Lefapheng la meriana, sodium carboxymethylcellulose (CMC) le hydroxypropyl methylcellulose (HPMC) ke li-excipients tse peli tse sebelisoang hangata tse nang le thepa le mesebetsi e fapaneng ea lik'hemik'hale.
Sebopeho sa lik'hemik'hale le thepa
CMC ke motsoako oa cellulose o qhibilihang ka metsing o fumanoang ka ho fetola karolo ea lihlopha tsa hydroxyl tsa selulose hore e be lihlopha tsa carboxymethyl. Ho qhibiliha ha metsi le viscosity ea CMC ho itšetlehile ka tekanyo ea eona ea ho fetola le boima ba limolek'hule, 'me hangata e sebetsa e le setei se setle le se emisang.
HPMC e fumanoa ka ho nkela karolo ea lihlopha tsa hydroxyl tsa cellulose sebaka ka lihlopha tsa methyl le hydroxypropyl. Ha e bapisoa le CMC, HPMC e na le solubility e pharaletseng, e ka qhibilihang metsing a batang le a chesang, 'me e bonts'a viscosity e tsitsitseng ka litekanyetso tse fapaneng tsa pH. HPMC e atisa ho sebelisoa e le filimi ea pele, e khomarelang, e teteaneng le e laoloang ea tokollo meriana.
Sebaka sa kopo
Matlapa
Ha ho etsoa matlapa, CMC e sebelisoa haholo-holo joalo ka sekhomaretsi le sekhomaretsi. E le disintegrant, CMC e ka monya metsi le ho ruruha, kahoo e khothalletsa ho arohana ha matlapa le ho eketsa sekhahla sa ho lokolloa ha lithethefatsi. Joalo ka setlamo, CMC e ka ntlafatsa matla a mochini a matlapa.
HPMC e sebelisoa haholo-holo e le moemeli oa pele oa filimi le o laoloang matlapeng. Filimi e entsoeng ke HPMC e na le matla a babatsehang a mochine le ho hanyetsa ho apara, e ka sireletsang lithethefatsi ho tloha tšusumetsong ea tikoloho ea ka ntle. Ka nako e ts'oanang, thepa ea ho etsa filimi ea HPMC e ka boela ea sebelisoa ho laola sekhahla sa ho lokolloa ha moriana. Ka ho fetola mofuta le litekanyetso tsa HPMC, tokollo e tsitsitseng kapa tokollo e laoloang e ka finyelloa.
Li-capsules
Ha ho etsoa capsule, CMC ha e sebelisoe hanyenyane, ha HPMC e sebelisoa haholo, haholo-holo tlhahiso ea li-capsules tsa meroho. Likhetla tsa setso tsa capsule hangata li entsoe ka gelatin, empa ka lebaka la bothata ba mehloli ea liphoofolo, HPMC e fetohile lisebelisoa tse ling tse loketseng. Khetla ea capsule e entsoeng ka HPMC ha e na feela biocompatibility e ntle, empa hape e kopana le litlhoko tsa batho ba jang meroho.
Litokiso tsa mokelikeli
Ka lebaka la thepa ea eona e ntle ea ho tenya le ho emisoa, CMC e sebelisoa haholo litokisetsong tsa mokelikeli tse kang litharollo tsa molomo, marotholi a mahlo le litokisetso tsa lihlooho. CMC e ka eketsa viscosity ea litokisetso tsa mokelikeli, kahoo e ntlafatsa ho fanyeha le botsitso ba lithethefatsi le ho thibela sedimentation ea lithethefatsi.
Tšebeliso ea HPMC litokisong tsa mokelikeli e tsepamisitsoe haholo ho li-thickeners le li-emulsifiers. HPMC e ka lula e tsitsitse ho feta mefuta e mengata ea pH mme e ka tsamaellana le mefuta e fapaneng ea lithethefatsi ntle le ho ama katleho ea lithethefatsi. Ho phaella moo, thepa ea ho etsa filimi ea HPMC e boetse e sebelisoa litokisetsong tsa lihlooho, tse kang phello ea tšireletso ea ho etsa filimi marotholi a mahlo.
Litokisetso tsa tokollo tse laoloang
Litokisetsong tsa tokollo tse laoloang, ts'ebeliso ea HPMC e hlahelletse ka ho khetheha. HPMC e khona ho theha marang-rang a gel, 'me sekhahla sa ho lokolloa ha moriana se ka laoloa ka ho fetola mahloriso le sebopeho sa HPMC. Thepa ena e 'nile ea sebelisoa haholo matlapeng le li-implants tse fanoang ka molomo. Ka lehlakoreng le leng, CMC ha e sebelisoe haholo litokisetsong tsa tokollo e laoloang, haholo hobane sebopeho sa gel seo e se etsang ha sea tsitsa joalo ka HPMC.
Ho tsitsa le ho lumellana
CMC e na le botsitso bo fokolang maemong a fapaneng a pH mme e angoa habonolo ke tikoloho ea acid-base. Ho feta moo, CMC ha e tsamaellane hantle le metsoako e itseng ea lithethefatsi, e ka bakang ho na kapa ho hloleha ha lithethefatsi.
HPMC e bontša botsitso bo botle holim'a mefuta e mengata ea pH, ha e amehe habonolo ke acid-base, 'me e na le tšebelisano e ntle haholo. HPMC e ka lumellana le metsoako e mengata ea lithethefatsi ntle le ho ama botsitso le katleho ea moriana.
Polokeho le melawana
Ka bobeli CMC le HPMC li nkuoa e le li-excipient tse sireletsehileng tsa meriana 'me li amohetsoe hore li sebelisoe litokisetsong tsa meriana ke li-pharmacopoeias le mekhatlo ea taolo linaheng tse fapaneng. Leha ho le joalo, nakong ea ts'ebeliso, CMC e ka baka maikutlo a mang kapa bohloko ba ka mpeng, athe HPMC ha se hangata e bakang litlamorao tse mpe.
CMC le HPMC li na le melemo ea tsona lits'ebetsong tsa meriana. CMC e nka boemo ba bohlokoa litokisetsong tsa mokelikeli ka lebaka la thepa ea eona e matla ea ho tenya le ho emisoa, ha HPMC e 'nile ea sebelisoa haholo matlapeng, li-capsules le litokisetso tsa tokollo e laoloang ka lebaka la thepa ea eona e babatsehang ea ho etsa lifilimi le ho lokolloa ka mokhoa o laoloang. Khetho ea litokisetso tsa meriana e lokela ho thehoa holim'a thepa e khethehileng ea lithethefatsi le litlhoko tsa ho itokisa, ho nahanela ka ho feletseng melemo le melemo ea bobeli, le ho khetha mothusi ea loketseng ka ho fetisisa.
Nako ea poso: Jul-19-2024