol, 15% starchs paseka, 10% PVP 50% Ethanol 15% Tharollo tharollo (5 Mpa ■ Bokaholimo ba le ho tšoaneleha, ba tšoanelehang, ba ka khotsofatsang litlhoko tsa ho koata. Ka hona, HPMC (5 mpa s) e ne e khethoa e le khomarela.
3.3 e le moemeli ea emisang
Sehlopha sa liketsahalo tse phahameng tsa sehlahisoa sena se sebelisoa e le moemeli ea emisang ho pheha mofuta oa ho emisoa ha mofuta oa ho emisoa. E na le phello e ntle e hooa, ho bonolo ho e nchafatsa, ha e tšoarelle leboteng, 'me e na le likarolo tse ntle tsa lipalesa. Tekanyetso e tloaelehileng e tloaelehileng ke 0.5% ho 1.5%. Song Tian Et al. o sebelisitse lisebelisoa tse tloaelehileng tsa polymerpropxpropyLe methylceMelose, sodium carboxlese, sodium carboxese, methylcellulose, jj) ho emisoa ho omileng. Ka karohano ea bophahamo ba bophahamo ba ho hlonepha, ho ile ha hlahlojoa liketsahalo tsa lithethefatsi tse ka tlas'a liteko tse potlakileng li ne li potlakile. Liphetho tse ommeng li lokiselitsoe ka 2% HPMC e le hore moemeli ea emisang o na le ts'ebetso e bonolo le ho tsitsa hantle.
Ha ho bapisoa le methyl cellulose, hydroxyproplay methyl methyl methyl methyl celdous Liu Jie et al. HPMC, hydroxypropyLel conlulose (HPC), carboetylene glycol (Pegth في li khethoa e le matšoao a tlhahlobo ho hlahloba moemeli ea emisang ka ho fetisisa. Liphetho li bontša hore ho emisoa ha Acylovir optholmir o lokiselitsoeng ka 0.05% Ha e ntse e hlophisitsoe, ho ba le phetoho e tsitsitseng, 'me tokiso ke ntho e tsitsitseng.
3.4 Joalokaha blocker, e le moemeli ea liehang le a laoloang le moemeli oa pore
Sehlopha sa liketsahalo tse phahameng tsa sehlahisoa sena se sebelisetsoa ho hlophisoa ha matla a tobileng, li-blocker le baemeli ba lokollotsoeng ba lisebelisoa tse kopaneng, mme ba na le phello ea ho lokolloa ha lithethefatsi. Tlhokomeliso ea eona ke 10% ho isa ho 80%. Mekha e tlase ea libaka e tlase e sebelisoa e le li-porogens bakeng sa litokisetso tse sireletsehileng kapa tse rekotiloeng tse laoloang. Teka ea pele e hlokoang bakeng sa phello ea matla a matlapa a joalo e ka fihleloa kapele, ebe phello e lokollotsoeng kapa e sebetsang ea ho lokolloa e bolokiloe 'meleng. . Hydroxypropypropike methylcelubulose ho theha sekala sa gel ha ho kopana le metsi. Mokhoa oa ho lokolloa ha lithethefatsi ho letšoele ho tsoa ho The Morix ho kenyelletsa phapang ea mokato oa li-gel le khoholeho ea mothapo oa gel. Jung Bo Shim et al
HydroxypropypropiypropyLulose e boetse e sebelisoa haholo matlaleng a moriti oa setso sa China, le litokisetso tse sebetsang tsa moriana oa China oa China o sebelisoang. Liu Wn et al. E sebelisitsoe makhetlo a 15% hydroxypropyl methylceluse e le thepa ea matrix Mohlala ke karolo ea tuguchisi. Sistimi ea Metsoako ea Metsoako e bonolo, tokisetso e bonolo, 'me data ea ho lokolloa e tsitsitse, e nang le litlhoko tsa litlhophiso tsa China. Tang Guanguang et CA. Seketisi sa Kakaretso sa Astragaluse e le lithethefatsi tsa mohlala, li lokisa matlapa a HPMC matrix, 'me li ile tsa hlahloba lintlha tse amang matlotlo a moriti libakeng tse tloaelehileng tsa China ho HPMC Matrix. Liphetho ha litekanyetso tsa HPMC li ntse li eketseha, ho lokolloa ha lithethefatsi ho fokotsehile, 'me liperesente tsa moriana li na le kamano e haufi le sekhahla sa dissulor sa Matrix. Ka letlapa la hypromelellose HpMC matrix, ho na le kamano e itseng lipakeng tsa moriana o sebetsang oa litlhare tsa setso sa hpdrophilic le eona. Hydroxypropypropinyl Methylcelulolose ha e lokele litsomi tsa hydrophphilic, empa hape le bakeng sa lintho tse se nang hydrophilic. Liu guihua e sebelisitsoeng 17% hydroxypropypropity Methylcelulo (HPMK15L MethylceLulo (HPMK15L ea Matla Phetoho ea tokollo e tsitsitseng e ne e hlakile, 'me ts'ebetso ea tokiso e ne e tsitsitse ebile e ka etsahala.
