Indastering ea meriana, hypromellose (Hpmc, Methocel ™) o ka sebelisoa e le filler, Binder, e apereng polymer le senotlolo sa ho laola ho lokolloa ha lithethefatsi. Hypromelllose e sebelisitsoe litafole ka lilemo tse fetang 60 mme ke ntho ea bohlokoa haholo e sebelisoang hohle ho hydrophilic gel matrix matlapa a hydrophilic gel matrix.
Likhamphani tse ngata tsa meriana li sebelisa hypromellolisese bakeng sa ho lokolloa ha lithethefatsi tse laoloang, haholo-holo ho hydrophilication lifono tsa mabitla a hydrophilic. Ha ho tluoa ka lihlahisoa tsa hypromelllose, u ka 'na ua ipotsa hore na u ka etsa khetho - haholo-holo haeba u batla ho hong ho hoteloang ho ngola le ho boloka lengolo la bareki. Tataisong ena, re tla bua ka lintho tsa bohlokoa tseo u hlokang ho li tseba ka hypromellose.
Hypromellose ke eng?
Hypromellose, hape e tsejoang ka joaloHydroxypropypropyLese (HPMC), na polymer e sebelisoa e le tlholisano ea meriana ea ho laola lithethefatsi ho tloha ka li-hydrophili matlapa a oral hydrophilic.
Hypromelllose ke ntho e ngotsoeng ka letsoho ea maiketsetso e tsoang celluddlese, polymer e ngata ka ho fetisisa ea tlhaho. Tse ling tsa thepa ea eona e tloaelehileng li kenyelletsa:
. ho qhibiliha ka metsing a batang
. e sa khathatse ka metsing a chesang
. UnionIC
. Ka mokhoa o ikhethileng ka li-solvents tsa khale
. Phetoho e Phethahetseng, Thepa ea Khauta ea Gel
. HYDRATE le pono e ikemetseng e ikemetseng ea PH
. Surfital
. e seng chefo
. Tatso le monko o bobebe
. Enzyme harona
. PH (2-13) e tsitsitseng
. E ka sebelisoa e le bolo ea thickener, emulfier, e tlama, e be morekisi, filimi e nakong e teng
Letlapa la hydrophilic gel matrix ke eng?
Letlapa la hydrophilic ke sebopeho sa drasage se ka laolang ho lokolloa ha lithethefatsi letlalong nako e telele.
Pydrophilic Gel Matrix Taolo ea Letlapa la Hydrophilic
. bonolo haholo
. E hloka lisebelisoa tse tloaelehileng tsa letlapa le tloaelehileng
. Thibela ho lahla lithethefatsi
. Ha e angoe ke matla a matla a lehong kapa ho qobella
. Ho lokolloa ha lithethefatsi ho ka fetoloa ho latela palo ea li-mokhethoa le polymer
Tšebeliso ea hypromellose ho hyprophphilic gel-gel-matrix matlamo a maholo a ho sebelisa le ho loketse ho sebelisoa le ho ba le rekoto e ntle ea polokeho. Hyppromellose e fetohile khetho e ntle bakeng sa lik'hamphani tsa meriana ho ntlafala le ho hlahisa matlapa a tokollo e lokollotsoeng.
Lintho tse amang matlotlo a lithethefatsi ho tloha litafoleng tsa matrix:
Ha re ntse re rala lebathepo e atolositsoeng-tokollo, ho na le lintlha tse peli tsa bohlokoa tseo u lokelang ho nahana ka tsona: Ho theha le ho li sebetsa. Ho boetse ho na le lintlha tse tlase tseo u lokelang ho nahana ka ho khetha ho theha le profeto ea lithethefatsi tsa lithethefatsi.
Foromo:
Lintlha tsa Bohlokoa Tseo U Lokelang ho li Bukae Bakeng sa Nts'etsopele ea Pele:
1. Polymer (mofuta oa sebaka, Viscosity, palo le boholo ba karolo)
2. Lithethefatsi (boholo ba litšoantšo le solubility)
3. Li-agents (tsa tuubility le Dosage)
4. Litsebi tse ling (li-stabilizer le li-buffers)
Craft:
Lintho tsena li amana le hore na sethethefatsi se entsoe joang:
1. Mekhoa ea tlhahiso
2. Boholo ba Letlapa le sebopeho
3. Matla a matala
4. Tikoloho ea PH
5. Coating Filimi
Li-chip tsa Skeleton li sebetsa joang:
Matlapa a hydrophilic a ka laola tšebeliso ea lithethefatsi ka lebaka la litlolo tse peli tsa lekhetho (metsoako e 'meli), ka hona pono ea polymer e na le tšusumetso e kholo ho profil. Ho sebelisa hypromelllose, mekhabiso ea meriana e ka sebelisa hydrophphili theknoloji ea motlakase oa hydrophilic tolate Mokhoa oa ho nka moriana hang ka letsatsi e hantle ho feta boiphihlelo ba ho nka litapa tsa makhetlo a 'maloa ka letsatsi.
Nako ea ho romella: April 25-2024