E-'nete - bakeng sa ho lokolloa ha lithethefatsi tse laoloang tsa lithethefatsi ka litsamaiso tsa hydrophilic matrix

E-'Ethey ea Centealose, haholo-holoHydroxypropypropyLese (HPMC), ba sebetsa haholo ka mekhoa ea meriana bakeng sa tokollo e laoloang ea lithethefatsi ka litsamaiso tsa hydrophilic matrix. Ho lokolloa ha lithethefatsi tse laoloang ho sebelisa sephetho sa kalafo, ho fokotsa litla-morao le ho ntlafatsa ho latela mamello. Mona ke kamoreng ea Contel e-mme e sebetsa joang ho hydrophilic matrix tsamaiso ea lithethefatsi tse laoloang:

1. Hydrophilic matrix:

• Tlhaloso: Sistimi ea hydrophphilic ea hydrophphilic
• Sepheo: Matlaka a laola ho lokolloa ha moriana ka ho etsa hore a feforeloe se fapaneng le polymer.

2. Karolo ea ethen e 'nete (mohlala, HPMC):

• Viscosity le thepa ea boqapi ea gel:
  • HPMC e tsejoa ka bokhoni ba eona ba ho theha li-gels ebe e eketsa pono ea tharollo ea metsi.
  • Ka mekhoa ea matrix, HPMC e kenya letsoho ho theha matrix ea gelatino e ka etsoang sethethefatsi.
• Tlhaho ea hydrophilic:
  • HPMC e Haholo ea hydrophilic, e tataisang tšebelisano ea eona ka metsi pampitšana ea libeso.
• Ho ruruha ho laoloang:
  • Ha u kopana le mokelikeli oa mala oa gasric, hydrophphilic matrix o hlapanya, o thehe bokaholimo ba letlalo ho potoloha le likaroloana tsa lithethefatsi.
• Lithuto tsa lithethefatsi:
  • Setlhare se hasana ka mokhoa o tšoanang kapa o holofalitsoe ka har'a gel matrix.

3. Mechanism ea tokollo e laoloang:

• Phapang le Khoholeho:
  • Kholo e laoloang e etsahala ka motsoako oa metsoako ea licha kapa tsa mobu.
  • Metsi a kenella matrix, 'me a lebisa ho ruruhang ka gel,' me moriana o tiisa ka seketsoana sa gl.
• Tokollo ea zero:
  • Pale e laoloang e Akaretsang hangata e latela li-kinotic tsa li-kinotics, li fana ka sekhahla sa lithethefatsi tse sa feleng ha nako e ntse e feta.

4. Lintlha tse susumetsang ho lokolloa ha lithethefatsi:

• Polymer Control:
  • Khatello ea HPMC ho Matrix e susumetsa sekhahla sa tokollo ea lithethefatsi.
• Boima ba limok'hule ba hpmc:
  • Lirade tse fapaneng tsa HPMC ka boima ba limolek'hule tsa limolek'hule li ka khethoa ho etsa moralo oa ho lokolloa.
• Motsoako oa lithethefatsi:
  • Setlhare sa lithethefatsi tse margen e ama litšobotsi tsa eona tsa ho lokolla.
• Matrix PROSity:
  • Tekanyo ea gel ea ruruha le phaello ea phaello ea motlakase.

5. Melemo ea ethe e bo-'mè ba cellulose Systems:

• Binompatication: Amelian e-'mè ea khetla ea selefoui a sa khonehe ebile ha a mamelle hantle pampiteng ea mpa ea gastrointestinal.
• Ho fapanyetsana: Maqephe a fapaneng a Liketso tsa celluulose a ka khethoa ho fihlela profil e lakatsehang.
• Ho tsitsa: Cellulose E-'-bo-mme e fana ka botsitso tsamaisong ea matrix, ba netefatsa hore lithethefatsi li lokolloa.

6. Likopo:

• Tsamaiso ea lithethefatsi ea molomo: Tsamaiso ea lithethefatsi ea hydrophphilic e sebelisoa hangata bakeng sa liforomo tsa lithethefatsi tsa molomo, ho fana ka phetohelo e tsitsitseng le e laoloang.
• Maemo a sa foleng: Ho loketse lithethefatsi tse sebelisoang ho tikolohong e sa foleng moo tokollo e tsoelang pele ea lithethefatsi e molemo.

7. LITLHAKISO:

• Ho etsa phello: Sebopeho se tlameha ho ntlafatsoa ho fihlela profe ea lithethefatsi tse lakatsehang ho ipapisitse le litlhoko tsa kalafo ea lithethefatsi.
• Ho latela melao-motheo: Celpelose Christians

Ho sebelisa li-ethe ea celdroulos matrix tsa hydrophphilic Mattrix.