HydroxypropypropinyL methylcelulose ha e sebelisoe matlapeng a matla a ho lokolloa le meriana e sebetsang ea meriana ea China ea China. Wu Huicuo et Al. E sebelisitsoe 20% hydroxypropypropyL methyl cellingulese (HPMCK4M Sapopon RG1, Ginsenoside Rb1 le Panax Notoginseng Sapolin RG1 Liphetho tsa lithethefatsi ho lokolla mochine o khahlano le equation ea zero-Order tsa zero-ea Riteger, moo likarolo tse tharo tsa Panatoginse li lokollotsoe ke khoho ea scheletal.
3.5 E sirelletsa glue e sirelletsang joalo ka thipa le colloid
Ha sehlahisoa sena se sebelisoa e le boloi, liperesente tse tloaelehileng tsa ho tsepamisa maikutlo ke 0.45% ho 1.0%. E ka boela ea eketsa botsitso ba sekhobo sa hydrophobic, se etsa hore likamore tse sirelletsang, li ka hlakoloa, ka ho etsa joalo li thibela ho etsoa ha leoatle. Li-porsess tsa eona tse tloaelehileng li na le 0.5% ho 1.5%.
Wang Zhen et al. Sebetsa Mokhoa oa Tlhaho ea Tlhaho ea L9 Orthogonal ho etsa lipatlisiso ka mokhoa oa ho hlophisa oa ho hlophisa khano ea meriana e kentsoeng. Maemo a tšebetso a ho qetela a qeto ea ho qetela ea khabone ea ho qetela ea khabone ea theko e tlase ea 0.0% e na le thipa, maemo a ts'ebetso a thusa ho ntlafatsa botsitso ba khabone ea mochini. Zhang Zhiqqiang et al. E thehiloe lebaleng la Levofloxitive Levoflonicin hydrochloride le sebelisa gel e tšehetsang Tlaleho e nepahetseng ea teko, qetellong fumana ngaka e nepahetseng ea Levoflox) 5 G, Hydropix , 0.03 g ea paraben, 'me metsi a ekelitsoe ho etsa 100 ml. Tlalelong, sengoli se ile sa hlalosa methylllulo ea methylfoulo tsa methylxl le methylcel le meth. Lehloeo la Levofloxiving Levofloxight hydrolonne le hydrohlomare
3.6 e le thepa ea cappule
Hangata, Sheplull Sheplull Sheplus, li-capsules ke gelatin haholo. Tsamaiso ea tlhahiso ea khetla ea likhechana e bonolo, empa lithethefatsi tse tebileng tse entsoeng ka oli le ho lieha ho senya mongobo nakong ea polokelo nakong ea polokelo. Ka hona, hydroxypropyproxyly Methylcell
Sebelisa Theophylline e le sethethefatsi sa taolo, podczeack et al. O fumane hore sekhahla sa discolos se itlhomphang se nang le hydroxypropyl methylceulo Shells e ne e kholo ho moo ea li-capsules tsa Gelatin. Lebaka la ho hlahlojoa ke hore ho qhalana ha HPMC ke ho senyeha ha sekoaelo sa gelatin pele, ebe se qhalana la capsule eohle, ka hona HPMC Capsule e loketse haholo ho likhetla tsa capleule tsa capsule bakeng sa likhatiso tsa kapele. Chiwele et al. Hape, sephetho se tšoanang mme ha se bapisoa le khefulolo ea Gelatin, Gelatin / Polyetylene Glycol le Hpmc likhetla. Liphello li bontšitse hore likhetla tsa HPMC li ile tsa qhibiliha ka potlako tlas'a maemo a ph, ha li-capsules tsa Glatin li angoa haholo ke maemo a fapaneng a ph. Tang Yue et al. E lekola mofuta o mocha oa khetla ea caplule bakeng sa sethunya sa lithethefatsi tse tlase tse nang le metsi a tlase ho phofo ea phofo. Ha ho bapisoa le khetla ea capstox ea li-hydroxypropypropy ea methylcelulose Khetla ea Celatin, 'me ho ile ha etsoa tlhahlobo ea likhoele. Liphetho li bontša le li-capsule tse ngata tse tsitsitseng tsa Gletin, li be le khatello e tlase bakeng sa li-capsules tsa phofo ea phofo.
