Lintlha tse Amang Tlhahiso ea Viscosity ea Hydroxypropyl Methylcellulose

Hydroxypropyl methylcellulose (HPMC)ke polymer e sebelisoang haholo liindastering tse fapaneng, ho kenyelletsa le tsa meriana, lijo, kaho le litlolo. Viscosity ea eona e bapala karolo ea bohlokoa lits'ebetsong tsa eona. Ho utloisisa lintlha tse amang tlhahiso ea viscosity ea HPMC ho bohlokoa bakeng sa ho ntlafatsa ts'ebetso ea eona maemong a fapaneng. Ka ho sekaseka lintlha tsena ka botlalo, bankakarolo ba ka sebelisa thepa ea HPMC hamolemo ho fihlela litlhoko tse ikhethileng tsa kopo.

Selelekela:
Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang e nang le lits'ebetso tse atileng ka lebaka la thepa ea eona e ikhethang, ho kenyeletsoa ho qhibiliha ha metsi, bokhoni ba ho etsa lifilimi, le biocompatibility. E 'ngoe ea likarolo tsa bohlokoa tse amang ts'ebetso ea eona ke viscosity. Viscosity ea tharollo ea HPMC e susumetsa boitšoaro ba eona lits'ebetsong tse fapaneng, joalo ka ho tenya, ho tlotsa, ho roala lifilimi, le tokollo e tsitsitseng mekhoeng ea meriana. Ho utloisisa lintlha tse laolang tlhahiso ea viscosity ea HPMC ho bohlokoa haholo bakeng sa ho ntlafatsa ts'ebetso ea eona ho liindasteri tse fapaneng.

Lintlha tse Amang Tlhahiso ea Viscosity ea HPMC:

Boima ba Molek'hule:
Boima ba molek'hule eaHPMCe ama viscosity ea eona haholo. Li-polymers tse phahameng tsa boima ba limolek'hule ka kakaretso li bonts'a viscosity e phahameng ka lebaka la ho hokahana ha ketane. Leha ho le joalo, boima bo feteletseng ba limolek'hule bo ka lebisa mathateng a ho lokisa le ho lokisa tharollo. Ka hona, ho khetha mofuta o nepahetseng oa boima ba limolek'hule ho bohlokoa bakeng sa ho leka-lekanya litlhoko tsa viscosity le lintlha tse sebetsang.

Degree of Substitution (DS):
Tekanyo ea phapanyetso e bolela palo e tloaelehileng ea hydroxypropyl le methoxy substitute per anhydroglucose unit ka har'a ketane ea cellulose. Litekanyetso tse phahameng tsa DS hangata li baka viscosity e phahameng ka lebaka la ho eketseha ha hydrophilicity le tšebelisano ea ketane. Leha ho le joalo, ho nkela sebaka ka mokhoa o feteletseng ho ka lebisa ho fokotseng ho solubility le litšekamelo tsa gelation. Ka hona, ho ntlafatsa DS ho bohlokoa bakeng sa ho fihlela viscosity e lakatsehang ha o ntse o boloka solubility le ts'ebetso.

Tsepamiso ea maikutlo:
Viscosity ea HPMC e lekana ka kotloloho le mahloriso a eona tharollong. Ha mahloriso a polymer a ntse a eketseha, palo ea liketane tsa polymer ho bophahamo ba yuniti le eona ea eketseha, e lebisang ho ntlafatseng ketane le viscosity e phahameng. Leha ho le joalo, maemong a phahameng haholo, viscosity e ka ba sehlaba kapa ea fokotseha ka lebaka la tšebelisano ea polymer-polymer mme qetellong ho etsoa li-gel. Ka hona, ho ntlafatsa mahloriso ho bohlokoa bakeng sa ho fihlela viscosity e lakatsehang ntle le ho senya botsitso ba tharollo.

Mocheso:
Mocheso o na le tšusumetso e kholo ho viscosity ea tharollo ea HPMC. Ka kakaretso, viscosity e fokotseha ka mocheso o ntseng o eketseha ka lebaka la tšebelisano e fokotsehileng ea polymer-polymer le motsamao o ntlafalitsoeng oa limolek'hule. Leha ho le joalo, phello ena e ka 'na ea fapana ho itšetlehile ka lintlha tse kang polymer concentration, boima ba molek'hule, le tšebelisano e khethehileng le li-solvents kapa li-additives. Boikutlo ba mocheso bo lokela ho nahanoa ha ho etsoa lihlahisoa tse thehiloeng ho HPMC ho netefatsa ts'ebetso e tsitsitseng maemong a fapaneng a mocheso.

pH:
PH ea tharollo e susumetsa viscosity ea HPMC ka phello ea eona ho solubility ea polymer le conformation. HPMC e qhibiliha haholo 'me e bonts'a viscosity e phahameng ka ho fetesisa ho isa ho maemo a pH a sa nke lehlakore. Ho kheloha ho tloha mofuteng ona oa pH ho ka lebisa ho fokotseng ho qhibiliha le viscosity ka lebaka la ho fetoha ha polymer conformation le ho sebelisana le limolek'hule tsa solvent. Ka hona, ho boloka maemo a pH a nepahetseng ho bohlokoa bakeng sa ho eketsa viscosity ea HPMC tharollong.

Kenyelletso:
Li-additives tse fapaneng, joalo ka matsoai, li-surfactants, le li-co-solvents, li ka ama viscosity ea HPMC ka ho fetola thepa ea tharollo le litšebelisano tsa polymer-solvent. Mohlala, matsoai a ka holisa viscosity ka phello ea letsoai, athe li-surfactants li ka susumetsa tsitsipano ea lefatše le ho qhibiliha ha polymer. Li-co-solvents li ka fetola polarity ea solvent le ho ntlafatsa ho qhibiliha ha polymer le viscosity. Leha ho le joalo, tšebelisano le litšebelisano lipakeng tsa HPMC le li-additives li tlameha ho hlahlojoa ka hloko ho qoba litlamorao tse sa batleheng ho viscosity le ts'ebetso ea sehlahisoa.

ke polymer e feto-fetohang e sebelisoang haholo indastering ea meriana, ea lijo, ea kaho le ea litlolo. Viscosity ea tharollo ea HPMC e bapala karolo ea bohlokoa ho tsebahatseng ts'ebetso ea eona lits'ebetsong tse fapaneng. Ho utloisisa lintlha tse amang tlhahiso ea viscosity ea HPMC, ho kenyelletsa boima ba limolek'hule, tekanyo ea ho fetola, mahloriso, mocheso, pH le li-additives, ho bohlokoa bakeng sa ho ntlafatsa ts'ebetso le ts'ebetso ea eona. Ka ho qhekella lintlha tsena ka hloko, ba amehang ba ka hlophisa thepa ea HPMC ho fihlela litlhoko tse ikhethileng tsa kopo ka nepo. Lipatlisiso tse ling mabapi le tšebelisano lipakeng tsa lintlha tsena li tla tsoela pele ho ntlafatsa kutloisiso ea rona le ts'ebeliso ea HPMC makaleng a fapaneng a indasteri.