Hydroxypropyl methylcellulose (HPMC) ke polymer e qhibilihang ka metsing e sebelisoang hangata, e sebelisoang haholo ho tsa meriana, litlolo, lijo le masimo a indasteri, haholo-holo ha ho etsoa li-gel. Litšobotsi tsa eona tsa 'mele le boits'oaro ba ho qhibiliha li na le phello e kholo ts'ebetsong ea ts'ebeliso e fapaneng. Mocheso oa mocheso oa gelation oa gel ea HPMC ke e 'ngoe ea thepa ea eona ea bohlokoa ea' mele, e amang ka ho toba ts'ebetso ea eona ka litokisetso tse sa tšoaneng, tse kang ho lokolloa ho laoloang, ho thehoa ha filimi, botsitso, joalo-joalo.
1. Sebopeho le thepa ea HPMC
HPMC ke polima e qhibilihang ka metsing e fumanoang ka ho hlahisa lintho tse ling tse peli, hydroxypropyl le methyl, ka har'a skeleton ea molek'hule ea cellulose. Sebopeho sa eona sa limolek'hule se na le mefuta e 'meli ea li-substitute: hydroxypropyl (-CH2CHOHCH3) le methyl (-CH3). Lintlha tse joalo ka litaba tse fapaneng tsa hydroxypropyl, degree of methylation, le degree of polymerization li tla ba le phello ea bohlokoa ho solubility, boitšoaro ba gelling, le thepa ea mochini ea HPMC.
Litharollong tse nang le metsi, AnxinCel®HPMC e etsa litharollo tse tsitsitseng tsa colloidal ka ho etsa litlamo tsa hydrogen ka limolek'hule tsa metsi le ho sebelisana le masapo a eona a thehiloeng selulose. Ha tikoloho e ka ntle (e kang mocheso, matla a ionic, joalo-joalo) e fetoha, tšebelisano pakeng tsa limolek'hule tsa HPMC e tla fetoha, e leng se hlahisang gelation.
2. Tlhaloso le lintlha tse susumetsang tsa mocheso oa gelation
Mocheso oa mocheso (Gelation Temperature, T_gel) o bolela mocheso oo tharollo ea HPMC e qalang ho fetoha ho tloha ho metsi ho ea ho tiileng ha mocheso oa tharollo o nyolohela boemong bo itseng. Ka mocheso ona, ho sisinyeha ha liketane tsa HPMC tsa limolek'hule ho tla thibeloa, ho etsa sebopeho sa marang-rang a mararo, se hlahisang ntho e kang ea gel.
Mocheso oa mocheso oa gelation oa HPMC o angoa ke lintlha tse ngata, e 'ngoe ea lintlha tsa bohlokoa ka ho fetisisa ke litaba tsa hydroxypropyl. Ntle le litaba tsa hydroxypropyl, lintlha tse ling tse amang mocheso oa gel li kenyelletsa boima ba limolek'hule, mahloriso a tharollo, boleng ba pH, mofuta oa solvent, matla a ionic, joalo-joalo.
3. Phello ea litaba tsa hydroxypropyl ho mocheso oa gel ea HPMC
3.1 Keketseho ea litaba tsa hydroxypropyl e lebisa ho eketseha ha mocheso oa gel
Thempereichara ea gelation ea HPMC e amana haufi-ufi le tekanyo ea hydroxypropyl substitution molek'hule ea eona. Ha litaba tsa hydroxypropyl li ntse li eketseha, palo ea li-substituent tsa hydrophilic ho ketane ea molek'hule ea HPMC ea eketseha, e leng se bakang tšebelisano e ntlafetseng lipakeng tsa molek'hule le metsi. Tšebelisano ena e etsa hore liketane tsa limolek'hule li otlolle ho feta, kahoo li fokotsa matla a ho sebelisana pakeng tsa liketane tsa limolek'hule. Ka har'a mefuta e itseng ea mahloriso, ho eketsa litaba tsa hydroxypropyl ho thusa ho ntlafatsa tekanyo ea hydration le ho khothalletsa tlhophiso e kopanetsoeng ea liketane tsa limolek'hule, e le hore mohaho oa marang-rang o ka thehoa mocheso o phahameng. Ka hona, mocheso oa gelation hangata oa eketseha ha hydroxypropyl e phahama ka litaba tse ntseng li eketseha.