3.7 joalo ka sejo se loketseng
Mahlale a Bioadhenion a sebelisa ho belaela le polymers tsa liphoofolo tse tloaelehileng. Ka ho latela mohaho oa bojale, ho ntlafatsa tsoelo-pele le ho tiea ha ho ikopanya le tokiso le mucosa, ke mucosa ho fihlela kalafo. E sebelisoa haholo hajoale. Phekolo ea mafu a mafu a gakrointestinal, Vagina, laral Mucsa le likarolo tse ling.
Theknoloji ea Gastrointestinun ke mokhoa o mocha oa ho tsamaisa lithethefatsi. Ha e lelekise nako ea ho itokisetsa lithethefatsi feela ka pampitšana pakeng tsa sethethefatsi sa bakuli le selefounu ea mokelikeli oa sele, 'me e etsa hore ho kenella ho sebelisa moriana ho Lisele tse nyane tsa ka mpeng li ntlafatsoa, ka ho etsa joalo li ntlafatsa puo ea tahevali motle ea moriana. Wei keda et al. E hlahlobisisa taelo ea matlapa le litekanyetso tsa HPMCK4M , mme qetellong a khethile litaba tsa HpMck40 le carbomer 940 ho ea ho ba 15 le 274. ho pholosoa ha litokelo tsa lithane.
Litokisetso tsa mahetla le tsona ke mofuta o mocha oa tsamaiso ea ho tsamaisa lithethefatsi tse ithutileng ho feta lilemong tsa morao tjena. Litokisetso tsa bolotsana tsa molomo li ka hlakisa moriana o amehang karolong e amehang ea moriana o rarahaneng oa lithethefatsi, empa hape e sireletsa mucosa ea molomo. Phello ea kalafo le ho ntlafatsa sethunya sa lithethefatsi. Xue xiaoyan et al. E ntlafalitse matlapa a matla a ho khomarela a ho khomarela ka molomo, Chitosan, cyboinxypropypropinyl methylceLulose (HPMC K392L. Pampiri e habeli e meralo. Letlapa le phekotsoeng la insulin la molomo le na le sebopeho se nang le seporo se nang le seporo, se ka netefatsang khohlano e se nang phepo e sa sebetsang, e ka netefatsa ho lahleheloa ke moriana le ho qoba ho lahleheloa ke moriana le ho qoba ho lahleheloa ke moriana. Hao Jifu et al. E boetse e lokisitse li-blues tse putsoa tse putsoa-e nang le li-blue-tse mosehla tse sebelisang baiji tse sebelisang Baiji Glue, HPMC le carboer e le lisebelisoa tsa sejo.
Ka litsamaiso tsa phepelo ea lits'oants'o tsa lithethefatsi, theknoloji ea bioadhenion le eona e sebelisitsoe haholo. Zhu Yuting et al. Carbomer e sebelisitsoeng (CP) le HPMC e le lisebelisoa tse khomarelang le li-profincheng tsa botšehali tikolohong ea tsona, nako ea ho ruruha. Ho fanoa ka taelo e loketseng joaloka CP-Hpmc1:
3.8 e le gel ea bophahamo
E le tokiso e khokhothetsoeng, gel e na le letoto la melemo e kang polokeho, botle, ho hloekisa habonolo ts'ebetsong, e bonolo ea ho hloekisa le ho ikamahanya le ho hlophisa lithethefatsi. Tataiso ea nts'etsopele. Mohlala, thydermal gel e leng sebopeho se secha se ithutoang haholo lilemong tsa morao tjena. E ke ke ea qoba ho timetsoa feela ha lithethefatsi ka pampitšana ea sehlekehleke sa lithethefatsi le sejana sa lipalesa tsa mali ho hlola litla-morao tsa lithethefatsi. .
