HPMC (hydroxypropyl methylcellulose) ke sesebelisoa sa polymer se qhibilihang ka metsing se sebelisoang haholo masimong a kaho, meriana, lijo le lik'hemik'hale tsa letsatsi le letsatsi. E na le botenya bo botle, emulsification, filimi-forming, colloid e sireletsang le lintho tse ling. Ka tsamaiso ea emulsion, HPMC ka laola viscosity ea emulsion ka litsela tse sa tšoaneng.
1. Sebopeho sa limolek'hule tsa HPMC
The viscosity ea HPMC e angoa haholo ke boima ba eona ba molek'hule le tekanyo ea ho fetola. Ha boima ba limolek'hule bo le boholo, bo phahamisa viscosity ea tharollo; le tekanyo ea ho kenya sebaka (ke hore, tekanyo ea ho kenya sebaka sa hydroxypropyl le lihlopha tsa methoxy) e ama ho qhibiliha ha metsi le li-viscosity properties tsa HPMC. Haholo-holo, ha tekanyo ea phetisetso e phahame, ho ba molemo ho qhibiliha ha metsi ho HPMC, 'me viscosity e eketseha ka tsela e nepahetseng. Hangata bahlahisi ba fana ka lihlahisoa tsa HPMC tse nang le boima bo fapaneng ba limolek'hule le likhato tsa ho fetola ho fihlela litlhoko tsa lits'ebetso tse fapaneng.
2. Sebelisa mahloriso
Khokahano ea HPMC ka tharollo ea metsi ke e 'ngoe ea lintlha tsa bohlokoa tse amang viscosity. Ha re bua ka kakaretso, ha HPMC e ntse e eketseha, ho na le viscosity e kholo ea tharollo. Leha ho le joalo, viscosity ea mefuta e fapaneng ea HPMC ka mahloriso a tšoanang e ka fapana haholo. Ka hona, lits'ebetsong tse sebetsang, hoa hlokahala ho khetha motsoako o nepahetseng oa tharollo ea HPMC ho latela litlhoko tse khethehileng tsa viscosity. Mohlala, lits'ebetsong tsa kaho, khatello ea HPMC hangata e laoloa lipakeng tsa 0.1% le 1% ho fana ka viscosity e loketseng ea ho sebetsa le ts'ebetso ea kaho.
3. Mokhoa oa ho qhala
Ts'ebetso ea ho felisoa ha HPMC e boetse e na le phello ea bohlokoa ho viscosity ea ho qetela. HPMC e bonolo ho qhalakana metsing a batang, empa sekhahla sa ho qhibiliha se lieha; e qhibiliha ka potlako metsing a chesang, empa ho bonolo ho kopanya. E le ho qoba agglomeration, mokhoa oa ho eketsa butle-butle o ka sebelisoa, ke hore, pele butle-butle eketsa HPMC metsing a batang ho qhalakanya, ebe o chesa le ho hlohlelletsa ho fihlela o qhibiliha ka ho feletseng. Ho feta moo, HPMC e ka boela ea kopanngoa le li-powders tse ling tse omeletseng ebe e kenngoa metsing ho qhibiliha ho ntlafatsa ts'ebetso ea ho qhibiliha le botsitso ba viscosity.
4. Mocheso
Mocheso o na le phello e kholo ho viscosity ea tharollo ea HPMC. Ka kakaretso, viscosity ea tharollo ea HPMC e fokotseha ha mocheso o ntse o eketseha. Lebaka ke hobane mocheso o ntseng o phahama o tla fokolisa maqhama a haedrojene pakeng tsa limolek'hule, ho etsa hore ketane ea limolek'hule ea HPMC e thellehe habonolo, ka tsela eo e fokotsa viscosity ea tharollo. Ka hona, lits'ebetsong tse hlokang viscosity e phahameng, tharollo ea HPMC hangata e sebelisoa ka mocheso o tlase. Ka mohlala, lits'ebetsong tsa meriana, tharollo ea HPMC e atisa ho sebelisoa mocheso oa kamore ho netefatsa botsitso le katleho ea lithethefatsi.
5. pH boleng
Viscosity ea tharollo ea HPMC e boetse e angoa ke boleng ba pH. HPMC e na le viscosity e phahameng ka ho fetisisa tlas'a maemo a sa nke lehlakore le a fokolang a acidic, ha viscosity e tla fokotseha haholo tlas'a maemo a matla a acidic kapa alkaline. Lebaka ke hobane litekanyetso tsa pH tse feteletseng li tla senya sebopeho sa limolek'hule tsa HPMC le ho fokolisa phello ea eona e teteaneng. Ka hona, lits'ebetsong tse sebetsang, boleng ba pH ba tharollo bo hloka ho laoloa le ho bolokoa ka har'a mefuta e tsitsitseng ea HPMC (hangata pH 3-11) ho netefatsa phello ea eona e teteaneng. Mohlala, lits'ebetsong tsa lijo, HPMC hangata e sebelisoa lijong tse nang le asiti joalo ka yoghurt le lero, mme viscosity e nepahetseng e ka fumanoa ka ho lokisa boleng ba pH.
6. Lisebelisoa tse ling
Litsamaisong tsa emulsion, viscosity ea HPMC e ka boela ea fetoloa ka ho eketsa li-thickeners tse ling kapa li-solvents. Ka mohlala, ho eketsa palo e loketseng ea matsoai a sa tloaelehang (joaloka sodium chloride) ho ka eketsa viscosity ea tharollo ea HPMC; ha ho eketsa metsoako ea lintho tse phelang tse kang ethanol ho ka fokotsa viscosity ea eona. Ho phaella moo, ha e sebelisoa hammoho le li-thickeners tse ling (tse kang xanthan gum, carbomer, joalo-joalo), viscosity le botsitso ba emulsion le tsona li ka ntlafatsoa haholo. Ka hona, molemong oa moralo oa 'nete, li-additives tse nepahetseng li ka khethoa ha ho hlokahala ho ntlafatsa viscosity le ts'ebetso ea emulsion.
HPMC e ka fihlela taolo e nepahetseng ea emulsion viscosity ka sebopeho sa eona sa limolek'hule, mahloriso a ts'ebeliso, mokhoa oa ho qhibiliha, mocheso, boleng ba pH le li-additives. Lits'ebetsong tse sebetsang, lintlha tsena li hloka ho nahanoa ka botlalo ho khetha mofuta o nepahetseng oa HPMC le maemo a ts'ebeliso ho fihlela phello e nepahetseng ea botenya. Ka moralo oa moralo oa mahlale le taolo ea ts'ebetso, HPMC e ka bapala karolo ea bohlokoa mafapheng a kaho, meriana, lijo le lik'hemik'hale tsa letsatsi le letsatsi, e fana ka ts'ebetso e ntle haholo le boiphihlelo ba basebelisi.
Nako ea poso: Jul-17-2024