HPMC e nang le dikahare tse phahameng tsa hydroxypropyl (jwalo ka HPMC K15M) e na le ho bontsha mocheso o phahameng wa gelation maemong a tshwanang ho feta AnxinCel®HPMC e nang le dikahare tse tlase tsa hydroxypropyl (jwalo ka HPMC K4M). Sena ke hobane litaba tse phahameng tsa hydroxypropyl li etsa hore ho be thata haholoanyane hore limolek'hule li sebelisane le ho theha marang-rang ka mocheso o tlase, o hlokang mocheso o phahameng ho hlola hydration ena le ho khothaletsa likamano tsa intermolecular ho theha sebopeho sa marang-rang a mararo. .
3.2 Kamano lipakeng tsa litaba tsa hydroxypropyl le mahloriso a tharollo
Tharollo ea tharollo e boetse ke ntlha ea bohlokoa e amang mocheso oa gelation oa HPMC. Litharollong tse phahameng tsa HPMC, litšebelisano tsa li-intermolecular li matla haholo, kahoo mocheso oa gelation o ka ba o phahameng le haeba hydroxypropyl e le tlase. Libakeng tse tlaase, tšebelisano pakeng tsa limolek'hule tsa HPMC e fokola, 'me tharollo e ka' na ea e-ba gel ka mocheso o tlase.
Ha hydroxypropyl content e eketseha, le hoja hydrophilicity e eketseha, mocheso o phahameng o ntse o hlokahala ho theha gel. Haholo-holo tlas'a maemo a tlaase a mahloriso, mocheso oa gelation o eketseha haholo. Sena ke hobane HPMC e nang le hydroxypropyl e phahameng e thatafalloa haholo ho kenya likamano lipakeng tsa liketane tsa limolek'hule ka liphetoho tsa mocheso, mme ts'ebetso ea gelation e hloka matla a eketsehileng a mocheso ho hlola phello ea hydration.
3.3 Phello ea litaba tsa hydroxypropyl ts'ebetsong ea gelation
Ka har'a mefuta e meng ea litaba tsa hydroxypropyl, ts'ebetso ea gelation e laoloa ke tšebelisano lipakeng tsa hydration le liketane tsa limolek'hule. Ha lihlahisoa tsa hydroxypropyl ka molek'hule ea HPMC li le tlaase, hydration e fokola, tšebelisano pakeng tsa limolek'hule e matla, 'me mocheso o tlaase o ka khothalletsa ho thehoa ha gel. Ha litaba tsa hydroxypropyl li phahame, hydration e matlafatsoa haholo, tšebelisano pakeng tsa liketane tsa limolek'hule e ea fokola, 'me mocheso oa gelation oa eketseha.
Likahare tse phahameng tsa hydroxypropyl li ka boela tsa lebisa ho eketseha ha viscosity ea tharollo ea HPMC, phetoho eo ka linako tse ling e eketsang mocheso oa ho qala ha gelation.
Likahare tsa Hydroxypropyl li na le tšusumetso e kholo ho mocheso oa gelation oaHPMC. Ha litaba tsa hydroxypropyl li ntse li eketseha, hydrophilicity ea HPMC ea eketseha 'me tšebelisano pakeng tsa liketane tsa limolek'hule ea fokola, kahoo mocheso oa eona oa gelation o atisa ho eketseha. Ketsahalo ena e ka hlalosoa ka mokhoa oa ho sebelisana pakeng tsa hydration le liketane tsa limolek'hule. Ka ho lokisa litaba tsa hydroxypropyl tsa HPMC, taolo e nepahetseng ea mocheso oa gelation e ka finyelloa, ka hona ho ntlafatsa ts'ebetso ea HPMC litlamong tsa meriana, lijo le lisebelisoa tse ling tsa indasteri.
Nako ea poso: Jan-04-2025