Zhu Jingjie et al. o ithutile phello ea matric e fapaneng mabapi le ho lokolloa ha scutlalin joala (480nf) le seldroxyl methylcelulon. Gel matrix ea pokello ea joala. Liphetho tsa liteko tsa tlhahlobo. 0% carbomer, 1. 5% carbomer + 1. 0% hpmc joalo ka gel matrix . Nakong ea liteko, ho ile ha fumaneha hore HPMC e ka fetola mokhoa oa ho lokolla lithethefatsi ka ho tsamaisa karolo ea lithibelo tsa lipalesa, le 1.5% carbomer matrix. Lebaka e ka ba hore hpmc ea hola, 'me keketseho e potlakileng ea liteko e etsa hore ho be le thepa e kholo ea lihlaseluoa tsa carbomer e kholo. Zhao Wennui et al. Carbomer-934 le hydroxyproppyproppyl methylceluse e le bakuli ho ea ho giel ea ho pheha Norflotacin. Ts'ebetso ea ho hlophisoa e bonolo ebile e ka etsahala, 'me boleng bo lumellana le leholiotsoana la "China Pharmacopoeia" (2010 Phatlalatso ea boleng.
3.9 Puriki ea bona bakeng sa sistimi e itlhomphang
Tsamaiso ea Lithethefatsi ea Boikoetliso ba Likoloi (SMDDS) ke mofuta o mocha oa tsamaiso ea lithethefatsi, e leng motsoako o tsitsitseng, o nang le motsoako o tsitsitseng, o mong o qabolang le omulpifier. Sebopeho sa ho fanoa ka mokhoa o bonolo, 'me polokeho le botsitso li lokile. Bakeng sa litlhare tse qhibilihang hantle, lisebelisoa tsa polymer tsa motlakase tsa metsi, tse kang HPMC, li lula li eketsoa ho Kotsi ea Kotsi ea Kotsi. Encord Eketsa ea koluoa ea lithethefatsi le ho ntlafatsa bilavalilical.
Peng Xuan et al. E lokisitse silingoeng e nang le moea e atisang ho ipolaea-pherekano ea ho imolisa (s-sedds). Onkeylene hydrogenated Castor One (Cremophor RH40), 12% Capry), le 50 mglc. Ho eketsa HPMC ho Ssedds e ka hlahisa sikininin ea mahala ho hlakola s-seds le ho thibela silibinin ho tsoa ho ea pele. Ha ho bapisoa le liforomo tsa setso tsa bosholu, hangata e eketsoa ka bongata ho thibela ho thibela ho qala ha lithethefatsi. Ho eketsoa ha HPMC ho ka boloka sello sa sizenin ka mokhoa o khelohileng o le teng khafetsa, o fokotsa ho hlonama ka mekhoa ea boithati. Tekanyetso ea moemeli.
4conlusion
Ho ka bonoa hore HPMC e sebelisoa haholo litokisetsong ka lebaka la thepa ea eona ea 'mele le tlhaho, empa HPMC e boetse e na le mefokolo e mengata ea ho lokolloa. Methyl methacrylay) ho ntlafatsa. Ka nako e ts'oanang, bafuputsi ba bang ba ile ba fuputsa ts'ebeliso ea khopolo ea asmotic ka HPMC ka ho lokisa matlapa a totiloeng le Verapamil hydrochloride e tšehelitsoeng ka ho hlakisa ho lokolla mochini oa ho lokolla. Ka mantsoe, bafuputsi ba bangata ba etsa mosebetsi o mongata bakeng sa ts'ebeliso e ngata ea HPMC batotong, le thuto ea bohlanya ba thepa ea boitlamo, HPMC e tla sebelisoa haholo liforomo tsa litekanyetso le liforomo tsa dosage tsa theko. Patlisisong ea tsamaiso ea meriana, ebe khothaletsa nts'etsopele e tsoelang pele ea armacy.
Nako ea poso: Oct-08-2022