1.Introduduction:
Mesebetsi ea meriana ea meriana, banyane ba bapala karolo ea bohlokoa ea ho netefatsa botšepehi le ts'ebetso ea liforomo. Har'a litsamaiso tse fapaneng tsa Binder tse fumanehang, hydroxypropyproppyl methylcelllulose (HPMC) e hlahile e le khetho e fapaneng le e sebelisitsoeng.
2.Koproperties ea litsamaiso tsa nalane tsa HPMC:
HPMC, semisynthetic polymer e tsoa ho Cellloulose, e fana ka sets'oants'o sa thepa e ntle ea phaello bakeng sa litlhahiso tsa meriana. Tsena li kenyeletsa:
Ho fapanyetsana litšoantšo: HPMC e bonts'a mefuta e mengata ea limaraka tsa Viscosto, e lumella mekhoa ea ho tsamaisa ts'ebetso ea eona ho liforomo tsa dosage le litlhokahalo tsa ho etsa. Ho fapanyetsana ena ho thibela boleng ba eona ho feta litlhare tse fapaneng tsa meriana, ho kenyeletsa le matlapa, li-capsules, lifilimi le litokisetso tsa holimo.
Tlatsetso ea Tlatsetso Mekhoa ena e nang le ts'ebetso ea ts'ebetso e ntse e tsoela pele le ho eketsa ts'ebetso ea liforomo tsa molomo, haholo-holo matlapa a tokollo e tobileng haholo.
Khokahano: HPMC e bontša ho tsamaisana le mefuta e fapaneng ea meriana ea meriana (APIS) le ho ba tsebiso, e etsa hore e be le lihlahisoa tse ngata tsa lithethefatsi. Tlhaho ea eona ea kahare le ho hloka tšebelisano ea tšebelisano ka metsoako e metle e tiisa hore ho tsitsipana le katleho.
Liphate tsa motlakase: HPMC e ka theha lifilimi tse feto-fetohang le tse futsanehileng ha li ntse li sa tsotelle ntlafatsong ea lifilimi tse tšesaane, le lits'ebetso tse ling tsa lifilimi. Lifilimi tsena li fana ka melemo e kang ea mamello e ntlafalitsoeng ea mamello, dosing e hlakileng le e potlakileng ea tšebetso.
Ho lokolloa ho laoloang: Ka ho fetola sehlopha sa Viscosity le tsepamiso ea kalafo ea kalafo Ho bohlokoa hona ho molemo haholo bakeng sa liforomo tse laoloang ke lisebelisoa tse laoloang tsa molomo, moo li bolokang maemo a lithethefatsi tse laoloang tsa molomo, moo a bolokang maemo a lithethefatsi a ho lokolla la molomo, moo a bolokang maemo a lithethefatsi a ho qetela a nako e telele a bohlokoa.
3.Lola le melemo le melemo ho tsa maano a foromo:
Melaoana ea Letlapa:
HPMC Binders e fa thepa e ntle ea ho phalla le ho phalla ho granules, ho thusa litšila tse sebetsang.
Boitšoaro bo laoloang le boits'oaro ba HPMC bo matlatleng a kenya letsoho ho senya lithethefatsi tse fapaneng le tse boletsoeng esale pele, li netefatsa sephetho se fetohang sa kalafo.
Mekhabiso e ka khona ho ba le tlhaiso-leseling ea HPMC e nang le litlolo tse ling ho nts'etsapele litlolo tse ling tsa letlapa le 'maloa, tse kenyelletsang tse kang ha li a masking, ts'ireletso ea mongobo le tokollo e fetotsoeng.
Litlhaloso tsa Capsule:
HPMC e sebetsa e le mokhoa o qaqileng oa li-capsulales tse omileng tse omileng, e nolofalletsang encaps ea li-hydrophilic le hydrophobic apis.
Bokhoni ba eona ba ho etsa lifilimi tse ngata bo nolofalletsa nts'etsopele ea lifofaneng tse koahetsoeng ke likhechana tsa mangolo a koahetsoeng ke li-capsile tse koahetsoeng ke li-capsile tse khothetseng, tse qalang aphavalical ona.
LITLHAKISO TSA BOPHELO:
Litšoantšo tse tšesaane tsa HPMC li fana ka melemo e mengata ho feta liforomo tsa setso, ho kenyelletsa le phepelo e matla, haholo-holo ho latela litsebi tsa makhopho le geriatric.
Tranerdermal methati e entsoeng ka lifilimi tsa HPMC e fana ka phepelo ea lithethefatsi ka letlalo, e fana ka likotsi tsa plasma le nyenyefatsa litlamorao tsa plasma le ho fokotsa litlamorao.
LITLHAKISO TSE KHOLO:
Ka mefuta ea lihlooho tse kang li-gels, lisele, tsa HPMC li sebeletsa e le mokuli oa Rheology, e fanang ka pono e lakatsehang le ho nka nako e lakatsehang.
Thepa ea eona e etsang filimi e ntlafatsa ho latela moea oa tokiso letlalong, nako ea ho nka mafu nako ea ho jala lithethefatsi le ho tsamaisa phallo ea lithethefatsi.
Lisebelisoa tsa HydroxypropypropyproPulpropyLulose (HPMC) litsamaiso tsa Binder Ho tloha litafoleng le li-capsules ho lifilimi le mekhoa ea lihlooho, HPMC e thusa litsebi ho fihlela taolo ea lithethefatsi holim'a moriana, le ntlafatsa ho tiisetsa mokuli, 'me u ntlafatse ho tiisetsa mokuli. Kaha indasteri ea meriana e ntse e tsoela pele ho fetoha, HPM e ntse e le lejoe la sekhutlo, le ho khanna ho ipholla le ho ntlafatsa litholoana tsa kalafo.
Nako ea poso: Mots'eanong-07-2024