Hajoale, lisebelisoa tse butsoitseng tsa li-capsules tsa semela haholo-holo ke hydroxypropyl methylcellulose (HPMC) le pullulan, mme starch ea hydroxypropyl e boetse e sebelisoa e le lisebelisoa tse tala.
Ho tloha qalong ea lilemo tsa 2010,HPMCe sebelisitsoe indastering ea tlhahiso ea li-capsules tsa semela sa China, 'me ho ipapisitse le ts'ebetso ea eona e ntle, li-capsules tse sekoti tsa HPMC li nkile sebaka' marakeng oa li-capsule, li bonts'a tlhokahalo e matla lilemong tse leshome tse fetileng.
Ho latela lintlha tsa indasteri, ka 2020, thekiso ea lehae ea li-capsules tse thata e tla ba li-capsules tse ka bang limilione tse likete tse 200 (liindasteri tsa meriana le tsa bophelo bo botle li kopantsoe), moo thekiso ea li-capsules tsa HPMC e tla ba li-capsules tse ka bang limilione tse likete tse 11.3 (ho kenyeletsoa le thepa e tsoang linaheng tse ling) , keketseho ea 4.2% ho feta 2019. %, e etsang karolo e ka bang 5.5%. Indasteri e seng ea meriana e etsa karolo ea 93.0% ea tšebeliso ea li-capsules tsa HPMC Chaena, 'me kholo ea indasteri ea lihlahisoa tsa bophelo bo botle e tsamaisa thekiso ea li-capsules tsa HPMC.
Ho tloha 2020 ho isa 2025, CAGR ea li-capsules tsa HPMC tse nang le li-gelling agents li lebelletsoe ho ba 6.7%, e leng holimo ho sekhahla sa kholo ea 3.8% bakeng sa li-capsules tsa gelatin. Ho feta moo, tlhoko ea li-capsules tsa HPMC indastering ea lihlahisoa tsa bophelo bo botle ba lapeng e phahame ho feta indastering ea meriana.HPMCLi-capsules li ka thusa ka liphephetso tsa lengolo la ngaka le ho amohela lithahasello tsa setso le lijo tsa bareki lefatšeng ka bophara. Leha tlhoko ea hajoale ea li-capsules tsa HPMC e ntse e le tlase haholo ho feta ea li-capsules tsa gelatin, sekhahla sa kholo ea tlhoko se phahame ho feta sa li-capsules tsa gelatin.
1) Tlhahiso ea katleho le ts'ebetso, ntle le moemeli oa gelling; e na le solubility e molemo, boitšoaro bo tsitsitseng ba ho qhibiliha mecheng e fapaneng ea litaba, e sa angoeng ke pH le matla a ionic, 'me e finyella litlhoko tsa pharmacopoeia tsa linaha tse kholo le libaka;
2) Bakeng sa litaba tse fokolang tsa alkaline, ntlafatsa bioavailability le ho ntlafatsa mokhoa oa ho ntlafatsa mokhoa oa litekanyetso;
3) Ponahalo e ntle, 'me likhetho tsa mebala li ngata haholo.
Soft capsule ke tokiso e entsoeng ka ho koala oli kapa ho emisoa ho thehiloeng ka oli ka har'a khetla ea capsule, 'me sebopeho sa eona se chitja, se bōpehileng joaloka mohloaare, se bōpehileng joaloka tlhapi e nyenyane, se bōpehileng joaloka lerotholi, joalo-joalo. oli, e nang le ts'ebetso e potlakileng ea ts'ebetso le bioavailability e phahameng ho feta ho etsa motsoako o ts'oanang o sebetsang matlapeng, 'me e sebelisitsoe haholo ho lokiseng lihlahisoa tsa tlhokomelo ea bophelo le meriana. Matsatsing ana, li-capsules tse bonolo tse nang le litšobotsi tse fapaneng tse kang enteric-coated, chewable, osmotic pump, tokollo e tsitsitseng, le li-suppositories tse bonolo li se li ntse li le 'marakeng. Khetla e bonolo ea capsule e entsoe ka li-colloid le li-additives tse thusang. Har'a tsona, li-colloids tse kang gelatin kapa gum ea meroho ke likarolo tse ka sehloohong, 'me boleng ba tsona bo ama ka ho toba tshebetso ea li-capsules tse bonolo. Ka mohlala, ho lutla ha likhetla tsa capsule, ho khomarela, ho falla ha thepa, ho senyeha butle-butle, le ho qhibiliha ha li-capsules tse bonolo li etsahala nakong ea polokelo Mathata a kang ho se latele a amana le eona.
Hona joale, boholo ba lisebelisoa tsa capsule tsa li-capsules tse bonolo tsa meriana naheng ea heso ke gelatin ea liphoofolo, empa ka tsoelo-pele e tebileng le ts'ebeliso ea li-capsules tse bonolo tsa gelatin, mefokolo ea eona le mefokolo e 'nile ea hlahella haholoanyane, e kang mehloli e rarahaneng ea lisebelisoa tse tala, le mekhoa e bonolo ea li-cross-linking le metsoako ea aldehyde Mathata a boleng bo kang nako e khutšoanyane ea polokelo le "litšila tse tharo" tse hlahisoang ka mokhoa oa ho hloekisa gelatin li na le tšusumetso e kholo ho sireletsa tikoloho. Ho phaella moo, ho boetse ho na le bothata ba ho thatafatsa mariha, e leng se nang le phello e mpe boleng ba ho itokisa. 'Me li-capsules tse bonolo tsa gum ha li na tšusumetso e fokolang tikolohong e potolohileng. Ka ho qhoma ho latellanang ha mafu a tšoaetsanoang a hlahang liphoofolong lefatšeng ka bophara, sechaba sa machaba se amehile ka ho eketsehileng ka polokeho ea lihlahisoa tsa liphoofolo. Ha li bapisoa le li-capsules tsa gelatin tsa liphoofolo, li-capsules tsa semela li na le melemo e ikhethang mabapi le ho sebetsa, polokeho, botsitso le ts'ireletso ea tikoloho.
Eketsahydroxypropyl methylcelluloseho nosetsa le ho hasanya ho fumana tharollo A; eketsa gelling agent, coagulant, plasticizer, opacifier le colorant ho metsi le ho hasana ho fumana tharollo B; kopanya litharollo A le B, 'me u chese ho fihlela ho 90 ~ 95 ° C, hlohlelletsa 'me u lule u futhumetse bakeng sa 0.5 ~ 2h, u pholile ho fihlela ho 55 ~ 70 ° C, u futhumale' me u eme bakeng sa defoaming ho fumana sekhomaretsi;
Mokhoa oa ho fumana metsi a sekhomaretsi kapele, ts'ebetso e akaretsang ke ho futhumatsa butle ka kettle ea karabelo nako e telele,
Baetsi ba bang ba feta ka potlako leloaleng la colloid ka sekhomaretsi sa lik'hemik'hale
Nako ea poso: Apr-25-2024