Ka indasteri ea meriana, hypromellose (HPMC, METHOCEL™) e ka sebelisoa e le filler, binder, polymer ea ho roala letlapa le motsoako oa bohlokoa ho laola tokollo ea lithethefatsi. Hypromellose e 'nile ea sebelisoa matlapeng ka lilemo tse fetang 60' me ke motsoako oa bohlokoa o sebelisoang haholo matlapeng a hydrophilic gel matrix.
Lik'hamphani tse ngata tsa meriana li sebelisa hypromellose bakeng sa tokollo ea lithethefatsi e laoloang, haholo-holo ka hydrophilic gel matrix tablet formulations. Ha ho tluoa ho lihlahisoa tsa hypromellose, u kanna oa ipotsa hore na u ka etsa khetho joang - haholo-holo haeba u batla ntho e fumanehang habonolo le e tšoarellang ho e bapatsa bareki ba hau. Ka tataiso ena, re tla bua ka lintho tsa bohlokoa tseo u hlokang ho li tseba ka hypromellose.
Hypromellose ke eng?
Hypromellose, e tsejoang hape e lehydroxypropyl methylcellulose (HPMC), ke polymer e sebelisoang e le motsoako oa meriana ho laola ho lokolloa ha lithethefatsi ho tloha matlapeng a oral hydrophilic gel matrix.
Hypromellose ke semi-synthetic material e nkiloeng ho selulose, polymer e ngata ka ho fetisisa tlhahong. Tse ling tsa litšobotsi tsa eona tse tloaelehileng li kenyelletsa:
. qhibilihang ka metsing a batang
. e sa qhibidihang metsing a chesang
. Nonionic
. Ka khetho e qhibilihang ka har'a li-solvents
. Reversible, thepa ea gel ea mocheso
. Hydration le viscosity e ikemetseng ho pH
. Surfactant
. e senang chefo
. Tatso le monko li bonolo
. Khanyetso ea li-enzyme
. pH (2-13) botsitso ba mefuta
. E ka sebelisoa e le thickener, emulsifier, binder, rate regulator, filimi ea pele
Letlapa la Hydrophilic Gel Matrix ke eng?
Hydrophilic gel matrix tablet ke mofuta oa litekanyetso o ka laolang ho lokolloa ha lithethefatsi ho tloha letlapeng ka nako e telele.
Ho lokisa letlapa la hydrophilic gel matrix:
. e batlang e le bonolo
. E hloka feela lisebelisoa tse tloaelehileng tsa ho hatella letlapa
. Thibela ho lahla tekanyo ea lithethefatsi
. Ha e angoe ke boima ba letlapa kapa matla a khatello
. Ho lokolloa ha lithethefatsi ho ka fetoloa ho latela palo ea li-excipients le li-polymers
Tšebeliso ea hypromellose matlapeng a hydrophilic gel-matrix e fumane tumello e pharaletseng ea taolo, 'me hypromellose e bonolo ho e sebelisa ebile e na le tlaleho e ntle ea polokeho, e bontšitsoeng ke lithuto tse ngata. Hypromellose e fetohile khetho e ntle ka ho fetisisa bakeng sa lik'hamphani tsa meriana ho nts'etsapele le ho hlahisa matlapa a sa feleng.
Lintlha tse Amang Phallo ea Lithethefatsi ho Matrix Tablets:
Ha ho etsoa letlapa la ho lokolloa ka nako e telele, ho na le lintlha tse peli tse ka sehloohong tse lokelang ho nahanoa: ho etsoa le ho sebetsa. Ho boetse ho na le lintlha tse nyane tse lokelang ho nahanoa ha ho etsoa qeto ea ho etsoa le ho lokolloa ha sehlahisoa sa ho qetela sa moriana.
Foromo:
Lintlha tsa bohlokoa tse lokelang ho nahanoa bakeng sa nts'etsopele ea pele:
1. Polymer (mofuta oa sebaka, viscosity, palo le boholo ba likaroloana)
2. Lithethefatsi (boholo ba likaroloana le ho qhibiliha)
3. Lintho tse kopanyang lintho (solubility le litekanyetso)
4. Lisebelisoa tse ling (li-stabilizers le buffers)
Mosebetsi oa matsoho:
Lintlha tsena li amana le tsela eo moriana o etsoang ka eona:
1. Mekhoa ea tlhahiso
2. Boholo ba Letlapa le Sebopeho
3. Matla a letlapa
4. pH tikoloho
5. Ho roala filimi
Kamoo skeleton chips e sebetsang kateng:
Matlapa a Hydrophilic gel matrix a ka laola ho lokolloa ha lithethefatsi ka lera la gel, ho kenyelletsa le mekhoa e 'meli ea ho hasana (lisebelisoa tse qhibilihang ka har'a metsi) le khoholeho ea mobu (lisebelisoa tse sa tsitsang tse sebetsang), kahoo viscosity ea polymer e na le tšusumetso e kholo ho profil ea tokollo. Ka ho sebelisa hypromellose, lik'hamphani tsa meriana li ka sebelisa theknoloji ea letlapa la hydrophilic gel matrix ho fetola boemo ba ho lokolloa ha moriana, ho fana ka tekanyo e sebetsang haholoanyane le ho latela mokuli hamolemo, kahoo ho fokotsa moroalo oa meriana ho bakuli. Mokhoa oa ho noa meriana hang ka letsatsi ehlile o betere ho feta boiphihlelo ba ho noa matlapa a mangata makhetlo a 'maloa ka letsatsi.
Nako ea poso: Apr-25-2024